Research ArticleArticle
Effects of Cytochrome P450 2C9 Polymorphism on Bosentan Metabolism
Mengchun Chen, Youting Zhang, Peipei Pan, Li Wang, Yunyun Zhan, Hui Jin, Mengmin Xia, Xianqin Wang, Dapeng Dai, Jianping Cai and Guoxin Hu
Drug Metabolism and Disposition November 2014, 42 (11) 1820-1825; DOI: https://doi.org/10.1124/dmd.114.060244
Mengchun Chen
School of Pharmacy of Wenzhou Medical University, Wenzhou (M.C., P.P., L.W., Y.Y.Z., H.J., M.X., X.W., G.H.), the 2nd Affiliated Hospital, Wenzhou Medical University, Wenzhou (Y.T.Z.), and the Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China (D.D., J.C.)
Youting Zhang
School of Pharmacy of Wenzhou Medical University, Wenzhou (M.C., P.P., L.W., Y.Y.Z., H.J., M.X., X.W., G.H.), the 2nd Affiliated Hospital, Wenzhou Medical University, Wenzhou (Y.T.Z.), and the Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China (D.D., J.C.)
Peipei Pan
School of Pharmacy of Wenzhou Medical University, Wenzhou (M.C., P.P., L.W., Y.Y.Z., H.J., M.X., X.W., G.H.), the 2nd Affiliated Hospital, Wenzhou Medical University, Wenzhou (Y.T.Z.), and the Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China (D.D., J.C.)
Li Wang
School of Pharmacy of Wenzhou Medical University, Wenzhou (M.C., P.P., L.W., Y.Y.Z., H.J., M.X., X.W., G.H.), the 2nd Affiliated Hospital, Wenzhou Medical University, Wenzhou (Y.T.Z.), and the Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China (D.D., J.C.)
Yunyun Zhan
School of Pharmacy of Wenzhou Medical University, Wenzhou (M.C., P.P., L.W., Y.Y.Z., H.J., M.X., X.W., G.H.), the 2nd Affiliated Hospital, Wenzhou Medical University, Wenzhou (Y.T.Z.), and the Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China (D.D., J.C.)
Hui Jin
School of Pharmacy of Wenzhou Medical University, Wenzhou (M.C., P.P., L.W., Y.Y.Z., H.J., M.X., X.W., G.H.), the 2nd Affiliated Hospital, Wenzhou Medical University, Wenzhou (Y.T.Z.), and the Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China (D.D., J.C.)
Mengmin Xia
School of Pharmacy of Wenzhou Medical University, Wenzhou (M.C., P.P., L.W., Y.Y.Z., H.J., M.X., X.W., G.H.), the 2nd Affiliated Hospital, Wenzhou Medical University, Wenzhou (Y.T.Z.), and the Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China (D.D., J.C.)
Xianqin Wang
School of Pharmacy of Wenzhou Medical University, Wenzhou (M.C., P.P., L.W., Y.Y.Z., H.J., M.X., X.W., G.H.), the 2nd Affiliated Hospital, Wenzhou Medical University, Wenzhou (Y.T.Z.), and the Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China (D.D., J.C.)
Dapeng Dai
School of Pharmacy of Wenzhou Medical University, Wenzhou (M.C., P.P., L.W., Y.Y.Z., H.J., M.X., X.W., G.H.), the 2nd Affiliated Hospital, Wenzhou Medical University, Wenzhou (Y.T.Z.), and the Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China (D.D., J.C.)
Jianping Cai
School of Pharmacy of Wenzhou Medical University, Wenzhou (M.C., P.P., L.W., Y.Y.Z., H.J., M.X., X.W., G.H.), the 2nd Affiliated Hospital, Wenzhou Medical University, Wenzhou (Y.T.Z.), and the Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China (D.D., J.C.)
Guoxin Hu
School of Pharmacy of Wenzhou Medical University, Wenzhou (M.C., P.P., L.W., Y.Y.Z., H.J., M.X., X.W., G.H.), the 2nd Affiliated Hospital, Wenzhou Medical University, Wenzhou (Y.T.Z.), and the Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China (D.D., J.C.)

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Research ArticleArticle
CYP2C9; Genetic Polymorphism; Bosentan Metabolism
Mengchun Chen, Youting Zhang, Peipei Pan, Li Wang, Yunyun Zhan, Hui Jin, Mengmin Xia, Xianqin Wang, Dapeng Dai, Jianping Cai and Guoxin Hu
Drug Metabolism and Disposition November 1, 2014, 42 (11) 1820-1825; DOI: https://doi.org/10.1124/dmd.114.060244
Research ArticleArticle
CYP2C9; Genetic Polymorphism; Bosentan Metabolism
Mengchun Chen, Youting Zhang, Peipei Pan, Li Wang, Yunyun Zhan, Hui Jin, Mengmin Xia, Xianqin Wang, Dapeng Dai, Jianping Cai and Guoxin Hu
Drug Metabolism and Disposition November 1, 2014, 42 (11) 1820-1825; DOI: https://doi.org/10.1124/dmd.114.060244