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Research ArticleSpecial Section on DMPK of Therapeutic Proteins—Minireview

Application of FcRn Binding Assays to Guide mAb Development

Amita Datta-Mannan and Victor J. Wroblewski
Drug Metabolism and Disposition November 2014, 42 (11) 1867-1872; DOI: https://doi.org/10.1124/dmd.114.059089
Amita Datta-Mannan
Department of Drug Disposition Development/Commercialization, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana
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Victor J. Wroblewski
Department of Drug Disposition Development/Commercialization, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana
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Article Information

vol. 42 no. 11 1867-1872
DOI 
https://doi.org/10.1124/dmd.114.059089
PubMed 
25024401

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 15, 2014
  • Accepted July 14, 2014
  • Published online September 29, 2014.

Article Versions

  • Earlier version (July 14, 2014 - 10:25).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Amita Datta-Mannan and
  2. Victor J. Wroblewski
  1. Department of Drug Disposition Development/Commercialization, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana
  1. Address correspondence to:
    Dr. Amita Datta-Mannan or Dr. Victor J. Wroblewski, Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285. E-mail: datta_amita{at}lilly.com or wroblewski_victor{at}lilly.com
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Drug Metabolism and Disposition: 42 (11)
Drug Metabolism and Disposition
Vol. 42, Issue 11
1 Nov 2014
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Research ArticleSpecial Section on DMPK of Therapeutic Proteins—Minireview

FcRn Binding Assays and mAb Development

Amita Datta-Mannan and Victor J. Wroblewski
Drug Metabolism and Disposition November 1, 2014, 42 (11) 1867-1872; DOI: https://doi.org/10.1124/dmd.114.059089

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Research ArticleSpecial Section on DMPK of Therapeutic Proteins—Minireview

FcRn Binding Assays and mAb Development

Amita Datta-Mannan and Victor J. Wroblewski
Drug Metabolism and Disposition November 1, 2014, 42 (11) 1867-1872; DOI: https://doi.org/10.1124/dmd.114.059089
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  • Article
    • Abstract
    • Introduction
    • The Receptor Interaction Assays
    • Applications and Interpretations of FcRn Binding Assays toward Understanding mAb Pharmacokinetics
    • Leveraging FcRn Binding Assays in an Integrated Manner
    • Summary and Future Perspectives
    • Footnotes
    • Abbreviations
    • References
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  • ADME Considerations for Antibody-Drug Conjugates
  • PK Modeling of Subcutaneous Absorption of Biotherapeutics
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