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Research ArticleSpecial Section on DMPK of Therapeutic Proteins

Evaluation of Near Infrared Fluorescent Labeling of Monoclonal Antibodies as a Tool for Tissue Distribution

Kip P. Conner, Brooke M. Rock, Gayle K. Kwon, Joseph P. Balthasar, Lubna Abuqayyas, Larry C. Wienkers and Dan A. Rock
Drug Metabolism and Disposition November 2014, 42 (11) 1906-1913; DOI: https://doi.org/10.1124/dmd.114.060319
Kip P. Conner
Biochemistry and Biophysics Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (K.P.C., B.M.R., G.K.K., L.C.W., D.A.R.); Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York (J.P.B.); and Quantitative Pharmacology Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (L.A.)
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Brooke M. Rock
Biochemistry and Biophysics Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (K.P.C., B.M.R., G.K.K., L.C.W., D.A.R.); Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York (J.P.B.); and Quantitative Pharmacology Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (L.A.)
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Gayle K. Kwon
Biochemistry and Biophysics Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (K.P.C., B.M.R., G.K.K., L.C.W., D.A.R.); Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York (J.P.B.); and Quantitative Pharmacology Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (L.A.)
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Joseph P. Balthasar
Biochemistry and Biophysics Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (K.P.C., B.M.R., G.K.K., L.C.W., D.A.R.); Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York (J.P.B.); and Quantitative Pharmacology Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (L.A.)
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Lubna Abuqayyas
Biochemistry and Biophysics Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (K.P.C., B.M.R., G.K.K., L.C.W., D.A.R.); Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York (J.P.B.); and Quantitative Pharmacology Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (L.A.)
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Larry C. Wienkers
Biochemistry and Biophysics Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (K.P.C., B.M.R., G.K.K., L.C.W., D.A.R.); Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York (J.P.B.); and Quantitative Pharmacology Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (L.A.)
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Dan A. Rock
Biochemistry and Biophysics Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (K.P.C., B.M.R., G.K.K., L.C.W., D.A.R.); Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York (J.P.B.); and Quantitative Pharmacology Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (L.A.)
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Article Information

vol. 42 no. 11 1906-1913
DOI 
https://doi.org/10.1124/dmd.114.060319
PubMed 
25209366

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 30, 2014
  • Accepted September 8, 2014
  • Published online September 29, 2014.

Article Versions

  • Earlier version (September 10, 2014 - 08:48).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kip P. Conner,
  2. Brooke M. Rock,
  3. Gayle K. Kwon,
  4. Joseph P. Balthasar,
  5. Lubna Abuqayyas,
  6. Larry C. Wienkers, and
  7. Dan A. Rock
  1. Biochemistry and Biophysics Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (K.P.C., B.M.R., G.K.K., L.C.W., D.A.R.); Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York (J.P.B.); and Quantitative Pharmacology Group in Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (L.A.)
  1. Address correspondence to:
    Dr. Dan A Rock, 1201 Amgen Court West, Seattle, WA 98119. E-mail: drock{at}amgen.com
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Drug Metabolism and Disposition: 42 (11)
Drug Metabolism and Disposition
Vol. 42, Issue 11
1 Nov 2014
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Research ArticleSpecial Section on DMPK of Therapeutic Proteins

Near IR Labeling for Tissue Distribution

Kip P. Conner, Brooke M. Rock, Gayle K. Kwon, Joseph P. Balthasar, Lubna Abuqayyas, Larry C. Wienkers and Dan A. Rock
Drug Metabolism and Disposition November 1, 2014, 42 (11) 1906-1913; DOI: https://doi.org/10.1124/dmd.114.060319

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Research ArticleSpecial Section on DMPK of Therapeutic Proteins

Near IR Labeling for Tissue Distribution

Kip P. Conner, Brooke M. Rock, Gayle K. Kwon, Joseph P. Balthasar, Lubna Abuqayyas, Larry C. Wienkers and Dan A. Rock
Drug Metabolism and Disposition November 1, 2014, 42 (11) 1906-1913; DOI: https://doi.org/10.1124/dmd.114.060319
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