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Research ArticleArticle

Metabolites in Safety Testing Assessment in Early Clinical Development: A Case Study with a Glucokinase Activator

Raman Sharma, John Litchfield, Karen Atkinson, Heather Eng, Neeta B. Amin, William S. Denney, John C. Pettersen, Theunis C. Goosen, Li Di, Esther Lee, Jeffrey A. Pfefferkorn, Deepak K. Dalvie and Amit S. Kalgutkar
Drug Metabolism and Disposition November 2014, 42 (11) 1926-1939; DOI: https://doi.org/10.1124/dmd.114.060087

Article Information

vol. 42 no. 11 1926-1939
DOI 
https://doi.org/10.1124/dmd.114.060087
PubMed 
25142735
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 16, 2014
  • Accepted August 19, 2014
  • Published online October 1, 2014.

Article Versions

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Raman Sharma,
  2. John Litchfield,
  3. Karen Atkinson,
  4. Heather Eng,
  5. Neeta B. Amin,
  6. William S. Denney,
  7. John C. Pettersen,
  8. Theunis C. Goosen,
  9. Li Di,
  10. Esther Lee,
  11. Jeffrey A. Pfefferkorn,
  12. Deepak K. Dalvie, and
  13. Amit S. Kalgutkar
  1. Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)
  1. Address correspondence to:
    Amit S. Kalgutkar, Pharmacokinetics, Dynamics, and Metabolism-New Chemical Entities, Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, MA 02139. E-mail: amit.kalgutkar{at}pfizer.com
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MIST Analysis of a Glucokinase Activator

Raman Sharma, John Litchfield, Karen Atkinson, Heather Eng, Neeta B. Amin, William S. Denney, John C. Pettersen, Theunis C. Goosen, Li Di, Esther Lee, Jeffrey A. Pfefferkorn, Deepak K. Dalvie and Amit S. Kalgutkar
Drug Metabolism and Disposition November 1, 2014, 42 (11) 1926-1939; DOI: https://doi.org/10.1124/dmd.114.060087
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