Research ArticleArticle
Metabolites in Safety Testing Assessment in Early Clinical Development: A Case Study with a Glucokinase Activator
Raman Sharma, John Litchfield, Karen Atkinson, Heather Eng, Neeta B. Amin, William S. Denney, John C. Pettersen, Theunis C. Goosen, Li Di, Esther Lee, Jeffrey A. Pfefferkorn, Deepak K. Dalvie and Amit S. Kalgutkar
Drug Metabolism and Disposition November 2014, 42 (11) 1926-1939; DOI: https://doi.org/10.1124/dmd.114.060087
Raman Sharma
Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)
John Litchfield
Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)
Karen Atkinson
Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)
Heather Eng
Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)
Neeta B. Amin
Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)
William S. Denney
Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)
John C. Pettersen
Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)
Theunis C. Goosen
Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)
Li Di
Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)
Esther Lee
Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)
Jeffrey A. Pfefferkorn
Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)
Deepak K. Dalvie
Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)
Amit S. Kalgutkar
Pfizer Inc., Groton, Connecticut (R.S., K.A., H.E., J.C.P., T.C.G., L.D.), San Diego, California (D.K.D.), and Cambridge, Massachusetts (J.L., N.B.A., W.S.D., E.L., J.A.P., A.S.K.)

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Research ArticleArticle
MIST Analysis of a Glucokinase Activator
Raman Sharma, John Litchfield, Karen Atkinson, Heather Eng, Neeta B. Amin, William S. Denney, John C. Pettersen, Theunis C. Goosen, Li Di, Esther Lee, Jeffrey A. Pfefferkorn, Deepak K. Dalvie and Amit S. Kalgutkar
Drug Metabolism and Disposition November 1, 2014, 42 (11) 1926-1939; DOI: https://doi.org/10.1124/dmd.114.060087
Research ArticleArticle
MIST Analysis of a Glucokinase Activator
Raman Sharma, John Litchfield, Karen Atkinson, Heather Eng, Neeta B. Amin, William S. Denney, John C. Pettersen, Theunis C. Goosen, Li Di, Esther Lee, Jeffrey A. Pfefferkorn, Deepak K. Dalvie and Amit S. Kalgutkar
Drug Metabolism and Disposition November 1, 2014, 42 (11) 1926-1939; DOI: https://doi.org/10.1124/dmd.114.060087
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