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Drug Metabolism & Disposition

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Table of Contents

December 01, 2014; Volume 42,Issue 12

Minireview

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    Drug Disposition and Drug-Drug Interaction Data in 2013 FDA New Drug Applications: A Systematic Review
    Jingjing Yu, Tasha K. Ritchie, Aditi Mulgaonkar and Isabelle Ragueneau-Majlessi
    Drug Metabolism and Disposition December 2014, 42 (12) 1991-2001; DOI: https://doi.org/10.1124/dmd.114.060392

Short Communication

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    Systematic Identification and Characterization of Carboxylesterases in Cynomolgus Macaques
    Yasuhiro Uno, Shotaro Uehara, Masakiyo Hosokawa and Teruko Imai
    Drug Metabolism and Disposition December 2014, 42 (12) 2002-2006; DOI: https://doi.org/10.1124/dmd.114.059972

Symposium Report

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    Role of (Drug) Transporters in Imaging in Health and Disease
    Bruno Stieger, Jashvant D. Unadkat, Bhagwat Prasad, Oliver Langer and Hariprasad Gali
    Drug Metabolism and Disposition December 2014, 42 (12) 2007-2015; DOI: https://doi.org/10.1124/dmd.114.059873

Articles

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    Wuzhi Tablet (Schisandra Sphenanthera Extract) Protects against Acetaminophen-Induced Hepatotoxicity by Inhibition of CYP-Mediated Bioactivation and Regulation of NRF2-ARE and p53/p21 Pathways
    Xiaomei Fan, Yiming Jiang, Ying Wang, Huasen Tan, Hang Zeng, Yongtao Wang, Pan Chen, Aijuan Qu, Frank J. Gonzalez, Min Huang and Huichang Bi
    Drug Metabolism and Disposition December 2014, 42 (12) 1982-1990; DOI: https://doi.org/10.1124/dmd.114.059535
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    Meta-Analysis of the Turnover of Intestinal Epithelia in Preclinical Animal Species and Humans
    Adam S. Darwich, Umair Aslam, Darren M. Ashcroft and Amin Rostami-Hodjegan
    Drug Metabolism and Disposition December 2014, 42 (12) 2016-2022; DOI: https://doi.org/10.1124/dmd.114.058404
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    Disposition and Metabolic Profiling of [14C]Cerlapirdine Using Accelerator Mass Spectrometry
    Susanna Tse, Louis Leung, Sangeeta Raje, Mark Seymour, Yoko Shishikura and R. Scott Obach
    Drug Metabolism and Disposition December 2014, 42 (12) 2023-2032; DOI: https://doi.org/10.1124/dmd.114.059675
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    Differential Expression of Drug Uptake and Efflux Transporters in Japanese Patients with Hepatocellular Carcinoma
    Tadashi Namisaki, Elke Schaeffeler, Hiroshi Fukui, Hitoshi Yoshiji, Yoshiyuki Nakajima, Peter Fritz, Matthias Schwab and Anne T. Nies
    Drug Metabolism and Disposition December 2014, 42 (12) 2033-2040; DOI: https://doi.org/10.1124/dmd.114.059832
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    Proton Pump Inhibitors Inhibit Methotrexate Transport by Renal Basolateral Organic Anion Transporter hOAT3
    Rym Chioukh, Marie-Sophie Noel-Hudson, Sandy Ribes, Natalie Fournier, Laurent Becquemont and Celine Verstuyft
    Drug Metabolism and Disposition December 2014, 42 (12) 2041-2048; DOI: https://doi.org/10.1124/dmd.114.058529
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    Aldehyde Oxidase Activity in Fresh Human Skin
    Nenad Manevski, Kamal Kumar Balavenkatraman, Barbara Bertschi, Piet Swart, Markus Walles, Gian Camenisch, Hilmar Schiller, Olivier Kretz, Barbara Ling, Reto Wettstein, Dirk J. Schaefer, Francois Pognan, Armin Wolf and Karine Litherland
    Drug Metabolism and Disposition December 2014, 42 (12) 2049-2057; DOI: https://doi.org/10.1124/dmd.114.060368
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    In Vitro Metabolism and Drug-Drug Interaction Potential of UTL-5g, a Novel Chemo- and Radioprotective Agent
    Jianmei Wu, Jiajiu Shaw, Sarah Dubaisi, Frederick Valeriote and Jing Li
    Drug Metabolism and Disposition December 2014, 42 (12) 2058-2067; DOI: https://doi.org/10.1124/dmd.114.060095
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    Paroxetine Markedly Increases Plasma Concentrations of Ophthalmic Timolol; CYP2D6 Inhibitors May Increase the Risk of Cardiovascular Adverse Effects of 0.5% Timolol Eye Drops
    Jukka Mäenpää, Marjo Volotinen-Maja, Hannu Kautiainen, Mikko Neuvonen, Mikko Niemi, Pertti J. Neuvonen and Janne T. Backman
    Drug Metabolism and Disposition December 2014, 42 (12) 2068-2076; DOI: https://doi.org/10.1124/dmd.114.059576
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    Effect of Prostaglandin E2 on Multidrug Resistance Transporters In Human Placental Cells
    Clifford W. Mason, Gene T. Lee, Yafeng Dong, Helen Zhou, Lily He and Carl P. Weiner
    Drug Metabolism and Disposition December 2014, 42 (12) 2077-2086; DOI: https://doi.org/10.1124/dmd.114.059477
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    Mechanism-Based Inactivation of Human Cytochrome P450 3A4 by Two Piperazine-Containing Compounds
    Amanda K. Bolles, Rina Fujiwara, Erran D. Briggs, Amin A. Nomeir and Laura Lowe Furge
    Drug Metabolism and Disposition December 2014, 42 (12) 2087-2096; DOI: https://doi.org/10.1124/dmd.114.060459
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    Enhanced Methamphetamine Metabolism in Rhesus Macaque as Compared with Human: An Analysis Using a Novel Method of Liquid Chromatography with Tandem Mass Spectrometry, Kinetic Study, and Substrate Docking
    Ravinder Earla, Santosh Kumar, Lei Wang, Steven Bosinger, Junhao Li, Ankit Shah, Mohitkumar Gangwani, Anantha Nookala, Xun Liu, Lu Cao, Austin Jackson, Peter S. Silverstein, Howard S. Fox, Weihua Li and Anil Kumar
    Drug Metabolism and Disposition December 2014, 42 (12) 2097-2108; DOI: https://doi.org/10.1124/dmd.114.059378
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    An Orphan Esterase ABHD10 Modulates Probenecid Acyl Glucuronidation in Human Liver
    Yusuke Ito, Tatsuki Fukami, Tsuyoshi Yokoi and Miki Nakajima
    Drug Metabolism and Disposition December 2014, 42 (12) 2109-2116; DOI: https://doi.org/10.1124/dmd.114.059485

Letters to the Editor

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    Breast Cancer Resistance Protein Substrate and Inhibition Evaluation: Why, When, and How?
    Joseph A. Ware, Bradley L. Urquhart, Yuichi Sugiyama and Maciej J. Zamek-Gliszczynski
    Drug Metabolism and Disposition December 2014, 42 (12) 1979-1980; DOI: https://doi.org/10.1124/dmd.114.060970
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    Response to “Breast Cancer Resistance Protein Substrate and Inhibition Evaluation: Why, When, and How?”
    Agnès Poirier, Mohammed Ullah and Christoph Funk
    Drug Metabolism and Disposition December 2014, 42 (12) 1981; DOI: https://doi.org/10.1124/dmd.114.061465
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In this issue

Drug Metabolism and Disposition: 42 (12)
Drug Metabolism and Disposition
Vol. 42, Issue 12
1 Dec 2014
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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