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Drug Metabolism & Disposition

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Cover Caption

About the cover: Expression of OCT3 protein in hepatocellular carcinoma and corresponding liver tissue. Immunohistochemical staining of drug uptake transporter OCT3 was performed on formalin-fixed and paraffin-embedded tissue samples from nontumor tissue (F) and HCC tissue of trabecular (G) or pseudoglandular (H) growth pattern. The median staining scores (blue horizontal lines) for OCT3 were significantly lower in HCC tissue than in nontumor tissue (E, P < 0.001). Scale bars, 20 μm. See the article by Namisaki et al. (dx.doi.org/10.1124/dmd.114.059832).

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Drug Metabolism and Disposition: 42 (12)
Drug Metabolism and Disposition
Vol. 42, Issue 12
1 Dec 2014
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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