Table of Contents

Articles

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  Identification of Carboxylesterase-Dependent Dabigatran Etexilate Hydrolysis

  S. Casey Laizure, Robert B. Parker, Vanessa L. Herring and Zhe-Yi Hu

  Drug Metabolism and Disposition February 2014, 42 (2) 201-206; DOI: https://doi.org/10.1124/dmd.113.054353
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  The Role of Lymphatic Transport on the Systemic Bioavailability of the Bcl-2 Protein Family Inhibitors Navitoclax (ABT-263) and ABT-199

  Edna F. Choo, Jason Boggs, Chunqiang Zhu, Joseph W. Lubach, Nathaniel D. Catron, Gary Jenkins, Andrew J. Souers and Richard Voorman

  Drug Metabolism and Disposition February 2014, 42 (2) 207-212; DOI: https://doi.org/10.1124/dmd.113.055053
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  CPY3A4-Mediated α-Hydroxyaldehyde Formation in Saquinavir Metabolism

  Feng Li, Jie Lu and Xiaochao Ma

  Drug Metabolism and Disposition February 2014, 42 (2) 213-220; DOI: https://doi.org/10.1124/dmd.113.054874
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  Protein Restoration in Low-Birth-Weight Rat Offspring Derived from Maternal Low-Protein Diet Leads to Elevated Hepatic CYP3A and CYP2C11 Activity in Adulthood

  Gurjeev Sohi, Eric J. Barry, Thomas J. Velenosi, Bradley L. Urquhart and Daniel B. Hardy

  Drug Metabolism and Disposition February 2014, 42 (2) 221-228; DOI: https://doi.org/10.1124/dmd.113.053538
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  Alteration of the Function of the UDP-Glucuronosyltransferase 1A Subfamily by Cytochrome P450 3A4: Different Susceptibility for UGT Isoforms and UGT1A1/7 Variants

  Yuji Ishii, Hiroki Koba, Kousuke Kinoshita, Toshiya Oizaki, Yuki Iwamoto, Shuso Takeda, Yuu Miyauchi, Yoshio Nishimura, Natsuki Egoshi, Futoshi Taura, Satoshi Morimoto, Shin’ichi Ikushiro, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie and Hideyuki Yamada

  Drug Metabolism and Disposition February 2014, 42 (2) 229-238; DOI: https://doi.org/10.1124/dmd.113.054833
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  Impact of Endogenous Esterase Activity on In Vitro P-Glycoprotein Profiling of Dabigatran Etexilate in Caco-2 Monolayers

  Naoki Ishiguro, Wataru Kishimoto, Astrid Volz, Eva Ludwig-Schwellinger, Thomas Ebner and Olaf Schaefer

  Drug Metabolism and Disposition February 2014, 42 (2) 250-256; DOI: https://doi.org/10.1124/dmd.113.053561
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  In Vitro Predictability of Drug-Drug Interaction Likelihood of P-Glycoprotein-Mediated Efflux of Dabigatran Etexilate Based on [I]₂/IC₅₀ Threshold

  Wataru Kishimoto, Naoki Ishiguro, Eva Ludwig-Schwellinger, Thomas Ebner and Olaf Schaefer

  Drug Metabolism and Disposition February 2014, 42 (2) 257-263; DOI: https://doi.org/10.1124/dmd.113.053769
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  Distinct Patterns of Aging Effects on the Expression and Activity of Carboxylesterases in Rat Liver and Intestine

  Kayoko Ohura, Katsumi Tasaka, Mitsuru Hashimoto and Teruko Imai

  Drug Metabolism and Disposition February 2014, 42 (2) 264-273; DOI: https://doi.org/10.1124/dmd.113.054551
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  Metabolism of Salvianolic Acid A and Antioxidant Activities of Its Methylated Metabolites

  Hui Xu, Yanli Li, Xin Che, Hongcui Tian, Huaying Fan and Ke Liu

  Drug Metabolism and Disposition February 2014, 42 (2) 274-281; DOI: https://doi.org/10.1124/dmd.113.053694
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  Enhanced Nicotine Metabolism in HIV-1–Positive Smokers Compared with HIV-Negative Smokers: Simultaneous Determination of Nicotine and its Four Metabolites in Their Plasma Using a Simple and Sensitive Electrospray Ionization Liquid Chromatography–Tandem Mass Spectrometry Technique

  Ravinder Earla, Anusha Ande, Carole McArthur, Anil Kumar and Santosh Kumar

  Drug Metabolism and Disposition February 2014, 42 (2) 282-293; DOI: https://doi.org/10.1124/dmd.113.055186
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  Increases in Levels of Epoxyeicosatrienoic and Dihydroxyeicosatrienoic Acids (EETs and DHETs) in Liver and Heart in Vivo by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and in Hepatic EET:DHET Ratios by Cotreatment with TCDD and the Soluble Epoxide Hydrolase Inhibitor AUDA

  Silvia Diani-Moore, Yuliang Ma, Steven S. Gross and Arleen B. Rifkind

  Drug Metabolism and Disposition February 2014, 42 (2) 294-300; DOI: https://doi.org/10.1124/dmd.113.055368