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Drug Metabolism & Disposition

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Table of Contents

February 01, 2014; Volume 42,Issue 2

Short Communications

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    Cytochrome P450 mRNA Expression in the Rodent Brain: Species-, Sex-, and Region-Dependent Differences
    Marianna Stamou, Xianai Wu, Izabela Kania-Korwel, Hans-Joachim Lehmler and Pamela J. Lein
    Drug Metabolism and Disposition February 2014, 42 (2) 239-244; DOI: https://doi.org/10.1124/dmd.113.054239
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    Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation
    Yanlin Zhu, Fen Wang, Quan Li, Mingshe Zhu, Alicia Du, Wei Tang and Weiqing Chen
    Drug Metabolism and Disposition February 2014, 42 (2) 245-249; DOI: https://doi.org/10.1124/dmd.113.055400

Articles

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    Identification of Carboxylesterase-Dependent Dabigatran Etexilate Hydrolysis
    S. Casey Laizure, Robert B. Parker, Vanessa L. Herring and Zhe-Yi Hu
    Drug Metabolism and Disposition February 2014, 42 (2) 201-206; DOI: https://doi.org/10.1124/dmd.113.054353
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    The Role of Lymphatic Transport on the Systemic Bioavailability of the Bcl-2 Protein Family Inhibitors Navitoclax (ABT-263) and ABT-199
    Edna F. Choo, Jason Boggs, Chunqiang Zhu, Joseph W. Lubach, Nathaniel D. Catron, Gary Jenkins, Andrew J. Souers and Richard Voorman
    Drug Metabolism and Disposition February 2014, 42 (2) 207-212; DOI: https://doi.org/10.1124/dmd.113.055053
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    CPY3A4-Mediated α-Hydroxyaldehyde Formation in Saquinavir Metabolism
    Feng Li, Jie Lu and Xiaochao Ma
    Drug Metabolism and Disposition February 2014, 42 (2) 213-220; DOI: https://doi.org/10.1124/dmd.113.054874
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    Protein Restoration in Low-Birth-Weight Rat Offspring Derived from Maternal Low-Protein Diet Leads to Elevated Hepatic CYP3A and CYP2C11 Activity in Adulthood
    Gurjeev Sohi, Eric J. Barry, Thomas J. Velenosi, Bradley L. Urquhart and Daniel B. Hardy
    Drug Metabolism and Disposition February 2014, 42 (2) 221-228; DOI: https://doi.org/10.1124/dmd.113.053538
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    Alteration of the Function of the UDP-Glucuronosyltransferase 1A Subfamily by Cytochrome P450 3A4: Different Susceptibility for UGT Isoforms and UGT1A1/7 Variants
    Yuji Ishii, Hiroki Koba, Kousuke Kinoshita, Toshiya Oizaki, Yuki Iwamoto, Shuso Takeda, Yuu Miyauchi, Yoshio Nishimura, Natsuki Egoshi, Futoshi Taura, Satoshi Morimoto, Shin’ichi Ikushiro, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie and Hideyuki Yamada
    Drug Metabolism and Disposition February 2014, 42 (2) 229-238; DOI: https://doi.org/10.1124/dmd.113.054833
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    Impact of Endogenous Esterase Activity on In Vitro P-Glycoprotein Profiling of Dabigatran Etexilate in Caco-2 Monolayers
    Naoki Ishiguro, Wataru Kishimoto, Astrid Volz, Eva Ludwig-Schwellinger, Thomas Ebner and Olaf Schaefer
    Drug Metabolism and Disposition February 2014, 42 (2) 250-256; DOI: https://doi.org/10.1124/dmd.113.053561
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    In Vitro Predictability of Drug-Drug Interaction Likelihood of P-Glycoprotein-Mediated Efflux of Dabigatran Etexilate Based on [I]2/IC50 Threshold
    Wataru Kishimoto, Naoki Ishiguro, Eva Ludwig-Schwellinger, Thomas Ebner and Olaf Schaefer
    Drug Metabolism and Disposition February 2014, 42 (2) 257-263; DOI: https://doi.org/10.1124/dmd.113.053769
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    Distinct Patterns of Aging Effects on the Expression and Activity of Carboxylesterases in Rat Liver and Intestine
    Kayoko Ohura, Katsumi Tasaka, Mitsuru Hashimoto and Teruko Imai
    Drug Metabolism and Disposition February 2014, 42 (2) 264-273; DOI: https://doi.org/10.1124/dmd.113.054551
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    Metabolism of Salvianolic Acid A and Antioxidant Activities of Its Methylated Metabolites
    Hui Xu, Yanli Li, Xin Che, Hongcui Tian, Huaying Fan and Ke Liu
    Drug Metabolism and Disposition February 2014, 42 (2) 274-281; DOI: https://doi.org/10.1124/dmd.113.053694
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    Enhanced Nicotine Metabolism in HIV-1–Positive Smokers Compared with HIV-Negative Smokers: Simultaneous Determination of Nicotine and its Four Metabolites in Their Plasma Using a Simple and Sensitive Electrospray Ionization Liquid Chromatography–Tandem Mass Spectrometry Technique
    Ravinder Earla, Anusha Ande, Carole McArthur, Anil Kumar and Santosh Kumar
    Drug Metabolism and Disposition February 2014, 42 (2) 282-293; DOI: https://doi.org/10.1124/dmd.113.055186
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    Increases in Levels of Epoxyeicosatrienoic and Dihydroxyeicosatrienoic Acids (EETs and DHETs) in Liver and Heart in Vivo by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and in Hepatic EET:DHET Ratios by Cotreatment with TCDD and the Soluble Epoxide Hydrolase Inhibitor AUDA
    Silvia Diani-Moore, Yuliang Ma, Steven S. Gross and Arleen B. Rifkind
    Drug Metabolism and Disposition February 2014, 42 (2) 294-300; DOI: https://doi.org/10.1124/dmd.113.055368
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Drug Metabolism and Disposition: 42 (2)
Drug Metabolism and Disposition
Vol. 42, Issue 2
1 Feb 2014
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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