Table of Contents

Articles

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  Alpha-Amylase Inhibitor, CS-1036 Binds to Serum Amylase in a Concentration-Dependent and Saturable Manner

  Tomohiro Honda, Yoko Kaneno-Urasaki, Takashi Ito, Takako Kimura, Nobuko Matsushima, Hiromi Okabe, Atsushi Yamasaki and Takashi Izumi

  Drug Metabolism and Disposition March 2014, 42 (3) 326-333; DOI: https://doi.org/10.1124/dmd.113.054452
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  Characterization of T-5 N-Oxide Formation as the First Highly Selective Measure of CYP3A5 Activity

  Xiaohai Li, Valer Jeso, Scott Heyward, Gregory S. Walker, Raman Sharma, Glenn C. Micalizio and Michael D. Cameron

  Drug Metabolism and Disposition March 2014, 42 (3) 334-342; DOI: https://doi.org/10.1124/dmd.113.054726
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  Investigations into the Mechanisms of Pyridine Ring Cleavage in Vismodegib

  S. Cyrus Khojasteh, Qin Yue, Shuguang Ma, Georgette Castanedo, Jacob Z Chen, Joseph Lyssikatos, Teresa Mulder, Ryan Takahashi, Justin Ly, Kirsten Messick, Wei Jia, Lichuan Liu, Cornelis E. C. A. Hop and Harvey Wong

  Drug Metabolism and Disposition March 2014, 42 (3) 343-351; DOI: https://doi.org/10.1124/dmd.113.055715
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  Expression of the Orphan Cytosolic Sulfotransferase SULT1C3 in Human Intestine: Characterization of the Transcript Variant and Implications for Function

  Zofia Duniec-Dmuchowski, Elizabeth A. Rondini, Zachary E. Tibbs, Charles N. Falany, Melissa Runge-Morris and Thomas A. Kocarek

  Drug Metabolism and Disposition March 2014, 42 (3) 352-360; DOI: https://doi.org/10.1124/dmd.113.055665
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  Regulation of Human Cytosolic Sulfotransferases 1C2 and 1C3 by Nuclear Signaling Pathways in LS180 Colorectal Adenocarcinoma Cells

  Elizabeth A. Rondini, Hailin Fang, Melissa Runge-Morris and Thomas A. Kocarek

  Drug Metabolism and Disposition March 2014, 42 (3) 361-368; DOI: https://doi.org/10.1124/dmd.113.055673
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  Expression and Characterization of Cynomolgus Monkey Cytochrome CYP3A4 in a Novel Human Embryonic Kidney Cell–Based Mammalian System

  Sindhuja Selvakumar, Priyadeep Bhutani, Kaushik Ghosh, Prasad Krishnamurthy, Sanjith Kallipatti, Sabariya Selvam, Manjunath Ramarao, Sandhya Mandlekar, Michael W. Sinz, A. David Rodrigues and Murali Subramanian

  Drug Metabolism and Disposition March 2014, 42 (3) 369-376; DOI: https://doi.org/10.1124/dmd.113.055491
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  Interaction of Human Arylamine N-Acetyltransferase 1 with Different Nanomaterials

  Zhou J. Deng, Neville J. Butcher, Gysell M. Mortimer, Zhongfan Jia, Michael J. Monteiro, Darren J. Martin and Rodney F. Minchin

  Drug Metabolism and Disposition March 2014, 42 (3) 377-383; DOI: https://doi.org/10.1124/dmd.113.055988
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  Enzyme-Transporter Interplay in the Formation and Clearance of Abundant Metabolites of Faldaprevir Found in Excreta but not in Circulation

  Yongmei Li, Jin Zhou, Diane Ramsden, Mitchell E. Taub, Drané O'Brien, Jun Xu, Carl A. Busacca, Nina Gonnella and Donald J. Tweedie

  Drug Metabolism and Disposition March 2014, 42 (3) 384-393; DOI: https://doi.org/10.1124/dmd.113.055863
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  Bridging In Vitro and In Vivo Metabolism and Transport of Faldaprevir in Human Using a Novel Cocultured Human Hepatocyte System, HepatoPac

  Diane Ramsden, Donald J. Tweedie, Tom S. Chan, Mitchell E. Taub and Yongmei Li

  Drug Metabolism and Disposition March 2014, 42 (3) 394-406; DOI: https://doi.org/10.1124/dmd.113.055897
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  Generating an In Vitro–In Vivo Correlation for Metabolism and Liver Enrichment of a Hepatitis C Virus Drug, Faldaprevir, Using a Rat Hepatocyte Model (HepatoPac)

  Diane Ramsden, Donald J. Tweedie, Roger St. George, Lin-Zhi Chen and Yongmei Li

  Drug Metabolism and Disposition March 2014, 42 (3) 407-414; DOI: https://doi.org/10.1124/dmd.113.055947
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  Disposition and Metabolism of Darapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, in Humans

  Mehul Dave, Mike Nash, Graeme C. Young, Harma Ellens, Mindy H. Magee, Andrew D. Roberts, Maxine A. Taylor, Robert W. Greenhill and Gary W. Boyle

  Drug Metabolism and Disposition March 2014, 42 (3) 415-430; DOI: https://doi.org/10.1124/dmd.113.054486
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  Biodistribution and Metabolism Studies of Lipid Nanoparticle–Formulated Internally [³H]-Labeled siRNA in Mice

  Jesper Christensen, Karine Litherland, Thomas Faller, Esther van de Kerkhof, François Natt, Jürg Hunziker, Julien Boos, Iwan Beuvink, Keith Bowman, Jeremy Baryza, Mike Beverly, Chandra Vargeese, Olivier Heudi, Markus Stoeckli, Joel Krauser and Piet Swart

  Drug Metabolism and Disposition March 2014, 42 (3) 431-440; DOI: https://doi.org/10.1124/dmd.113.055434
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  Cytochrome P450 Inhibitory Properties of Common Efflux Transporter Inhibitors

  Gunilla Englund, Patrik Lundquist, Cristine Skogastierna, Jenny Johansson, Janet Hoogstraate, Lovisa Afzelius, Tommy B. Andersson and Denis Projean

  Drug Metabolism and Disposition March 2014, 42 (3) 441-447; DOI: https://doi.org/10.1124/dmd.113.054932
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  Functional ATP-Binding Cassette Drug Efflux Transporters in Isolated Human and Rat Hepatocytes Significantly Affect Assessment of Drug Disposition

  Patrik Lundquist, Gunilla Englund, Cristine Skogastierna, Johan Lööf, Jenny Johansson, Janet Hoogstraate, Lovisa Afzelius and Tommy B. Andersson

  Drug Metabolism and Disposition March 2014, 42 (3) 448-458; DOI: https://doi.org/10.1124/dmd.113.054528
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  Prediction of In Vivo Rat Biliary Drug Clearance from an In Vitro Hepatocyte Efflux Model

  Patrik Lundquist, Johan Lööf, Urban Fagerholm, Ingemo Sjögren, Jenny Johansson, Sveinn Briem, Janet Hoogstraate, Lovisa Afzelius and Tommy B. Andersson

  Drug Metabolism and Disposition March 2014, 42 (3) 459-468; DOI: https://doi.org/10.1124/dmd.113.054155
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  The Impact of Solute Carrier (SLC) Drug Uptake Transporter Loss in Human and Rat Cryopreserved Hepatocytes on Clearance Predictions

  Patrik Lundquist, Johan Lööf, Anna-Karin Sohlenius-Sternbeck, Eva Floby, Jenny Johansson, Johan Bylund, Janet Hoogstraate, Lovisa Afzelius and Tommy B. Andersson

  Drug Metabolism and Disposition March 2014, 42 (3) 469-480; DOI: https://doi.org/10.1124/dmd.113.054676