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Drug Metabolism & Disposition

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Table of Contents

March 01, 2014; Volume 42,Issue 3

Perspective

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    Herb–Drug Interactions: Challenges and Opportunities for Improved Predictions
    Scott J. Brantley, Aneesh A. Argikar, Yvonne S. Lin, Swati Nagar and Mary F. Paine
    Drug Metabolism and Disposition March 2014, 42 (3) 301-317; DOI: https://doi.org/10.1124/dmd.113.055236

Short Communications

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    The Role of Bile Salt Export Pump Gene Repression in Drug-Induced Cholestatic Liver Toxicity
    Brandy Garzel, Hui Yang, Lei Zhang, Shiew-Mei Huang, James E. Polli and Hongbing Wang
    Drug Metabolism and Disposition March 2014, 42 (3) 318-322; DOI: https://doi.org/10.1124/dmd.113.054189
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    An Ethinyl Estradiol-Levonorgestrel Containing Oral Contraceptive Does Not Alter Cytochrome P4502C9 In Vivo Activity
    Ganesh Cherala, Jacob Pearson, Cheryl Maslen and Alison Edelman
    Drug Metabolism and Disposition March 2014, 42 (3) 323-325; DOI: https://doi.org/10.1124/dmd.113.054346

Articles

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    Alpha-Amylase Inhibitor, CS-1036 Binds to Serum Amylase in a Concentration-Dependent and Saturable Manner
    Tomohiro Honda, Yoko Kaneno-Urasaki, Takashi Ito, Takako Kimura, Nobuko Matsushima, Hiromi Okabe, Atsushi Yamasaki and Takashi Izumi
    Drug Metabolism and Disposition March 2014, 42 (3) 326-333; DOI: https://doi.org/10.1124/dmd.113.054452
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    Characterization of T-5 N-Oxide Formation as the First Highly Selective Measure of CYP3A5 Activity
    Xiaohai Li, Valer Jeso, Scott Heyward, Gregory S. Walker, Raman Sharma, Glenn C. Micalizio and Michael D. Cameron
    Drug Metabolism and Disposition March 2014, 42 (3) 334-342; DOI: https://doi.org/10.1124/dmd.113.054726
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    Investigations into the Mechanisms of Pyridine Ring Cleavage in Vismodegib
    S. Cyrus Khojasteh, Qin Yue, Shuguang Ma, Georgette Castanedo, Jacob Z Chen, Joseph Lyssikatos, Teresa Mulder, Ryan Takahashi, Justin Ly, Kirsten Messick, Wei Jia, Lichuan Liu, Cornelis E. C. A. Hop and Harvey Wong
    Drug Metabolism and Disposition March 2014, 42 (3) 343-351; DOI: https://doi.org/10.1124/dmd.113.055715
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    Expression of the Orphan Cytosolic Sulfotransferase SULT1C3 in Human Intestine: Characterization of the Transcript Variant and Implications for Function
    Zofia Duniec-Dmuchowski, Elizabeth A. Rondini, Zachary E. Tibbs, Charles N. Falany, Melissa Runge-Morris and Thomas A. Kocarek
    Drug Metabolism and Disposition March 2014, 42 (3) 352-360; DOI: https://doi.org/10.1124/dmd.113.055665
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    Regulation of Human Cytosolic Sulfotransferases 1C2 and 1C3 by Nuclear Signaling Pathways in LS180 Colorectal Adenocarcinoma Cells
    Elizabeth A. Rondini, Hailin Fang, Melissa Runge-Morris and Thomas A. Kocarek
    Drug Metabolism and Disposition March 2014, 42 (3) 361-368; DOI: https://doi.org/10.1124/dmd.113.055673
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    Expression and Characterization of Cynomolgus Monkey Cytochrome CYP3A4 in a Novel Human Embryonic Kidney Cell–Based Mammalian System
    Sindhuja Selvakumar, Priyadeep Bhutani, Kaushik Ghosh, Prasad Krishnamurthy, Sanjith Kallipatti, Sabariya Selvam, Manjunath Ramarao, Sandhya Mandlekar, Michael W. Sinz, A. David Rodrigues and Murali Subramanian
    Drug Metabolism and Disposition March 2014, 42 (3) 369-376; DOI: https://doi.org/10.1124/dmd.113.055491
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    Interaction of Human Arylamine N-Acetyltransferase 1 with Different Nanomaterials
    Zhou J. Deng, Neville J. Butcher, Gysell M. Mortimer, Zhongfan Jia, Michael J. Monteiro, Darren J. Martin and Rodney F. Minchin
    Drug Metabolism and Disposition March 2014, 42 (3) 377-383; DOI: https://doi.org/10.1124/dmd.113.055988
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    Enzyme-Transporter Interplay in the Formation and Clearance of Abundant Metabolites of Faldaprevir Found in Excreta but not in Circulation
    Yongmei Li, Jin Zhou, Diane Ramsden, Mitchell E. Taub, Drané O'Brien, Jun Xu, Carl A. Busacca, Nina Gonnella and Donald J. Tweedie
    Drug Metabolism and Disposition March 2014, 42 (3) 384-393; DOI: https://doi.org/10.1124/dmd.113.055863
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    Bridging In Vitro and In Vivo Metabolism and Transport of Faldaprevir in Human Using a Novel Cocultured Human Hepatocyte System, HepatoPac
    Diane Ramsden, Donald J. Tweedie, Tom S. Chan, Mitchell E. Taub and Yongmei Li
    Drug Metabolism and Disposition March 2014, 42 (3) 394-406; DOI: https://doi.org/10.1124/dmd.113.055897
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    Generating an In Vitro–In Vivo Correlation for Metabolism and Liver Enrichment of a Hepatitis C Virus Drug, Faldaprevir, Using a Rat Hepatocyte Model (HepatoPac)
    Diane Ramsden, Donald J. Tweedie, Roger St. George, Lin-Zhi Chen and Yongmei Li
    Drug Metabolism and Disposition March 2014, 42 (3) 407-414; DOI: https://doi.org/10.1124/dmd.113.055947
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    Disposition and Metabolism of Darapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, in Humans
    Mehul Dave, Mike Nash, Graeme C. Young, Harma Ellens, Mindy H. Magee, Andrew D. Roberts, Maxine A. Taylor, Robert W. Greenhill and Gary W. Boyle
    Drug Metabolism and Disposition March 2014, 42 (3) 415-430; DOI: https://doi.org/10.1124/dmd.113.054486
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    Biodistribution and Metabolism Studies of Lipid Nanoparticle–Formulated Internally [3H]-Labeled siRNA in Mice
    Jesper Christensen, Karine Litherland, Thomas Faller, Esther van de Kerkhof, François Natt, Jürg Hunziker, Julien Boos, Iwan Beuvink, Keith Bowman, Jeremy Baryza, Mike Beverly, Chandra Vargeese, Olivier Heudi, Markus Stoeckli, Joel Krauser and Piet Swart
    Drug Metabolism and Disposition March 2014, 42 (3) 431-440; DOI: https://doi.org/10.1124/dmd.113.055434
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    Cytochrome P450 Inhibitory Properties of Common Efflux Transporter Inhibitors
    Gunilla Englund, Patrik Lundquist, Cristine Skogastierna, Jenny Johansson, Janet Hoogstraate, Lovisa Afzelius, Tommy B. Andersson and Denis Projean
    Drug Metabolism and Disposition March 2014, 42 (3) 441-447; DOI: https://doi.org/10.1124/dmd.113.054932
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    Functional ATP-Binding Cassette Drug Efflux Transporters in Isolated Human and Rat Hepatocytes Significantly Affect Assessment of Drug Disposition
    Patrik Lundquist, Gunilla Englund, Cristine Skogastierna, Johan Lööf, Jenny Johansson, Janet Hoogstraate, Lovisa Afzelius and Tommy B. Andersson
    Drug Metabolism and Disposition March 2014, 42 (3) 448-458; DOI: https://doi.org/10.1124/dmd.113.054528
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    Prediction of In Vivo Rat Biliary Drug Clearance from an In Vitro Hepatocyte Efflux Model
    Patrik Lundquist, Johan Lööf, Urban Fagerholm, Ingemo Sjögren, Jenny Johansson, Sveinn Briem, Janet Hoogstraate, Lovisa Afzelius and Tommy B. Andersson
    Drug Metabolism and Disposition March 2014, 42 (3) 459-468; DOI: https://doi.org/10.1124/dmd.113.054155
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    The Impact of Solute Carrier (SLC) Drug Uptake Transporter Loss in Human and Rat Cryopreserved Hepatocytes on Clearance Predictions
    Patrik Lundquist, Johan Lööf, Anna-Karin Sohlenius-Sternbeck, Eva Floby, Jenny Johansson, Johan Bylund, Janet Hoogstraate, Lovisa Afzelius and Tommy B. Andersson
    Drug Metabolism and Disposition March 2014, 42 (3) 469-480; DOI: https://doi.org/10.1124/dmd.113.054676

Letter to the Editor

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    Lack of In Vitro–In Vivo Correlation of Adulthood Cytochrome P450 Activities in Low-Birth-Weight Rats
    Ganesh Cherala, Jacob Pearson, Barent DuBois and Tahir Mahmood
    Drug Metabolism and Disposition March 2014, 42 (3) 481; DOI: https://doi.org/10.1124/dmd.113.056721
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Drug Metabolism and Disposition: 42 (3)
Drug Metabolism and Disposition
Vol. 42, Issue 3
1 Mar 2014
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