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Research ArticleArticle

Characterization of T-5 N-Oxide Formation as the First Highly Selective Measure of CYP3A5 Activity

Xiaohai Li, Valer Jeso, Scott Heyward, Gregory S. Walker, Raman Sharma, Glenn C. Micalizio and Michael D. Cameron
Drug Metabolism and Disposition March 2014, 42 (3) 334-342; DOI: https://doi.org/10.1124/dmd.113.054726
Xiaohai Li
Department of Molecular Therapeutics, Scripps Research Institute, Jupiter, Florida (M.D.C., X.L.); Celsis In Vitro Technologies, Baltimore Maryland (S.H.); Department of Chemistry, Dartmouth College, Hanover, New Hampshire (V.J., G.C.M.), Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, Groton, Connecticut (G.S.W., R.S.)
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Valer Jeso
Department of Molecular Therapeutics, Scripps Research Institute, Jupiter, Florida (M.D.C., X.L.); Celsis In Vitro Technologies, Baltimore Maryland (S.H.); Department of Chemistry, Dartmouth College, Hanover, New Hampshire (V.J., G.C.M.), Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, Groton, Connecticut (G.S.W., R.S.)
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Scott Heyward
Department of Molecular Therapeutics, Scripps Research Institute, Jupiter, Florida (M.D.C., X.L.); Celsis In Vitro Technologies, Baltimore Maryland (S.H.); Department of Chemistry, Dartmouth College, Hanover, New Hampshire (V.J., G.C.M.), Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, Groton, Connecticut (G.S.W., R.S.)
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Gregory S. Walker
Department of Molecular Therapeutics, Scripps Research Institute, Jupiter, Florida (M.D.C., X.L.); Celsis In Vitro Technologies, Baltimore Maryland (S.H.); Department of Chemistry, Dartmouth College, Hanover, New Hampshire (V.J., G.C.M.), Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, Groton, Connecticut (G.S.W., R.S.)
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Raman Sharma
Department of Molecular Therapeutics, Scripps Research Institute, Jupiter, Florida (M.D.C., X.L.); Celsis In Vitro Technologies, Baltimore Maryland (S.H.); Department of Chemistry, Dartmouth College, Hanover, New Hampshire (V.J., G.C.M.), Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, Groton, Connecticut (G.S.W., R.S.)
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Glenn C. Micalizio
Department of Molecular Therapeutics, Scripps Research Institute, Jupiter, Florida (M.D.C., X.L.); Celsis In Vitro Technologies, Baltimore Maryland (S.H.); Department of Chemistry, Dartmouth College, Hanover, New Hampshire (V.J., G.C.M.), Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, Groton, Connecticut (G.S.W., R.S.)
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Michael D. Cameron
Department of Molecular Therapeutics, Scripps Research Institute, Jupiter, Florida (M.D.C., X.L.); Celsis In Vitro Technologies, Baltimore Maryland (S.H.); Department of Chemistry, Dartmouth College, Hanover, New Hampshire (V.J., G.C.M.), Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, Groton, Connecticut (G.S.W., R.S.)
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Article Information

vol. 42 no. 3 334-342
DOI 
https://doi.org/10.1124/dmd.113.054726
PubMed 
24335391

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 3, 2013
  • Accepted December 6, 2013
  • Published online February 4, 2014.

Article Versions

  • Earlier version (December 11, 2013 - 09:09).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Xiaohai Li,
  2. Valer Jeso,
  3. Scott Heyward,
  4. Gregory S. Walker,
  5. Raman Sharma,
  6. Glenn C. Micalizio, and
  7. Michael D. Cameron
  1. Department of Molecular Therapeutics, Scripps Research Institute, Jupiter, Florida (M.D.C., X.L.); Celsis In Vitro Technologies, Baltimore Maryland (S.H.); Department of Chemistry, Dartmouth College, Hanover, New Hampshire (V.J., G.C.M.), Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, Groton, Connecticut (G.S.W., R.S.)
  1. Address correspondence to:
    Michael D. Cameron, Scripps Florida, Department of Molecular Therapeutics, 130 Scripps Way, Jupiter, FL 33458. E-mail: cameron{at}scripps.edu
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Drug Metabolism and Disposition: 42 (3)
Drug Metabolism and Disposition
Vol. 42, Issue 3
1 Mar 2014
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Research ArticleArticle

Selective CYP3A5 Marker Reaction

Xiaohai Li, Valer Jeso, Scott Heyward, Gregory S. Walker, Raman Sharma, Glenn C. Micalizio and Michael D. Cameron
Drug Metabolism and Disposition March 1, 2014, 42 (3) 334-342; DOI: https://doi.org/10.1124/dmd.113.054726

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Research ArticleArticle

Selective CYP3A5 Marker Reaction

Xiaohai Li, Valer Jeso, Scott Heyward, Gregory S. Walker, Raman Sharma, Glenn C. Micalizio and Michael D. Cameron
Drug Metabolism and Disposition March 1, 2014, 42 (3) 334-342; DOI: https://doi.org/10.1124/dmd.113.054726
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