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Research ArticleArticle

Functional ATP-Binding Cassette Drug Efflux Transporters in Isolated Human and Rat Hepatocytes Significantly Affect Assessment of Drug Disposition

Patrik Lundquist, Gunilla Englund, Cristine Skogastierna, Johan Lööf, Jenny Johansson, Janet Hoogstraate, Lovisa Afzelius and Tommy B. Andersson
Drug Metabolism and Disposition March 2014, 42 (3) 448-458; DOI: https://doi.org/10.1124/dmd.113.054528

Article Information

vol. 42 no. 3 448-458
DOI 
https://doi.org/10.1124/dmd.113.054528
PubMed 
24396144
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 26, 2013
  • Accepted January 6, 2014
  • Published online February 12, 2014.

Article Versions

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Patrik Lundquist,
  2. Gunilla Englund,
  3. Cristine Skogastierna,
  4. Johan Lööf,
  5. Jenny Johansson,
  6. Janet Hoogstraate,
  7. Lovisa Afzelius, and
  8. Tommy B. Andersson
  1. CNS and Pain Innovative Medicines DMPK, AstraZeneca R&D, Södertälje, (P.L., G.E., C.S., J.L., J.J., J.H., L.A.); Cardiovascular and Gastrointestinal Innovative Medicines DMPK, AstraZeneca R&D, Mölndal, (P.L., T.B.A.); Department of Pharmacy, Uppsala University, Uppsala, (P.L.); and Section of Pharmacogenetics, Departments of Physiology and Pharmacology, Karolinska Institutet, Stockholm, (T.B.A.), Sweden
  1. Address correspondence to:
    Dr. Tommy B. Andersson, Cardiovascular and Metabolic Diseases Innovative Medicines DMPK, AstraZeneca R&D, Pepparedsleden 1, SE-431 83 Mölndal, Sweden. E-mail: Tommy.B.Andersson{at}astrazeneca.com
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ABC Efflux Transporters in Cryopreserved Hepatocytes

Patrik Lundquist, Gunilla Englund, Cristine Skogastierna, Johan Lööf, Jenny Johansson, Janet Hoogstraate, Lovisa Afzelius and Tommy B. Andersson
Drug Metabolism and Disposition March 1, 2014, 42 (3) 448-458; DOI: https://doi.org/10.1124/dmd.113.054528
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