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The Impact of Solute Carrier (SLC) Drug Uptake Transporter Loss in Human and Rat Cryopreserved Hepatocytes on Clearance Predictions

Patrik Lundquist, Johan Lööf, Anna-Karin Sohlenius-Sternbeck, Eva Floby, Jenny Johansson, Johan Bylund, Janet Hoogstraate, Lovisa Afzelius and Tommy B. Andersson
Drug Metabolism and Disposition March 2014, 42 (3) 469-480; DOI: https://doi.org/10.1124/dmd.113.054676

Article Information

vol. 42 no. 3 469-480
DOI 
https://doi.org/10.1124/dmd.113.054676
PubMed 
24396146
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 2, 2013
  • Accepted January 6, 2014
  • Published online February 12, 2014.

Article Versions

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Patrik Lundquist,
  2. Johan Lööf,
  3. Anna-Karin Sohlenius-Sternbeck,
  4. Eva Floby,
  5. Jenny Johansson,
  6. Johan Bylund,
  7. Janet Hoogstraate,
  8. Lovisa Afzelius, and
  9. Tommy B. Andersson
  1. CNS and Pain Innovative Medicines DMPK, AstraZeneca R&D, Södertälje, (P.L., J.L., A.-K.S.-S., E.F., J.J., J.B., J.H., L.A.); Cardiovascular and Metabolic Diseases Innovative Medicines DMPK, AstraZeneca R&D, Mölndal, (P.L., T.B.A.); Department of Pharmacy, Uppsala University, Uppsala, (P.L.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, (T.B.A.), Sweden
  1. Address correspondence to:
    Tommy B. Andersson, Cardiovascular and Metabolic Diseases Innovative Medicines DMPK, AstraZeneca R&D, Pepparedsleden 1, SE-431 83 Mölndal, Sweden. E-mail: Tommy.B.Andersson{at}astrazeneca.com
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Research ArticleArticle

Drug Uptake Transporters in Cryopreserved Hepatocytes

Patrik Lundquist, Johan Lööf, Anna-Karin Sohlenius-Sternbeck, Eva Floby, Jenny Johansson, Johan Bylund, Janet Hoogstraate, Lovisa Afzelius and Tommy B. Andersson
Drug Metabolism and Disposition March 1, 2014, 42 (3) 469-480; DOI: https://doi.org/10.1124/dmd.113.054676
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