Drug Metabolism and Disposition: 42 (4)

April 01, 2014; Volume 42,Issue 4

Special Section on Transporters in Toxicity and Disease

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The Role of Transporters in Toxicity and Disease
John D. Schuetz, Peter W. Swaan and Donald J. Tweedie

Drug Metabolism and Disposition April 2014, 42 (4) 541-545; DOI: https://doi.org/10.1124/dmd.114.057539
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The Role of Canalicular ABC Transporters in Cholestasis
Frans J. C. Cuperus, Thierry Claudel, Julien Gautherot, Emina Halilbasic and Michael Trauner

Drug Metabolism and Disposition April 2014, 42 (4) 546-560; DOI: https://doi.org/10.1124/dmd.113.056358
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The Roles of MRP2, MRP3, OATP1B1, and OATP1B3 in Conjugated Hyperbilirubinemia
Dietrich Keppler

Drug Metabolism and Disposition April 2014, 42 (4) 561-565; DOI: https://doi.org/10.1124/dmd.113.055772
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Drug-Induced Perturbations of the Bile Acid Pool, Cholestasis, and Hepatotoxicity: Mechanistic Considerations beyond the Direct Inhibition of the Bile Salt Export Pump
A. David Rodrigues, Yurong Lai, Mary Ellen Cvijic, Lisa L. Elkin, Tatyana Zvyaga and Matthew G. Soars

Drug Metabolism and Disposition April 2014, 42 (4) 566-574; DOI: https://doi.org/10.1124/dmd.113.054205
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Regulation of the Function of the Human ABCG2 Multidrug Transporter by Cholesterol and Bile Acids: Effects of Mutations in Potential Substrate and Steroid Binding Sites
Ágnes Telbisz, Csilla Hegedüs, András Váradi, Balázs Sarkadi and Csilla Özvegy-Laczka

Drug Metabolism and Disposition April 2014, 42 (4) 575-585; DOI: https://doi.org/10.1124/dmd.113.055731
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Modeling Human Nonalcoholic Steatohepatitis-Associated Changes in Drug Transporter Expression Using Experimental Rodent Models
Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke and Nathan J. Cherrington

Drug Metabolism and Disposition April 2014, 42 (4) 586-595; DOI: https://doi.org/10.1124/dmd.113.055996
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Selective and Cytokine-Dependent Regulation of Hepatic Transporters and Bile Acid Homeostasis during Infectious Colitis in Mice
Matthew D. Merrell, Beatrice A. Nyagode, John D. Clarke, Nathan J. Cherrington and Edward T. Morgan

Drug Metabolism and Disposition April 2014, 42 (4) 596-602; DOI: https://doi.org/10.1124/dmd.113.055525
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Malaria Infection Alters the Expression of Hepatobiliary and Placental Drug Transporters in Pregnant Mice
Alex M. Cressman, Chloe R. McDonald, Karlee Silver, Kevin C. Kain and Micheline Piquette-Miller

Drug Metabolism and Disposition April 2014, 42 (4) 603-610; DOI: https://doi.org/10.1124/dmd.113.053983
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Uptake Carriers and Oncology Drug Safety
Jason A. Sprowl and Alex Sparreboom

Drug Metabolism and Disposition April 2014, 42 (4) 611-622; DOI: https://doi.org/10.1124/dmd.113.055806
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Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?
Richard Callaghan, Frederick Luk and Mary Bebawy

Drug Metabolism and Disposition April 2014, 42 (4) 623-631; DOI: https://doi.org/10.1124/dmd.113.056176
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The Major Facilitative Folate Transporters Solute Carrier 19A1 and Solute Carrier 46A1: Biology and Role in Antifolate Chemotherapy of Cancer
Larry H. Matherly, Mike R. Wilson and Zhanjun Hou

Drug Metabolism and Disposition April 2014, 42 (4) 632-649; DOI: https://doi.org/10.1124/dmd.113.055723
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Understanding the Transport Properties of Metabolites: Case Studies and Considerations for Drug Development
Maciej J. Zamek-Gliszczynski, Xiaoyan Chu, Joseph W. Polli, Mary F. Paine and Aleksandra Galetin

Drug Metabolism and Disposition April 2014, 42 (4) 650-664; DOI: https://doi.org/10.1124/dmd.113.055558
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Risk Factors for Development of Cholestatic Drug-Induced Liver Injury: Inhibition of Hepatic Basolateral Bile Acid Transporters Multidrug Resistance-Associated Proteins 3 and 4
Kathleen Köck, Brian C. Ferslew, Ida Netterberg, Kyunghee Yang, Thomas J. Urban, Peter W. Swaan, Paul W. Stewart and Kim L. R. Brouwer

Drug Metabolism and Disposition April 2014, 42 (4) 665-674; DOI: https://doi.org/10.1124/dmd.113.054304
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The Role of Organic Anion Transporters in Diagnosing Liver Diseases by Magnetic Resonance Imaging
Catherine M. Pastor, Beat Müllhaupt and Bruno Stieger

Drug Metabolism and Disposition April 2014, 42 (4) 675-684; DOI: https://doi.org/10.1124/dmd.113.055707
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6β-Hydroxycortisol Is an Endogenous Probe for Evaluation of Drug–Drug Interactions Involving a Multispecific Renal Organic Anion Transporter, OAT3/SLC22A8, in Healthy Subjects
Yuichiro Imamura, Yuri Tsuruya, Katja Damme, Dominik Heer, Yuji Kumagai, Kazuya Maeda, Nobuyuki Murayama, Noriko Okudaira, Atsushi Kurihara, Takashi Izumi, Yuichi Sugiyama and Hiroyuki Kusuhara

Drug Metabolism and Disposition April 2014, 42 (4) 685-694; DOI: https://doi.org/10.1124/dmd.113.055475

Short Communication

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The Effect of ABCG2 and ABCC4 on the Pharmacokinetics of Methotrexate in the Brain
Ramola Sane, Shu-Pei Wu, Rong Zhang and James M. Gallo

Drug Metabolism and Disposition April 2014, 42 (4) 537-540; DOI: https://doi.org/10.1124/dmd.113.055228

Accelerated Communication

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Why Do Most Human Liver Cytosol Preparations Lack Xanthine Oxidase Activity?
John T. Barr, Kanika V. Choughule, Sahadev Nepal, Timothy Wong, Amarjit S. Chaudhry, Carolyn A. Joswig-Jones, Michael Zientek, Stephen C. Strom, Erin G. Schuetz, Kenneth E. Thummel and Jeffrey P. Jones

Drug Metabolism and Disposition April 2014, 42 (4) 695-699; DOI: https://doi.org/10.1124/dmd.113.056374

Articles

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Use of Cassette Dosing Approach to Examine the Effects of P-Glycoprotein on the Brain and Cerebrospinal Fluid Concentrations in Wild-Type and P-Glycoprotein Knockout Rats
Xingrong Liu, Jonathan Cheong, Xiao Ding and Gauri Deshmukh

Drug Metabolism and Disposition April 2014, 42 (4) 482-491; DOI: https://doi.org/10.1124/dmd.113.055590
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Human Placental Lactogen Induces CYP2E1 Expression via PI 3-Kinase Pathway in Female Human Hepatocytes
Jin Kyung Lee, Hye Jin Chung, Liam Fischer, James Fischer, Frank J. Gonzalez and Hyunyoung Jeong

Drug Metabolism and Disposition April 2014, 42 (4) 492-499; DOI: https://doi.org/10.1124/dmd.113.055384
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Simultaneous Quantification of the Abundance of Several Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzymes in Human Liver Microsomes Using Multiplexed Targeted Proteomics
Brahim Achour, Matthew R. Russell, Jill Barber and Amin Rostami-Hodjegan

Drug Metabolism and Disposition April 2014, 42 (4) 500-510; DOI: https://doi.org/10.1124/dmd.113.055632
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N-Oxide Reduction of Quinoxaline-1,4-Dioxides Catalyzed by Porcine Aldehyde Oxidase SsAOX1
Peiqiang Mu, Ming Zheng, Ming Xu, Yuanming Zheng, Xianqing Tang, Yufan Wang, Kaixin Wu, Qingmei Chen, Lijuan Wang and Yiqun Deng

Drug Metabolism and Disposition April 2014, 42 (4) 511-519; DOI: https://doi.org/10.1124/dmd.113.055418
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Edoxaban Transport via P-Glycoprotein Is a Key Factor for the Drug’s Disposition
Tsuyoshi Mikkaichi, Yasushi Yoshigae, Hiroshi Masumoto, Tomoki Imaoka, Veronika Rozehnal, Thomas Fischer, Noriko Okudaira and Takashi Izumi

Drug Metabolism and Disposition April 2014, 42 (4) 520-528; DOI: https://doi.org/10.1124/dmd.113.054866
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UGT2B Gene Expression Analysis in Multiple Tobacco Carcinogen-Targeted Tissues
Nathan R. Jones and Philip Lazarus

Drug Metabolism and Disposition April 2014, 42 (4) 529-536; DOI: https://doi.org/10.1124/dmd.113.054718
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Coadministration of P-Glycoprotein Modulators on Loperamide Pharmacokinetics and Brain Distribution
Rita Nieto Montesinos, Brice Moulari, Jessica Gromand, Arnaud Beduneau, Alf Lamprecht and Yann Pellequer

Drug Metabolism and Disposition April 2014, 42 (4) 700-706; DOI: https://doi.org/10.1124/dmd.113.055566
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Species Difference in Glucuronidation Formation Kinetics with a Selective mTOR Inhibitor
Loren M. Berry, Jingzhou Liu, Adria Colletti, Paul Krolikowski, Zhiyang Zhao and Yohannes Teffera

Drug Metabolism and Disposition April 2014, 42 (4) 707-717; DOI: https://doi.org/10.1124/dmd.113.054809
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Functional Characterization of Protein Variants Encoded by Nonsynonymous Single Nucleotide Polymorphisms in MARC1 and MARC2 in Healthy Caucasians
Gudrun Ott, Debora Reichmann, Cornelia Boerger, Ingolf Cascorbi, Florian Bittner, Ralf-Rainer Mendel, Thomas Kunze, Bernd Clement and Antje Havemeyer

Drug Metabolism and Disposition April 2014, 42 (4) 718-725; DOI: https://doi.org/10.1124/dmd.113.055202
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Interaction of Novel Platelet-Increasing Agent Eltrombopag with Rosuvastatin via Breast Cancer Resistance Protein in Humans
Kazuya Takeuchi, Tomoko Sugiura, Kazuki Matsubara, Ren Sato, Takuya Shimizu, Yusuke Masuo, Masato Horikawa, Noritaka Nakamichi, Norihisa Ishiwata and Yukio Kato

Drug Metabolism and Disposition April 2014, 42 (4) 726-734; DOI: https://doi.org/10.1124/dmd.113.054767
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Hepatic Glucuronidation of Isoneochamaejasmin A from the Traditional Chinese Medicine Stellera Chamaejasme L. Root
Lushan Yu, Jianbin Pu, Minjuan Zuo, Xia Zhang, Yang Cao, Shifeng Chen, Yan Lou, Quan Zhou, Haihong Hu, Huidi Jiang, Jianzhong Chen and Su Zeng

Drug Metabolism and Disposition April 2014, 42 (4) 735-743; DOI: https://doi.org/10.1124/dmd.113.055962
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High Daily Dose and Being a Substrate of Cytochrome P450 Enzymes Are Two Important Predictors of Drug-Induced Liver Injury
Ke Yu, Xingchao Geng, Minjun Chen, Jie Zhang, Bingshun Wang, Katarina Ilic and Weida Tong

Drug Metabolism and Disposition April 2014, 42 (4) 744-750; DOI: https://doi.org/10.1124/dmd.113.056267
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Indiplon Is Hydrolyzed by Arylacetamide Deacetylase in Human Liver
Mai Shimizu, Tatsuki Fukami, Yusuke Ito, Takaya Kurokawa, Motoki Kariya, Miki Nakajima and Tsuyoshi Yokoi

Drug Metabolism and Disposition April 2014, 42 (4) 751-758; DOI: https://doi.org/10.1124/dmd.113.056184
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The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Tofacitinib, a Janus Kinase Inhibitor, in Humans
Martin E. Dowty, Jinyan Lin, Tim F. Ryder, Weiwei Wang, Gregory S. Walker, Alfin Vaz, Gary L. Chan, Sriram Krishnaswami and Chandra Prakash

Drug Metabolism and Disposition April 2014, 42 (4) 759-773; DOI: https://doi.org/10.1124/dmd.113.054940
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Bioactivation of 3-n-Butylphthalide via Sulfation of Its Major Metabolite 3-Hydroxy-NBP: Mediated Mainly by Sulfotransferase 1A1
Xingxing Diao, Xiaoyan Pang, Cen Xie, Zitao Guo, Dafang Zhong and Xiaoyan Chen

Drug Metabolism and Disposition April 2014, 42 (4) 774-781; DOI: https://doi.org/10.1124/dmd.113.056218
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Pathway-Dependent Inhibition of Paclitaxel Hydroxylation by Kinase Inhibitors and Assessment of Drug–Drug Interaction Potentials
Yedong Wang, Meiyu Wang, Huixin Qi, Peichen Pan, Tingjun Hou, Jiajun Li, Guangzhao He and Hongjian Zhang

Drug Metabolism and Disposition April 2014, 42 (4) 782-795; DOI: https://doi.org/10.1124/dmd.113.053793
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17β-Estradiol Induces Sulfotransferase 2A1 Expression through Estrogen Receptor α
Wei Li, Miaoran Ning, Kwi Hye Koh, Heesue Kim and Hyunyoung Jeong

Drug Metabolism and Disposition April 2014, 42 (4) 796-802; DOI: https://doi.org/10.1124/dmd.113.055178
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Cloning and Characterization of Four Rabbit Aldo-Keto Reductases Featuring Broad Substrate Specificity for Xenobiotic and Endogenous Carbonyl Compounds: Relationship with Multiple Forms of Drug Ketone Reductases
Satoshi Endo, Toshiyuki Matsunaga, Yuki Arai, Akira Ikari, Kazuo Tajima, Ossama El-Kabbani, Shigeru Yamano, Akira Hara and Yukio Kitade

Drug Metabolism and Disposition April 2014, 42 (4) 803-812; DOI: https://doi.org/10.1124/dmd.113.056044

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