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Research ArticleArticle

Use of Cassette Dosing Approach to Examine the Effects of P-Glycoprotein on the Brain and Cerebrospinal Fluid Concentrations in Wild-Type and P-Glycoprotein Knockout Rats

Xingrong Liu, Jonathan Cheong, Xiao Ding and Gauri Deshmukh
Drug Metabolism and Disposition April 2014, 42 (4) 482-491; DOI: https://doi.org/10.1124/dmd.113.055590

Article Information

vol. 42 no. 4 482-491
DOI 
https://doi.org/10.1124/dmd.113.055590
PubMed 
24398459
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 26, 2013
  • Accepted January 7, 2014
  • Published online February 28, 2014.

Article Versions

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Xingrong Liu,
  2. Jonathan Cheong,
  3. Xiao Ding, and
  4. Gauri Deshmukh
  1. Genentech, Inc., South San Francisco, California
  1. Address correspondence to:
    Dr. Xingrong Liu, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080. E-mail: liu.xingrong{at}gene.com
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Brain Penetration in Wild-Type and P-gp Knockout Rats

Xingrong Liu, Jonathan Cheong, Xiao Ding and Gauri Deshmukh
Drug Metabolism and Disposition April 1, 2014, 42 (4) 482-491; DOI: https://doi.org/10.1124/dmd.113.055590
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