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Research ArticleSpecial Section on Transporters in Toxicity and Disease

The Role of Transporters in Toxicity and Disease

John D. Schuetz, Peter W. Swaan and Donald J. Tweedie
Drug Metabolism and Disposition April 2014, 42 (4) 541-545; DOI: https://doi.org/10.1124/dmd.114.057539
John D. Schuetz
Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (J.D.S); Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (P.W.S); and Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim, Ridgefield, Connecticut (D.J.T.)
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Peter W. Swaan
Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (J.D.S); Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (P.W.S); and Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim, Ridgefield, Connecticut (D.J.T.)
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Donald J. Tweedie
Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (J.D.S); Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (P.W.S); and Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim, Ridgefield, Connecticut (D.J.T.)
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Abstract

The significance of transporters in the disposition, metabolism, and elimination of drugs is well recognized. One gap in our knowledge is a comprehensive understanding of how drug transporters change functionality (their amount and activity) in response to disease and how disease and its inevitable pathology change transporter expression. In this issue of Drug Metabolism and Disposition a series of review and primary research articles are presented to highlight the importance of transporters in toxicity and disease. Because of the central role of the liver in drug metabolism, many of the articles in this theme issue focus on transporters in the liver and how pathology or alterations in physiology affects transporter expression. The contributing authors have also considered the role of transporters in drug interactions as well as drug-induced liver injury. Noninvasive approaches to assessing transporter function in vivo are also described. Several articles highlight important issues in oncology where toxicity must be balanced against efficacy. In total, this theme issue will provide a stepping-stone to future studies that will establish a more comprehensive understanding of transporters in disease.

Footnotes

    • Received February 5, 2014.
    • Accepted February 7, 2014.
  • This work was supported by the National Institutes of Health National Institute of General Medical Sciences [Grant 2R01GM60964]; National Cancer Institute [Grants P30CA21745 and CA21865]; and by ALSAC.

  • dx.doi.org/10.1124/dmd.114.057539.

  • Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition: 42 (4)
Drug Metabolism and Disposition
Vol. 42, Issue 4
1 Apr 2014
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Research ArticleSpecial Section on Transporters in Toxicity and Disease

Transporters in Toxicity and Disease

John D. Schuetz, Peter W. Swaan and Donald J. Tweedie
Drug Metabolism and Disposition April 1, 2014, 42 (4) 541-545; DOI: https://doi.org/10.1124/dmd.114.057539

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Research ArticleSpecial Section on Transporters in Toxicity and Disease

Transporters in Toxicity and Disease

John D. Schuetz, Peter W. Swaan and Donald J. Tweedie
Drug Metabolism and Disposition April 1, 2014, 42 (4) 541-545; DOI: https://doi.org/10.1124/dmd.114.057539
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  • Article
    • Abstract
    • Introduction
    • Liver Transporters in Health and Disease
    • Transporters and Oncology
    • Transporters and Drug Interactions
    • In Vivo Probes to Dissect Transporter Interaction
    • Conclusions
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