Regulation of the Function of the Human ABCG2 Multidrug Transporter by Cholesterol and Bile Acids: Effects of Mutations in Potential Substrate and Steroid Binding Sites

Ágnes Telbisz; Csilla Hegedüs; András Váradi; Balázs Sarkadi; Csilla Özvegy-Laczka

doi:10.1124/dmd.113.055731

Research ArticleSpecial Section on Transporters in Toxicity and Disease

Regulation of the Function of the Human ABCG2 Multidrug Transporter by Cholesterol and Bile Acids: Effects of Mutations in Potential Substrate and Steroid Binding Sites

Ágnes Telbisz, Csilla Hegedüs, András Váradi, Balázs Sarkadi and Csilla Özvegy-Laczka

Drug Metabolism and Disposition April 2014, 42 (4) 575-585; DOI: https://doi.org/10.1124/dmd.113.055731

Ágnes Telbisz

Institute of Molecular Pharmacology, Research Centre for Natural Sciences, Hungarian Academy of Sciences (A.T., B.S.); Molecular Biophysics Research Group, Hungarian Academy of Sciences and Semmelweis University (C.H.); and Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences (A.V., C.O.-L.), Budapest, Hungary

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Csilla Hegedüs

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András Váradi

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Balázs Sarkadi

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Csilla Özvegy-Laczka

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Drug Metabolism and Disposition

Vol. 42, Issue 4

1 Apr 2014

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Research ArticleSpecial Section on Transporters in Toxicity and Disease

Sterol Modulation of ABCG2 Function

Ágnes Telbisz, Csilla Hegedüs, András Váradi, Balázs Sarkadi and Csilla Özvegy-Laczka

Drug Metabolism and Disposition April 1, 2014, 42 (4) 575-585; DOI: https://doi.org/10.1124/dmd.113.055731

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Research ArticleSpecial Section on Transporters in Toxicity and Disease

Sterol Modulation of ABCG2 Function

Ágnes Telbisz, Csilla Hegedüs, András Váradi, Balázs Sarkadi and Csilla Özvegy-Laczka

Drug Metabolism and Disposition April 1, 2014, 42 (4) 575-585; DOI: https://doi.org/10.1124/dmd.113.055731

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