Research ArticleSpecial Section on Transporters in Toxicity and Disease
Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?
Richard Callaghan, Frederick Luk and Mary Bebawy
Drug Metabolism and Disposition April 2014, 42 (4) 623-631; DOI: https://doi.org/10.1124/dmd.113.056176
Richard Callaghan
Division of Biomedical Science & Biochemistry, Research School of Biology, College of Medicine, Biology & Environment, The Australian National University, Canberra, New South Wales, Australia (R.C.); and School of Pharmacy, Graduate School of Health, The University of Technology, Sydney, New South Wales, Australia (F.L., M.B.)
Frederick Luk
Division of Biomedical Science & Biochemistry, Research School of Biology, College of Medicine, Biology & Environment, The Australian National University, Canberra, New South Wales, Australia (R.C.); and School of Pharmacy, Graduate School of Health, The University of Technology, Sydney, New South Wales, Australia (F.L., M.B.)
Mary Bebawy
Division of Biomedical Science & Biochemistry, Research School of Biology, College of Medicine, Biology & Environment, The Australian National University, Canberra, New South Wales, Australia (R.C.); and School of Pharmacy, Graduate School of Health, The University of Technology, Sydney, New South Wales, Australia (F.L., M.B.)
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Research ArticleSpecial Section on Transporters in Toxicity and Disease
Novel Strategies to Inhibit P-Glycoprotein
Richard Callaghan, Frederick Luk and Mary Bebawy
Drug Metabolism and Disposition April 1, 2014, 42 (4) 623-631; DOI: https://doi.org/10.1124/dmd.113.056176
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- Article
- Abstract
- Introduction
- Overcoming Drug Resistance to Chemotherapy Caused by P-gp
- Novel Approaches to Overcoming the Actions of P-gp
- Collateral Sensitivity
- Cytotoxic Drug Delivery Using Particles or Polymers
- Microparticles as Novel Therapeutic Targets for the Prevention of MDR
- Altered Expression of P-gp
- Differential Modulation of P-gp
- Perspectives and Summary
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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