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Research ArticleArticle

Hepatic Glucuronidation of Isoneochamaejasmin A from the Traditional Chinese Medicine Stellera Chamaejasme L. Root

Lushan Yu, Jianbin Pu, Minjuan Zuo, Xia Zhang, Yang Cao, Shifeng Chen, Yan Lou, Quan Zhou, Haihong Hu, Huidi Jiang, Jianzhong Chen and Su Zeng
Drug Metabolism and Disposition April 2014, 42 (4) 735-743; DOI: https://doi.org/10.1124/dmd.113.055962
Lushan Yu
Department of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (L.Y., M.Z., X.Z., Y.L., H.H., H.J., S.Z.); Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (J.P., Y.C., S.C., J.C.); and Department of Pharmacy, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (Q.Z.)
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Jianbin Pu
Department of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (L.Y., M.Z., X.Z., Y.L., H.H., H.J., S.Z.); Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (J.P., Y.C., S.C., J.C.); and Department of Pharmacy, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (Q.Z.)
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Minjuan Zuo
Department of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (L.Y., M.Z., X.Z., Y.L., H.H., H.J., S.Z.); Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (J.P., Y.C., S.C., J.C.); and Department of Pharmacy, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (Q.Z.)
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Xia Zhang
Department of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (L.Y., M.Z., X.Z., Y.L., H.H., H.J., S.Z.); Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (J.P., Y.C., S.C., J.C.); and Department of Pharmacy, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (Q.Z.)
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Yang Cao
Department of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (L.Y., M.Z., X.Z., Y.L., H.H., H.J., S.Z.); Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (J.P., Y.C., S.C., J.C.); and Department of Pharmacy, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (Q.Z.)
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Shifeng Chen
Department of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (L.Y., M.Z., X.Z., Y.L., H.H., H.J., S.Z.); Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (J.P., Y.C., S.C., J.C.); and Department of Pharmacy, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (Q.Z.)
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Yan Lou
Department of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (L.Y., M.Z., X.Z., Y.L., H.H., H.J., S.Z.); Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (J.P., Y.C., S.C., J.C.); and Department of Pharmacy, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (Q.Z.)
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Quan Zhou
Department of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (L.Y., M.Z., X.Z., Y.L., H.H., H.J., S.Z.); Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (J.P., Y.C., S.C., J.C.); and Department of Pharmacy, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (Q.Z.)
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Haihong Hu
Department of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (L.Y., M.Z., X.Z., Y.L., H.H., H.J., S.Z.); Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (J.P., Y.C., S.C., J.C.); and Department of Pharmacy, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (Q.Z.)
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Huidi Jiang
Department of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (L.Y., M.Z., X.Z., Y.L., H.H., H.J., S.Z.); Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (J.P., Y.C., S.C., J.C.); and Department of Pharmacy, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (Q.Z.)
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Jianzhong Chen
Department of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (L.Y., M.Z., X.Z., Y.L., H.H., H.J., S.Z.); Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (J.P., Y.C., S.C., J.C.); and Department of Pharmacy, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (Q.Z.)
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Su Zeng
Department of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (L.Y., M.Z., X.Z., Y.L., H.H., H.J., S.Z.); Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (J.P., Y.C., S.C., J.C.); and Department of Pharmacy, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (Q.Z.)
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Article Information

vol. 42 no. 4 735-743
DOI 
https://doi.org/10.1124/dmd.113.055962
PubMed 
24452863

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 14, 2013
  • Accepted January 22, 2014
  • Published online March 11, 2014.

Article Versions

  • Earlier version (January 22, 2014 - 11:35).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lushan Yu,
  2. Jianbin Pu,
  3. Minjuan Zuo,
  4. Xia Zhang,
  5. Yang Cao,
  6. Shifeng Chen,
  7. Yan Lou,
  8. Quan Zhou,
  9. Haihong Hu,
  10. Huidi Jiang,
  11. Jianzhong Chen, and
  12. Su Zeng
  1. Department of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (L.Y., M.Z., X.Z., Y.L., H.H., H.J., S.Z.); Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (J.P., Y.C., S.C., J.C.); and Department of Pharmacy, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (Q.Z.)
  1. Address correspondence to:
    Jianzhong Chen or Su Zeng, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. E-mail: chjz{at}zju.edu.cn or zengsu{at}zju.edu.cn
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Drug Metabolism and Disposition: 42 (4)
Drug Metabolism and Disposition
Vol. 42, Issue 4
1 Apr 2014
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Research ArticleArticle

UGTs Involved in Isoneochamaejasmin A Metabolism

Lushan Yu, Jianbin Pu, Minjuan Zuo, Xia Zhang, Yang Cao, Shifeng Chen, Yan Lou, Quan Zhou, Haihong Hu, Huidi Jiang, Jianzhong Chen and Su Zeng
Drug Metabolism and Disposition April 1, 2014, 42 (4) 735-743; DOI: https://doi.org/10.1124/dmd.113.055962

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Research ArticleArticle

UGTs Involved in Isoneochamaejasmin A Metabolism

Lushan Yu, Jianbin Pu, Minjuan Zuo, Xia Zhang, Yang Cao, Shifeng Chen, Yan Lou, Quan Zhou, Haihong Hu, Huidi Jiang, Jianzhong Chen and Su Zeng
Drug Metabolism and Disposition April 1, 2014, 42 (4) 735-743; DOI: https://doi.org/10.1124/dmd.113.055962
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