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Drug Metabolism & Disposition

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Table of Contents

May 01, 2014; Volume 42,Issue 5

Short Communications

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    1-Aminobenzotriazole Coincubated with (S)-Warfarin Results in Potent Inactivation of CYP2C9
    Jasleen K. Sodhi, Kevin A. Ford, Sophie Mukadam, Susan Wong, Cornelis E. C. A. Hop, S. Cyrus Khojasteh and Jason S. Halladay
    Drug Metabolism and Disposition May 2014, 42 (5) 813-817; DOI: https://doi.org/10.1124/dmd.113.055913
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    4β-Hydroxycholesterol as an Endogenous Biomarker of CYP3A Activity in Cynomolgus Monkeys
    Ke Li, Sylvia Zhao, Lingling Zhang, Xiaoyun Wu, Pan Shu, Yang Wang, Hao Feng, Zheming Gu and Helen Han Hsu
    Drug Metabolism and Disposition May 2014, 42 (5) 839-843; DOI: https://doi.org/10.1124/dmd.114.057224
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    Bedaquiline Metabolism: Enzymes and Novel Metabolites
    Ke Liu, Feng Li, Jie Lu, Shinlan Liu, Kenneth Dorko, Wen Xie and Xiaochao Ma
    Drug Metabolism and Disposition May 2014, 42 (5) 863-866; DOI: https://doi.org/10.1124/dmd.113.056119
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    Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450
    Kanako Yajima, Yasuhiro Uno, Norie Murayama, Shotaro Uehara, Makiko Shimizu, Chika Nakamura, Kazuhide Iwasaki, Masahiro Utoh and Hiroshi Yamazaki
    Drug Metabolism and Disposition May 2014, 42 (5) 867-871; DOI: https://doi.org/10.1124/dmd.113.056804
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    Generation of Major Human Excretory and Circulating Drug Metabolites Using a Hepatocyte Relay Method
    T. Eric Ballard, Christine C. Orozco and R. Scott Obach
    Drug Metabolism and Disposition May 2014, 42 (5) 899-902; DOI: https://doi.org/10.1124/dmd.114.057026
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    Role of ABCG2 in Transport of the Mammalian Lignan Enterolactone and its Secretion into Milk in Abcg2 Knockout Mice
    Verónica Miguel, Jon Andoni Otero, Rocío García-Villalba, Francisco Tomás-Barberán, Juan Carlos Espín, Gracia Merino and Ana I. Álvarez
    Drug Metabolism and Disposition May 2014, 42 (5) 943-946; DOI: https://doi.org/10.1124/dmd.113.055970

Articles

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    Disposition and Metabolism of the Cathepsin K Inhibitor Odanacatib in Humans
    Kelem Kassahun, Ian McIntosh, Kenneth Koeplinger, Li Sun, Jennifer E. Talaty, Deborah L. Miller, Russell Dixon, Stefan Zajic and S. Aubrey Stoch
    Drug Metabolism and Disposition May 2014, 42 (5) 818-827; DOI: https://doi.org/10.1124/dmd.113.056580
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    Carbon-Carbon Bond Cleavage in Activation of the Prodrug Nabumetone
    Fatbardha Varfaj, Siti N. A. Zulkifli, Hyoung-Goo Park, Victoria L. Challinor, James J. De Voss and Paul R. Ortiz de Montellano
    Drug Metabolism and Disposition May 2014, 42 (5) 828-838; DOI: https://doi.org/10.1124/dmd.114.056903
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    Low Dose of Oleanolic Acid Protects against Lithocholic Acid–Induced Cholestasis in Mice: Potential Involvement of Nuclear Factor-E2-Related Factor 2-Mediated Upregulation of Multidrug Resistance-Associated Proteins
    Pan Chen, Hang Zeng, Yongtao Wang, Xiaomei Fan, Chenshu Xu, Rongrong Deng, Xunian Zhou, Huichang Bi and Min Huang
    Drug Metabolism and Disposition May 2014, 42 (5) 844-852; DOI: https://doi.org/10.1124/dmd.113.056549
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    Polymorphisms and Haplotypes of the UDP-Glucuronosyltransferase 2B7 Gene Promoter
    Dong Gui Hu, Robyn Meech, Lu Lu, Ross A. McKinnon and Peter I. Mackenzie
    Drug Metabolism and Disposition May 2014, 42 (5) 854-862; DOI: https://doi.org/10.1124/dmd.113.056630
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    Metabolism and Pharmacokinetics of Allitinib in Cancer Patients: The Roles of Cytochrome P450s and Epoxide Hydrolase in its Biotransformation
    Lishan Lin, Cen Xie, Zhiwei Gao, Xiaoyan Chen and Dafang Zhong
    Drug Metabolism and Disposition May 2014, 42 (5) 872-884; DOI: https://doi.org/10.1124/dmd.113.056341
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    Optimized Methods for Targeted Peptide-Based Quantification of Human Uridine 5′-Diphosphate-Glucuronosyltransferases in Biological Specimens Using Liquid Chromatography–Tandem Mass Spectrometry
    Yuichiro Sato, Masanori Nagata, Kazuhiro Tetsuka, Kouichi Tamura, Aiji Miyashita, Akio Kawamura and Takashi Usui
    Drug Metabolism and Disposition May 2014, 42 (5) 885-889; DOI: https://doi.org/10.1124/dmd.113.056291
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    Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
    Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
    Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141
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    Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
    Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
    Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440
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    Pharmacokinetics, Metabolism, and Excretion of [14C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans
    Bill J. Smith, Yazdi Pithavala, Hai-Zhi Bu, Ping Kang, Brian Hee, Alan J. Deese, William F. Pool, Karen J. Klamerus, Ellen Y. Wu and Deepak K. Dalvie
    Drug Metabolism and Disposition May 2014, 42 (5) 918-931; DOI: https://doi.org/10.1124/dmd.113.056531
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    Assessment of the Mass Balance Recovery and Metabolite Profile of Avibactam in Humans and In Vitro Drug-Drug Interaction Potential
    Karthick Vishwanathan, Stuart Mair, Anshul Gupta, James Atherton, Jacqueline Clarkson-Jones, Timi Edeki and Shampa Das
    Drug Metabolism and Disposition May 2014, 42 (5) 932-942; DOI: https://doi.org/10.1124/dmd.113.055335
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    Inhibition of SULT4A1 Expression Induces Up-Regulation of Phototransduction Gene Expression in 72-Hour Postfertilization Zebrafish Larvae
    Frank Crittenden, Holly Thomas, Cheryl M. Ethen, Zhengliang L. Wu, Dongquan Chen, Timothy W. Kraft, John M. Parant and Charles N. Falany
    Drug Metabolism and Disposition May 2014, 42 (5) 947-953; DOI: https://doi.org/10.1124/dmd.114.057042
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    Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF1 Antagonist
    Rowan A. Stringer, Gareth Williams, Franck Picard, Bindi Sohal, Olivier Kretz, Jeff McKenna and Joel A. Krauser
    Drug Metabolism and Disposition May 2014, 42 (5) 954-962; DOI: https://doi.org/10.1124/dmd.114.057265

Errata

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    Correction to “Expression of the Orphan Cytosolic Sulfotransferase SULT1C3 in Human Intestine: Characterization of the Transcript Variant and Implications for Function”
    Drug Metabolism and Disposition May 2014, 42 (5) 853; DOI: https://doi.org/10.1124/dmd.114.05er14
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    Correction to “Genetic Variation in Aldo-Keto Reductase 1D1 (AKR1D1) Affects the Expression and Activity of Multiple Cytochrome P450s”
    Drug Metabolism and Disposition May 2014, 42 (5) 917; DOI: https://doi.org/10.1124/dmd.114.05er14a
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In this issue

Drug Metabolism and Disposition: 42 (5)
Drug Metabolism and Disposition
Vol. 42, Issue 5
1 May 2014
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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