Table of Contents

Articles

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  Disposition and Metabolism of the Cathepsin K Inhibitor Odanacatib in Humans

  Kelem Kassahun, Ian McIntosh, Kenneth Koeplinger, Li Sun, Jennifer E. Talaty, Deborah L. Miller, Russell Dixon, Stefan Zajic and S. Aubrey Stoch

  Drug Metabolism and Disposition May 2014, 42 (5) 818-827; DOI: https://doi.org/10.1124/dmd.113.056580
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  Carbon-Carbon Bond Cleavage in Activation of the Prodrug Nabumetone

  Fatbardha Varfaj, Siti N. A. Zulkifli, Hyoung-Goo Park, Victoria L. Challinor, James J. De Voss and Paul R. Ortiz de Montellano

  Drug Metabolism and Disposition May 2014, 42 (5) 828-838; DOI: https://doi.org/10.1124/dmd.114.056903
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  Low Dose of Oleanolic Acid Protects against Lithocholic Acid–Induced Cholestasis in Mice: Potential Involvement of Nuclear Factor-E2-Related Factor 2-Mediated Upregulation of Multidrug Resistance-Associated Proteins

  Pan Chen, Hang Zeng, Yongtao Wang, Xiaomei Fan, Chenshu Xu, Rongrong Deng, Xunian Zhou, Huichang Bi and Min Huang

  Drug Metabolism and Disposition May 2014, 42 (5) 844-852; DOI: https://doi.org/10.1124/dmd.113.056549
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  Polymorphisms and Haplotypes of the UDP-Glucuronosyltransferase 2B7 Gene Promoter

  Dong Gui Hu, Robyn Meech, Lu Lu, Ross A. McKinnon and Peter I. Mackenzie

  Drug Metabolism and Disposition May 2014, 42 (5) 854-862; DOI: https://doi.org/10.1124/dmd.113.056630
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  Metabolism and Pharmacokinetics of Allitinib in Cancer Patients: The Roles of Cytochrome P450s and Epoxide Hydrolase in its Biotransformation

  Lishan Lin, Cen Xie, Zhiwei Gao, Xiaoyan Chen and Dafang Zhong

  Drug Metabolism and Disposition May 2014, 42 (5) 872-884; DOI: https://doi.org/10.1124/dmd.113.056341
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  Optimized Methods for Targeted Peptide-Based Quantification of Human Uridine 5′-Diphosphate-Glucuronosyltransferases in Biological Specimens Using Liquid Chromatography–Tandem Mass Spectrometry

  Yuichiro Sato, Masanori Nagata, Kazuhiro Tetsuka, Kouichi Tamura, Aiji Miyashita, Akio Kawamura and Takashi Usui

  Drug Metabolism and Disposition May 2014, 42 (5) 885-889; DOI: https://doi.org/10.1124/dmd.113.056291
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  Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats

  Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh

  Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141
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  Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans

  Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim

  Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440
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  Pharmacokinetics, Metabolism, and Excretion of [¹⁴C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans

  Bill J. Smith, Yazdi Pithavala, Hai-Zhi Bu, Ping Kang, Brian Hee, Alan J. Deese, William F. Pool, Karen J. Klamerus, Ellen Y. Wu and Deepak K. Dalvie

  Drug Metabolism and Disposition May 2014, 42 (5) 918-931; DOI: https://doi.org/10.1124/dmd.113.056531
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  Assessment of the Mass Balance Recovery and Metabolite Profile of Avibactam in Humans and In Vitro Drug-Drug Interaction Potential

  Karthick Vishwanathan, Stuart Mair, Anshul Gupta, James Atherton, Jacqueline Clarkson-Jones, Timi Edeki and Shampa Das

  Drug Metabolism and Disposition May 2014, 42 (5) 932-942; DOI: https://doi.org/10.1124/dmd.113.055335
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  Inhibition of SULT4A1 Expression Induces Up-Regulation of Phototransduction Gene Expression in 72-Hour Postfertilization Zebrafish Larvae

  Frank Crittenden, Holly Thomas, Cheryl M. Ethen, Zhengliang L. Wu, Dongquan Chen, Timothy W. Kraft, John M. Parant and Charles N. Falany

  Drug Metabolism and Disposition May 2014, 42 (5) 947-953; DOI: https://doi.org/10.1124/dmd.114.057042
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  Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF₁ Antagonist

  Rowan A. Stringer, Gareth Williams, Franck Picard, Bindi Sohal, Olivier Kretz, Jeff McKenna and Joel A. Krauser

  Drug Metabolism and Disposition May 2014, 42 (5) 954-962; DOI: https://doi.org/10.1124/dmd.114.057265