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Index by author

May 01, 2014; Volume 42,Issue 5

A

  1. Álvarez, Ana I.

    1. Role of ABCG2 in Transport of the Mammalian Lignan Enterolactone and its Secretion into Milk in Abcg2 Knockout Mice
      Verónica Miguel, Jon Andoni Otero, Rocío García-Villalba, Francisco Tomás-Barberán, Juan Carlos Espín, Gracia Merino and Ana I. Álvarez
      Drug Metabolism and Disposition May 2014, 42 (5) 943-946; DOI: https://doi.org/10.1124/dmd.113.055970

  2. Atherton, James

    1. Assessment of the Mass Balance Recovery and Metabolite Profile of Avibactam in Humans and In Vitro Drug-Drug Interaction Potential
      Karthick Vishwanathan, Stuart Mair, Anshul Gupta, James Atherton, Jacqueline Clarkson-Jones, Timi Edeki and Shampa Das
      Drug Metabolism and Disposition May 2014, 42 (5) 932-942; DOI: https://doi.org/10.1124/dmd.113.055335

B

  1. Ballard, T. Eric

    1. Generation of Major Human Excretory and Circulating Drug Metabolites Using a Hepatocyte Relay Method
      T. Eric Ballard, Christine C. Orozco and R. Scott Obach
      Drug Metabolism and Disposition May 2014, 42 (5) 899-902; DOI: https://doi.org/10.1124/dmd.114.057026

  2. Bi, Huichang

    1. Low Dose of Oleanolic Acid Protects against Lithocholic Acid–Induced Cholestasis in Mice: Potential Involvement of Nuclear Factor-E2-Related Factor 2-Mediated Upregulation of Multidrug Resistance-Associated Proteins
      Pan Chen, Hang Zeng, Yongtao Wang, Xiaomei Fan, Chenshu Xu, Rongrong Deng, Xunian Zhou, Huichang Bi and Min Huang
      Drug Metabolism and Disposition May 2014, 42 (5) 844-852; DOI: https://doi.org/10.1124/dmd.113.056549

  3. Bu, Hai-Zhi

    1. Pharmacokinetics, Metabolism, and Excretion of [14C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans
      Bill J. Smith, Yazdi Pithavala, Hai-Zhi Bu, Ping Kang, Brian Hee, Alan J. Deese, William F. Pool, Karen J. Klamerus, Ellen Y. Wu and Deepak K. Dalvie
      Drug Metabolism and Disposition May 2014, 42 (5) 918-931; DOI: https://doi.org/10.1124/dmd.113.056531

C

  1. Challinor, Victoria L.

    1. Carbon-Carbon Bond Cleavage in Activation of the Prodrug Nabumetone
      Fatbardha Varfaj, Siti N. A. Zulkifli, Hyoung-Goo Park, Victoria L. Challinor, James J. De Voss and Paul R. Ortiz de Montellano
      Drug Metabolism and Disposition May 2014, 42 (5) 828-838; DOI: https://doi.org/10.1124/dmd.114.056903

  2. Chen, Dongquan

    1. Inhibition of SULT4A1 Expression Induces Up-Regulation of Phototransduction Gene Expression in 72-Hour Postfertilization Zebrafish Larvae
      Frank Crittenden, Holly Thomas, Cheryl M. Ethen, Zhengliang L. Wu, Dongquan Chen, Timothy W. Kraft, John M. Parant and Charles N. Falany
      Drug Metabolism and Disposition May 2014, 42 (5) 947-953; DOI: https://doi.org/10.1124/dmd.114.057042

  3. Chen, Jie

    1. Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
      Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
      Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440

  4. Chen, Pan

    1. Low Dose of Oleanolic Acid Protects against Lithocholic Acid–Induced Cholestasis in Mice: Potential Involvement of Nuclear Factor-E2-Related Factor 2-Mediated Upregulation of Multidrug Resistance-Associated Proteins
      Pan Chen, Hang Zeng, Yongtao Wang, Xiaomei Fan, Chenshu Xu, Rongrong Deng, Xunian Zhou, Huichang Bi and Min Huang
      Drug Metabolism and Disposition May 2014, 42 (5) 844-852; DOI: https://doi.org/10.1124/dmd.113.056549

  5. Chen, Xiaoyan

    1. Metabolism and Pharmacokinetics of Allitinib in Cancer Patients: The Roles of Cytochrome P450s and Epoxide Hydrolase in its Biotransformation
      Lishan Lin, Cen Xie, Zhiwei Gao, Xiaoyan Chen and Dafang Zhong
      Drug Metabolism and Disposition May 2014, 42 (5) 872-884; DOI: https://doi.org/10.1124/dmd.113.056341

  6. Clarkson-Jones, Jacqueline

    1. Assessment of the Mass Balance Recovery and Metabolite Profile of Avibactam in Humans and In Vitro Drug-Drug Interaction Potential
      Karthick Vishwanathan, Stuart Mair, Anshul Gupta, James Atherton, Jacqueline Clarkson-Jones, Timi Edeki and Shampa Das
      Drug Metabolism and Disposition May 2014, 42 (5) 932-942; DOI: https://doi.org/10.1124/dmd.113.055335

  7. Crittenden, Frank

    1. Inhibition of SULT4A1 Expression Induces Up-Regulation of Phototransduction Gene Expression in 72-Hour Postfertilization Zebrafish Larvae
      Frank Crittenden, Holly Thomas, Cheryl M. Ethen, Zhengliang L. Wu, Dongquan Chen, Timothy W. Kraft, John M. Parant and Charles N. Falany
      Drug Metabolism and Disposition May 2014, 42 (5) 947-953; DOI: https://doi.org/10.1124/dmd.114.057042

  8. Cuyckens, Filip

    1. Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
      Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
      Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440

D

  1. Dalvie, Deepak K.

    1. Pharmacokinetics, Metabolism, and Excretion of [14C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans
      Bill J. Smith, Yazdi Pithavala, Hai-Zhi Bu, Ping Kang, Brian Hee, Alan J. Deese, William F. Pool, Karen J. Klamerus, Ellen Y. Wu and Deepak K. Dalvie
      Drug Metabolism and Disposition May 2014, 42 (5) 918-931; DOI: https://doi.org/10.1124/dmd.113.056531

  2. Das, Shampa

    1. Assessment of the Mass Balance Recovery and Metabolite Profile of Avibactam in Humans and In Vitro Drug-Drug Interaction Potential
      Karthick Vishwanathan, Stuart Mair, Anshul Gupta, James Atherton, Jacqueline Clarkson-Jones, Timi Edeki and Shampa Das
      Drug Metabolism and Disposition May 2014, 42 (5) 932-942; DOI: https://doi.org/10.1124/dmd.113.055335

  3. Deese, Alan

    1. Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
      Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
      Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141

  4. Deese, Alan J.

    1. Pharmacokinetics, Metabolism, and Excretion of [14C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans
      Bill J. Smith, Yazdi Pithavala, Hai-Zhi Bu, Ping Kang, Brian Hee, Alan J. Deese, William F. Pool, Karen J. Klamerus, Ellen Y. Wu and Deepak K. Dalvie
      Drug Metabolism and Disposition May 2014, 42 (5) 918-931; DOI: https://doi.org/10.1124/dmd.113.056531

  5. Deng, Rongrong

    1. Low Dose of Oleanolic Acid Protects against Lithocholic Acid–Induced Cholestasis in Mice: Potential Involvement of Nuclear Factor-E2-Related Factor 2-Mediated Upregulation of Multidrug Resistance-Associated Proteins
      Pan Chen, Hang Zeng, Yongtao Wang, Xiaomei Fan, Chenshu Xu, Rongrong Deng, Xunian Zhou, Huichang Bi and Min Huang
      Drug Metabolism and Disposition May 2014, 42 (5) 844-852; DOI: https://doi.org/10.1124/dmd.113.056549

  6. Devineni, Damayanthi

    1. Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
      Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
      Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440

  7. De Voss, James J.

    1. Carbon-Carbon Bond Cleavage in Activation of the Prodrug Nabumetone
      Fatbardha Varfaj, Siti N. A. Zulkifli, Hyoung-Goo Park, Victoria L. Challinor, James J. De Voss and Paul R. Ortiz de Montellano
      Drug Metabolism and Disposition May 2014, 42 (5) 828-838; DOI: https://doi.org/10.1124/dmd.114.056903

  8. Dixon, Russell

    1. Disposition and Metabolism of the Cathepsin K Inhibitor Odanacatib in Humans
      Kelem Kassahun, Ian McIntosh, Kenneth Koeplinger, Li Sun, Jennifer E. Talaty, Deborah L. Miller, Russell Dixon, Stefan Zajic and S. Aubrey Stoch
      Drug Metabolism and Disposition May 2014, 42 (5) 818-827; DOI: https://doi.org/10.1124/dmd.113.056580

  9. Dorko, Kenneth

    1. Bedaquiline Metabolism: Enzymes and Novel Metabolites
      Ke Liu, Feng Li, Jie Lu, Shinlan Liu, Kenneth Dorko, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition May 2014, 42 (5) 863-866; DOI: https://doi.org/10.1124/dmd.113.056119

E

  1. Edeki, Timi

    1. Assessment of the Mass Balance Recovery and Metabolite Profile of Avibactam in Humans and In Vitro Drug-Drug Interaction Potential
      Karthick Vishwanathan, Stuart Mair, Anshul Gupta, James Atherton, Jacqueline Clarkson-Jones, Timi Edeki and Shampa Das
      Drug Metabolism and Disposition May 2014, 42 (5) 932-942; DOI: https://doi.org/10.1124/dmd.113.055335

  2. Espín, Juan Carlos

    1. Role of ABCG2 in Transport of the Mammalian Lignan Enterolactone and its Secretion into Milk in Abcg2 Knockout Mice
      Verónica Miguel, Jon Andoni Otero, Rocío García-Villalba, Francisco Tomás-Barberán, Juan Carlos Espín, Gracia Merino and Ana I. Álvarez
      Drug Metabolism and Disposition May 2014, 42 (5) 943-946; DOI: https://doi.org/10.1124/dmd.113.055970

  3. Ethen, Cheryl M.

    1. Inhibition of SULT4A1 Expression Induces Up-Regulation of Phototransduction Gene Expression in 72-Hour Postfertilization Zebrafish Larvae
      Frank Crittenden, Holly Thomas, Cheryl M. Ethen, Zhengliang L. Wu, Dongquan Chen, Timothy W. Kraft, John M. Parant and Charles N. Falany
      Drug Metabolism and Disposition May 2014, 42 (5) 947-953; DOI: https://doi.org/10.1124/dmd.114.057042

  4. Evans, David C.

    1. Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
      Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
      Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440

F

  1. Falany, Charles N.

    1. Inhibition of SULT4A1 Expression Induces Up-Regulation of Phototransduction Gene Expression in 72-Hour Postfertilization Zebrafish Larvae
      Frank Crittenden, Holly Thomas, Cheryl M. Ethen, Zhengliang L. Wu, Dongquan Chen, Timothy W. Kraft, John M. Parant and Charles N. Falany
      Drug Metabolism and Disposition May 2014, 42 (5) 947-953; DOI: https://doi.org/10.1124/dmd.114.057042

  2. Fan, Xiaomei

    1. Low Dose of Oleanolic Acid Protects against Lithocholic Acid–Induced Cholestasis in Mice: Potential Involvement of Nuclear Factor-E2-Related Factor 2-Mediated Upregulation of Multidrug Resistance-Associated Proteins
      Pan Chen, Hang Zeng, Yongtao Wang, Xiaomei Fan, Chenshu Xu, Rongrong Deng, Xunian Zhou, Huichang Bi and Min Huang
      Drug Metabolism and Disposition May 2014, 42 (5) 844-852; DOI: https://doi.org/10.1124/dmd.113.056549

  3. Feng, Hao

    1. 4β-Hydroxycholesterol as an Endogenous Biomarker of CYP3A Activity in Cynomolgus Monkeys
      Ke Li, Sylvia Zhao, Lingling Zhang, Xiaoyun Wu, Pan Shu, Yang Wang, Hao Feng, Zheming Gu and Helen Han Hsu
      Drug Metabolism and Disposition May 2014, 42 (5) 839-843; DOI: https://doi.org/10.1124/dmd.114.057224

  4. Ford, Kevin A.

    1. 1-Aminobenzotriazole Coincubated with (S)-Warfarin Results in Potent Inactivation of CYP2C9
      Jasleen K. Sodhi, Kevin A. Ford, Sophie Mukadam, Susan Wong, Cornelis E. C. A. Hop, S. Cyrus Khojasteh and Jason S. Halladay
      Drug Metabolism and Disposition May 2014, 42 (5) 813-817; DOI: https://doi.org/10.1124/dmd.113.055913

G

  1. Gao, Zhiwei

    1. Metabolism and Pharmacokinetics of Allitinib in Cancer Patients: The Roles of Cytochrome P450s and Epoxide Hydrolase in its Biotransformation
      Lishan Lin, Cen Xie, Zhiwei Gao, Xiaoyan Chen and Dafang Zhong
      Drug Metabolism and Disposition May 2014, 42 (5) 872-884; DOI: https://doi.org/10.1124/dmd.113.056341

  2. García-Villalba, Rocío

    1. Role of ABCG2 in Transport of the Mammalian Lignan Enterolactone and its Secretion into Milk in Abcg2 Knockout Mice
      Verónica Miguel, Jon Andoni Otero, Rocío García-Villalba, Francisco Tomás-Barberán, Juan Carlos Espín, Gracia Merino and Ana I. Álvarez
      Drug Metabolism and Disposition May 2014, 42 (5) 943-946; DOI: https://doi.org/10.1124/dmd.113.055970

  3. Gu, Zheming

    1. 4β-Hydroxycholesterol as an Endogenous Biomarker of CYP3A Activity in Cynomolgus Monkeys
      Ke Li, Sylvia Zhao, Lingling Zhang, Xiaoyun Wu, Pan Shu, Yang Wang, Hao Feng, Zheming Gu and Helen Han Hsu
      Drug Metabolism and Disposition May 2014, 42 (5) 839-843; DOI: https://doi.org/10.1124/dmd.114.057224

  4. Gupta, Anshul

    1. Assessment of the Mass Balance Recovery and Metabolite Profile of Avibactam in Humans and In Vitro Drug-Drug Interaction Potential
      Karthick Vishwanathan, Stuart Mair, Anshul Gupta, James Atherton, Jacqueline Clarkson-Jones, Timi Edeki and Shampa Das
      Drug Metabolism and Disposition May 2014, 42 (5) 932-942; DOI: https://doi.org/10.1124/dmd.113.055335

H

  1. Halladay, Jason S.

    1. 1-Aminobenzotriazole Coincubated with (S)-Warfarin Results in Potent Inactivation of CYP2C9
      Jasleen K. Sodhi, Kevin A. Ford, Sophie Mukadam, Susan Wong, Cornelis E. C. A. Hop, S. Cyrus Khojasteh and Jason S. Halladay
      Drug Metabolism and Disposition May 2014, 42 (5) 813-817; DOI: https://doi.org/10.1124/dmd.113.055913

  2. Han Hsu, Helen

    1. 4β-Hydroxycholesterol as an Endogenous Biomarker of CYP3A Activity in Cynomolgus Monkeys
      Ke Li, Sylvia Zhao, Lingling Zhang, Xiaoyun Wu, Pan Shu, Yang Wang, Hao Feng, Zheming Gu and Helen Han Hsu
      Drug Metabolism and Disposition May 2014, 42 (5) 839-843; DOI: https://doi.org/10.1124/dmd.114.057224

  3. Hee, Brian

    1. Pharmacokinetics, Metabolism, and Excretion of [14C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans
      Bill J. Smith, Yazdi Pithavala, Hai-Zhi Bu, Ping Kang, Brian Hee, Alan J. Deese, William F. Pool, Karen J. Klamerus, Ellen Y. Wu and Deepak K. Dalvie
      Drug Metabolism and Disposition May 2014, 42 (5) 918-931; DOI: https://doi.org/10.1124/dmd.113.056531

  4. Hop, Cornelis E. C. A.

    1. 1-Aminobenzotriazole Coincubated with (S)-Warfarin Results in Potent Inactivation of CYP2C9
      Jasleen K. Sodhi, Kevin A. Ford, Sophie Mukadam, Susan Wong, Cornelis E. C. A. Hop, S. Cyrus Khojasteh and Jason S. Halladay
      Drug Metabolism and Disposition May 2014, 42 (5) 813-817; DOI: https://doi.org/10.1124/dmd.113.055913

  5. Hop, Cornelis E.C.A.

    1. Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
      Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
      Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141

  6. Hu, Dong Gui

    1. Polymorphisms and Haplotypes of the UDP-Glucuronosyltransferase 2B7 Gene Promoter
      Dong Gui Hu, Robyn Meech, Lu Lu, Ross A. McKinnon and Peter I. Mackenzie
      Drug Metabolism and Disposition May 2014, 42 (5) 854-862; DOI: https://doi.org/10.1124/dmd.113.056630

  7. Huang, Min

    1. Low Dose of Oleanolic Acid Protects against Lithocholic Acid–Induced Cholestasis in Mice: Potential Involvement of Nuclear Factor-E2-Related Factor 2-Mediated Upregulation of Multidrug Resistance-Associated Proteins
      Pan Chen, Hang Zeng, Yongtao Wang, Xiaomei Fan, Chenshu Xu, Rongrong Deng, Xunian Zhou, Huichang Bi and Min Huang
      Drug Metabolism and Disposition May 2014, 42 (5) 844-852; DOI: https://doi.org/10.1124/dmd.113.056549

  8. Hunt, Kevin W.

    1. Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
      Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
      Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141

I

  1. Iwasaki, Kazuhide

    1. Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450
      Kanako Yajima, Yasuhiro Uno, Norie Murayama, Shotaro Uehara, Makiko Shimizu, Chika Nakamura, Kazuhide Iwasaki, Masahiro Utoh and Hiroshi Yamazaki
      Drug Metabolism and Disposition May 2014, 42 (5) 867-871; DOI: https://doi.org/10.1124/dmd.113.056804

J

  1. Johnson, Mark D.

    1. Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
      Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
      Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440

K

  1. Kalamaridis, Dennis

    1. Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
      Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
      Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440

  2. Kallan, Nicholas C.

    1. Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
      Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
      Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141

  3. Kang, Ping

    1. Pharmacokinetics, Metabolism, and Excretion of [14C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans
      Bill J. Smith, Yazdi Pithavala, Hai-Zhi Bu, Ping Kang, Brian Hee, Alan J. Deese, William F. Pool, Karen J. Klamerus, Ellen Y. Wu and Deepak K. Dalvie
      Drug Metabolism and Disposition May 2014, 42 (5) 918-931; DOI: https://doi.org/10.1124/dmd.113.056531

  4. Kassahun, Kelem

    1. Disposition and Metabolism of the Cathepsin K Inhibitor Odanacatib in Humans
      Kelem Kassahun, Ian McIntosh, Kenneth Koeplinger, Li Sun, Jennifer E. Talaty, Deborah L. Miller, Russell Dixon, Stefan Zajic and S. Aubrey Stoch
      Drug Metabolism and Disposition May 2014, 42 (5) 818-827; DOI: https://doi.org/10.1124/dmd.113.056580

  5. Kawamura, Akio

    1. Optimized Methods for Targeted Peptide-Based Quantification of Human Uridine 5′-Diphosphate-Glucuronosyltransferases in Biological Specimens Using Liquid Chromatography–Tandem Mass Spectrometry
      Yuichiro Sato, Masanori Nagata, Kazuhiro Tetsuka, Kouichi Tamura, Aiji Miyashita, Akio Kawamura and Takashi Usui
      Drug Metabolism and Disposition May 2014, 42 (5) 885-889; DOI: https://doi.org/10.1124/dmd.113.056291

  6. Kelley, Michael F.

    1. Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
      Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
      Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440

  7. Khojasteh, S. Cyrus

    1. 1-Aminobenzotriazole Coincubated with (S)-Warfarin Results in Potent Inactivation of CYP2C9
      Jasleen K. Sodhi, Kevin A. Ford, Sophie Mukadam, Susan Wong, Cornelis E. C. A. Hop, S. Cyrus Khojasteh and Jason S. Halladay
      Drug Metabolism and Disposition May 2014, 42 (5) 813-817; DOI: https://doi.org/10.1124/dmd.113.055913
    2. Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
      Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
      Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141

  8. Kim-Kang, Heasook

    1. Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
      Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
      Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141

  9. Klamerus, Karen J.

    1. Pharmacokinetics, Metabolism, and Excretion of [14C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans
      Bill J. Smith, Yazdi Pithavala, Hai-Zhi Bu, Ping Kang, Brian Hee, Alan J. Deese, William F. Pool, Karen J. Klamerus, Ellen Y. Wu and Deepak K. Dalvie
      Drug Metabolism and Disposition May 2014, 42 (5) 918-931; DOI: https://doi.org/10.1124/dmd.113.056531

  10. Koeplinger, Kenneth

    1. Disposition and Metabolism of the Cathepsin K Inhibitor Odanacatib in Humans
      Kelem Kassahun, Ian McIntosh, Kenneth Koeplinger, Li Sun, Jennifer E. Talaty, Deborah L. Miller, Russell Dixon, Stefan Zajic and S. Aubrey Stoch
      Drug Metabolism and Disposition May 2014, 42 (5) 818-827; DOI: https://doi.org/10.1124/dmd.113.056580

  11. Kraft, Timothy W.

    1. Inhibition of SULT4A1 Expression Induces Up-Regulation of Phototransduction Gene Expression in 72-Hour Postfertilization Zebrafish Larvae
      Frank Crittenden, Holly Thomas, Cheryl M. Ethen, Zhengliang L. Wu, Dongquan Chen, Timothy W. Kraft, John M. Parant and Charles N. Falany
      Drug Metabolism and Disposition May 2014, 42 (5) 947-953; DOI: https://doi.org/10.1124/dmd.114.057042

  12. Krauser, Joel A.

    1. Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF1 Antagonist
      Rowan A. Stringer, Gareth Williams, Franck Picard, Bindi Sohal, Olivier Kretz, Jeff McKenna and Joel A. Krauser
      Drug Metabolism and Disposition May 2014, 42 (5) 954-962; DOI: https://doi.org/10.1124/dmd.114.057265

  13. Kretz, Olivier

    1. Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF1 Antagonist
      Rowan A. Stringer, Gareth Williams, Franck Picard, Bindi Sohal, Olivier Kretz, Jeff McKenna and Joel A. Krauser
      Drug Metabolism and Disposition May 2014, 42 (5) 954-962; DOI: https://doi.org/10.1124/dmd.114.057265

L

  1. Li, Feng

    1. Bedaquiline Metabolism: Enzymes and Novel Metabolites
      Ke Liu, Feng Li, Jie Lu, Shinlan Liu, Kenneth Dorko, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition May 2014, 42 (5) 863-866; DOI: https://doi.org/10.1124/dmd.113.056119

  2. Li, Ke

    1. 4β-Hydroxycholesterol as an Endogenous Biomarker of CYP3A Activity in Cynomolgus Monkeys
      Ke Li, Sylvia Zhao, Lingling Zhang, Xiaoyun Wu, Pan Shu, Yang Wang, Hao Feng, Zheming Gu and Helen Han Hsu
      Drug Metabolism and Disposition May 2014, 42 (5) 839-843; DOI: https://doi.org/10.1124/dmd.114.057224

  3. Lim, Heng Keang

    1. Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
      Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
      Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440

  4. Lin, Lishan

    1. Metabolism and Pharmacokinetics of Allitinib in Cancer Patients: The Roles of Cytochrome P450s and Epoxide Hydrolase in its Biotransformation
      Lishan Lin, Cen Xie, Zhiwei Gao, Xiaoyan Chen and Dafang Zhong
      Drug Metabolism and Disposition May 2014, 42 (5) 872-884; DOI: https://doi.org/10.1124/dmd.113.056341

  5. Lin, Ronghui

    1. Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
      Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
      Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440

  6. Liu, Ke

    1. Bedaquiline Metabolism: Enzymes and Novel Metabolites
      Ke Liu, Feng Li, Jie Lu, Shinlan Liu, Kenneth Dorko, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition May 2014, 42 (5) 863-866; DOI: https://doi.org/10.1124/dmd.113.056119

  7. Liu, Shinlan

    1. Bedaquiline Metabolism: Enzymes and Novel Metabolites
      Ke Liu, Feng Li, Jie Lu, Shinlan Liu, Kenneth Dorko, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition May 2014, 42 (5) 863-866; DOI: https://doi.org/10.1124/dmd.113.056119

  8. Liu, Xingrong

    1. Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
      Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
      Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141

  9. Lu, Jie

    1. Bedaquiline Metabolism: Enzymes and Novel Metabolites
      Ke Liu, Feng Li, Jie Lu, Shinlan Liu, Kenneth Dorko, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition May 2014, 42 (5) 863-866; DOI: https://doi.org/10.1124/dmd.113.056119

  10. Lu, Lu

    1. Polymorphisms and Haplotypes of the UDP-Glucuronosyltransferase 2B7 Gene Promoter
      Dong Gui Hu, Robyn Meech, Lu Lu, Ross A. McKinnon and Peter I. Mackenzie
      Drug Metabolism and Disposition May 2014, 42 (5) 854-862; DOI: https://doi.org/10.1124/dmd.113.056630

M

  1. Ma, Shuguang

    1. Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
      Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
      Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141

  2. Ma, Xiaochao

    1. Bedaquiline Metabolism: Enzymes and Novel Metabolites
      Ke Liu, Feng Li, Jie Lu, Shinlan Liu, Kenneth Dorko, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition May 2014, 42 (5) 863-866; DOI: https://doi.org/10.1124/dmd.113.056119

  3. Mackenzie, Peter I.

    1. Polymorphisms and Haplotypes of the UDP-Glucuronosyltransferase 2B7 Gene Promoter
      Dong Gui Hu, Robyn Meech, Lu Lu, Ross A. McKinnon and Peter I. Mackenzie
      Drug Metabolism and Disposition May 2014, 42 (5) 854-862; DOI: https://doi.org/10.1124/dmd.113.056630

  4. Mair, Stuart

    1. Assessment of the Mass Balance Recovery and Metabolite Profile of Avibactam in Humans and In Vitro Drug-Drug Interaction Potential
      Karthick Vishwanathan, Stuart Mair, Anshul Gupta, James Atherton, Jacqueline Clarkson-Jones, Timi Edeki and Shampa Das
      Drug Metabolism and Disposition May 2014, 42 (5) 932-942; DOI: https://doi.org/10.1124/dmd.113.055335

  5. Mamidi, Rao N. V. S.

    1. Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
      Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
      Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440

  6. McIntosh, Ian

    1. Disposition and Metabolism of the Cathepsin K Inhibitor Odanacatib in Humans
      Kelem Kassahun, Ian McIntosh, Kenneth Koeplinger, Li Sun, Jennifer E. Talaty, Deborah L. Miller, Russell Dixon, Stefan Zajic and S. Aubrey Stoch
      Drug Metabolism and Disposition May 2014, 42 (5) 818-827; DOI: https://doi.org/10.1124/dmd.113.056580

  7. McKenna, Jeff

    1. Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF1 Antagonist
      Rowan A. Stringer, Gareth Williams, Franck Picard, Bindi Sohal, Olivier Kretz, Jeff McKenna and Joel A. Krauser
      Drug Metabolism and Disposition May 2014, 42 (5) 954-962; DOI: https://doi.org/10.1124/dmd.114.057265

  8. McKinnon, Ross A.

    1. Polymorphisms and Haplotypes of the UDP-Glucuronosyltransferase 2B7 Gene Promoter
      Dong Gui Hu, Robyn Meech, Lu Lu, Ross A. McKinnon and Peter I. Mackenzie
      Drug Metabolism and Disposition May 2014, 42 (5) 854-862; DOI: https://doi.org/10.1124/dmd.113.056630

  9. Meech, Robyn

    1. Polymorphisms and Haplotypes of the UDP-Glucuronosyltransferase 2B7 Gene Promoter
      Dong Gui Hu, Robyn Meech, Lu Lu, Ross A. McKinnon and Peter I. Mackenzie
      Drug Metabolism and Disposition May 2014, 42 (5) 854-862; DOI: https://doi.org/10.1124/dmd.113.056630

  10. Merino, Gracia

    1. Role of ABCG2 in Transport of the Mammalian Lignan Enterolactone and its Secretion into Milk in Abcg2 Knockout Mice
      Verónica Miguel, Jon Andoni Otero, Rocío García-Villalba, Francisco Tomás-Barberán, Juan Carlos Espín, Gracia Merino and Ana I. Álvarez
      Drug Metabolism and Disposition May 2014, 42 (5) 943-946; DOI: https://doi.org/10.1124/dmd.113.055970

  11. Miguel, Verónica

    1. Role of ABCG2 in Transport of the Mammalian Lignan Enterolactone and its Secretion into Milk in Abcg2 Knockout Mice
      Verónica Miguel, Jon Andoni Otero, Rocío García-Villalba, Francisco Tomás-Barberán, Juan Carlos Espín, Gracia Merino and Ana I. Álvarez
      Drug Metabolism and Disposition May 2014, 42 (5) 943-946; DOI: https://doi.org/10.1124/dmd.113.055970

  12. Miller, Deborah L.

    1. Disposition and Metabolism of the Cathepsin K Inhibitor Odanacatib in Humans
      Kelem Kassahun, Ian McIntosh, Kenneth Koeplinger, Li Sun, Jennifer E. Talaty, Deborah L. Miller, Russell Dixon, Stefan Zajic and S. Aubrey Stoch
      Drug Metabolism and Disposition May 2014, 42 (5) 818-827; DOI: https://doi.org/10.1124/dmd.113.056580

  13. Miyashita, Aiji

    1. Optimized Methods for Targeted Peptide-Based Quantification of Human Uridine 5′-Diphosphate-Glucuronosyltransferases in Biological Specimens Using Liquid Chromatography–Tandem Mass Spectrometry
      Yuichiro Sato, Masanori Nagata, Kazuhiro Tetsuka, Kouichi Tamura, Aiji Miyashita, Akio Kawamura and Takashi Usui
      Drug Metabolism and Disposition May 2014, 42 (5) 885-889; DOI: https://doi.org/10.1124/dmd.113.056291

  14. Mukadam, Sophie

    1. 1-Aminobenzotriazole Coincubated with (S)-Warfarin Results in Potent Inactivation of CYP2C9
      Jasleen K. Sodhi, Kevin A. Ford, Sophie Mukadam, Susan Wong, Cornelis E. C. A. Hop, S. Cyrus Khojasteh and Jason S. Halladay
      Drug Metabolism and Disposition May 2014, 42 (5) 813-817; DOI: https://doi.org/10.1124/dmd.113.055913

  15. Murayama, Norie

    1. Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450
      Kanako Yajima, Yasuhiro Uno, Norie Murayama, Shotaro Uehara, Makiko Shimizu, Chika Nakamura, Kazuhide Iwasaki, Masahiro Utoh and Hiroshi Yamazaki
      Drug Metabolism and Disposition May 2014, 42 (5) 867-871; DOI: https://doi.org/10.1124/dmd.113.056804

N

  1. Nagata, Masanori

    1. Optimized Methods for Targeted Peptide-Based Quantification of Human Uridine 5′-Diphosphate-Glucuronosyltransferases in Biological Specimens Using Liquid Chromatography–Tandem Mass Spectrometry
      Yuichiro Sato, Masanori Nagata, Kazuhiro Tetsuka, Kouichi Tamura, Aiji Miyashita, Akio Kawamura and Takashi Usui
      Drug Metabolism and Disposition May 2014, 42 (5) 885-889; DOI: https://doi.org/10.1124/dmd.113.056291

  2. Nakamura, Chika

    1. Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450
      Kanako Yajima, Yasuhiro Uno, Norie Murayama, Shotaro Uehara, Makiko Shimizu, Chika Nakamura, Kazuhide Iwasaki, Masahiro Utoh and Hiroshi Yamazaki
      Drug Metabolism and Disposition May 2014, 42 (5) 867-871; DOI: https://doi.org/10.1124/dmd.113.056804

O

  1. Obach, R. Scott

    1. Generation of Major Human Excretory and Circulating Drug Metabolites Using a Hepatocyte Relay Method
      T. Eric Ballard, Christine C. Orozco and R. Scott Obach
      Drug Metabolism and Disposition May 2014, 42 (5) 899-902; DOI: https://doi.org/10.1124/dmd.114.057026

  2. Orozco, Christine C.

    1. Generation of Major Human Excretory and Circulating Drug Metabolites Using a Hepatocyte Relay Method
      T. Eric Ballard, Christine C. Orozco and R. Scott Obach
      Drug Metabolism and Disposition May 2014, 42 (5) 899-902; DOI: https://doi.org/10.1124/dmd.114.057026

  3. Ortiz de Montellano, Paul R.

    1. Carbon-Carbon Bond Cleavage in Activation of the Prodrug Nabumetone
      Fatbardha Varfaj, Siti N. A. Zulkifli, Hyoung-Goo Park, Victoria L. Challinor, James J. De Voss and Paul R. Ortiz de Montellano
      Drug Metabolism and Disposition May 2014, 42 (5) 828-838; DOI: https://doi.org/10.1124/dmd.114.056903

  4. Otero, Jon Andoni

    1. Role of ABCG2 in Transport of the Mammalian Lignan Enterolactone and its Secretion into Milk in Abcg2 Knockout Mice
      Verónica Miguel, Jon Andoni Otero, Rocío García-Villalba, Francisco Tomás-Barberán, Juan Carlos Espín, Gracia Merino and Ana I. Álvarez
      Drug Metabolism and Disposition May 2014, 42 (5) 943-946; DOI: https://doi.org/10.1124/dmd.113.055970

P

  1. Parant, John M.

    1. Inhibition of SULT4A1 Expression Induces Up-Regulation of Phototransduction Gene Expression in 72-Hour Postfertilization Zebrafish Larvae
      Frank Crittenden, Holly Thomas, Cheryl M. Ethen, Zhengliang L. Wu, Dongquan Chen, Timothy W. Kraft, John M. Parant and Charles N. Falany
      Drug Metabolism and Disposition May 2014, 42 (5) 947-953; DOI: https://doi.org/10.1124/dmd.114.057042

  2. Park, Hyoung-Goo

    1. Carbon-Carbon Bond Cleavage in Activation of the Prodrug Nabumetone
      Fatbardha Varfaj, Siti N. A. Zulkifli, Hyoung-Goo Park, Victoria L. Challinor, James J. De Voss and Paul R. Ortiz de Montellano
      Drug Metabolism and Disposition May 2014, 42 (5) 828-838; DOI: https://doi.org/10.1124/dmd.114.056903

  3. Picard, Franck

    1. Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF1 Antagonist
      Rowan A. Stringer, Gareth Williams, Franck Picard, Bindi Sohal, Olivier Kretz, Jeff McKenna and Joel A. Krauser
      Drug Metabolism and Disposition May 2014, 42 (5) 954-962; DOI: https://doi.org/10.1124/dmd.114.057265

  4. Pithavala, Yazdi

    1. Pharmacokinetics, Metabolism, and Excretion of [14C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans
      Bill J. Smith, Yazdi Pithavala, Hai-Zhi Bu, Ping Kang, Brian Hee, Alan J. Deese, William F. Pool, Karen J. Klamerus, Ellen Y. Wu and Deepak K. Dalvie
      Drug Metabolism and Disposition May 2014, 42 (5) 918-931; DOI: https://doi.org/10.1124/dmd.113.056531

  5. Pool, William F.

    1. Pharmacokinetics, Metabolism, and Excretion of [14C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans
      Bill J. Smith, Yazdi Pithavala, Hai-Zhi Bu, Ping Kang, Brian Hee, Alan J. Deese, William F. Pool, Karen J. Klamerus, Ellen Y. Wu and Deepak K. Dalvie
      Drug Metabolism and Disposition May 2014, 42 (5) 918-931; DOI: https://doi.org/10.1124/dmd.113.056531

S

  1. Sato, Yuichiro

    1. Optimized Methods for Targeted Peptide-Based Quantification of Human Uridine 5′-Diphosphate-Glucuronosyltransferases in Biological Specimens Using Liquid Chromatography–Tandem Mass Spectrometry
      Yuichiro Sato, Masanori Nagata, Kazuhiro Tetsuka, Kouichi Tamura, Aiji Miyashita, Akio Kawamura and Takashi Usui
      Drug Metabolism and Disposition May 2014, 42 (5) 885-889; DOI: https://doi.org/10.1124/dmd.113.056291

  2. Scheers, Ellen

    1. Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
      Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
      Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440

  3. Sha, Sue

    1. Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
      Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
      Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440

  4. Shimizu, Makiko

    1. Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450
      Kanako Yajima, Yasuhiro Uno, Norie Murayama, Shotaro Uehara, Makiko Shimizu, Chika Nakamura, Kazuhide Iwasaki, Masahiro Utoh and Hiroshi Yamazaki
      Drug Metabolism and Disposition May 2014, 42 (5) 867-871; DOI: https://doi.org/10.1124/dmd.113.056804

  5. Shu, Pan

    1. 4β-Hydroxycholesterol as an Endogenous Biomarker of CYP3A Activity in Cynomolgus Monkeys
      Ke Li, Sylvia Zhao, Lingling Zhang, Xiaoyun Wu, Pan Shu, Yang Wang, Hao Feng, Zheming Gu and Helen Han Hsu
      Drug Metabolism and Disposition May 2014, 42 (5) 839-843; DOI: https://doi.org/10.1124/dmd.114.057224

  6. Silva, Jose

    1. Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans
      Rao N. V. S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Heng Keang Lim
      Drug Metabolism and Disposition May 2014, 42 (5) 903-916; DOI: https://doi.org/10.1124/dmd.113.056440

  7. Siu, Michael

    1. Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
      Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
      Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141

  8. Smith, Bill J.

    1. Pharmacokinetics, Metabolism, and Excretion of [14C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans
      Bill J. Smith, Yazdi Pithavala, Hai-Zhi Bu, Ping Kang, Brian Hee, Alan J. Deese, William F. Pool, Karen J. Klamerus, Ellen Y. Wu and Deepak K. Dalvie
      Drug Metabolism and Disposition May 2014, 42 (5) 918-931; DOI: https://doi.org/10.1124/dmd.113.056531

  9. Sodhi, Jasleen K.

    1. 1-Aminobenzotriazole Coincubated with (S)-Warfarin Results in Potent Inactivation of CYP2C9
      Jasleen K. Sodhi, Kevin A. Ford, Sophie Mukadam, Susan Wong, Cornelis E. C. A. Hop, S. Cyrus Khojasteh and Jason S. Halladay
      Drug Metabolism and Disposition May 2014, 42 (5) 813-817; DOI: https://doi.org/10.1124/dmd.113.055913

  10. Sohal, Bindi

    1. Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF1 Antagonist
      Rowan A. Stringer, Gareth Williams, Franck Picard, Bindi Sohal, Olivier Kretz, Jeff McKenna and Joel A. Krauser
      Drug Metabolism and Disposition May 2014, 42 (5) 954-962; DOI: https://doi.org/10.1124/dmd.114.057265

  11. Stoch, S. Aubrey

    1. Disposition and Metabolism of the Cathepsin K Inhibitor Odanacatib in Humans
      Kelem Kassahun, Ian McIntosh, Kenneth Koeplinger, Li Sun, Jennifer E. Talaty, Deborah L. Miller, Russell Dixon, Stefan Zajic and S. Aubrey Stoch
      Drug Metabolism and Disposition May 2014, 42 (5) 818-827; DOI: https://doi.org/10.1124/dmd.113.056580

  12. Stringer, Rowan A.

    1. Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF1 Antagonist
      Rowan A. Stringer, Gareth Williams, Franck Picard, Bindi Sohal, Olivier Kretz, Jeff McKenna and Joel A. Krauser
      Drug Metabolism and Disposition May 2014, 42 (5) 954-962; DOI: https://doi.org/10.1124/dmd.114.057265

  13. Sun, Li

    1. Disposition and Metabolism of the Cathepsin K Inhibitor Odanacatib in Humans
      Kelem Kassahun, Ian McIntosh, Kenneth Koeplinger, Li Sun, Jennifer E. Talaty, Deborah L. Miller, Russell Dixon, Stefan Zajic and S. Aubrey Stoch
      Drug Metabolism and Disposition May 2014, 42 (5) 818-827; DOI: https://doi.org/10.1124/dmd.113.056580

T

  1. Takahashi, Ryan

    1. Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
      Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
      Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141

  2. Talaty, Jennifer E.

    1. Disposition and Metabolism of the Cathepsin K Inhibitor Odanacatib in Humans
      Kelem Kassahun, Ian McIntosh, Kenneth Koeplinger, Li Sun, Jennifer E. Talaty, Deborah L. Miller, Russell Dixon, Stefan Zajic and S. Aubrey Stoch
      Drug Metabolism and Disposition May 2014, 42 (5) 818-827; DOI: https://doi.org/10.1124/dmd.113.056580

  3. Tamura, Kouichi

    1. Optimized Methods for Targeted Peptide-Based Quantification of Human Uridine 5′-Diphosphate-Glucuronosyltransferases in Biological Specimens Using Liquid Chromatography–Tandem Mass Spectrometry
      Yuichiro Sato, Masanori Nagata, Kazuhiro Tetsuka, Kouichi Tamura, Aiji Miyashita, Akio Kawamura and Takashi Usui
      Drug Metabolism and Disposition May 2014, 42 (5) 885-889; DOI: https://doi.org/10.1124/dmd.113.056291

  4. Tetsuka, Kazuhiro

    1. Optimized Methods for Targeted Peptide-Based Quantification of Human Uridine 5′-Diphosphate-Glucuronosyltransferases in Biological Specimens Using Liquid Chromatography–Tandem Mass Spectrometry
      Yuichiro Sato, Masanori Nagata, Kazuhiro Tetsuka, Kouichi Tamura, Aiji Miyashita, Akio Kawamura and Takashi Usui
      Drug Metabolism and Disposition May 2014, 42 (5) 885-889; DOI: https://doi.org/10.1124/dmd.113.056291

  5. Thomas, Holly

    1. Inhibition of SULT4A1 Expression Induces Up-Regulation of Phototransduction Gene Expression in 72-Hour Postfertilization Zebrafish Larvae
      Frank Crittenden, Holly Thomas, Cheryl M. Ethen, Zhengliang L. Wu, Dongquan Chen, Timothy W. Kraft, John M. Parant and Charles N. Falany
      Drug Metabolism and Disposition May 2014, 42 (5) 947-953; DOI: https://doi.org/10.1124/dmd.114.057042

  6. Tomás-Barberán, Francisco

    1. Role of ABCG2 in Transport of the Mammalian Lignan Enterolactone and its Secretion into Milk in Abcg2 Knockout Mice
      Verónica Miguel, Jon Andoni Otero, Rocío García-Villalba, Francisco Tomás-Barberán, Juan Carlos Espín, Gracia Merino and Ana I. Álvarez
      Drug Metabolism and Disposition May 2014, 42 (5) 943-946; DOI: https://doi.org/10.1124/dmd.113.055970

U

  1. Uehara, Shotaro

    1. Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450
      Kanako Yajima, Yasuhiro Uno, Norie Murayama, Shotaro Uehara, Makiko Shimizu, Chika Nakamura, Kazuhide Iwasaki, Masahiro Utoh and Hiroshi Yamazaki
      Drug Metabolism and Disposition May 2014, 42 (5) 867-871; DOI: https://doi.org/10.1124/dmd.113.056804

  2. Uno, Yasuhiro

    1. Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450
      Kanako Yajima, Yasuhiro Uno, Norie Murayama, Shotaro Uehara, Makiko Shimizu, Chika Nakamura, Kazuhide Iwasaki, Masahiro Utoh and Hiroshi Yamazaki
      Drug Metabolism and Disposition May 2014, 42 (5) 867-871; DOI: https://doi.org/10.1124/dmd.113.056804

  3. Usui, Takashi

    1. Optimized Methods for Targeted Peptide-Based Quantification of Human Uridine 5′-Diphosphate-Glucuronosyltransferases in Biological Specimens Using Liquid Chromatography–Tandem Mass Spectrometry
      Yuichiro Sato, Masanori Nagata, Kazuhiro Tetsuka, Kouichi Tamura, Aiji Miyashita, Akio Kawamura and Takashi Usui
      Drug Metabolism and Disposition May 2014, 42 (5) 885-889; DOI: https://doi.org/10.1124/dmd.113.056291

  4. Utoh, Masahiro

    1. Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450
      Kanako Yajima, Yasuhiro Uno, Norie Murayama, Shotaro Uehara, Makiko Shimizu, Chika Nakamura, Kazuhide Iwasaki, Masahiro Utoh and Hiroshi Yamazaki
      Drug Metabolism and Disposition May 2014, 42 (5) 867-871; DOI: https://doi.org/10.1124/dmd.113.056804

V

  1. Varfaj, Fatbardha

    1. Carbon-Carbon Bond Cleavage in Activation of the Prodrug Nabumetone
      Fatbardha Varfaj, Siti N. A. Zulkifli, Hyoung-Goo Park, Victoria L. Challinor, James J. De Voss and Paul R. Ortiz de Montellano
      Drug Metabolism and Disposition May 2014, 42 (5) 828-838; DOI: https://doi.org/10.1124/dmd.114.056903

  2. Vishwanathan, Karthick

    1. Assessment of the Mass Balance Recovery and Metabolite Profile of Avibactam in Humans and In Vitro Drug-Drug Interaction Potential
      Karthick Vishwanathan, Stuart Mair, Anshul Gupta, James Atherton, Jacqueline Clarkson-Jones, Timi Edeki and Shampa Das
      Drug Metabolism and Disposition May 2014, 42 (5) 932-942; DOI: https://doi.org/10.1124/dmd.113.055335

W

  1. Wang, Yang

    1. 4β-Hydroxycholesterol as an Endogenous Biomarker of CYP3A Activity in Cynomolgus Monkeys
      Ke Li, Sylvia Zhao, Lingling Zhang, Xiaoyun Wu, Pan Shu, Yang Wang, Hao Feng, Zheming Gu and Helen Han Hsu
      Drug Metabolism and Disposition May 2014, 42 (5) 839-843; DOI: https://doi.org/10.1124/dmd.114.057224

  2. Wang, Yongtao

    1. Low Dose of Oleanolic Acid Protects against Lithocholic Acid–Induced Cholestasis in Mice: Potential Involvement of Nuclear Factor-E2-Related Factor 2-Mediated Upregulation of Multidrug Resistance-Associated Proteins
      Pan Chen, Hang Zeng, Yongtao Wang, Xiaomei Fan, Chenshu Xu, Rongrong Deng, Xunian Zhou, Huichang Bi and Min Huang
      Drug Metabolism and Disposition May 2014, 42 (5) 844-852; DOI: https://doi.org/10.1124/dmd.113.056549

  3. Williams, Gareth

    1. Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF1 Antagonist
      Rowan A. Stringer, Gareth Williams, Franck Picard, Bindi Sohal, Olivier Kretz, Jeff McKenna and Joel A. Krauser
      Drug Metabolism and Disposition May 2014, 42 (5) 954-962; DOI: https://doi.org/10.1124/dmd.114.057265

  4. Wong, Susan

    1. 1-Aminobenzotriazole Coincubated with (S)-Warfarin Results in Potent Inactivation of CYP2C9
      Jasleen K. Sodhi, Kevin A. Ford, Sophie Mukadam, Susan Wong, Cornelis E. C. A. Hop, S. Cyrus Khojasteh and Jason S. Halladay
      Drug Metabolism and Disposition May 2014, 42 (5) 813-817; DOI: https://doi.org/10.1124/dmd.113.055913

  5. Wu, Ellen Y.

    1. Pharmacokinetics, Metabolism, and Excretion of [14C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans
      Bill J. Smith, Yazdi Pithavala, Hai-Zhi Bu, Ping Kang, Brian Hee, Alan J. Deese, William F. Pool, Karen J. Klamerus, Ellen Y. Wu and Deepak K. Dalvie
      Drug Metabolism and Disposition May 2014, 42 (5) 918-931; DOI: https://doi.org/10.1124/dmd.113.056531

  6. Wu, Xiaoyun

    1. 4β-Hydroxycholesterol as an Endogenous Biomarker of CYP3A Activity in Cynomolgus Monkeys
      Ke Li, Sylvia Zhao, Lingling Zhang, Xiaoyun Wu, Pan Shu, Yang Wang, Hao Feng, Zheming Gu and Helen Han Hsu
      Drug Metabolism and Disposition May 2014, 42 (5) 839-843; DOI: https://doi.org/10.1124/dmd.114.057224

  7. Wu, Zhengliang L.

    1. Inhibition of SULT4A1 Expression Induces Up-Regulation of Phototransduction Gene Expression in 72-Hour Postfertilization Zebrafish Larvae
      Frank Crittenden, Holly Thomas, Cheryl M. Ethen, Zhengliang L. Wu, Dongquan Chen, Timothy W. Kraft, John M. Parant and Charles N. Falany
      Drug Metabolism and Disposition May 2014, 42 (5) 947-953; DOI: https://doi.org/10.1124/dmd.114.057042

X

  1. Xie, Cen

    1. Metabolism and Pharmacokinetics of Allitinib in Cancer Patients: The Roles of Cytochrome P450s and Epoxide Hydrolase in its Biotransformation
      Lishan Lin, Cen Xie, Zhiwei Gao, Xiaoyan Chen and Dafang Zhong
      Drug Metabolism and Disposition May 2014, 42 (5) 872-884; DOI: https://doi.org/10.1124/dmd.113.056341

  2. Xie, Wen

    1. Bedaquiline Metabolism: Enzymes and Novel Metabolites
      Ke Liu, Feng Li, Jie Lu, Shinlan Liu, Kenneth Dorko, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition May 2014, 42 (5) 863-866; DOI: https://doi.org/10.1124/dmd.113.056119

  3. Xu, Chenshu

    1. Low Dose of Oleanolic Acid Protects against Lithocholic Acid–Induced Cholestasis in Mice: Potential Involvement of Nuclear Factor-E2-Related Factor 2-Mediated Upregulation of Multidrug Resistance-Associated Proteins
      Pan Chen, Hang Zeng, Yongtao Wang, Xiaomei Fan, Chenshu Xu, Rongrong Deng, Xunian Zhou, Huichang Bi and Min Huang
      Drug Metabolism and Disposition May 2014, 42 (5) 844-852; DOI: https://doi.org/10.1124/dmd.113.056549

Y

  1. Yajima, Kanako

    1. Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450
      Kanako Yajima, Yasuhiro Uno, Norie Murayama, Shotaro Uehara, Makiko Shimizu, Chika Nakamura, Kazuhide Iwasaki, Masahiro Utoh and Hiroshi Yamazaki
      Drug Metabolism and Disposition May 2014, 42 (5) 867-871; DOI: https://doi.org/10.1124/dmd.113.056804

  2. Yamazaki, Hiroshi

    1. Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450
      Kanako Yajima, Yasuhiro Uno, Norie Murayama, Shotaro Uehara, Makiko Shimizu, Chika Nakamura, Kazuhide Iwasaki, Masahiro Utoh and Hiroshi Yamazaki
      Drug Metabolism and Disposition May 2014, 42 (5) 867-871; DOI: https://doi.org/10.1124/dmd.113.056804

  3. Yi, Yijun

    1. Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
      Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
      Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141

  4. Yue, Qin

    1. Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
      Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
      Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141

Z

  1. Zajic, Stefan

    1. Disposition and Metabolism of the Cathepsin K Inhibitor Odanacatib in Humans
      Kelem Kassahun, Ian McIntosh, Kenneth Koeplinger, Li Sun, Jennifer E. Talaty, Deborah L. Miller, Russell Dixon, Stefan Zajic and S. Aubrey Stoch
      Drug Metabolism and Disposition May 2014, 42 (5) 818-827; DOI: https://doi.org/10.1124/dmd.113.056580

  2. Zeng, Hang

    1. Low Dose of Oleanolic Acid Protects against Lithocholic Acid–Induced Cholestasis in Mice: Potential Involvement of Nuclear Factor-E2-Related Factor 2-Mediated Upregulation of Multidrug Resistance-Associated Proteins
      Pan Chen, Hang Zeng, Yongtao Wang, Xiaomei Fan, Chenshu Xu, Rongrong Deng, Xunian Zhou, Huichang Bi and Min Huang
      Drug Metabolism and Disposition May 2014, 42 (5) 844-852; DOI: https://doi.org/10.1124/dmd.113.056549

  3. Zhang, Lingling

    1. 4β-Hydroxycholesterol as an Endogenous Biomarker of CYP3A Activity in Cynomolgus Monkeys
      Ke Li, Sylvia Zhao, Lingling Zhang, Xiaoyun Wu, Pan Shu, Yang Wang, Hao Feng, Zheming Gu and Helen Han Hsu
      Drug Metabolism and Disposition May 2014, 42 (5) 839-843; DOI: https://doi.org/10.1124/dmd.114.057224

  4. Zhao, Sylvia

    1. 4β-Hydroxycholesterol as an Endogenous Biomarker of CYP3A Activity in Cynomolgus Monkeys
      Ke Li, Sylvia Zhao, Lingling Zhang, Xiaoyun Wu, Pan Shu, Yang Wang, Hao Feng, Zheming Gu and Helen Han Hsu
      Drug Metabolism and Disposition May 2014, 42 (5) 839-843; DOI: https://doi.org/10.1124/dmd.114.057224

  5. Zhong, Dafang

    1. Metabolism and Pharmacokinetics of Allitinib in Cancer Patients: The Roles of Cytochrome P450s and Epoxide Hydrolase in its Biotransformation
      Lishan Lin, Cen Xie, Zhiwei Gao, Xiaoyan Chen and Dafang Zhong
      Drug Metabolism and Disposition May 2014, 42 (5) 872-884; DOI: https://doi.org/10.1124/dmd.113.056341

  6. Zhou, Xunian

    1. Low Dose of Oleanolic Acid Protects against Lithocholic Acid–Induced Cholestasis in Mice: Potential Involvement of Nuclear Factor-E2-Related Factor 2-Mediated Upregulation of Multidrug Resistance-Associated Proteins
      Pan Chen, Hang Zeng, Yongtao Wang, Xiaomei Fan, Chenshu Xu, Rongrong Deng, Xunian Zhou, Huichang Bi and Min Huang
      Drug Metabolism and Disposition May 2014, 42 (5) 844-852; DOI: https://doi.org/10.1124/dmd.113.056549

  7. Zulkifli, Siti N. A.

    1. Carbon-Carbon Bond Cleavage in Activation of the Prodrug Nabumetone
      Fatbardha Varfaj, Siti N. A. Zulkifli, Hyoung-Goo Park, Victoria L. Challinor, James J. De Voss and Paul R. Ortiz de Montellano
      Drug Metabolism and Disposition May 2014, 42 (5) 828-838; DOI: https://doi.org/10.1124/dmd.114.056903
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