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Drug Metabolism & Disposition

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Table of Contents

June 01, 2014; Volume 42,Issue 6

Short Communication

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    Validation of uPA/SCID Mouse with Humanized Liver as a Human Liver Model: Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases by LC-MS/MS
    Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Kenji Nakamura, Chise Tateno, Yuki Katsukura, Wataru Obuchi, Yasuo Uchida, Junichi Kamiie, Toru Horie and Tetsuya Terasaki
    Drug Metabolism and Disposition June 2014, 42 (6) 1039-1043; DOI: https://doi.org/10.1124/dmd.114.057646

Articles

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    Paradoxical Attenuation of Autoimmune Hepatitis by Oral Isoniazid in Wild-Type and N-Acetyltransferase–Deficient Mice
    Imir G. Metushi, Ping Cai, Libia Vega, Denis M. Grant and Jack Uetrecht
    Drug Metabolism and Disposition June 2014, 42 (6) 963-973; DOI: https://doi.org/10.1124/dmd.113.056622
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    Quantitative Determination of Absorption and First-Pass Metabolism of Apicidin, a Potent Histone Deacetylase Inhibitor
    Beom Soo Shin, Sun Dong Yoo, Tae Hwan Kim, Jurgen B. Bulitta, Cornelia B. Landersdorfer, Jeong Cheol Shin, Jin Ho Choi, Kwon-Yeon Weon, Sang Hoon Joo and Soyoung Shin
    Drug Metabolism and Disposition June 2014, 42 (6) 974-982; DOI: https://doi.org/10.1124/dmd.113.056713
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    Quantitative Investigation of the Brain-to-Cerebrospinal Fluid Unbound Drug Concentration Ratio under Steady-State Conditions in Rats Using a Pharmacokinetic Model and Scaling Factors for Active Efflux Transporters
    Hiroshi Kodaira, Hiroyuki Kusuhara, Eiichi Fuse, Junko Ushiki and Yuichi Sugiyama
    Drug Metabolism and Disposition June 2014, 42 (6) 983-989; DOI: https://doi.org/10.1124/dmd.113.056606
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    Common Drugs Inhibit Human Organic Cation Transporter 1 (OCT1)-Mediated Neurotransmitter Uptake
    Kelli H. Boxberger, Bruno Hagenbuch and Jed N. Lampe
    Drug Metabolism and Disposition June 2014, 42 (6) 990-995; DOI: https://doi.org/10.1124/dmd.113.055095
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    Aspirin and Probenecid Inhibit Organic Anion Transporter 3–Mediated Renal Uptake of Cilostazol and Probenecid Induces Metabolism of Cilostazol in the Rat
    Chong Wang, Changyuan Wang, Qi Liu, Qiang Meng, Jian Cang, Huijun Sun, Jinyong Peng, Xiaochi Ma, Xiaokui Huo and Kexin Liu
    Drug Metabolism and Disposition June 2014, 42 (6) 996-1007; DOI: https://doi.org/10.1124/dmd.113.055194
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    Investigational Small-Molecule Drug Selectively Suppresses Constitutive CYP2B6 Activity at the Gene Transcription Level: Physiologically Based Pharmacokinetic Model Assessment of Clinical Drug Interaction Risk
    Maciej J. Zamek-Gliszczynski, Michael A. Mohutsky, Jessica L. F. Rehmel and Alice B. Ke
    Drug Metabolism and Disposition June 2014, 42 (6) 1008-1015; DOI: https://doi.org/10.1124/dmd.114.057018
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    Systemic Exposure to the Metabolites of Lesogaberan in Humans and Animals: A Case Study of Metabolites in Safety Testing
    Ann Aurell Holmberg, Anja Ekdahl and Lars Weidolf
    Drug Metabolism and Disposition June 2014, 42 (6) 1016-1021; DOI: https://doi.org/10.1124/dmd.113.056614
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    Deletion of 30 Murine Cytochrome P450 Genes Results In Viable Mice With Compromised Drug Metabolism
    Nico Scheer, Lesley A. McLaughlin, Anja Rode, A. Kenneth MacLeod, Colin J. Henderson and C. Roland Wolf
    Drug Metabolism and Disposition June 2014, 42 (6) 1022-1030; DOI: https://doi.org/10.1124/dmd.114.057885
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    Identification of Bioactivating Enzymes Involved in the Hydrolysis of Laninamivir Octanoate, a Long-Acting Neuraminidase Inhibitor, in Human Pulmonary Tissue
    Kumiko Koyama, Yuji Ogura, Daisuke Nakai, Mihoko Watanabe, Toshiko Munemasa, Yuka Oofune, Kazuishi Kubota, Akira Shinagawa and Takashi Izumi
    Drug Metabolism and Disposition June 2014, 42 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.114.057620
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    Metabolic Activation of the Indoloquinazoline Alkaloids Evodiamine and Rutaecarpine by Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4
    Bo Wen, Vikram Roongta, Liling Liu and David J. Moore
    Drug Metabolism and Disposition June 2014, 42 (6) 1044-1054; DOI: https://doi.org/10.1124/dmd.114.057414
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    Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism
    Thomas J. Bateman, Vijay G.B. Reddy, Masakazu Kakuni, Yoshio Morikawa and Sanjeev Kumar
    Drug Metabolism and Disposition June 2014, 42 (6) 1055-1065; DOI: https://doi.org/10.1124/dmd.114.056978
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    Differential Effects of Rifampin and Ketoconazole on the Blood and Liver Concentration of Atorvastatin in Wild-Type and Cyp3a and Oatp1a/b Knockout Mice
    Jae H. Chang, Justin Ly, Emile Plise, Xiaolin Zhang, Kirsten Messick, Matthew Wright and Jonathan Cheong
    Drug Metabolism and Disposition June 2014, 42 (6) 1067-1073; DOI: https://doi.org/10.1124/dmd.114.057968
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    Mice Lacking Three Loci Encoding 14 Glutathione Transferase Genes: A Novel Tool for Assigning Function to the GSTP, GSTM, and GSTT Families
    Zhidan Xiang, John N. Snouwaert, Martina Kovarova, MyTrang Nguyen, Peter W. Repenning, Anne M. Latour, Jaime M. Cyphert and Beverly H. Koller
    Drug Metabolism and Disposition June 2014, 42 (6) 1074-1083; DOI: https://doi.org/10.1124/dmd.113.056481
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    Nigramide C Is a Natural Agonist of Human Pregnane X Receptor
    Yuichiro Kanno, Tomofumi Yatsu, Wei Li, Kazuo Koike and Yoshio Inouye
    Drug Metabolism and Disposition June 2014, 42 (6) 1084-1089; DOI: https://doi.org/10.1124/dmd.114.057810
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    Aldehyde Oxidase Activity in Donor-Matched Fresh and Cryopreserved Human Hepatocytes and Assessment of Variability in 75 Donors
    J. Matthew Hutzler, Young-Sun Yang, Caitlin Brown, Scott Heyward and Timothy Moeller
    Drug Metabolism and Disposition June 2014, 42 (6) 1090-1097; DOI: https://doi.org/10.1124/dmd.114.057984

Erratum

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    Correction to “Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis”
    Drug Metabolism and Disposition June 2014, 42 (6) 1066; DOI: https://doi.org/10.1124/dmd.114.06er14
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Drug Metabolism and Disposition: 42 (6)
Drug Metabolism and Disposition
Vol. 42, Issue 6
1 Jun 2014
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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