Table of Contents

Articles

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  Paradoxical Attenuation of Autoimmune Hepatitis by Oral Isoniazid in Wild-Type and N-Acetyltransferase–Deficient Mice

  Imir G. Metushi, Ping Cai, Libia Vega, Denis M. Grant and Jack Uetrecht

  Drug Metabolism and Disposition June 2014, 42 (6) 963-973; DOI: https://doi.org/10.1124/dmd.113.056622
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  Quantitative Determination of Absorption and First-Pass Metabolism of Apicidin, a Potent Histone Deacetylase Inhibitor

  Beom Soo Shin, Sun Dong Yoo, Tae Hwan Kim, Jurgen B. Bulitta, Cornelia B. Landersdorfer, Jeong Cheol Shin, Jin Ho Choi, Kwon-Yeon Weon, Sang Hoon Joo and Soyoung Shin

  Drug Metabolism and Disposition June 2014, 42 (6) 974-982; DOI: https://doi.org/10.1124/dmd.113.056713
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  Quantitative Investigation of the Brain-to-Cerebrospinal Fluid Unbound Drug Concentration Ratio under Steady-State Conditions in Rats Using a Pharmacokinetic Model and Scaling Factors for Active Efflux Transporters

  Hiroshi Kodaira, Hiroyuki Kusuhara, Eiichi Fuse, Junko Ushiki and Yuichi Sugiyama

  Drug Metabolism and Disposition June 2014, 42 (6) 983-989; DOI: https://doi.org/10.1124/dmd.113.056606
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  Common Drugs Inhibit Human Organic Cation Transporter 1 (OCT1)-Mediated Neurotransmitter Uptake

  Kelli H. Boxberger, Bruno Hagenbuch and Jed N. Lampe

  Drug Metabolism and Disposition June 2014, 42 (6) 990-995; DOI: https://doi.org/10.1124/dmd.113.055095
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  Aspirin and Probenecid Inhibit Organic Anion Transporter 3–Mediated Renal Uptake of Cilostazol and Probenecid Induces Metabolism of Cilostazol in the Rat

  Chong Wang, Changyuan Wang, Qi Liu, Qiang Meng, Jian Cang, Huijun Sun, Jinyong Peng, Xiaochi Ma, Xiaokui Huo and Kexin Liu

  Drug Metabolism and Disposition June 2014, 42 (6) 996-1007; DOI: https://doi.org/10.1124/dmd.113.055194
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  Investigational Small-Molecule Drug Selectively Suppresses Constitutive CYP2B6 Activity at the Gene Transcription Level: Physiologically Based Pharmacokinetic Model Assessment of Clinical Drug Interaction Risk

  Maciej J. Zamek-Gliszczynski, Michael A. Mohutsky, Jessica L. F. Rehmel and Alice B. Ke

  Drug Metabolism and Disposition June 2014, 42 (6) 1008-1015; DOI: https://doi.org/10.1124/dmd.114.057018
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  Systemic Exposure to the Metabolites of Lesogaberan in Humans and Animals: A Case Study of Metabolites in Safety Testing

  Ann Aurell Holmberg, Anja Ekdahl and Lars Weidolf

  Drug Metabolism and Disposition June 2014, 42 (6) 1016-1021; DOI: https://doi.org/10.1124/dmd.113.056614
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  Deletion of 30 Murine Cytochrome P450 Genes Results In Viable Mice With Compromised Drug Metabolism

  Nico Scheer, Lesley A. McLaughlin, Anja Rode, A. Kenneth MacLeod, Colin J. Henderson and C. Roland Wolf

  Drug Metabolism and Disposition June 2014, 42 (6) 1022-1030; DOI: https://doi.org/10.1124/dmd.114.057885
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  Identification of Bioactivating Enzymes Involved in the Hydrolysis of Laninamivir Octanoate, a Long-Acting Neuraminidase Inhibitor, in Human Pulmonary Tissue

  Kumiko Koyama, Yuji Ogura, Daisuke Nakai, Mihoko Watanabe, Toshiko Munemasa, Yuka Oofune, Kazuishi Kubota, Akira Shinagawa and Takashi Izumi

  Drug Metabolism and Disposition June 2014, 42 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.114.057620
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  Metabolic Activation of the Indoloquinazoline Alkaloids Evodiamine and Rutaecarpine by Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4

  Bo Wen, Vikram Roongta, Liling Liu and David J. Moore

  Drug Metabolism and Disposition June 2014, 42 (6) 1044-1054; DOI: https://doi.org/10.1124/dmd.114.057414
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  Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism

  Thomas J. Bateman, Vijay G.B. Reddy, Masakazu Kakuni, Yoshio Morikawa and Sanjeev Kumar

  Drug Metabolism and Disposition June 2014, 42 (6) 1055-1065; DOI: https://doi.org/10.1124/dmd.114.056978
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  Differential Effects of Rifampin and Ketoconazole on the Blood and Liver Concentration of Atorvastatin in Wild-Type and Cyp3a and Oatp1a/b Knockout Mice

  Jae H. Chang, Justin Ly, Emile Plise, Xiaolin Zhang, Kirsten Messick, Matthew Wright and Jonathan Cheong

  Drug Metabolism and Disposition June 2014, 42 (6) 1067-1073; DOI: https://doi.org/10.1124/dmd.114.057968
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  Mice Lacking Three Loci Encoding 14 Glutathione Transferase Genes: A Novel Tool for Assigning Function to the GSTP, GSTM, and GSTT Families

  Zhidan Xiang, John N. Snouwaert, Martina Kovarova, MyTrang Nguyen, Peter W. Repenning, Anne M. Latour, Jaime M. Cyphert and Beverly H. Koller

  Drug Metabolism and Disposition June 2014, 42 (6) 1074-1083; DOI: https://doi.org/10.1124/dmd.113.056481
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  Nigramide C Is a Natural Agonist of Human Pregnane X Receptor

  Yuichiro Kanno, Tomofumi Yatsu, Wei Li, Kazuo Koike and Yoshio Inouye

  Drug Metabolism and Disposition June 2014, 42 (6) 1084-1089; DOI: https://doi.org/10.1124/dmd.114.057810
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  Aldehyde Oxidase Activity in Donor-Matched Fresh and Cryopreserved Human Hepatocytes and Assessment of Variability in 75 Donors

  J. Matthew Hutzler, Young-Sun Yang, Caitlin Brown, Scott Heyward and Timothy Moeller

  Drug Metabolism and Disposition June 2014, 42 (6) 1090-1097; DOI: https://doi.org/10.1124/dmd.114.057984