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Investigational Small-Molecule Drug Selectively Suppresses Constitutive CYP2B6 Activity at the Gene Transcription Level: Physiologically Based Pharmacokinetic Model Assessment of Clinical Drug Interaction Risk

Maciej J. Zamek-Gliszczynski, Michael A. Mohutsky, Jessica L. F. Rehmel and Alice B. Ke
Drug Metabolism and Disposition June 2014, 42 (6) 1008-1015; DOI: https://doi.org/10.1124/dmd.114.057018

Article Information

vol. 42 no. 6 1008-1015
DOI 
https://doi.org/10.1124/dmd.114.057018
PubMed 
24658455
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 13, 2014
  • Accepted March 19, 2014
  • Published online April 25, 2014.

Article Versions

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Maciej J. Zamek-Gliszczynski,
  2. Michael A. Mohutsky,
  3. Jessica L. F. Rehmel, and
  4. Alice B. Ke
  1. Drug Disposition, Lilly Research Laboratories, Indianapolis, Indiana
  1. Address correspondence to:
    Dr. Maciej J. Zamek-Gliszczynski, Lilly Corporate Center, Indianapolis, IN 46285. E-mail: m_zamek-gliszczynski{at}lilly.com
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Xenobiotic Selectively Suppresses CYP2B6

Maciej J. Zamek-Gliszczynski, Michael A. Mohutsky, Jessica L. F. Rehmel and Alice B. Ke
Drug Metabolism and Disposition June 1, 2014, 42 (6) 1008-1015; DOI: https://doi.org/10.1124/dmd.114.057018
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