Table of Contents

Articles

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  1-Aminobenzotriazole Modulates Oral Drug Pharmacokinetics through Cytochrome P450 Inhibition and Delay of Gastric Emptying in Rats

  Rowan A. Stringer, Eckhard Weber, Bruno Tigani, Paul Lavan, Stephen Medhurst and Bindi Sohal

  Drug Metabolism and Disposition July 2014, 42 (7) 1117-1124; DOI: https://doi.org/10.1124/dmd.113.056408
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  A Recombinant Humanized Anti-Cocaine Monoclonal Antibody Inhibits the Distribution of Cocaine to the Brain in Rats

  Andrew B. Norman, Felicia C. T. Gooden, Michael R. Tabet and William J. Ball

  Drug Metabolism and Disposition July 2014, 42 (7) 1125-1131; DOI: https://doi.org/10.1124/dmd.114.057034
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  Comparative Metabolism of Furan in Rodent and Human Cryopreserved Hepatocytes

  Leah A. Gates, Martin B. Phillips, Brock A. Matter and Lisa A. Peterson

  Drug Metabolism and Disposition July 2014, 42 (7) 1132-1136; DOI: https://doi.org/10.1124/dmd.114.057794
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  Hepatic Microsomal Thiol Methyltransferase Is Involved in Stereoselective Methylation of Pharmacologically Active Metabolite of Prasugrel

  Miho Kazui, Katsunobu Hagihara, Takashi Izumi, Toshihiko Ikeda and Atsushi Kurihara

  Drug Metabolism and Disposition July 2014, 42 (7) 1138-1145; DOI: https://doi.org/10.1124/dmd.114.057661
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  Glucuronidation of Drugs and Drug-Induced Toxicity in Humanized UDP-Glucuronosyltransferase 1 Mice

  Yuki Kutsuno, Tomoo Itoh, Robert H. Tukey and Ryoichi Fujiwara

  Drug Metabolism and Disposition July 2014, 42 (7) 1146-1152; DOI: https://doi.org/10.1124/dmd.114.057083
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  Identification of a Functional Homolog of the Mammalian CYP3A4 in Locusts

  Line Rørbæk Olsen, Charlotte Gabel-Jensen, Peter Aadal Nielsen, Steen Honoré Hansen and Lassina Badolo

  Drug Metabolism and Disposition July 2014, 42 (7) 1153-1162; DOI: https://doi.org/10.1124/dmd.114.057430
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  Relative Contributions of Cytochrome CYP3A4 Versus CYP3A5 for CYP3A-Cleared Drugs Assessed In Vitro Using a CYP3A4-Selective Inactivator (CYP3cide)

  Elaine Tseng, Robert L. Walsky, Ricardo A. Luzietti, Jennifer J. Harris, Rachel E. Kosa, Theunis C. Goosen, Michael A. Zientek and R. Scott Obach

  Drug Metabolism and Disposition July 2014, 42 (7) 1163-1173; DOI: https://doi.org/10.1124/dmd.114.057000
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  Effects of Proton Pump Inhibitors on Metformin Pharmacokinetics and Pharmacodynamics

  AnHye Kim, Inbum Chung, Seo Hyun Yoon, Kyung-Sang Yu, Kyoung Soo Lim, Joo-Youn Cho, Howard Lee, In-Jin Jang and Jae Yong Chung

  Drug Metabolism and Disposition July 2014, 42 (7) 1174-1179; DOI: https://doi.org/10.1124/dmd.113.055616
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  The Metabolic Drug-Drug Interaction Profile of Dabrafenib: In Vitro Investigations and Quantitative Extrapolation of the P450-Mediated DDI Risk

  Sarah K. Lawrence, Dung Nguyen, Chet Bowen, Lauren Richards-Peterson and Konstantine W. Skordos

  Drug Metabolism and Disposition July 2014, 42 (7) 1180-1190; DOI: https://doi.org/10.1124/dmd.114.057778
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  Evaluation of the HC-04 Cell Line as an In Vitro Model for Mechanistic Assessment of Changes in Hepatic Cytochrome P450 3A during Adenovirus Infection

  Piyanuch Wonganan, Kristina Jonsson-Schmunk, Shellie M. Callahan, Jin Huk Choi and Maria A. Croyle

  Drug Metabolism and Disposition July 2014, 42 (7) 1191-1201; DOI: https://doi.org/10.1124/dmd.113.056663
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  In Vitro Assessment of Time-Dependent Inhibitory Effects on CYP2C8 and CYP3A Activity by Fourteen Protein Kinase Inhibitors

  Anne M. Filppula, Pertti J. Neuvonen and Janne T. Backman

  Drug Metabolism and Disposition July 2014, 42 (7) 1202-1209; DOI: https://doi.org/10.1124/dmd.114.057695
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  Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

  Anna Vildhede, Maria Karlgren, Elin K. Svedberg, Jacek R. Wisniewski, Yurong Lai, Agneta Norén and Per Artursson

  Drug Metabolism and Disposition July 2014, 42 (7) 1210-1218; DOI: https://doi.org/10.1124/dmd.113.056309
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  Hepatocellular Exposure of Troglitazone Metabolites in Rat Sandwich-Cultured Hepatocytes Lacking Bcrp and Mrp2: Interplay between Formation and Excretion

  Kyunghee Yang and Kim L. R. Brouwer

  Drug Metabolism and Disposition July 2014, 42 (7) 1219-1226; DOI: https://doi.org/10.1124/dmd.114.057190
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  The Contribution of Human OCT1, OCT3, and CYP3A4 to Nitidine Chloride–Induced Hepatocellular Toxicity

  Liping Li, Meijuan Tu, Xi Yang, Siyuan Sun, Xiaodan Wu, Hui Zhou, Su Zeng and Huidi Jiang

  Drug Metabolism and Disposition July 2014, 42 (7) 1227-1234; DOI: https://doi.org/10.1124/dmd.113.056689