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Drug Metabolism & Disposition

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Table of Contents

July 01, 2014; Volume 42,Issue 7

Short Communications

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    Metabolic Activation of the Antibacterial Agent Triclocarban by Cytochrome P450 1A1 Yielding Glutathione Adducts
    Nils Helge Schebb, Jaya B. Muvvala, Dexter Morin, Alan R. Buckpitt, Bruce D. Hammock and Robert H. Rice
    Drug Metabolism and Disposition July 2014, 42 (7) 1098-1102; DOI: https://doi.org/10.1124/dmd.114.058206
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    Screening of Specific Inhibitors for Human Carboxylesterases or Arylacetamide Deacetylase
    Mai Shimizu, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition July 2014, 42 (7) 1103-1109; DOI: https://doi.org/10.1124/dmd.114.056994

Accelerated Communication

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    Distribution of the Phosphatidylinositol 3-Kinase Inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 Intracranial Glioblastoma Models—Assessment by Matrix-Assisted Laser Desorption Ionization Imaging
    Laurent Salphati, Sheerin Shahidi-Latham, Cristine Quiason, Kai Barck, Merry Nishimura, Bruno Alicke, Jodie Pang, Richard A. Carano, Alan G. Olivero and Heidi S. Phillips
    Drug Metabolism and Disposition July 2014, 42 (7) 1110-1116; DOI: https://doi.org/10.1124/dmd.114.057513

Articles

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    1-Aminobenzotriazole Modulates Oral Drug Pharmacokinetics through Cytochrome P450 Inhibition and Delay of Gastric Emptying in Rats
    Rowan A. Stringer, Eckhard Weber, Bruno Tigani, Paul Lavan, Stephen Medhurst and Bindi Sohal
    Drug Metabolism and Disposition July 2014, 42 (7) 1117-1124; DOI: https://doi.org/10.1124/dmd.113.056408
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    A Recombinant Humanized Anti-Cocaine Monoclonal Antibody Inhibits the Distribution of Cocaine to the Brain in Rats
    Andrew B. Norman, Felicia C. T. Gooden, Michael R. Tabet and William J. Ball
    Drug Metabolism and Disposition July 2014, 42 (7) 1125-1131; DOI: https://doi.org/10.1124/dmd.114.057034
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    Comparative Metabolism of Furan in Rodent and Human Cryopreserved Hepatocytes
    Leah A. Gates, Martin B. Phillips, Brock A. Matter and Lisa A. Peterson
    Drug Metabolism and Disposition July 2014, 42 (7) 1132-1136; DOI: https://doi.org/10.1124/dmd.114.057794
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    Hepatic Microsomal Thiol Methyltransferase Is Involved in Stereoselective Methylation of Pharmacologically Active Metabolite of Prasugrel
    Miho Kazui, Katsunobu Hagihara, Takashi Izumi, Toshihiko Ikeda and Atsushi Kurihara
    Drug Metabolism and Disposition July 2014, 42 (7) 1138-1145; DOI: https://doi.org/10.1124/dmd.114.057661
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    Glucuronidation of Drugs and Drug-Induced Toxicity in Humanized UDP-Glucuronosyltransferase 1 Mice
    Yuki Kutsuno, Tomoo Itoh, Robert H. Tukey and Ryoichi Fujiwara
    Drug Metabolism and Disposition July 2014, 42 (7) 1146-1152; DOI: https://doi.org/10.1124/dmd.114.057083
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    Identification of a Functional Homolog of the Mammalian CYP3A4 in Locusts
    Line Rørbæk Olsen, Charlotte Gabel-Jensen, Peter Aadal Nielsen, Steen Honoré Hansen and Lassina Badolo
    Drug Metabolism and Disposition July 2014, 42 (7) 1153-1162; DOI: https://doi.org/10.1124/dmd.114.057430
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    Relative Contributions of Cytochrome CYP3A4 Versus CYP3A5 for CYP3A-Cleared Drugs Assessed In Vitro Using a CYP3A4-Selective Inactivator (CYP3cide)
    Elaine Tseng, Robert L. Walsky, Ricardo A. Luzietti, Jennifer J. Harris, Rachel E. Kosa, Theunis C. Goosen, Michael A. Zientek and R. Scott Obach
    Drug Metabolism and Disposition July 2014, 42 (7) 1163-1173; DOI: https://doi.org/10.1124/dmd.114.057000
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    Effects of Proton Pump Inhibitors on Metformin Pharmacokinetics and Pharmacodynamics
    AnHye Kim, Inbum Chung, Seo Hyun Yoon, Kyung-Sang Yu, Kyoung Soo Lim, Joo-Youn Cho, Howard Lee, In-Jin Jang and Jae Yong Chung
    Drug Metabolism and Disposition July 2014, 42 (7) 1174-1179; DOI: https://doi.org/10.1124/dmd.113.055616
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    The Metabolic Drug-Drug Interaction Profile of Dabrafenib: In Vitro Investigations and Quantitative Extrapolation of the P450-Mediated DDI Risk
    Sarah K. Lawrence, Dung Nguyen, Chet Bowen, Lauren Richards-Peterson and Konstantine W. Skordos
    Drug Metabolism and Disposition July 2014, 42 (7) 1180-1190; DOI: https://doi.org/10.1124/dmd.114.057778
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    Evaluation of the HC-04 Cell Line as an In Vitro Model for Mechanistic Assessment of Changes in Hepatic Cytochrome P450 3A during Adenovirus Infection
    Piyanuch Wonganan, Kristina Jonsson-Schmunk, Shellie M. Callahan, Jin Huk Choi and Maria A. Croyle
    Drug Metabolism and Disposition July 2014, 42 (7) 1191-1201; DOI: https://doi.org/10.1124/dmd.113.056663
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    In Vitro Assessment of Time-Dependent Inhibitory Effects on CYP2C8 and CYP3A Activity by Fourteen Protein Kinase Inhibitors
    Anne M. Filppula, Pertti J. Neuvonen and Janne T. Backman
    Drug Metabolism and Disposition July 2014, 42 (7) 1202-1209; DOI: https://doi.org/10.1124/dmd.114.057695
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    Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug InteractionsGraphic
    Anna Vildhede, Maria Karlgren, Elin K. Svedberg, Jacek R. Wisniewski, Yurong Lai, Agneta Norén and Per Artursson
    Drug Metabolism and Disposition July 2014, 42 (7) 1210-1218; DOI: https://doi.org/10.1124/dmd.113.056309
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    Hepatocellular Exposure of Troglitazone Metabolites in Rat Sandwich-Cultured Hepatocytes Lacking Bcrp and Mrp2: Interplay between Formation and Excretion
    Kyunghee Yang and Kim L. R. Brouwer
    Drug Metabolism and Disposition July 2014, 42 (7) 1219-1226; DOI: https://doi.org/10.1124/dmd.114.057190
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    The Contribution of Human OCT1, OCT3, and CYP3A4 to Nitidine Chloride–Induced Hepatocellular Toxicity
    Liping Li, Meijuan Tu, Xi Yang, Siyuan Sun, Xiaodan Wu, Hui Zhou, Su Zeng and Huidi Jiang
    Drug Metabolism and Disposition July 2014, 42 (7) 1227-1234; DOI: https://doi.org/10.1124/dmd.113.056689

Erratum

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    Correction to “The Influence of Sex, Ethnicity, and CYP2B6 Genotype on Bupropion Metabolism as an Index of Hepatic CYP2B6 Activity in Humans”
    Drug Metabolism and Disposition July 2014, 42 (7) 1137; DOI: https://doi.org/10.1124/dmd.114.07er14
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Drug Metabolism and Disposition: 42 (7)
Drug Metabolism and Disposition
Vol. 42, Issue 7
1 Jul 2014
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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