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Rapid CommunicationAccelerated Communication

Distribution of the Phosphatidylinositol 3-Kinase Inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 Intracranial Glioblastoma Models—Assessment by Matrix-Assisted Laser Desorption Ionization Imaging

Laurent Salphati, Sheerin Shahidi-Latham, Cristine Quiason, Kai Barck, Merry Nishimura, Bruno Alicke, Jodie Pang, Richard A. Carano, Alan G. Olivero and Heidi S. Phillips
Drug Metabolism and Disposition July 2014, 42 (7) 1110-1116; DOI: https://doi.org/10.1124/dmd.114.057513
Laurent Salphati
Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California
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Sheerin Shahidi-Latham
Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California
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Cristine Quiason
Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California
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Kai Barck
Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California
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Merry Nishimura
Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California
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Bruno Alicke
Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California
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Jodie Pang
Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California
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Richard A. Carano
Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California
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Alan G. Olivero
Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California
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Heidi S. Phillips
Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California
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Article Information

vol. 42 no. 7 1110-1116
DOI 
https://doi.org/10.1124/dmd.114.057513
PubMed 
24754926

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 4, 2014
  • Accepted April 22, 2014
  • Published online May 21, 2014.

Article Versions

  • Earlier version (April 22, 2014 - 10:49).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Laurent Salphati,
  2. Sheerin Shahidi-Latham,
  3. Cristine Quiason,
  4. Kai Barck,
  5. Merry Nishimura,
  6. Bruno Alicke,
  7. Jodie Pang,
  8. Richard A. Carano,
  9. Alan G. Olivero, and
  10. Heidi S. Phillips
  1. Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California
  1. Address correspondence to:
    Dr. Laurent Salphati, Department of Drug Metabolism and Pharmacokinetics, MS 412A, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080. E-mail: salphati.laurent{at}gene.com
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Drug Metabolism and Disposition: 42 (7)
Drug Metabolism and Disposition
Vol. 42, Issue 7
1 Jul 2014
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Distribution of the Phosphatidylinositol 3-Kinase Inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 Intracranial Glioblastoma Models—Assessment by Matrix-Assisted Laser Desorption Ionization Imaging
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Rapid CommunicationAccelerated Communication

MALDI Imaging of PI3K Inhibitor Distribution in Brain Tumors

Laurent Salphati, Sheerin Shahidi-Latham, Cristine Quiason, Kai Barck, Merry Nishimura, Bruno Alicke, Jodie Pang, Richard A. Carano, Alan G. Olivero and Heidi S. Phillips
Drug Metabolism and Disposition July 1, 2014, 42 (7) 1110-1116; DOI: https://doi.org/10.1124/dmd.114.057513

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Rapid CommunicationAccelerated Communication

MALDI Imaging of PI3K Inhibitor Distribution in Brain Tumors

Laurent Salphati, Sheerin Shahidi-Latham, Cristine Quiason, Kai Barck, Merry Nishimura, Bruno Alicke, Jodie Pang, Richard A. Carano, Alan G. Olivero and Heidi S. Phillips
Drug Metabolism and Disposition July 1, 2014, 42 (7) 1110-1116; DOI: https://doi.org/10.1124/dmd.114.057513
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