Drug Metabolism and Disposition: 42 (9)

September 01, 2014; Volume 42,Issue 9

Short Communications

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Long-Term Chronic Toxicity Testing Using Human Pluripotent Stem Cell–Derived Hepatocytes
Gustav Holmgren, Anna-Karin Sjögren, Isabel Barragan, Alan Sabirsh, Peter Sartipy, Jane Synnergren, Petter Björquist, Magnus Ingelman-Sundberg, Tommy B. Andersson and Josefina Edsbagge

Drug Metabolism and Disposition September 2014, 42 (9) 1401-1406; DOI: https://doi.org/10.1124/dmd.114.059154
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Polymorphisms of CYP2D17 in Cynomolgus and Rhesus Macaques: an Evidence of the Genetic Basis for the Variability of CYP2D-Dependent Drug Metabolism
Yasuhiro Uno, Shotaro Uehara, Sakae Kohara, Norie Murayama and Hiroshi Yamazaki

Drug Metabolism and Disposition September 2014, 42 (9) 1407-1410; DOI: https://doi.org/10.1124/dmd.114.059220
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Regioselective Hydroxylation of Omeprazole Enantiomers by Bacterial CYP102A1 Mutants
Sang Hoon Ryu, Bo-Yeon Park, So-Young Kim, Sun-Ha Park, Hyun-Jin Jung, Min Park, Ki Deok Park, Taeho Ahn, Hyung-Sik Kang and Chul-Ho Yun

Drug Metabolism and Disposition September 2014, 42 (9) 1493-1497; DOI: https://doi.org/10.1124/dmd.114.058636

Articles

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Flavonoids Are Inhibitors of Human Organic Anion Transporter 1 (OAT1)–Mediated Transport
Guohua An, Xiaodong Wang and Marilyn E. Morris

Drug Metabolism and Disposition September 2014, 42 (9) 1357-1366; DOI: https://doi.org/10.1124/dmd.114.059337
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Translational Pharmacokinetic Modeling of Fingolimod (FTY720) as a Paradigm Compound Subject to Sphingosine Kinase-Mediated Phosphorylation
Nelleke Snelder, Bart A. Ploeger, Olivier Luttringer, Donald. R. Stanski and Meindert Danhof

Drug Metabolism and Disposition September 2014, 42 (9) 1367-1378; DOI: https://doi.org/10.1124/dmd.113.056770
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Evaluation of Calibration Curve–Based Approaches to Predict Clinical Inducers and Noninducers of CYP3A4 with Plated Human Hepatocytes
J. George Zhang, Thuy Ho, Alanna L. Callendrello, Robert J. Clark, Elizabeth A. Santone, Sarah Kinsman, Deqing Xiao, Lisa G. Fox, Heidi J. Einolf and David M. Stresser

Drug Metabolism and Disposition September 2014, 42 (9) 1379-1391; DOI: https://doi.org/10.1124/dmd.114.058602
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A Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its Derivatives
Aleksandra K. Greer, Centdrika R. Dates, Athena Starlard-Davenport, Vineetha K. Edavana, Stacie M. Bratton, Ishwori B. Dhakal, Moshe Finel, Susan A. Kadlubar and Anna Radominska-Pandya

Drug Metabolism and Disposition September 2014, 42 (9) 1392-1400; DOI: https://doi.org/10.1124/dmd.114.058016
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Calibration of In Vitro Multidrug Resistance Protein 1 Substrate and Inhibition Assays as a Basis to Support the Prediction of Clinically Relevant Interactions In Vivo
Agnès Poirier, Anne-Christine Cascais, Urs Bader, Renée Portmann, Marie-Elise Brun, Isabelle Walter, Alexander Hillebrecht, Mohammed Ullah and Christoph Funk

Drug Metabolism and Disposition September 2014, 42 (9) 1411-1422; DOI: https://doi.org/10.1124/dmd.114.057943
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Inflammatory Bowel Disease Alters Intestinal Bile Acid Transporter Expression
Jörg Jahnel, Peter Fickert, Almuthe C. Hauer, Christoph Högenauer, Alexander Avian and Michael Trauner

Drug Metabolism and Disposition September 2014, 42 (9) 1423-1431; DOI: https://doi.org/10.1124/dmd.114.058065
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Identification and Functional Characterization of Novel Nonsynonymous Variants in the Human Multidrug and Toxin Extrusion 2-K
Kenta Nishimura, Ryosuke Ide, Takeshi Hirota, Kana Kawazu, Sho Kodama, Hiroaki Takesue and Ichiro Ieiri

Drug Metabolism and Disposition September 2014, 42 (9) 1432-1437; DOI: https://doi.org/10.1124/dmd.114.056887
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Time- and NADPH-Dependent Inhibition of Cytochrome P450 3A4 by the Cyclopentapeptide Cilengitide: Significance of the Guanidine Group and Accompanying Spectral Changes
Mirza Bojić, Luca Barbero, Hugues Dolgos, Achim Freisleben, Dieter Gallemann, Simona Riva and F. Peter Guengerich

Drug Metabolism and Disposition September 2014, 42 (9) 1438-1446; DOI: https://doi.org/10.1124/dmd.114.059295
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Nicotine Pharmacokinetics in Rats Is Altered as a Function of Age, Impacting the Interpretation of Animal Model Data
Evelyn L. Craig, Bin Zhao, Jason Z. Cui, Maria Novalen, Sharon Miksys and Rachel F. Tyndale

Drug Metabolism and Disposition September 2014, 42 (9) 1447-1455; DOI: https://doi.org/10.1124/dmd.114.058719
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A Strategy for Assessing Potential Drug-Drug Interactions of a Concomitant Agent against a Drug Absorbed via an Intestinal Transporter in Humans
Akiko Mizuno-Yasuhira, Yasuhiro Nakai, Emi Gunji, Saeko Uchida, Teisuke Takahashi, Kohnosuke Kinoshita, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa and Jun-ichi Yamaguchi

Drug Metabolism and Disposition September 2014, 42 (9) 1456-1465; DOI: https://doi.org/10.1124/dmd.114.058305
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The Need for Human Breast Cancer Resistance Protein Substrate and Inhibition Evaluation in Drug Discovery and Development: Why, When, and How?
Agnès Poirier, Renée Portmann, Anne-Christine Cascais, Urs Bader, Isabelle Walter, Mohammed Ullah and Christoph Funk

Drug Metabolism and Disposition September 2014, 42 (9) 1466-1477; DOI: https://doi.org/10.1124/dmd.114.058248
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Deciding on Success Criteria for Predictability of Pharmacokinetic Parameters from In Vitro Studies: An Analysis Based on In Vivo Observations
Khaled Abduljalil, Theresa Cain, Helen Humphries and Amin Rostami-Hodjegan

Drug Metabolism and Disposition September 2014, 42 (9) 1478-1484; DOI: https://doi.org/10.1124/dmd.114.058099
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Effect of CYP2A6 Genetic Polymorphism on the Metabolic Conversion of Tegafur to 5-Fluorouracil and Its Enantioselectivity
Ikuo Yamamiya, Kunihiro Yoshisue, Yuji Ishii, Hideyuki Yamada and Masato Chiba

Drug Metabolism and Disposition September 2014, 42 (9) 1485-1492; DOI: https://doi.org/10.1124/dmd.114.058008
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Characterization of Arachidonic Acid Metabolism by Rat Cytochrome P450 Enzymes: The Involvement of CYP1As
Ahmed A. El-Sherbeni and Ayman O.S. El-Kadi

Drug Metabolism and Disposition September 2014, 42 (9) 1498-1507; DOI: https://doi.org/10.1124/dmd.114.057836
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Gut Microbiota-Mediated Drug Interactions between Lovastatin and Antibiotics
Dae-Hyoung Yoo, In Sook Kim, Thi Kim Van Le, Il-Hoon Jung, Hye Hyun Yoo and Dong-Hyun Kim

Drug Metabolism and Disposition September 2014, 42 (9) 1508-1513; DOI: https://doi.org/10.1124/dmd.114.058354
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Prediction of Organic Anion-Transporting Polypeptide 1B1- and 1B3-Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity Data
Annett Kunze, Jörg Huwyler, Gian Camenisch and Birk Poller

Drug Metabolism and Disposition September 2014, 42 (9) 1514-1521; DOI: https://doi.org/10.1124/dmd.114.058412
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Hepatic, Intestinal, Renal, and Plasma Hydrolysis of Prodrugs in Human, Cynomolgus Monkey, Dog, and Rat: Implications for In Vitro–In Vivo Extrapolation of Clearance of Prodrugs
Haruka Nishimuta, J. Brian Houston and Aleksandra Galetin

Drug Metabolism and Disposition September 2014, 42 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.114.057372
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Dynamic and Coordinated Regulation of KEAP1-NRF2-ARE and p53/p21 Signaling Pathways Is Associated with Acetaminophen Injury Responsive Liver Regeneration
Xiaomei Fan, Pan Chen, Huasen Tan, Hang Zeng, Yiming Jiang, Ying Wang, Yongtao Wang, Xiangyu Hou, Huichang Bi and Min Huang

Drug Metabolism and Disposition September 2014, 42 (9) 1532-1539; DOI: https://doi.org/10.1124/dmd.114.059394
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A Useful Model Capable of Predicting the Clearance of Cytochrome P450 3A4 (CYP3A4) Substrates in Humans: Validity of CYP3A4 Transgenic Mice Lacking Their Own Cyp3a Enzymes
Tetsuya Mitsui, Takayuki Nemoto, Taiji Miyake, Shunsuke Nagao, Kotaro Ogawa, Motohiro Kato, Masaki Ishigai and Hideyuki Yamada

Drug Metabolism and Disposition September 2014, 42 (9) 1540-1547; DOI: https://doi.org/10.1124/dmd.114.057935
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Interindividual Variations in Metabolism and Pharmacokinetics of 3-(6-Methylpyridine-3-yl-sulfanyl)-6-(4H-[1,2,4]triazole-3-yl-sulfanyl)-N-(1,3-thiazole-2-yl)-2-pyridine carboxamide, a Glucokinase Activator, in Rats Caused by the Genetic Polymorphism of CYP2D1
Takuro Hasegawa, Jun-ichi Eiki and Masato Chiba

Drug Metabolism and Disposition September 2014, 42 (9) 1548-1555; DOI: https://doi.org/10.1124/dmd.114.058081
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Impact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG Cells
Pamela Bachour-El Azzi, Ahmad Sharanek, Ziad Abdel-Razzak, Sebastien Antherieu, Houssein Al-Attrache, Camille C. Savary, Sylvie Lepage, Isabelle Morel, Gilles Labbe, Christiane Guguen-Guillouzo and André Guillouzo

Drug Metabolism and Disposition September 2014, 42 (9) 1556-1566; DOI: https://doi.org/10.1124/dmd.114.058123
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Role of Multidrug Resistance–Associated Protein 4 in the Basolateral Efflux of Hepatically Derived Enalaprilat
Brian C. Ferslew, Kathleen Köck, Arlene S. Bridges and Kim L. R. Brouwer

Drug Metabolism and Disposition September 2014, 42 (9) 1567-1574; DOI: https://doi.org/10.1124/dmd.114.057554
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A Numerical Method for Analysis of In Vitro Time-Dependent Inhibition Data. Part 1. Theoretical Considerations
Swati Nagar, Jeffrey P. Jones and Ken Korzekwa

Drug Metabolism and Disposition September 2014, 42 (9) 1575-1586; DOI: https://doi.org/10.1124/dmd.114.058289
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A Numerical Method for Analysis of In Vitro Time-Dependent Inhibition Data. Part 2. Application to Experimental Data
Ken Korzekwa, Donald Tweedie, Upendra A. Argikar, Andrea Whitcher-Johnstone, Leslie Bell, Shari Bickford and Swati Nagar

Drug Metabolism and Disposition September 2014, 42 (9) 1587-1595; DOI: https://doi.org/10.1124/dmd.114.058297

Erratum

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Correction to “Enhanced Nicotine Metabolism in HIV-1–Positive Smokers Compared with HIV-Negative Smokers: Simultaneous Determination of Nicotine and its Four Metabolites in Their Plasma Using a Simple and Sensitive Electrospray Ionization Liquid Chromatography–Tandem Mass Spectrometry Technique”
Drug Metabolism and Disposition September 2014, 42 (9) 1596-1598; DOI: https://doi.org/10.1124/dmd.114.055186err

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