Index by author
September 01, 2014; Volume 42,Issue 9
A
Abdel-Razzak, Ziad
- You have accessImpact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG CellsPamela Bachour-El Azzi, Ahmad Sharanek, Ziad Abdel-Razzak, Sebastien Antherieu, Houssein Al-Attrache, Camille C. Savary, Sylvie Lepage, Isabelle Morel, Gilles Labbe, Christiane Guguen-Guillouzo and André GuillouzoDrug Metabolism and Disposition September 2014, 42 (9) 1556-1566; DOI: https://doi.org/10.1124/dmd.114.058123
Abduljalil, Khaled
- You have accessDeciding on Success Criteria for Predictability of Pharmacokinetic Parameters from In Vitro Studies: An Analysis Based on In Vivo ObservationsKhaled Abduljalil, Theresa Cain, Helen Humphries and Amin Rostami-HodjeganDrug Metabolism and Disposition September 2014, 42 (9) 1478-1484; DOI: https://doi.org/10.1124/dmd.114.058099
Ahn, Taeho
- You have accessRegioselective Hydroxylation of Omeprazole Enantiomers by Bacterial CYP102A1 MutantsSang Hoon Ryu, Bo-Yeon Park, So-Young Kim, Sun-Ha Park, Hyun-Jin Jung, Min Park, Ki Deok Park, Taeho Ahn, Hyung-Sik Kang and Chul-Ho YunDrug Metabolism and Disposition September 2014, 42 (9) 1493-1497; DOI: https://doi.org/10.1124/dmd.114.058636
Al-Attrache, Houssein
- You have accessImpact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG CellsPamela Bachour-El Azzi, Ahmad Sharanek, Ziad Abdel-Razzak, Sebastien Antherieu, Houssein Al-Attrache, Camille C. Savary, Sylvie Lepage, Isabelle Morel, Gilles Labbe, Christiane Guguen-Guillouzo and André GuillouzoDrug Metabolism and Disposition September 2014, 42 (9) 1556-1566; DOI: https://doi.org/10.1124/dmd.114.058123
An, Guohua
- You have accessFlavonoids Are Inhibitors of Human Organic Anion Transporter 1 (OAT1)–Mediated TransportGuohua An, Xiaodong Wang and Marilyn E. MorrisDrug Metabolism and Disposition September 2014, 42 (9) 1357-1366; DOI: https://doi.org/10.1124/dmd.114.059337
Andersson, Tommy B.
- You have accessLong-Term Chronic Toxicity Testing Using Human Pluripotent Stem Cell–Derived HepatocytesGustav Holmgren, Anna-Karin Sjögren, Isabel Barragan, Alan Sabirsh, Peter Sartipy, Jane Synnergren, Petter Björquist, Magnus Ingelman-Sundberg, Tommy B. Andersson and Josefina EdsbaggeDrug Metabolism and Disposition September 2014, 42 (9) 1401-1406; DOI: https://doi.org/10.1124/dmd.114.059154
Antherieu, Sebastien
- You have accessImpact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG CellsPamela Bachour-El Azzi, Ahmad Sharanek, Ziad Abdel-Razzak, Sebastien Antherieu, Houssein Al-Attrache, Camille C. Savary, Sylvie Lepage, Isabelle Morel, Gilles Labbe, Christiane Guguen-Guillouzo and André GuillouzoDrug Metabolism and Disposition September 2014, 42 (9) 1556-1566; DOI: https://doi.org/10.1124/dmd.114.058123
Argikar, Upendra A.
- You have accessA Numerical Method for Analysis of In Vitro Time-Dependent Inhibition Data. Part 2. Application to Experimental DataKen Korzekwa, Donald Tweedie, Upendra A. Argikar, Andrea Whitcher-Johnstone, Leslie Bell, Shari Bickford and Swati NagarDrug Metabolism and Disposition September 2014, 42 (9) 1587-1595; DOI: https://doi.org/10.1124/dmd.114.058297
Avian, Alexander
- You have accessInflammatory Bowel Disease Alters Intestinal Bile Acid Transporter ExpressionJörg Jahnel, Peter Fickert, Almuthe C. Hauer, Christoph Högenauer, Alexander Avian and Michael TraunerDrug Metabolism and Disposition September 2014, 42 (9) 1423-1431; DOI: https://doi.org/10.1124/dmd.114.058065
B
Bachour-El Azzi, Pamela
- You have accessImpact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG CellsPamela Bachour-El Azzi, Ahmad Sharanek, Ziad Abdel-Razzak, Sebastien Antherieu, Houssein Al-Attrache, Camille C. Savary, Sylvie Lepage, Isabelle Morel, Gilles Labbe, Christiane Guguen-Guillouzo and André GuillouzoDrug Metabolism and Disposition September 2014, 42 (9) 1556-1566; DOI: https://doi.org/10.1124/dmd.114.058123
Bader, Urs
- You have accessCalibration of In Vitro Multidrug Resistance Protein 1 Substrate and Inhibition Assays as a Basis to Support the Prediction of Clinically Relevant Interactions In VivoAgnès Poirier, Anne-Christine Cascais, Urs Bader, Renée Portmann, Marie-Elise Brun, Isabelle Walter, Alexander Hillebrecht, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1411-1422; DOI: https://doi.org/10.1124/dmd.114.057943
- You have accessThe Need for Human Breast Cancer Resistance Protein Substrate and Inhibition Evaluation in Drug Discovery and Development: Why, When, and How?Agnès Poirier, Renée Portmann, Anne-Christine Cascais, Urs Bader, Isabelle Walter, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1466-1477; DOI: https://doi.org/10.1124/dmd.114.058248
Barbero, Luca
- You have accessTime- and NADPH-Dependent Inhibition of Cytochrome P450 3A4 by the Cyclopentapeptide Cilengitide: Significance of the Guanidine Group and Accompanying Spectral ChangesMirza Bojić, Luca Barbero, Hugues Dolgos, Achim Freisleben, Dieter Gallemann, Simona Riva and F. Peter GuengerichDrug Metabolism and Disposition September 2014, 42 (9) 1438-1446; DOI: https://doi.org/10.1124/dmd.114.059295
Barragan, Isabel
- You have accessLong-Term Chronic Toxicity Testing Using Human Pluripotent Stem Cell–Derived HepatocytesGustav Holmgren, Anna-Karin Sjögren, Isabel Barragan, Alan Sabirsh, Peter Sartipy, Jane Synnergren, Petter Björquist, Magnus Ingelman-Sundberg, Tommy B. Andersson and Josefina EdsbaggeDrug Metabolism and Disposition September 2014, 42 (9) 1401-1406; DOI: https://doi.org/10.1124/dmd.114.059154
Bell, Leslie
- You have accessA Numerical Method for Analysis of In Vitro Time-Dependent Inhibition Data. Part 2. Application to Experimental DataKen Korzekwa, Donald Tweedie, Upendra A. Argikar, Andrea Whitcher-Johnstone, Leslie Bell, Shari Bickford and Swati NagarDrug Metabolism and Disposition September 2014, 42 (9) 1587-1595; DOI: https://doi.org/10.1124/dmd.114.058297
Bi, Huichang
- You have accessDynamic and Coordinated Regulation of KEAP1-NRF2-ARE and p53/p21 Signaling Pathways Is Associated with Acetaminophen Injury Responsive Liver RegenerationXiaomei Fan, Pan Chen, Huasen Tan, Hang Zeng, Yiming Jiang, Ying Wang, Yongtao Wang, Xiangyu Hou, Huichang Bi and Min HuangDrug Metabolism and Disposition September 2014, 42 (9) 1532-1539; DOI: https://doi.org/10.1124/dmd.114.059394
Bickford, Shari
- You have accessA Numerical Method for Analysis of In Vitro Time-Dependent Inhibition Data. Part 2. Application to Experimental DataKen Korzekwa, Donald Tweedie, Upendra A. Argikar, Andrea Whitcher-Johnstone, Leslie Bell, Shari Bickford and Swati NagarDrug Metabolism and Disposition September 2014, 42 (9) 1587-1595; DOI: https://doi.org/10.1124/dmd.114.058297
Björquist, Petter
- You have accessLong-Term Chronic Toxicity Testing Using Human Pluripotent Stem Cell–Derived HepatocytesGustav Holmgren, Anna-Karin Sjögren, Isabel Barragan, Alan Sabirsh, Peter Sartipy, Jane Synnergren, Petter Björquist, Magnus Ingelman-Sundberg, Tommy B. Andersson and Josefina EdsbaggeDrug Metabolism and Disposition September 2014, 42 (9) 1401-1406; DOI: https://doi.org/10.1124/dmd.114.059154
Bojić, Mirza
- You have accessTime- and NADPH-Dependent Inhibition of Cytochrome P450 3A4 by the Cyclopentapeptide Cilengitide: Significance of the Guanidine Group and Accompanying Spectral ChangesMirza Bojić, Luca Barbero, Hugues Dolgos, Achim Freisleben, Dieter Gallemann, Simona Riva and F. Peter GuengerichDrug Metabolism and Disposition September 2014, 42 (9) 1438-1446; DOI: https://doi.org/10.1124/dmd.114.059295
Bratton, Stacie M.
- You have accessA Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its DerivativesAleksandra K. Greer, Centdrika R. Dates, Athena Starlard-Davenport, Vineetha K. Edavana, Stacie M. Bratton, Ishwori B. Dhakal, Moshe Finel, Susan A. Kadlubar and Anna Radominska-PandyaDrug Metabolism and Disposition September 2014, 42 (9) 1392-1400; DOI: https://doi.org/10.1124/dmd.114.058016
Bridges, Arlene S.
- You have accessRole of Multidrug Resistance–Associated Protein 4 in the Basolateral Efflux of Hepatically Derived EnalaprilatBrian C. Ferslew, Kathleen Köck, Arlene S. Bridges and Kim L. R. BrouwerDrug Metabolism and Disposition September 2014, 42 (9) 1567-1574; DOI: https://doi.org/10.1124/dmd.114.057554
Brouwer, Kim L. R.
- You have accessRole of Multidrug Resistance–Associated Protein 4 in the Basolateral Efflux of Hepatically Derived EnalaprilatBrian C. Ferslew, Kathleen Köck, Arlene S. Bridges and Kim L. R. BrouwerDrug Metabolism and Disposition September 2014, 42 (9) 1567-1574; DOI: https://doi.org/10.1124/dmd.114.057554
Brun, Marie-Elise
- You have accessCalibration of In Vitro Multidrug Resistance Protein 1 Substrate and Inhibition Assays as a Basis to Support the Prediction of Clinically Relevant Interactions In VivoAgnès Poirier, Anne-Christine Cascais, Urs Bader, Renée Portmann, Marie-Elise Brun, Isabelle Walter, Alexander Hillebrecht, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1411-1422; DOI: https://doi.org/10.1124/dmd.114.057943
C
Cain, Theresa
- You have accessDeciding on Success Criteria for Predictability of Pharmacokinetic Parameters from In Vitro Studies: An Analysis Based on In Vivo ObservationsKhaled Abduljalil, Theresa Cain, Helen Humphries and Amin Rostami-HodjeganDrug Metabolism and Disposition September 2014, 42 (9) 1478-1484; DOI: https://doi.org/10.1124/dmd.114.058099
Callendrello, Alanna L.
- You have accessEvaluation of Calibration Curve–Based Approaches to Predict Clinical Inducers and Noninducers of CYP3A4 with Plated Human HepatocytesJ. George Zhang, Thuy Ho, Alanna L. Callendrello, Robert J. Clark, Elizabeth A. Santone, Sarah Kinsman, Deqing Xiao, Lisa G. Fox, Heidi J. Einolf and David M. StresserDrug Metabolism and Disposition September 2014, 42 (9) 1379-1391; DOI: https://doi.org/10.1124/dmd.114.058602
Camenisch, Gian
- You have accessPrediction of Organic Anion-Transporting Polypeptide 1B1- and 1B3-Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity DataAnnett Kunze, Jörg Huwyler, Gian Camenisch and Birk PollerDrug Metabolism and Disposition September 2014, 42 (9) 1514-1521; DOI: https://doi.org/10.1124/dmd.114.058412
Cascais, Anne-Christine
- You have accessCalibration of In Vitro Multidrug Resistance Protein 1 Substrate and Inhibition Assays as a Basis to Support the Prediction of Clinically Relevant Interactions In VivoAgnès Poirier, Anne-Christine Cascais, Urs Bader, Renée Portmann, Marie-Elise Brun, Isabelle Walter, Alexander Hillebrecht, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1411-1422; DOI: https://doi.org/10.1124/dmd.114.057943
- You have accessThe Need for Human Breast Cancer Resistance Protein Substrate and Inhibition Evaluation in Drug Discovery and Development: Why, When, and How?Agnès Poirier, Renée Portmann, Anne-Christine Cascais, Urs Bader, Isabelle Walter, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1466-1477; DOI: https://doi.org/10.1124/dmd.114.058248
Chen, Pan
- You have accessDynamic and Coordinated Regulation of KEAP1-NRF2-ARE and p53/p21 Signaling Pathways Is Associated with Acetaminophen Injury Responsive Liver RegenerationXiaomei Fan, Pan Chen, Huasen Tan, Hang Zeng, Yiming Jiang, Ying Wang, Yongtao Wang, Xiangyu Hou, Huichang Bi and Min HuangDrug Metabolism and Disposition September 2014, 42 (9) 1532-1539; DOI: https://doi.org/10.1124/dmd.114.059394
Chiba, Masato
- You have accessEffect of CYP2A6 Genetic Polymorphism on the Metabolic Conversion of Tegafur to 5-Fluorouracil and Its EnantioselectivityIkuo Yamamiya, Kunihiro Yoshisue, Yuji Ishii, Hideyuki Yamada and Masato ChibaDrug Metabolism and Disposition September 2014, 42 (9) 1485-1492; DOI: https://doi.org/10.1124/dmd.114.058008
- You have accessInterindividual Variations in Metabolism and Pharmacokinetics of 3-(6-Methylpyridine-3-yl-sulfanyl)-6-(4H-[1,2,4]triazole-3-yl-sulfanyl)-N-(1,3-thiazole-2-yl)-2-pyridine carboxamide, a Glucokinase Activator, in Rats Caused by the Genetic Polymorphism of CYP2D1Takuro Hasegawa, Jun-ichi Eiki and Masato ChibaDrug Metabolism and Disposition September 2014, 42 (9) 1548-1555; DOI: https://doi.org/10.1124/dmd.114.058081
Clark, Robert J.
- You have accessEvaluation of Calibration Curve–Based Approaches to Predict Clinical Inducers and Noninducers of CYP3A4 with Plated Human HepatocytesJ. George Zhang, Thuy Ho, Alanna L. Callendrello, Robert J. Clark, Elizabeth A. Santone, Sarah Kinsman, Deqing Xiao, Lisa G. Fox, Heidi J. Einolf and David M. StresserDrug Metabolism and Disposition September 2014, 42 (9) 1379-1391; DOI: https://doi.org/10.1124/dmd.114.058602
Craig, Evelyn L.
- You have accessNicotine Pharmacokinetics in Rats Is Altered as a Function of Age, Impacting the Interpretation of Animal Model DataEvelyn L. Craig, Bin Zhao, Jason Z. Cui, Maria Novalen, Sharon Miksys and Rachel F. TyndaleDrug Metabolism and Disposition September 2014, 42 (9) 1447-1455; DOI: https://doi.org/10.1124/dmd.114.058719
Cui, Jason Z.
- You have accessNicotine Pharmacokinetics in Rats Is Altered as a Function of Age, Impacting the Interpretation of Animal Model DataEvelyn L. Craig, Bin Zhao, Jason Z. Cui, Maria Novalen, Sharon Miksys and Rachel F. TyndaleDrug Metabolism and Disposition September 2014, 42 (9) 1447-1455; DOI: https://doi.org/10.1124/dmd.114.058719
D
Danhof, Meindert
- You have accessTranslational Pharmacokinetic Modeling of Fingolimod (FTY720) as a Paradigm Compound Subject to Sphingosine Kinase-Mediated PhosphorylationNelleke Snelder, Bart A. Ploeger, Olivier Luttringer, Donald. R. Stanski and Meindert DanhofDrug Metabolism and Disposition September 2014, 42 (9) 1367-1378; DOI: https://doi.org/10.1124/dmd.113.056770
Dates, Centdrika R.
- You have accessA Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its DerivativesAleksandra K. Greer, Centdrika R. Dates, Athena Starlard-Davenport, Vineetha K. Edavana, Stacie M. Bratton, Ishwori B. Dhakal, Moshe Finel, Susan A. Kadlubar and Anna Radominska-PandyaDrug Metabolism and Disposition September 2014, 42 (9) 1392-1400; DOI: https://doi.org/10.1124/dmd.114.058016
Dhakal, Ishwori B.
- You have accessA Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its DerivativesAleksandra K. Greer, Centdrika R. Dates, Athena Starlard-Davenport, Vineetha K. Edavana, Stacie M. Bratton, Ishwori B. Dhakal, Moshe Finel, Susan A. Kadlubar and Anna Radominska-PandyaDrug Metabolism and Disposition September 2014, 42 (9) 1392-1400; DOI: https://doi.org/10.1124/dmd.114.058016
Dolgos, Hugues
- You have accessTime- and NADPH-Dependent Inhibition of Cytochrome P450 3A4 by the Cyclopentapeptide Cilengitide: Significance of the Guanidine Group and Accompanying Spectral ChangesMirza Bojić, Luca Barbero, Hugues Dolgos, Achim Freisleben, Dieter Gallemann, Simona Riva and F. Peter GuengerichDrug Metabolism and Disposition September 2014, 42 (9) 1438-1446; DOI: https://doi.org/10.1124/dmd.114.059295
E
Edavana, Vineetha K.
- You have accessA Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its DerivativesAleksandra K. Greer, Centdrika R. Dates, Athena Starlard-Davenport, Vineetha K. Edavana, Stacie M. Bratton, Ishwori B. Dhakal, Moshe Finel, Susan A. Kadlubar and Anna Radominska-PandyaDrug Metabolism and Disposition September 2014, 42 (9) 1392-1400; DOI: https://doi.org/10.1124/dmd.114.058016
Edsbagge, Josefina
- You have accessLong-Term Chronic Toxicity Testing Using Human Pluripotent Stem Cell–Derived HepatocytesGustav Holmgren, Anna-Karin Sjögren, Isabel Barragan, Alan Sabirsh, Peter Sartipy, Jane Synnergren, Petter Björquist, Magnus Ingelman-Sundberg, Tommy B. Andersson and Josefina EdsbaggeDrug Metabolism and Disposition September 2014, 42 (9) 1401-1406; DOI: https://doi.org/10.1124/dmd.114.059154
Eiki, Jun-ichi
- You have accessInterindividual Variations in Metabolism and Pharmacokinetics of 3-(6-Methylpyridine-3-yl-sulfanyl)-6-(4H-[1,2,4]triazole-3-yl-sulfanyl)-N-(1,3-thiazole-2-yl)-2-pyridine carboxamide, a Glucokinase Activator, in Rats Caused by the Genetic Polymorphism of CYP2D1Takuro Hasegawa, Jun-ichi Eiki and Masato ChibaDrug Metabolism and Disposition September 2014, 42 (9) 1548-1555; DOI: https://doi.org/10.1124/dmd.114.058081
Einolf, Heidi J.
- You have accessEvaluation of Calibration Curve–Based Approaches to Predict Clinical Inducers and Noninducers of CYP3A4 with Plated Human HepatocytesJ. George Zhang, Thuy Ho, Alanna L. Callendrello, Robert J. Clark, Elizabeth A. Santone, Sarah Kinsman, Deqing Xiao, Lisa G. Fox, Heidi J. Einolf and David M. StresserDrug Metabolism and Disposition September 2014, 42 (9) 1379-1391; DOI: https://doi.org/10.1124/dmd.114.058602
El-Kadi, Ayman O.S.
- You have accessCharacterization of Arachidonic Acid Metabolism by Rat Cytochrome P450 Enzymes: The Involvement of CYP1AsAhmed A. El-Sherbeni and Ayman O.S. El-KadiDrug Metabolism and Disposition September 2014, 42 (9) 1498-1507; DOI: https://doi.org/10.1124/dmd.114.057836
El-Sherbeni, Ahmed A.
- You have accessCharacterization of Arachidonic Acid Metabolism by Rat Cytochrome P450 Enzymes: The Involvement of CYP1AsAhmed A. El-Sherbeni and Ayman O.S. El-KadiDrug Metabolism and Disposition September 2014, 42 (9) 1498-1507; DOI: https://doi.org/10.1124/dmd.114.057836
F
Fan, Xiaomei
- You have accessDynamic and Coordinated Regulation of KEAP1-NRF2-ARE and p53/p21 Signaling Pathways Is Associated with Acetaminophen Injury Responsive Liver RegenerationXiaomei Fan, Pan Chen, Huasen Tan, Hang Zeng, Yiming Jiang, Ying Wang, Yongtao Wang, Xiangyu Hou, Huichang Bi and Min HuangDrug Metabolism and Disposition September 2014, 42 (9) 1532-1539; DOI: https://doi.org/10.1124/dmd.114.059394
Ferslew, Brian C.
- You have accessRole of Multidrug Resistance–Associated Protein 4 in the Basolateral Efflux of Hepatically Derived EnalaprilatBrian C. Ferslew, Kathleen Köck, Arlene S. Bridges and Kim L. R. BrouwerDrug Metabolism and Disposition September 2014, 42 (9) 1567-1574; DOI: https://doi.org/10.1124/dmd.114.057554
Fickert, Peter
- You have accessInflammatory Bowel Disease Alters Intestinal Bile Acid Transporter ExpressionJörg Jahnel, Peter Fickert, Almuthe C. Hauer, Christoph Högenauer, Alexander Avian and Michael TraunerDrug Metabolism and Disposition September 2014, 42 (9) 1423-1431; DOI: https://doi.org/10.1124/dmd.114.058065
Finel, Moshe
- You have accessA Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its DerivativesAleksandra K. Greer, Centdrika R. Dates, Athena Starlard-Davenport, Vineetha K. Edavana, Stacie M. Bratton, Ishwori B. Dhakal, Moshe Finel, Susan A. Kadlubar and Anna Radominska-PandyaDrug Metabolism and Disposition September 2014, 42 (9) 1392-1400; DOI: https://doi.org/10.1124/dmd.114.058016
Fox, Lisa G.
- You have accessEvaluation of Calibration Curve–Based Approaches to Predict Clinical Inducers and Noninducers of CYP3A4 with Plated Human HepatocytesJ. George Zhang, Thuy Ho, Alanna L. Callendrello, Robert J. Clark, Elizabeth A. Santone, Sarah Kinsman, Deqing Xiao, Lisa G. Fox, Heidi J. Einolf and David M. StresserDrug Metabolism and Disposition September 2014, 42 (9) 1379-1391; DOI: https://doi.org/10.1124/dmd.114.058602
Freisleben, Achim
- You have accessTime- and NADPH-Dependent Inhibition of Cytochrome P450 3A4 by the Cyclopentapeptide Cilengitide: Significance of the Guanidine Group and Accompanying Spectral ChangesMirza Bojić, Luca Barbero, Hugues Dolgos, Achim Freisleben, Dieter Gallemann, Simona Riva and F. Peter GuengerichDrug Metabolism and Disposition September 2014, 42 (9) 1438-1446; DOI: https://doi.org/10.1124/dmd.114.059295
Funk, Christoph
- You have accessCalibration of In Vitro Multidrug Resistance Protein 1 Substrate and Inhibition Assays as a Basis to Support the Prediction of Clinically Relevant Interactions In VivoAgnès Poirier, Anne-Christine Cascais, Urs Bader, Renée Portmann, Marie-Elise Brun, Isabelle Walter, Alexander Hillebrecht, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1411-1422; DOI: https://doi.org/10.1124/dmd.114.057943
- You have accessThe Need for Human Breast Cancer Resistance Protein Substrate and Inhibition Evaluation in Drug Discovery and Development: Why, When, and How?Agnès Poirier, Renée Portmann, Anne-Christine Cascais, Urs Bader, Isabelle Walter, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1466-1477; DOI: https://doi.org/10.1124/dmd.114.058248
G
Galetin, Aleksandra
- You have accessHepatic, Intestinal, Renal, and Plasma Hydrolysis of Prodrugs in Human, Cynomolgus Monkey, Dog, and Rat: Implications for In Vitro–In Vivo Extrapolation of Clearance of ProdrugsHaruka Nishimuta, J. Brian Houston and Aleksandra GaletinDrug Metabolism and Disposition September 2014, 42 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.114.057372
Gallemann, Dieter
- You have accessTime- and NADPH-Dependent Inhibition of Cytochrome P450 3A4 by the Cyclopentapeptide Cilengitide: Significance of the Guanidine Group and Accompanying Spectral ChangesMirza Bojić, Luca Barbero, Hugues Dolgos, Achim Freisleben, Dieter Gallemann, Simona Riva and F. Peter GuengerichDrug Metabolism and Disposition September 2014, 42 (9) 1438-1446; DOI: https://doi.org/10.1124/dmd.114.059295
Greer, Aleksandra K.
- You have accessA Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its DerivativesAleksandra K. Greer, Centdrika R. Dates, Athena Starlard-Davenport, Vineetha K. Edavana, Stacie M. Bratton, Ishwori B. Dhakal, Moshe Finel, Susan A. Kadlubar and Anna Radominska-PandyaDrug Metabolism and Disposition September 2014, 42 (9) 1392-1400; DOI: https://doi.org/10.1124/dmd.114.058016
Guengerich, F. Peter
- You have accessTime- and NADPH-Dependent Inhibition of Cytochrome P450 3A4 by the Cyclopentapeptide Cilengitide: Significance of the Guanidine Group and Accompanying Spectral ChangesMirza Bojić, Luca Barbero, Hugues Dolgos, Achim Freisleben, Dieter Gallemann, Simona Riva and F. Peter GuengerichDrug Metabolism and Disposition September 2014, 42 (9) 1438-1446; DOI: https://doi.org/10.1124/dmd.114.059295
Guguen-Guillouzo, Christiane
- You have accessImpact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG CellsPamela Bachour-El Azzi, Ahmad Sharanek, Ziad Abdel-Razzak, Sebastien Antherieu, Houssein Al-Attrache, Camille C. Savary, Sylvie Lepage, Isabelle Morel, Gilles Labbe, Christiane Guguen-Guillouzo and André GuillouzoDrug Metabolism and Disposition September 2014, 42 (9) 1556-1566; DOI: https://doi.org/10.1124/dmd.114.058123
Guillouzo, André
- You have accessImpact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG CellsPamela Bachour-El Azzi, Ahmad Sharanek, Ziad Abdel-Razzak, Sebastien Antherieu, Houssein Al-Attrache, Camille C. Savary, Sylvie Lepage, Isabelle Morel, Gilles Labbe, Christiane Guguen-Guillouzo and André GuillouzoDrug Metabolism and Disposition September 2014, 42 (9) 1556-1566; DOI: https://doi.org/10.1124/dmd.114.058123
Gunji, Emi
- You have accessA Strategy for Assessing Potential Drug-Drug Interactions of a Concomitant Agent against a Drug Absorbed via an Intestinal Transporter in HumansAkiko Mizuno-Yasuhira, Yasuhiro Nakai, Emi Gunji, Saeko Uchida, Teisuke Takahashi, Kohnosuke Kinoshita, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa and Jun-ichi YamaguchiDrug Metabolism and Disposition September 2014, 42 (9) 1456-1465; DOI: https://doi.org/10.1124/dmd.114.058305
H
Hasegawa, Takuro
- You have accessInterindividual Variations in Metabolism and Pharmacokinetics of 3-(6-Methylpyridine-3-yl-sulfanyl)-6-(4H-[1,2,4]triazole-3-yl-sulfanyl)-N-(1,3-thiazole-2-yl)-2-pyridine carboxamide, a Glucokinase Activator, in Rats Caused by the Genetic Polymorphism of CYP2D1Takuro Hasegawa, Jun-ichi Eiki and Masato ChibaDrug Metabolism and Disposition September 2014, 42 (9) 1548-1555; DOI: https://doi.org/10.1124/dmd.114.058081
Hauer, Almuthe C.
- You have accessInflammatory Bowel Disease Alters Intestinal Bile Acid Transporter ExpressionJörg Jahnel, Peter Fickert, Almuthe C. Hauer, Christoph Högenauer, Alexander Avian and Michael TraunerDrug Metabolism and Disposition September 2014, 42 (9) 1423-1431; DOI: https://doi.org/10.1124/dmd.114.058065
Hillebrecht, Alexander
- You have accessCalibration of In Vitro Multidrug Resistance Protein 1 Substrate and Inhibition Assays as a Basis to Support the Prediction of Clinically Relevant Interactions In VivoAgnès Poirier, Anne-Christine Cascais, Urs Bader, Renée Portmann, Marie-Elise Brun, Isabelle Walter, Alexander Hillebrecht, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1411-1422; DOI: https://doi.org/10.1124/dmd.114.057943
Hirota, Takeshi
- You have accessIdentification and Functional Characterization of Novel Nonsynonymous Variants in the Human Multidrug and Toxin Extrusion 2-KKenta Nishimura, Ryosuke Ide, Takeshi Hirota, Kana Kawazu, Sho Kodama, Hiroaki Takesue and Ichiro IeiriDrug Metabolism and Disposition September 2014, 42 (9) 1432-1437; DOI: https://doi.org/10.1124/dmd.114.056887
Ho, Thuy
- You have accessEvaluation of Calibration Curve–Based Approaches to Predict Clinical Inducers and Noninducers of CYP3A4 with Plated Human HepatocytesJ. George Zhang, Thuy Ho, Alanna L. Callendrello, Robert J. Clark, Elizabeth A. Santone, Sarah Kinsman, Deqing Xiao, Lisa G. Fox, Heidi J. Einolf and David M. StresserDrug Metabolism and Disposition September 2014, 42 (9) 1379-1391; DOI: https://doi.org/10.1124/dmd.114.058602
Högenauer, Christoph
- You have accessInflammatory Bowel Disease Alters Intestinal Bile Acid Transporter ExpressionJörg Jahnel, Peter Fickert, Almuthe C. Hauer, Christoph Högenauer, Alexander Avian and Michael TraunerDrug Metabolism and Disposition September 2014, 42 (9) 1423-1431; DOI: https://doi.org/10.1124/dmd.114.058065
Holmgren, Gustav
- You have accessLong-Term Chronic Toxicity Testing Using Human Pluripotent Stem Cell–Derived HepatocytesGustav Holmgren, Anna-Karin Sjögren, Isabel Barragan, Alan Sabirsh, Peter Sartipy, Jane Synnergren, Petter Björquist, Magnus Ingelman-Sundberg, Tommy B. Andersson and Josefina EdsbaggeDrug Metabolism and Disposition September 2014, 42 (9) 1401-1406; DOI: https://doi.org/10.1124/dmd.114.059154
Hou, Xiangyu
- You have accessDynamic and Coordinated Regulation of KEAP1-NRF2-ARE and p53/p21 Signaling Pathways Is Associated with Acetaminophen Injury Responsive Liver RegenerationXiaomei Fan, Pan Chen, Huasen Tan, Hang Zeng, Yiming Jiang, Ying Wang, Yongtao Wang, Xiangyu Hou, Huichang Bi and Min HuangDrug Metabolism and Disposition September 2014, 42 (9) 1532-1539; DOI: https://doi.org/10.1124/dmd.114.059394
Houston, J. Brian
- You have accessHepatic, Intestinal, Renal, and Plasma Hydrolysis of Prodrugs in Human, Cynomolgus Monkey, Dog, and Rat: Implications for In Vitro–In Vivo Extrapolation of Clearance of ProdrugsHaruka Nishimuta, J. Brian Houston and Aleksandra GaletinDrug Metabolism and Disposition September 2014, 42 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.114.057372
Huang, Min
- You have accessDynamic and Coordinated Regulation of KEAP1-NRF2-ARE and p53/p21 Signaling Pathways Is Associated with Acetaminophen Injury Responsive Liver RegenerationXiaomei Fan, Pan Chen, Huasen Tan, Hang Zeng, Yiming Jiang, Ying Wang, Yongtao Wang, Xiangyu Hou, Huichang Bi and Min HuangDrug Metabolism and Disposition September 2014, 42 (9) 1532-1539; DOI: https://doi.org/10.1124/dmd.114.059394
Humphries, Helen
- You have accessDeciding on Success Criteria for Predictability of Pharmacokinetic Parameters from In Vitro Studies: An Analysis Based on In Vivo ObservationsKhaled Abduljalil, Theresa Cain, Helen Humphries and Amin Rostami-HodjeganDrug Metabolism and Disposition September 2014, 42 (9) 1478-1484; DOI: https://doi.org/10.1124/dmd.114.058099
Huwyler, Jörg
- You have accessPrediction of Organic Anion-Transporting Polypeptide 1B1- and 1B3-Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity DataAnnett Kunze, Jörg Huwyler, Gian Camenisch and Birk PollerDrug Metabolism and Disposition September 2014, 42 (9) 1514-1521; DOI: https://doi.org/10.1124/dmd.114.058412
I
Ide, Ryosuke
- You have accessIdentification and Functional Characterization of Novel Nonsynonymous Variants in the Human Multidrug and Toxin Extrusion 2-KKenta Nishimura, Ryosuke Ide, Takeshi Hirota, Kana Kawazu, Sho Kodama, Hiroaki Takesue and Ichiro IeiriDrug Metabolism and Disposition September 2014, 42 (9) 1432-1437; DOI: https://doi.org/10.1124/dmd.114.056887
Ieiri, Ichiro
- You have accessIdentification and Functional Characterization of Novel Nonsynonymous Variants in the Human Multidrug and Toxin Extrusion 2-KKenta Nishimura, Ryosuke Ide, Takeshi Hirota, Kana Kawazu, Sho Kodama, Hiroaki Takesue and Ichiro IeiriDrug Metabolism and Disposition September 2014, 42 (9) 1432-1437; DOI: https://doi.org/10.1124/dmd.114.056887
Ingelman-Sundberg, Magnus
- You have accessLong-Term Chronic Toxicity Testing Using Human Pluripotent Stem Cell–Derived HepatocytesGustav Holmgren, Anna-Karin Sjögren, Isabel Barragan, Alan Sabirsh, Peter Sartipy, Jane Synnergren, Petter Björquist, Magnus Ingelman-Sundberg, Tommy B. Andersson and Josefina EdsbaggeDrug Metabolism and Disposition September 2014, 42 (9) 1401-1406; DOI: https://doi.org/10.1124/dmd.114.059154
Ishigai, Masaki
- You have accessA Useful Model Capable of Predicting the Clearance of Cytochrome P450 3A4 (CYP3A4) Substrates in Humans: Validity of CYP3A4 Transgenic Mice Lacking Their Own Cyp3a EnzymesTetsuya Mitsui, Takayuki Nemoto, Taiji Miyake, Shunsuke Nagao, Kotaro Ogawa, Motohiro Kato, Masaki Ishigai and Hideyuki YamadaDrug Metabolism and Disposition September 2014, 42 (9) 1540-1547; DOI: https://doi.org/10.1124/dmd.114.057935
Ishii, Yuji
- You have accessEffect of CYP2A6 Genetic Polymorphism on the Metabolic Conversion of Tegafur to 5-Fluorouracil and Its EnantioselectivityIkuo Yamamiya, Kunihiro Yoshisue, Yuji Ishii, Hideyuki Yamada and Masato ChibaDrug Metabolism and Disposition September 2014, 42 (9) 1485-1492; DOI: https://doi.org/10.1124/dmd.114.058008
J
Jahnel, Jörg
- You have accessInflammatory Bowel Disease Alters Intestinal Bile Acid Transporter ExpressionJörg Jahnel, Peter Fickert, Almuthe C. Hauer, Christoph Högenauer, Alexander Avian and Michael TraunerDrug Metabolism and Disposition September 2014, 42 (9) 1423-1431; DOI: https://doi.org/10.1124/dmd.114.058065
Jiang, Yiming
- You have accessDynamic and Coordinated Regulation of KEAP1-NRF2-ARE and p53/p21 Signaling Pathways Is Associated with Acetaminophen Injury Responsive Liver RegenerationXiaomei Fan, Pan Chen, Huasen Tan, Hang Zeng, Yiming Jiang, Ying Wang, Yongtao Wang, Xiangyu Hou, Huichang Bi and Min HuangDrug Metabolism and Disposition September 2014, 42 (9) 1532-1539; DOI: https://doi.org/10.1124/dmd.114.059394
Jingu, Shigeji
- You have accessA Strategy for Assessing Potential Drug-Drug Interactions of a Concomitant Agent against a Drug Absorbed via an Intestinal Transporter in HumansAkiko Mizuno-Yasuhira, Yasuhiro Nakai, Emi Gunji, Saeko Uchida, Teisuke Takahashi, Kohnosuke Kinoshita, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa and Jun-ichi YamaguchiDrug Metabolism and Disposition September 2014, 42 (9) 1456-1465; DOI: https://doi.org/10.1124/dmd.114.058305
Jones, Jeffrey P.
- You have accessA Numerical Method for Analysis of In Vitro Time-Dependent Inhibition Data. Part 1. Theoretical ConsiderationsSwati Nagar, Jeffrey P. Jones and Ken KorzekwaDrug Metabolism and Disposition September 2014, 42 (9) 1575-1586; DOI: https://doi.org/10.1124/dmd.114.058289
Jung, Hyun-Jin
- You have accessRegioselective Hydroxylation of Omeprazole Enantiomers by Bacterial CYP102A1 MutantsSang Hoon Ryu, Bo-Yeon Park, So-Young Kim, Sun-Ha Park, Hyun-Jin Jung, Min Park, Ki Deok Park, Taeho Ahn, Hyung-Sik Kang and Chul-Ho YunDrug Metabolism and Disposition September 2014, 42 (9) 1493-1497; DOI: https://doi.org/10.1124/dmd.114.058636
Jung, Il-Hoon
- You have accessGut Microbiota-Mediated Drug Interactions between Lovastatin and AntibioticsDae-Hyoung Yoo, In Sook Kim, Thi Kim Van Le, Il-Hoon Jung, Hye Hyun Yoo and Dong-Hyun KimDrug Metabolism and Disposition September 2014, 42 (9) 1508-1513; DOI: https://doi.org/10.1124/dmd.114.058354
K
Kadlubar, Susan A.
- You have accessA Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its DerivativesAleksandra K. Greer, Centdrika R. Dates, Athena Starlard-Davenport, Vineetha K. Edavana, Stacie M. Bratton, Ishwori B. Dhakal, Moshe Finel, Susan A. Kadlubar and Anna Radominska-PandyaDrug Metabolism and Disposition September 2014, 42 (9) 1392-1400; DOI: https://doi.org/10.1124/dmd.114.058016
Kang, Hyung-Sik
- You have accessRegioselective Hydroxylation of Omeprazole Enantiomers by Bacterial CYP102A1 MutantsSang Hoon Ryu, Bo-Yeon Park, So-Young Kim, Sun-Ha Park, Hyun-Jin Jung, Min Park, Ki Deok Park, Taeho Ahn, Hyung-Sik Kang and Chul-Ho YunDrug Metabolism and Disposition September 2014, 42 (9) 1493-1497; DOI: https://doi.org/10.1124/dmd.114.058636
Kato, Motohiro
- You have accessA Useful Model Capable of Predicting the Clearance of Cytochrome P450 3A4 (CYP3A4) Substrates in Humans: Validity of CYP3A4 Transgenic Mice Lacking Their Own Cyp3a EnzymesTetsuya Mitsui, Takayuki Nemoto, Taiji Miyake, Shunsuke Nagao, Kotaro Ogawa, Motohiro Kato, Masaki Ishigai and Hideyuki YamadaDrug Metabolism and Disposition September 2014, 42 (9) 1540-1547; DOI: https://doi.org/10.1124/dmd.114.057935
Kawazu, Kana
- You have accessIdentification and Functional Characterization of Novel Nonsynonymous Variants in the Human Multidrug and Toxin Extrusion 2-KKenta Nishimura, Ryosuke Ide, Takeshi Hirota, Kana Kawazu, Sho Kodama, Hiroaki Takesue and Ichiro IeiriDrug Metabolism and Disposition September 2014, 42 (9) 1432-1437; DOI: https://doi.org/10.1124/dmd.114.056887
Kim, Dong-Hyun
- You have accessGut Microbiota-Mediated Drug Interactions between Lovastatin and AntibioticsDae-Hyoung Yoo, In Sook Kim, Thi Kim Van Le, Il-Hoon Jung, Hye Hyun Yoo and Dong-Hyun KimDrug Metabolism and Disposition September 2014, 42 (9) 1508-1513; DOI: https://doi.org/10.1124/dmd.114.058354
Kim, In Sook
- You have accessGut Microbiota-Mediated Drug Interactions between Lovastatin and AntibioticsDae-Hyoung Yoo, In Sook Kim, Thi Kim Van Le, Il-Hoon Jung, Hye Hyun Yoo and Dong-Hyun KimDrug Metabolism and Disposition September 2014, 42 (9) 1508-1513; DOI: https://doi.org/10.1124/dmd.114.058354
Kim, So-Young
- You have accessRegioselective Hydroxylation of Omeprazole Enantiomers by Bacterial CYP102A1 MutantsSang Hoon Ryu, Bo-Yeon Park, So-Young Kim, Sun-Ha Park, Hyun-Jin Jung, Min Park, Ki Deok Park, Taeho Ahn, Hyung-Sik Kang and Chul-Ho YunDrug Metabolism and Disposition September 2014, 42 (9) 1493-1497; DOI: https://doi.org/10.1124/dmd.114.058636
Kinoshita, Kohnosuke
- You have accessA Strategy for Assessing Potential Drug-Drug Interactions of a Concomitant Agent against a Drug Absorbed via an Intestinal Transporter in HumansAkiko Mizuno-Yasuhira, Yasuhiro Nakai, Emi Gunji, Saeko Uchida, Teisuke Takahashi, Kohnosuke Kinoshita, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa and Jun-ichi YamaguchiDrug Metabolism and Disposition September 2014, 42 (9) 1456-1465; DOI: https://doi.org/10.1124/dmd.114.058305
Kinsman, Sarah
- You have accessEvaluation of Calibration Curve–Based Approaches to Predict Clinical Inducers and Noninducers of CYP3A4 with Plated Human HepatocytesJ. George Zhang, Thuy Ho, Alanna L. Callendrello, Robert J. Clark, Elizabeth A. Santone, Sarah Kinsman, Deqing Xiao, Lisa G. Fox, Heidi J. Einolf and David M. StresserDrug Metabolism and Disposition September 2014, 42 (9) 1379-1391; DOI: https://doi.org/10.1124/dmd.114.058602
Köck, Kathleen
- You have accessRole of Multidrug Resistance–Associated Protein 4 in the Basolateral Efflux of Hepatically Derived EnalaprilatBrian C. Ferslew, Kathleen Köck, Arlene S. Bridges and Kim L. R. BrouwerDrug Metabolism and Disposition September 2014, 42 (9) 1567-1574; DOI: https://doi.org/10.1124/dmd.114.057554
Kodama, Sho
- You have accessIdentification and Functional Characterization of Novel Nonsynonymous Variants in the Human Multidrug and Toxin Extrusion 2-KKenta Nishimura, Ryosuke Ide, Takeshi Hirota, Kana Kawazu, Sho Kodama, Hiroaki Takesue and Ichiro IeiriDrug Metabolism and Disposition September 2014, 42 (9) 1432-1437; DOI: https://doi.org/10.1124/dmd.114.056887
Kohara, Sakae
- You have accessPolymorphisms of CYP2D17 in Cynomolgus and Rhesus Macaques: an Evidence of the Genetic Basis for the Variability of CYP2D-Dependent Drug MetabolismYasuhiro Uno, Shotaro Uehara, Sakae Kohara, Norie Murayama and Hiroshi YamazakiDrug Metabolism and Disposition September 2014, 42 (9) 1407-1410; DOI: https://doi.org/10.1124/dmd.114.059220
Korzekwa, Ken
- You have accessA Numerical Method for Analysis of In Vitro Time-Dependent Inhibition Data. Part 1. Theoretical ConsiderationsSwati Nagar, Jeffrey P. Jones and Ken KorzekwaDrug Metabolism and Disposition September 2014, 42 (9) 1575-1586; DOI: https://doi.org/10.1124/dmd.114.058289
- You have accessA Numerical Method for Analysis of In Vitro Time-Dependent Inhibition Data. Part 2. Application to Experimental DataKen Korzekwa, Donald Tweedie, Upendra A. Argikar, Andrea Whitcher-Johnstone, Leslie Bell, Shari Bickford and Swati NagarDrug Metabolism and Disposition September 2014, 42 (9) 1587-1595; DOI: https://doi.org/10.1124/dmd.114.058297
Kunze, Annett
- You have accessPrediction of Organic Anion-Transporting Polypeptide 1B1- and 1B3-Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity DataAnnett Kunze, Jörg Huwyler, Gian Camenisch and Birk PollerDrug Metabolism and Disposition September 2014, 42 (9) 1514-1521; DOI: https://doi.org/10.1124/dmd.114.058412
L
Labbe, Gilles
- You have accessImpact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG CellsPamela Bachour-El Azzi, Ahmad Sharanek, Ziad Abdel-Razzak, Sebastien Antherieu, Houssein Al-Attrache, Camille C. Savary, Sylvie Lepage, Isabelle Morel, Gilles Labbe, Christiane Guguen-Guillouzo and André GuillouzoDrug Metabolism and Disposition September 2014, 42 (9) 1556-1566; DOI: https://doi.org/10.1124/dmd.114.058123
Lepage, Sylvie
- You have accessImpact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG CellsPamela Bachour-El Azzi, Ahmad Sharanek, Ziad Abdel-Razzak, Sebastien Antherieu, Houssein Al-Attrache, Camille C. Savary, Sylvie Lepage, Isabelle Morel, Gilles Labbe, Christiane Guguen-Guillouzo and André GuillouzoDrug Metabolism and Disposition September 2014, 42 (9) 1556-1566; DOI: https://doi.org/10.1124/dmd.114.058123
Luttringer, Olivier
- You have accessTranslational Pharmacokinetic Modeling of Fingolimod (FTY720) as a Paradigm Compound Subject to Sphingosine Kinase-Mediated PhosphorylationNelleke Snelder, Bart A. Ploeger, Olivier Luttringer, Donald. R. Stanski and Meindert DanhofDrug Metabolism and Disposition September 2014, 42 (9) 1367-1378; DOI: https://doi.org/10.1124/dmd.113.056770
M
Miksys, Sharon
- You have accessNicotine Pharmacokinetics in Rats Is Altered as a Function of Age, Impacting the Interpretation of Animal Model DataEvelyn L. Craig, Bin Zhao, Jason Z. Cui, Maria Novalen, Sharon Miksys and Rachel F. TyndaleDrug Metabolism and Disposition September 2014, 42 (9) 1447-1455; DOI: https://doi.org/10.1124/dmd.114.058719
Mitsui, Tetsuya
- You have accessA Useful Model Capable of Predicting the Clearance of Cytochrome P450 3A4 (CYP3A4) Substrates in Humans: Validity of CYP3A4 Transgenic Mice Lacking Their Own Cyp3a EnzymesTetsuya Mitsui, Takayuki Nemoto, Taiji Miyake, Shunsuke Nagao, Kotaro Ogawa, Motohiro Kato, Masaki Ishigai and Hideyuki YamadaDrug Metabolism and Disposition September 2014, 42 (9) 1540-1547; DOI: https://doi.org/10.1124/dmd.114.057935
Miyake, Taiji
- You have accessA Useful Model Capable of Predicting the Clearance of Cytochrome P450 3A4 (CYP3A4) Substrates in Humans: Validity of CYP3A4 Transgenic Mice Lacking Their Own Cyp3a EnzymesTetsuya Mitsui, Takayuki Nemoto, Taiji Miyake, Shunsuke Nagao, Kotaro Ogawa, Motohiro Kato, Masaki Ishigai and Hideyuki YamadaDrug Metabolism and Disposition September 2014, 42 (9) 1540-1547; DOI: https://doi.org/10.1124/dmd.114.057935
Mizuno-Yasuhira, Akiko
- You have accessA Strategy for Assessing Potential Drug-Drug Interactions of a Concomitant Agent against a Drug Absorbed via an Intestinal Transporter in HumansAkiko Mizuno-Yasuhira, Yasuhiro Nakai, Emi Gunji, Saeko Uchida, Teisuke Takahashi, Kohnosuke Kinoshita, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa and Jun-ichi YamaguchiDrug Metabolism and Disposition September 2014, 42 (9) 1456-1465; DOI: https://doi.org/10.1124/dmd.114.058305
Morel, Isabelle
- You have accessImpact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG CellsPamela Bachour-El Azzi, Ahmad Sharanek, Ziad Abdel-Razzak, Sebastien Antherieu, Houssein Al-Attrache, Camille C. Savary, Sylvie Lepage, Isabelle Morel, Gilles Labbe, Christiane Guguen-Guillouzo and André GuillouzoDrug Metabolism and Disposition September 2014, 42 (9) 1556-1566; DOI: https://doi.org/10.1124/dmd.114.058123
Morris, Marilyn E.
- You have accessFlavonoids Are Inhibitors of Human Organic Anion Transporter 1 (OAT1)–Mediated TransportGuohua An, Xiaodong Wang and Marilyn E. MorrisDrug Metabolism and Disposition September 2014, 42 (9) 1357-1366; DOI: https://doi.org/10.1124/dmd.114.059337
Murayama, Norie
- You have accessPolymorphisms of CYP2D17 in Cynomolgus and Rhesus Macaques: an Evidence of the Genetic Basis for the Variability of CYP2D-Dependent Drug MetabolismYasuhiro Uno, Shotaro Uehara, Sakae Kohara, Norie Murayama and Hiroshi YamazakiDrug Metabolism and Disposition September 2014, 42 (9) 1407-1410; DOI: https://doi.org/10.1124/dmd.114.059220
N
Nagao, Shunsuke
- You have accessA Useful Model Capable of Predicting the Clearance of Cytochrome P450 3A4 (CYP3A4) Substrates in Humans: Validity of CYP3A4 Transgenic Mice Lacking Their Own Cyp3a EnzymesTetsuya Mitsui, Takayuki Nemoto, Taiji Miyake, Shunsuke Nagao, Kotaro Ogawa, Motohiro Kato, Masaki Ishigai and Hideyuki YamadaDrug Metabolism and Disposition September 2014, 42 (9) 1540-1547; DOI: https://doi.org/10.1124/dmd.114.057935
Nagar, Swati
- You have accessA Numerical Method for Analysis of In Vitro Time-Dependent Inhibition Data. Part 1. Theoretical ConsiderationsSwati Nagar, Jeffrey P. Jones and Ken KorzekwaDrug Metabolism and Disposition September 2014, 42 (9) 1575-1586; DOI: https://doi.org/10.1124/dmd.114.058289
- You have accessA Numerical Method for Analysis of In Vitro Time-Dependent Inhibition Data. Part 2. Application to Experimental DataKen Korzekwa, Donald Tweedie, Upendra A. Argikar, Andrea Whitcher-Johnstone, Leslie Bell, Shari Bickford and Swati NagarDrug Metabolism and Disposition September 2014, 42 (9) 1587-1595; DOI: https://doi.org/10.1124/dmd.114.058297
Nakai, Yasuhiro
- You have accessA Strategy for Assessing Potential Drug-Drug Interactions of a Concomitant Agent against a Drug Absorbed via an Intestinal Transporter in HumansAkiko Mizuno-Yasuhira, Yasuhiro Nakai, Emi Gunji, Saeko Uchida, Teisuke Takahashi, Kohnosuke Kinoshita, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa and Jun-ichi YamaguchiDrug Metabolism and Disposition September 2014, 42 (9) 1456-1465; DOI: https://doi.org/10.1124/dmd.114.058305
Nemoto, Takayuki
- You have accessA Useful Model Capable of Predicting the Clearance of Cytochrome P450 3A4 (CYP3A4) Substrates in Humans: Validity of CYP3A4 Transgenic Mice Lacking Their Own Cyp3a EnzymesTetsuya Mitsui, Takayuki Nemoto, Taiji Miyake, Shunsuke Nagao, Kotaro Ogawa, Motohiro Kato, Masaki Ishigai and Hideyuki YamadaDrug Metabolism and Disposition September 2014, 42 (9) 1540-1547; DOI: https://doi.org/10.1124/dmd.114.057935
Nishimura, Kenta
- You have accessIdentification and Functional Characterization of Novel Nonsynonymous Variants in the Human Multidrug and Toxin Extrusion 2-KKenta Nishimura, Ryosuke Ide, Takeshi Hirota, Kana Kawazu, Sho Kodama, Hiroaki Takesue and Ichiro IeiriDrug Metabolism and Disposition September 2014, 42 (9) 1432-1437; DOI: https://doi.org/10.1124/dmd.114.056887
Nishimuta, Haruka
- You have accessHepatic, Intestinal, Renal, and Plasma Hydrolysis of Prodrugs in Human, Cynomolgus Monkey, Dog, and Rat: Implications for In Vitro–In Vivo Extrapolation of Clearance of ProdrugsHaruka Nishimuta, J. Brian Houston and Aleksandra GaletinDrug Metabolism and Disposition September 2014, 42 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.114.057372
Novalen, Maria
- You have accessNicotine Pharmacokinetics in Rats Is Altered as a Function of Age, Impacting the Interpretation of Animal Model DataEvelyn L. Craig, Bin Zhao, Jason Z. Cui, Maria Novalen, Sharon Miksys and Rachel F. TyndaleDrug Metabolism and Disposition September 2014, 42 (9) 1447-1455; DOI: https://doi.org/10.1124/dmd.114.058719
O
Ogawa, Kotaro
- You have accessA Useful Model Capable of Predicting the Clearance of Cytochrome P450 3A4 (CYP3A4) Substrates in Humans: Validity of CYP3A4 Transgenic Mice Lacking Their Own Cyp3a EnzymesTetsuya Mitsui, Takayuki Nemoto, Taiji Miyake, Shunsuke Nagao, Kotaro Ogawa, Motohiro Kato, Masaki Ishigai and Hideyuki YamadaDrug Metabolism and Disposition September 2014, 42 (9) 1540-1547; DOI: https://doi.org/10.1124/dmd.114.057935
P
Park, Bo-Yeon
- You have accessRegioselective Hydroxylation of Omeprazole Enantiomers by Bacterial CYP102A1 MutantsSang Hoon Ryu, Bo-Yeon Park, So-Young Kim, Sun-Ha Park, Hyun-Jin Jung, Min Park, Ki Deok Park, Taeho Ahn, Hyung-Sik Kang and Chul-Ho YunDrug Metabolism and Disposition September 2014, 42 (9) 1493-1497; DOI: https://doi.org/10.1124/dmd.114.058636
Park, Ki Deok
- You have accessRegioselective Hydroxylation of Omeprazole Enantiomers by Bacterial CYP102A1 MutantsSang Hoon Ryu, Bo-Yeon Park, So-Young Kim, Sun-Ha Park, Hyun-Jin Jung, Min Park, Ki Deok Park, Taeho Ahn, Hyung-Sik Kang and Chul-Ho YunDrug Metabolism and Disposition September 2014, 42 (9) 1493-1497; DOI: https://doi.org/10.1124/dmd.114.058636
Park, Min
- You have accessRegioselective Hydroxylation of Omeprazole Enantiomers by Bacterial CYP102A1 MutantsSang Hoon Ryu, Bo-Yeon Park, So-Young Kim, Sun-Ha Park, Hyun-Jin Jung, Min Park, Ki Deok Park, Taeho Ahn, Hyung-Sik Kang and Chul-Ho YunDrug Metabolism and Disposition September 2014, 42 (9) 1493-1497; DOI: https://doi.org/10.1124/dmd.114.058636
Park, Sun-Ha
- You have accessRegioselective Hydroxylation of Omeprazole Enantiomers by Bacterial CYP102A1 MutantsSang Hoon Ryu, Bo-Yeon Park, So-Young Kim, Sun-Ha Park, Hyun-Jin Jung, Min Park, Ki Deok Park, Taeho Ahn, Hyung-Sik Kang and Chul-Ho YunDrug Metabolism and Disposition September 2014, 42 (9) 1493-1497; DOI: https://doi.org/10.1124/dmd.114.058636
Ploeger, Bart A.
- You have accessTranslational Pharmacokinetic Modeling of Fingolimod (FTY720) as a Paradigm Compound Subject to Sphingosine Kinase-Mediated PhosphorylationNelleke Snelder, Bart A. Ploeger, Olivier Luttringer, Donald. R. Stanski and Meindert DanhofDrug Metabolism and Disposition September 2014, 42 (9) 1367-1378; DOI: https://doi.org/10.1124/dmd.113.056770
Poirier, Agnès
- You have accessCalibration of In Vitro Multidrug Resistance Protein 1 Substrate and Inhibition Assays as a Basis to Support the Prediction of Clinically Relevant Interactions In VivoAgnès Poirier, Anne-Christine Cascais, Urs Bader, Renée Portmann, Marie-Elise Brun, Isabelle Walter, Alexander Hillebrecht, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1411-1422; DOI: https://doi.org/10.1124/dmd.114.057943
- You have accessThe Need for Human Breast Cancer Resistance Protein Substrate and Inhibition Evaluation in Drug Discovery and Development: Why, When, and How?Agnès Poirier, Renée Portmann, Anne-Christine Cascais, Urs Bader, Isabelle Walter, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1466-1477; DOI: https://doi.org/10.1124/dmd.114.058248
Poller, Birk
- You have accessPrediction of Organic Anion-Transporting Polypeptide 1B1- and 1B3-Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity DataAnnett Kunze, Jörg Huwyler, Gian Camenisch and Birk PollerDrug Metabolism and Disposition September 2014, 42 (9) 1514-1521; DOI: https://doi.org/10.1124/dmd.114.058412
Portmann, Renée
- You have accessCalibration of In Vitro Multidrug Resistance Protein 1 Substrate and Inhibition Assays as a Basis to Support the Prediction of Clinically Relevant Interactions In VivoAgnès Poirier, Anne-Christine Cascais, Urs Bader, Renée Portmann, Marie-Elise Brun, Isabelle Walter, Alexander Hillebrecht, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1411-1422; DOI: https://doi.org/10.1124/dmd.114.057943
- You have accessThe Need for Human Breast Cancer Resistance Protein Substrate and Inhibition Evaluation in Drug Discovery and Development: Why, When, and How?Agnès Poirier, Renée Portmann, Anne-Christine Cascais, Urs Bader, Isabelle Walter, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1466-1477; DOI: https://doi.org/10.1124/dmd.114.058248
R
Radominska-Pandya, Anna
- You have accessA Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its DerivativesAleksandra K. Greer, Centdrika R. Dates, Athena Starlard-Davenport, Vineetha K. Edavana, Stacie M. Bratton, Ishwori B. Dhakal, Moshe Finel, Susan A. Kadlubar and Anna Radominska-PandyaDrug Metabolism and Disposition September 2014, 42 (9) 1392-1400; DOI: https://doi.org/10.1124/dmd.114.058016
Riva, Simona
- You have accessTime- and NADPH-Dependent Inhibition of Cytochrome P450 3A4 by the Cyclopentapeptide Cilengitide: Significance of the Guanidine Group and Accompanying Spectral ChangesMirza Bojić, Luca Barbero, Hugues Dolgos, Achim Freisleben, Dieter Gallemann, Simona Riva and F. Peter GuengerichDrug Metabolism and Disposition September 2014, 42 (9) 1438-1446; DOI: https://doi.org/10.1124/dmd.114.059295
Rostami-Hodjegan, Amin
- You have accessDeciding on Success Criteria for Predictability of Pharmacokinetic Parameters from In Vitro Studies: An Analysis Based on In Vivo ObservationsKhaled Abduljalil, Theresa Cain, Helen Humphries and Amin Rostami-HodjeganDrug Metabolism and Disposition September 2014, 42 (9) 1478-1484; DOI: https://doi.org/10.1124/dmd.114.058099
Ryu, Sang Hoon
- You have accessRegioselective Hydroxylation of Omeprazole Enantiomers by Bacterial CYP102A1 MutantsSang Hoon Ryu, Bo-Yeon Park, So-Young Kim, Sun-Ha Park, Hyun-Jin Jung, Min Park, Ki Deok Park, Taeho Ahn, Hyung-Sik Kang and Chul-Ho YunDrug Metabolism and Disposition September 2014, 42 (9) 1493-1497; DOI: https://doi.org/10.1124/dmd.114.058636
S
Sabirsh, Alan
- You have accessLong-Term Chronic Toxicity Testing Using Human Pluripotent Stem Cell–Derived HepatocytesGustav Holmgren, Anna-Karin Sjögren, Isabel Barragan, Alan Sabirsh, Peter Sartipy, Jane Synnergren, Petter Björquist, Magnus Ingelman-Sundberg, Tommy B. Andersson and Josefina EdsbaggeDrug Metabolism and Disposition September 2014, 42 (9) 1401-1406; DOI: https://doi.org/10.1124/dmd.114.059154
Sakai, Soichi
- You have accessA Strategy for Assessing Potential Drug-Drug Interactions of a Concomitant Agent against a Drug Absorbed via an Intestinal Transporter in HumansAkiko Mizuno-Yasuhira, Yasuhiro Nakai, Emi Gunji, Saeko Uchida, Teisuke Takahashi, Kohnosuke Kinoshita, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa and Jun-ichi YamaguchiDrug Metabolism and Disposition September 2014, 42 (9) 1456-1465; DOI: https://doi.org/10.1124/dmd.114.058305
Samukawa, Yoshishige
- You have accessA Strategy for Assessing Potential Drug-Drug Interactions of a Concomitant Agent against a Drug Absorbed via an Intestinal Transporter in HumansAkiko Mizuno-Yasuhira, Yasuhiro Nakai, Emi Gunji, Saeko Uchida, Teisuke Takahashi, Kohnosuke Kinoshita, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa and Jun-ichi YamaguchiDrug Metabolism and Disposition September 2014, 42 (9) 1456-1465; DOI: https://doi.org/10.1124/dmd.114.058305
Santone, Elizabeth A.
- You have accessEvaluation of Calibration Curve–Based Approaches to Predict Clinical Inducers and Noninducers of CYP3A4 with Plated Human HepatocytesJ. George Zhang, Thuy Ho, Alanna L. Callendrello, Robert J. Clark, Elizabeth A. Santone, Sarah Kinsman, Deqing Xiao, Lisa G. Fox, Heidi J. Einolf and David M. StresserDrug Metabolism and Disposition September 2014, 42 (9) 1379-1391; DOI: https://doi.org/10.1124/dmd.114.058602
Sartipy, Peter
- You have accessLong-Term Chronic Toxicity Testing Using Human Pluripotent Stem Cell–Derived HepatocytesGustav Holmgren, Anna-Karin Sjögren, Isabel Barragan, Alan Sabirsh, Peter Sartipy, Jane Synnergren, Petter Björquist, Magnus Ingelman-Sundberg, Tommy B. Andersson and Josefina EdsbaggeDrug Metabolism and Disposition September 2014, 42 (9) 1401-1406; DOI: https://doi.org/10.1124/dmd.114.059154
Savary, Camille C.
- You have accessImpact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG CellsPamela Bachour-El Azzi, Ahmad Sharanek, Ziad Abdel-Razzak, Sebastien Antherieu, Houssein Al-Attrache, Camille C. Savary, Sylvie Lepage, Isabelle Morel, Gilles Labbe, Christiane Guguen-Guillouzo and André GuillouzoDrug Metabolism and Disposition September 2014, 42 (9) 1556-1566; DOI: https://doi.org/10.1124/dmd.114.058123
Sharanek, Ahmad
- You have accessImpact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG CellsPamela Bachour-El Azzi, Ahmad Sharanek, Ziad Abdel-Razzak, Sebastien Antherieu, Houssein Al-Attrache, Camille C. Savary, Sylvie Lepage, Isabelle Morel, Gilles Labbe, Christiane Guguen-Guillouzo and André GuillouzoDrug Metabolism and Disposition September 2014, 42 (9) 1556-1566; DOI: https://doi.org/10.1124/dmd.114.058123
Sjögren, Anna-Karin
- You have accessLong-Term Chronic Toxicity Testing Using Human Pluripotent Stem Cell–Derived HepatocytesGustav Holmgren, Anna-Karin Sjögren, Isabel Barragan, Alan Sabirsh, Peter Sartipy, Jane Synnergren, Petter Björquist, Magnus Ingelman-Sundberg, Tommy B. Andersson and Josefina EdsbaggeDrug Metabolism and Disposition September 2014, 42 (9) 1401-1406; DOI: https://doi.org/10.1124/dmd.114.059154
Snelder, Nelleke
- You have accessTranslational Pharmacokinetic Modeling of Fingolimod (FTY720) as a Paradigm Compound Subject to Sphingosine Kinase-Mediated PhosphorylationNelleke Snelder, Bart A. Ploeger, Olivier Luttringer, Donald. R. Stanski and Meindert DanhofDrug Metabolism and Disposition September 2014, 42 (9) 1367-1378; DOI: https://doi.org/10.1124/dmd.113.056770
Stanski, Donald. R.
- You have accessTranslational Pharmacokinetic Modeling of Fingolimod (FTY720) as a Paradigm Compound Subject to Sphingosine Kinase-Mediated PhosphorylationNelleke Snelder, Bart A. Ploeger, Olivier Luttringer, Donald. R. Stanski and Meindert DanhofDrug Metabolism and Disposition September 2014, 42 (9) 1367-1378; DOI: https://doi.org/10.1124/dmd.113.056770
Starlard-Davenport, Athena
- You have accessA Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its DerivativesAleksandra K. Greer, Centdrika R. Dates, Athena Starlard-Davenport, Vineetha K. Edavana, Stacie M. Bratton, Ishwori B. Dhakal, Moshe Finel, Susan A. Kadlubar and Anna Radominska-PandyaDrug Metabolism and Disposition September 2014, 42 (9) 1392-1400; DOI: https://doi.org/10.1124/dmd.114.058016
Stresser, David M.
- You have accessEvaluation of Calibration Curve–Based Approaches to Predict Clinical Inducers and Noninducers of CYP3A4 with Plated Human HepatocytesJ. George Zhang, Thuy Ho, Alanna L. Callendrello, Robert J. Clark, Elizabeth A. Santone, Sarah Kinsman, Deqing Xiao, Lisa G. Fox, Heidi J. Einolf and David M. StresserDrug Metabolism and Disposition September 2014, 42 (9) 1379-1391; DOI: https://doi.org/10.1124/dmd.114.058602
Synnergren, Jane
- You have accessLong-Term Chronic Toxicity Testing Using Human Pluripotent Stem Cell–Derived HepatocytesGustav Holmgren, Anna-Karin Sjögren, Isabel Barragan, Alan Sabirsh, Peter Sartipy, Jane Synnergren, Petter Björquist, Magnus Ingelman-Sundberg, Tommy B. Andersson and Josefina EdsbaggeDrug Metabolism and Disposition September 2014, 42 (9) 1401-1406; DOI: https://doi.org/10.1124/dmd.114.059154
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Takahashi, Teisuke
- You have accessA Strategy for Assessing Potential Drug-Drug Interactions of a Concomitant Agent against a Drug Absorbed via an Intestinal Transporter in HumansAkiko Mizuno-Yasuhira, Yasuhiro Nakai, Emi Gunji, Saeko Uchida, Teisuke Takahashi, Kohnosuke Kinoshita, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa and Jun-ichi YamaguchiDrug Metabolism and Disposition September 2014, 42 (9) 1456-1465; DOI: https://doi.org/10.1124/dmd.114.058305
Takesue, Hiroaki
- You have accessIdentification and Functional Characterization of Novel Nonsynonymous Variants in the Human Multidrug and Toxin Extrusion 2-KKenta Nishimura, Ryosuke Ide, Takeshi Hirota, Kana Kawazu, Sho Kodama, Hiroaki Takesue and Ichiro IeiriDrug Metabolism and Disposition September 2014, 42 (9) 1432-1437; DOI: https://doi.org/10.1124/dmd.114.056887
Tan, Huasen
- You have accessDynamic and Coordinated Regulation of KEAP1-NRF2-ARE and p53/p21 Signaling Pathways Is Associated with Acetaminophen Injury Responsive Liver RegenerationXiaomei Fan, Pan Chen, Huasen Tan, Hang Zeng, Yiming Jiang, Ying Wang, Yongtao Wang, Xiangyu Hou, Huichang Bi and Min HuangDrug Metabolism and Disposition September 2014, 42 (9) 1532-1539; DOI: https://doi.org/10.1124/dmd.114.059394
Trauner, Michael
- You have accessInflammatory Bowel Disease Alters Intestinal Bile Acid Transporter ExpressionJörg Jahnel, Peter Fickert, Almuthe C. Hauer, Christoph Högenauer, Alexander Avian and Michael TraunerDrug Metabolism and Disposition September 2014, 42 (9) 1423-1431; DOI: https://doi.org/10.1124/dmd.114.058065
Tweedie, Donald
- You have accessA Numerical Method for Analysis of In Vitro Time-Dependent Inhibition Data. Part 2. Application to Experimental DataKen Korzekwa, Donald Tweedie, Upendra A. Argikar, Andrea Whitcher-Johnstone, Leslie Bell, Shari Bickford and Swati NagarDrug Metabolism and Disposition September 2014, 42 (9) 1587-1595; DOI: https://doi.org/10.1124/dmd.114.058297
Tyndale, Rachel F.
- You have accessNicotine Pharmacokinetics in Rats Is Altered as a Function of Age, Impacting the Interpretation of Animal Model DataEvelyn L. Craig, Bin Zhao, Jason Z. Cui, Maria Novalen, Sharon Miksys and Rachel F. TyndaleDrug Metabolism and Disposition September 2014, 42 (9) 1447-1455; DOI: https://doi.org/10.1124/dmd.114.058719
U
Uchida, Saeko
- You have accessA Strategy for Assessing Potential Drug-Drug Interactions of a Concomitant Agent against a Drug Absorbed via an Intestinal Transporter in HumansAkiko Mizuno-Yasuhira, Yasuhiro Nakai, Emi Gunji, Saeko Uchida, Teisuke Takahashi, Kohnosuke Kinoshita, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa and Jun-ichi YamaguchiDrug Metabolism and Disposition September 2014, 42 (9) 1456-1465; DOI: https://doi.org/10.1124/dmd.114.058305
Uehara, Shotaro
- You have accessPolymorphisms of CYP2D17 in Cynomolgus and Rhesus Macaques: an Evidence of the Genetic Basis for the Variability of CYP2D-Dependent Drug MetabolismYasuhiro Uno, Shotaro Uehara, Sakae Kohara, Norie Murayama and Hiroshi YamazakiDrug Metabolism and Disposition September 2014, 42 (9) 1407-1410; DOI: https://doi.org/10.1124/dmd.114.059220
Ullah, Mohammed
- You have accessCalibration of In Vitro Multidrug Resistance Protein 1 Substrate and Inhibition Assays as a Basis to Support the Prediction of Clinically Relevant Interactions In VivoAgnès Poirier, Anne-Christine Cascais, Urs Bader, Renée Portmann, Marie-Elise Brun, Isabelle Walter, Alexander Hillebrecht, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1411-1422; DOI: https://doi.org/10.1124/dmd.114.057943
- You have accessThe Need for Human Breast Cancer Resistance Protein Substrate and Inhibition Evaluation in Drug Discovery and Development: Why, When, and How?Agnès Poirier, Renée Portmann, Anne-Christine Cascais, Urs Bader, Isabelle Walter, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1466-1477; DOI: https://doi.org/10.1124/dmd.114.058248
Uno, Yasuhiro
- You have accessPolymorphisms of CYP2D17 in Cynomolgus and Rhesus Macaques: an Evidence of the Genetic Basis for the Variability of CYP2D-Dependent Drug MetabolismYasuhiro Uno, Shotaro Uehara, Sakae Kohara, Norie Murayama and Hiroshi YamazakiDrug Metabolism and Disposition September 2014, 42 (9) 1407-1410; DOI: https://doi.org/10.1124/dmd.114.059220
V
Van Le, Thi Kim
- You have accessGut Microbiota-Mediated Drug Interactions between Lovastatin and AntibioticsDae-Hyoung Yoo, In Sook Kim, Thi Kim Van Le, Il-Hoon Jung, Hye Hyun Yoo and Dong-Hyun KimDrug Metabolism and Disposition September 2014, 42 (9) 1508-1513; DOI: https://doi.org/10.1124/dmd.114.058354
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Walter, Isabelle
- You have accessCalibration of In Vitro Multidrug Resistance Protein 1 Substrate and Inhibition Assays as a Basis to Support the Prediction of Clinically Relevant Interactions In VivoAgnès Poirier, Anne-Christine Cascais, Urs Bader, Renée Portmann, Marie-Elise Brun, Isabelle Walter, Alexander Hillebrecht, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1411-1422; DOI: https://doi.org/10.1124/dmd.114.057943
- You have accessThe Need for Human Breast Cancer Resistance Protein Substrate and Inhibition Evaluation in Drug Discovery and Development: Why, When, and How?Agnès Poirier, Renée Portmann, Anne-Christine Cascais, Urs Bader, Isabelle Walter, Mohammed Ullah and Christoph FunkDrug Metabolism and Disposition September 2014, 42 (9) 1466-1477; DOI: https://doi.org/10.1124/dmd.114.058248
Wang, Xiaodong
- You have accessFlavonoids Are Inhibitors of Human Organic Anion Transporter 1 (OAT1)–Mediated TransportGuohua An, Xiaodong Wang and Marilyn E. MorrisDrug Metabolism and Disposition September 2014, 42 (9) 1357-1366; DOI: https://doi.org/10.1124/dmd.114.059337
Wang, Ying
- You have accessDynamic and Coordinated Regulation of KEAP1-NRF2-ARE and p53/p21 Signaling Pathways Is Associated with Acetaminophen Injury Responsive Liver RegenerationXiaomei Fan, Pan Chen, Huasen Tan, Hang Zeng, Yiming Jiang, Ying Wang, Yongtao Wang, Xiangyu Hou, Huichang Bi and Min HuangDrug Metabolism and Disposition September 2014, 42 (9) 1532-1539; DOI: https://doi.org/10.1124/dmd.114.059394
Wang, Yongtao
- You have accessDynamic and Coordinated Regulation of KEAP1-NRF2-ARE and p53/p21 Signaling Pathways Is Associated with Acetaminophen Injury Responsive Liver RegenerationXiaomei Fan, Pan Chen, Huasen Tan, Hang Zeng, Yiming Jiang, Ying Wang, Yongtao Wang, Xiangyu Hou, Huichang Bi and Min HuangDrug Metabolism and Disposition September 2014, 42 (9) 1532-1539; DOI: https://doi.org/10.1124/dmd.114.059394
Whitcher-Johnstone, Andrea
- You have accessA Numerical Method for Analysis of In Vitro Time-Dependent Inhibition Data. Part 2. Application to Experimental DataKen Korzekwa, Donald Tweedie, Upendra A. Argikar, Andrea Whitcher-Johnstone, Leslie Bell, Shari Bickford and Swati NagarDrug Metabolism and Disposition September 2014, 42 (9) 1587-1595; DOI: https://doi.org/10.1124/dmd.114.058297
X
Xiao, Deqing
- You have accessEvaluation of Calibration Curve–Based Approaches to Predict Clinical Inducers and Noninducers of CYP3A4 with Plated Human HepatocytesJ. George Zhang, Thuy Ho, Alanna L. Callendrello, Robert J. Clark, Elizabeth A. Santone, Sarah Kinsman, Deqing Xiao, Lisa G. Fox, Heidi J. Einolf and David M. StresserDrug Metabolism and Disposition September 2014, 42 (9) 1379-1391; DOI: https://doi.org/10.1124/dmd.114.058602
Y
Yamada, Hideyuki
- You have accessEffect of CYP2A6 Genetic Polymorphism on the Metabolic Conversion of Tegafur to 5-Fluorouracil and Its EnantioselectivityIkuo Yamamiya, Kunihiro Yoshisue, Yuji Ishii, Hideyuki Yamada and Masato ChibaDrug Metabolism and Disposition September 2014, 42 (9) 1485-1492; DOI: https://doi.org/10.1124/dmd.114.058008
- You have accessA Useful Model Capable of Predicting the Clearance of Cytochrome P450 3A4 (CYP3A4) Substrates in Humans: Validity of CYP3A4 Transgenic Mice Lacking Their Own Cyp3a EnzymesTetsuya Mitsui, Takayuki Nemoto, Taiji Miyake, Shunsuke Nagao, Kotaro Ogawa, Motohiro Kato, Masaki Ishigai and Hideyuki YamadaDrug Metabolism and Disposition September 2014, 42 (9) 1540-1547; DOI: https://doi.org/10.1124/dmd.114.057935
Yamaguchi, Jun-ichi
- You have accessA Strategy for Assessing Potential Drug-Drug Interactions of a Concomitant Agent against a Drug Absorbed via an Intestinal Transporter in HumansAkiko Mizuno-Yasuhira, Yasuhiro Nakai, Emi Gunji, Saeko Uchida, Teisuke Takahashi, Kohnosuke Kinoshita, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa and Jun-ichi YamaguchiDrug Metabolism and Disposition September 2014, 42 (9) 1456-1465; DOI: https://doi.org/10.1124/dmd.114.058305
Yamamiya, Ikuo
- You have accessEffect of CYP2A6 Genetic Polymorphism on the Metabolic Conversion of Tegafur to 5-Fluorouracil and Its EnantioselectivityIkuo Yamamiya, Kunihiro Yoshisue, Yuji Ishii, Hideyuki Yamada and Masato ChibaDrug Metabolism and Disposition September 2014, 42 (9) 1485-1492; DOI: https://doi.org/10.1124/dmd.114.058008
Yamazaki, Hiroshi
- You have accessPolymorphisms of CYP2D17 in Cynomolgus and Rhesus Macaques: an Evidence of the Genetic Basis for the Variability of CYP2D-Dependent Drug MetabolismYasuhiro Uno, Shotaro Uehara, Sakae Kohara, Norie Murayama and Hiroshi YamazakiDrug Metabolism and Disposition September 2014, 42 (9) 1407-1410; DOI: https://doi.org/10.1124/dmd.114.059220
Yoo, Dae-Hyoung
- You have accessGut Microbiota-Mediated Drug Interactions between Lovastatin and AntibioticsDae-Hyoung Yoo, In Sook Kim, Thi Kim Van Le, Il-Hoon Jung, Hye Hyun Yoo and Dong-Hyun KimDrug Metabolism and Disposition September 2014, 42 (9) 1508-1513; DOI: https://doi.org/10.1124/dmd.114.058354
Yoo, Hye Hyun
- You have accessGut Microbiota-Mediated Drug Interactions between Lovastatin and AntibioticsDae-Hyoung Yoo, In Sook Kim, Thi Kim Van Le, Il-Hoon Jung, Hye Hyun Yoo and Dong-Hyun KimDrug Metabolism and Disposition September 2014, 42 (9) 1508-1513; DOI: https://doi.org/10.1124/dmd.114.058354
Yoshisue, Kunihiro
- You have accessEffect of CYP2A6 Genetic Polymorphism on the Metabolic Conversion of Tegafur to 5-Fluorouracil and Its EnantioselectivityIkuo Yamamiya, Kunihiro Yoshisue, Yuji Ishii, Hideyuki Yamada and Masato ChibaDrug Metabolism and Disposition September 2014, 42 (9) 1485-1492; DOI: https://doi.org/10.1124/dmd.114.058008
Yun, Chul-Ho
- You have accessRegioselective Hydroxylation of Omeprazole Enantiomers by Bacterial CYP102A1 MutantsSang Hoon Ryu, Bo-Yeon Park, So-Young Kim, Sun-Ha Park, Hyun-Jin Jung, Min Park, Ki Deok Park, Taeho Ahn, Hyung-Sik Kang and Chul-Ho YunDrug Metabolism and Disposition September 2014, 42 (9) 1493-1497; DOI: https://doi.org/10.1124/dmd.114.058636
Z
Zeng, Hang
- You have accessDynamic and Coordinated Regulation of KEAP1-NRF2-ARE and p53/p21 Signaling Pathways Is Associated with Acetaminophen Injury Responsive Liver RegenerationXiaomei Fan, Pan Chen, Huasen Tan, Hang Zeng, Yiming Jiang, Ying Wang, Yongtao Wang, Xiangyu Hou, Huichang Bi and Min HuangDrug Metabolism and Disposition September 2014, 42 (9) 1532-1539; DOI: https://doi.org/10.1124/dmd.114.059394
Zhang, J. George
- You have accessEvaluation of Calibration Curve–Based Approaches to Predict Clinical Inducers and Noninducers of CYP3A4 with Plated Human HepatocytesJ. George Zhang, Thuy Ho, Alanna L. Callendrello, Robert J. Clark, Elizabeth A. Santone, Sarah Kinsman, Deqing Xiao, Lisa G. Fox, Heidi J. Einolf and David M. StresserDrug Metabolism and Disposition September 2014, 42 (9) 1379-1391; DOI: https://doi.org/10.1124/dmd.114.058602
Zhao, Bin
- You have accessNicotine Pharmacokinetics in Rats Is Altered as a Function of Age, Impacting the Interpretation of Animal Model DataEvelyn L. Craig, Bin Zhao, Jason Z. Cui, Maria Novalen, Sharon Miksys and Rachel F. TyndaleDrug Metabolism and Disposition September 2014, 42 (9) 1447-1455; DOI: https://doi.org/10.1124/dmd.114.058719
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