Research ArticleArticle
Time- and NADPH-Dependent Inhibition of Cytochrome P450 3A4 by the Cyclopentapeptide Cilengitide: Significance of the Guanidine Group and Accompanying Spectral Changes
Mirza Bojić, Luca Barbero, Hugues Dolgos, Achim Freisleben, Dieter Gallemann, Simona Riva and F. Peter Guengerich
Drug Metabolism and Disposition September 2014, 42 (9) 1438-1446; DOI: https://doi.org/10.1124/dmd.114.059295
Mirza Bojić
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (M.B., F.P.G.); Merck-Serono, RBM S.p.A. Istituto di Ricerche Biomediche A. Marxer, Colleretto Giacosa, Torino, Italy (L.B., S.R.); Merck-Serono, Global Early Development, Darmstadt, Germany (H.D.); and Merck-Serono, Global Early Development, Darmstadt/Global DMPK, Grafing, Germany (A.F., D.G.)
Luca Barbero
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (M.B., F.P.G.); Merck-Serono, RBM S.p.A. Istituto di Ricerche Biomediche A. Marxer, Colleretto Giacosa, Torino, Italy (L.B., S.R.); Merck-Serono, Global Early Development, Darmstadt, Germany (H.D.); and Merck-Serono, Global Early Development, Darmstadt/Global DMPK, Grafing, Germany (A.F., D.G.)
Hugues Dolgos
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (M.B., F.P.G.); Merck-Serono, RBM S.p.A. Istituto di Ricerche Biomediche A. Marxer, Colleretto Giacosa, Torino, Italy (L.B., S.R.); Merck-Serono, Global Early Development, Darmstadt, Germany (H.D.); and Merck-Serono, Global Early Development, Darmstadt/Global DMPK, Grafing, Germany (A.F., D.G.)
Achim Freisleben
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (M.B., F.P.G.); Merck-Serono, RBM S.p.A. Istituto di Ricerche Biomediche A. Marxer, Colleretto Giacosa, Torino, Italy (L.B., S.R.); Merck-Serono, Global Early Development, Darmstadt, Germany (H.D.); and Merck-Serono, Global Early Development, Darmstadt/Global DMPK, Grafing, Germany (A.F., D.G.)
Dieter Gallemann
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (M.B., F.P.G.); Merck-Serono, RBM S.p.A. Istituto di Ricerche Biomediche A. Marxer, Colleretto Giacosa, Torino, Italy (L.B., S.R.); Merck-Serono, Global Early Development, Darmstadt, Germany (H.D.); and Merck-Serono, Global Early Development, Darmstadt/Global DMPK, Grafing, Germany (A.F., D.G.)
Simona Riva
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (M.B., F.P.G.); Merck-Serono, RBM S.p.A. Istituto di Ricerche Biomediche A. Marxer, Colleretto Giacosa, Torino, Italy (L.B., S.R.); Merck-Serono, Global Early Development, Darmstadt, Germany (H.D.); and Merck-Serono, Global Early Development, Darmstadt/Global DMPK, Grafing, Germany (A.F., D.G.)
F. Peter Guengerich
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (M.B., F.P.G.); Merck-Serono, RBM S.p.A. Istituto di Ricerche Biomediche A. Marxer, Colleretto Giacosa, Torino, Italy (L.B., S.R.); Merck-Serono, Global Early Development, Darmstadt, Germany (H.D.); and Merck-Serono, Global Early Development, Darmstadt/Global DMPK, Grafing, Germany (A.F., D.G.)
Submit a Response to This Article
Jump to comment:
No eLetters have been published for this article.
In this issue
Research ArticleArticle
Cilengitide Inhibition of P450 3A4
Mirza Bojić, Luca Barbero, Hugues Dolgos, Achim Freisleben, Dieter Gallemann, Simona Riva and F. Peter Guengerich
Drug Metabolism and Disposition September 1, 2014, 42 (9) 1438-1446; DOI: https://doi.org/10.1124/dmd.114.059295
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement