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Research ArticleArticle

The Need for Human Breast Cancer Resistance Protein Substrate and Inhibition Evaluation in Drug Discovery and Development: Why, When, and How?

Agnès Poirier, Renée Portmann, Anne-Christine Cascais, Urs Bader, Isabelle Walter, Mohammed Ullah and Christoph Funk
Drug Metabolism and Disposition September 2014, 42 (9) 1466-1477; DOI: https://doi.org/10.1124/dmd.114.058248
Agnès Poirier
Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland
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Renée Portmann
Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland
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Anne-Christine Cascais
Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland
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Urs Bader
Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland
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Isabelle Walter
Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland
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Mohammed Ullah
Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland
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Christoph Funk
Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland
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Article Information

vol. 42 no. 9 1466-1477
DOI 
https://doi.org/10.1124/dmd.114.058248
PubMed 
24989889

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 19, 2014
  • Accepted July 2, 2014
  • Published online August 6, 2014.

Article Versions

  • Earlier version (July 2, 2014 - 08:07).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Agnès Poirier,
  2. Renée Portmann,
  3. Anne-Christine Cascais,
  4. Urs Bader,
  5. Isabelle Walter,
  6. Mohammed Ullah, and
  7. Christoph Funk
  1. Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland
  1. Address correspondence to:
    Christoph Funk, F. Hoffmann-La Roche Ltd., B69/R154, Grenzacherstrasse 124, CH-4070 Basel, Switzerland. E-mail: christoph.funk{at}roche.com
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Drug Metabolism and Disposition: 42 (9)
Drug Metabolism and Disposition
Vol. 42, Issue 9
1 Sep 2014
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Research ArticleArticle

BCRP In Vitro Assays

Agnès Poirier, Renée Portmann, Anne-Christine Cascais, Urs Bader, Isabelle Walter, Mohammed Ullah and Christoph Funk
Drug Metabolism and Disposition September 1, 2014, 42 (9) 1466-1477; DOI: https://doi.org/10.1124/dmd.114.058248

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Research ArticleArticle

BCRP In Vitro Assays

Agnès Poirier, Renée Portmann, Anne-Christine Cascais, Urs Bader, Isabelle Walter, Mohammed Ullah and Christoph Funk
Drug Metabolism and Disposition September 1, 2014, 42 (9) 1466-1477; DOI: https://doi.org/10.1124/dmd.114.058248
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