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Research ArticleArticle

Prediction of Organic Anion-Transporting Polypeptide 1B1- and 1B3-Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity Data

Annett Kunze, Jörg Huwyler, Gian Camenisch and Birk Poller
Drug Metabolism and Disposition September 2014, 42 (9) 1514-1521; DOI: https://doi.org/10.1124/dmd.114.058412
Annett Kunze
Division of Drug Metabolism and Pharmacokinetics, Drug-Drug Interactions Section, Novartis Institutes for BioMedical Research, Basel, Switzerland (A.K., G.C., B.P.); and Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel, Switzerland (A.K., J.H.)
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Jörg Huwyler
Division of Drug Metabolism and Pharmacokinetics, Drug-Drug Interactions Section, Novartis Institutes for BioMedical Research, Basel, Switzerland (A.K., G.C., B.P.); and Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel, Switzerland (A.K., J.H.)
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Gian Camenisch
Division of Drug Metabolism and Pharmacokinetics, Drug-Drug Interactions Section, Novartis Institutes for BioMedical Research, Basel, Switzerland (A.K., G.C., B.P.); and Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel, Switzerland (A.K., J.H.)
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Birk Poller
Division of Drug Metabolism and Pharmacokinetics, Drug-Drug Interactions Section, Novartis Institutes for BioMedical Research, Basel, Switzerland (A.K., G.C., B.P.); and Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel, Switzerland (A.K., J.H.)
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Article Information

vol. 42 no. 9 1514-1521
DOI 
https://doi.org/10.1124/dmd.114.058412
PubMed 
24989890

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 4, 2014
  • Accepted July 2, 2014
  • Published online August 6, 2014.

Article Versions

  • Earlier version (July 2, 2014 - 08:07).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Annett Kunze,
  2. Jörg Huwyler,
  3. Gian Camenisch, and
  4. Birk Poller
  1. Division of Drug Metabolism and Pharmacokinetics, Drug-Drug Interactions Section, Novartis Institutes for BioMedical Research, Basel, Switzerland (A.K., G.C., B.P.); and Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel, Switzerland (A.K., J.H.)
  1. Address correspondence to:
    Dr. Birk Poller, Novartis Pharma AG, Fabrikstrasse 14, CH-4056 Basel, Switzerland. E-mail: birk.poller{at}novartis.com
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Drug Metabolism and Disposition: 42 (9)
Drug Metabolism and Disposition
Vol. 42, Issue 9
1 Sep 2014
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Research ArticleArticle

Prediction of OATP-Mediated Hepatic Uptake of Statins

Annett Kunze, Jörg Huwyler, Gian Camenisch and Birk Poller
Drug Metabolism and Disposition September 1, 2014, 42 (9) 1514-1521; DOI: https://doi.org/10.1124/dmd.114.058412

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Research ArticleArticle

Prediction of OATP-Mediated Hepatic Uptake of Statins

Annett Kunze, Jörg Huwyler, Gian Camenisch and Birk Poller
Drug Metabolism and Disposition September 1, 2014, 42 (9) 1514-1521; DOI: https://doi.org/10.1124/dmd.114.058412
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