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Drug Metabolism & Disposition

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Table of Contents

January 01, 2015; Volume 43,Issue 1

Minireview

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    Reaction Phenotyping: Advances in the Experimental Strategies Used to Characterize the Contribution of Drug-Metabolizing Enzymes
    Michael A. Zientek and Kuresh Youdim
    Drug Metabolism and Disposition January 2015, 43 (1) 163-181; DOI: https://doi.org/10.1124/dmd.114.058750

Short Communication

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    Involvement of the H+/Organic Cation Antiporter in Nicotine Transport in Rat Liver
    Yuma Tega, Shin-ichi Akanuma, Yoshiyuki Kubo and Ken-ichi Hosoya
    Drug Metabolism and Disposition January 2015, 43 (1) 89-92; DOI: https://doi.org/10.1124/dmd.114.061002

Articles

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    Age-Dependent Activity of the Uptake Transporters Ntcp and Oatp1b2 in Male Rat Hepatocytes: From Birth Till Adulthood
    Sarinj Fattah, Patrick Augustijns and Pieter Annaert
    Drug Metabolism and Disposition January 2015, 43 (1) 1-8; DOI: https://doi.org/10.1124/dmd.114.059212
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    Modulation of (–)-Epicatechin Metabolism by Coadministration with Other Polyphenols in Caco-2 Cell Model
    Belén Sanchez-Bridge, Antoine Lévèques, Hequn Li, Emmanuelle Bertschy, Amaury Patin and Lucas Actis-Goretta
    Drug Metabolism and Disposition January 2015, 43 (1) 9-16; DOI: https://doi.org/10.1124/dmd.114.060590
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    A Nonradioactive Approach to Investigate the Metabolism of Therapeutic Peptides by Tagging with 127I and Using Inductively-Coupled Plasma Mass Spectrometry Analysis
    Heng-Keang Lim, Yuan Cao, Xi Qiu, Jose Silva and David C. Evans
    Drug Metabolism and Disposition January 2015, 43 (1) 17-26; DOI: https://doi.org/10.1124/dmd.114.059774
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    Evaluation of 89 Compounds for Identification of Substrates for Cynomolgus Monkey CYP2C76, a New Bupropion/Nifedipine Oxidase
    Shinya Hosaka, Norie Murayama, Masahiro Satsukawa, Makiko Shimizu, Shotaro Uehara, Hideki Fujino, Kazuhide Iwasaki, Shunsuke Iwano, Yasuhiro Uno and Hiroshi Yamazaki
    Drug Metabolism and Disposition January 2015, 43 (1) 27-33; DOI: https://doi.org/10.1124/dmd.114.061275
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    Inhibition of Human Aldehyde Oxidase Activity by Diet-Derived Constituents: Structural Influence, Enzyme-Ligand Interactions, and Clinical Relevance
    John T. Barr, Jeffrey P. Jones, Nicholas H. Oberlies and Mary F. Paine
    Drug Metabolism and Disposition January 2015, 43 (1) 34-41; DOI: https://doi.org/10.1124/dmd.114.061192
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    Anti-CD28 Monoclonal Antibody–Stimulated Cytokines Released from Blood Suppress CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes In VitroGraphic
    Maciej Czerwiński, Faraz Kazmi, Andrew Parkinson and David B. Buckley
    Drug Metabolism and Disposition January 2015, 43 (1) 42-52; DOI: https://doi.org/10.1124/dmd.114.060186
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    Mechanistic Understanding of Translational Pharmacokinetic-Pharmacodynamic Relationships in Nonclinical Tumor Models: A Case Study of Orally Available Novel Inhibitors of Anaplastic Lymphoma Kinase
    Shinji Yamazaki, Justine L Lam, Helen Y Zou, Hui Wang, Tod Smeal and Paolo Vicini
    Drug Metabolism and Disposition January 2015, 43 (1) 54-62; DOI: https://doi.org/10.1124/dmd.114.061143
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    The Hepatobiliary Disposition of Timosaponin B2 Is Highly Dependent on Influx/Efflux Transporters but Not Metabolism
    Jingjing Sheng, Xiaoting Tian, Guanglin Xu, Zhitao Wu, Chen Chen, Le Wang, Lili Pan, Chenggang Huang and Guoyu Pan
    Drug Metabolism and Disposition January 2015, 43 (1) 63-72; DOI: https://doi.org/10.1124/dmd.114.059923
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    Quantitative Structure-Pharmacokinetic Relationships for the Prediction of Renal Clearance in Humans
    Rutwij A. Dave and Marilyn E. Morris
    Drug Metabolism and Disposition January 2015, 43 (1) 73-81; DOI: https://doi.org/10.1124/dmd.114.059857
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    Imperatorin Is a Mechanism-Based Inactivator of CYP2B6
    Liwei Zheng, Jiaojiao Cao, Dan Lu, Lin Ji, Ying Peng and Jiang Zheng
    Drug Metabolism and Disposition January 2015, 43 (1) 82-88; DOI: https://doi.org/10.1124/dmd.114.060558
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    Identification of a Functional Antioxidant Response Element within the Eighth Intron of the Human ABCC3 Gene
    Mark J. Canet, Matthew D. Merrell, Bryan G. Harder, Jonathan M. Maher, Tongde Wu, Andrew J. Lickteig, Jonathan P. Jackson, Donna D. Zhang, Masayuki Yamamoto and Nathan J. Cherrington
    Drug Metabolism and Disposition January 2015, 43 (1) 93-99; DOI: https://doi.org/10.1124/dmd.114.060103
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    Effect of Experimental Kidney Disease on the Functional Expression of Hepatic Reductases
    Osama Y. Alshogran, Judith Naud, Andrew J. Ocque, François A. Leblond, Vincent Pichette and Thomas D. Nolin
    Drug Metabolism and Disposition January 2015, 43 (1) 100-106; DOI: https://doi.org/10.1124/dmd.114.061150
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    Dog UDP-Glucuronosyltransferase Enzymes of Subfamily 1A: Cloning, Expression, and Activity
    Johanna Troberg, Erkka Järvinen, Maria Muniz, Nina Sneitz, Johanna Mosorin, Marja Hagström and Moshe Finel
    Drug Metabolism and Disposition January 2015, 43 (1) 107-118; DOI: https://doi.org/10.1124/dmd.114.059303
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    HepaRG Cells as Human-Relevant In Vitro Model to Study the Effects of Inflammatory Stimuli on Cytochrome P450 Isoenzymes
    Katarina Rubin, Annika Janefeldt, Linda Andersson, Zsofia Berke, Ken Grime and Tommy B. Andersson
    Drug Metabolism and Disposition January 2015, 43 (1) 119-125; DOI: https://doi.org/10.1124/dmd.114.059246
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    Phase II Metabolism in Human Skin: Skin Explants Show Full Coverage for Glucuronidation, Sulfation, N-Acetylation, Catechol Methylation, and Glutathione Conjugation
    Nenad Manevski, Piet Swart, Kamal Kumar Balavenkatraman, Barbara Bertschi, Gian Camenisch, Olivier Kretz, Hilmar Schiller, Markus Walles, Barbara Ling, Reto Wettstein, Dirk J. Schaefer, Peter Itin, Joanna Ashton-Chess, Francois Pognan, Armin Wolf and Karine Litherland
    Drug Metabolism and Disposition January 2015, 43 (1) 126-139; DOI: https://doi.org/10.1124/dmd.114.060350
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    Brain Pharmacokinetics of Ganciclovir in Rats with Orthotopic BT4C Glioma
    Mikko Gynther, Tiina M. Kääriäinen, Jenni J. Hakkarainen, Aaro J. Jalkanen, Aleksanteri Petsalo, Marko Lehtonen, Lauri Peura, Jere Kurkipuro, Haritha Samaranayake, Seppo Ylä-Herttuala, Jarkko Rautio and Markus M. Forsberg
    Drug Metabolism and Disposition January 2015, 43 (1) 140-146; DOI: https://doi.org/10.1124/dmd.114.059840
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    Transporter-Mediated Uptake of UDP–Glucuronic Acid by Human Liver Microsomes: Assay Conditions, Kinetics, and Inhibition
    Andrew Rowland, Peter I. Mackenzie and John O. Miners
    Drug Metabolism and Disposition January 2015, 43 (1) 147-153; DOI: https://doi.org/10.1124/dmd.114.060509
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    Assessing Steatotic Liver Function after Ischemia-Reperfusion Injury by In Vivo Multiphoton Imaging of Fluorescein Disposition
    Camilla A. Thorling, Lu Jin, Michael Weiss, Darrell Crawford, Xin Liu, Frank J. Burczynski, David Liu, Haolu Wang and Michael S. Roberts
    Drug Metabolism and Disposition January 2015, 43 (1) 154-162; DOI: https://doi.org/10.1124/dmd.114.060848

Erratum

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    Correction to “Evaluation of Near Infrared Fluorescent Labeling of Monoclonal Antibodies as a Tool for Tissue Distribution”
    Drug Metabolism and Disposition January 2015, 43 (1) 53; DOI: https://doi.org/10.1124/dmd.114.060319err
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Drug Metabolism and Disposition: 43 (1)
Drug Metabolism and Disposition
Vol. 43, Issue 1
1 Jan 2015
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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