Table of Contents

Articles

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  Age-Dependent Activity of the Uptake Transporters Ntcp and Oatp1b2 in Male Rat Hepatocytes: From Birth Till Adulthood

  Sarinj Fattah, Patrick Augustijns and Pieter Annaert

  Drug Metabolism and Disposition January 2015, 43 (1) 1-8; DOI: https://doi.org/10.1124/dmd.114.059212
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  Modulation of (–)-Epicatechin Metabolism by Coadministration with Other Polyphenols in Caco-2 Cell Model

  Belén Sanchez-Bridge, Antoine Lévèques, Hequn Li, Emmanuelle Bertschy, Amaury Patin and Lucas Actis-Goretta

  Drug Metabolism and Disposition January 2015, 43 (1) 9-16; DOI: https://doi.org/10.1124/dmd.114.060590
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  A Nonradioactive Approach to Investigate the Metabolism of Therapeutic Peptides by Tagging with ¹²⁷I and Using Inductively-Coupled Plasma Mass Spectrometry Analysis

  Heng-Keang Lim, Yuan Cao, Xi Qiu, Jose Silva and David C. Evans

  Drug Metabolism and Disposition January 2015, 43 (1) 17-26; DOI: https://doi.org/10.1124/dmd.114.059774
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  Evaluation of 89 Compounds for Identification of Substrates for Cynomolgus Monkey CYP2C76, a New Bupropion/Nifedipine Oxidase

  Shinya Hosaka, Norie Murayama, Masahiro Satsukawa, Makiko Shimizu, Shotaro Uehara, Hideki Fujino, Kazuhide Iwasaki, Shunsuke Iwano, Yasuhiro Uno and Hiroshi Yamazaki

  Drug Metabolism and Disposition January 2015, 43 (1) 27-33; DOI: https://doi.org/10.1124/dmd.114.061275
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  Inhibition of Human Aldehyde Oxidase Activity by Diet-Derived Constituents: Structural Influence, Enzyme-Ligand Interactions, and Clinical Relevance

  John T. Barr, Jeffrey P. Jones, Nicholas H. Oberlies and Mary F. Paine

  Drug Metabolism and Disposition January 2015, 43 (1) 34-41; DOI: https://doi.org/10.1124/dmd.114.061192
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  Anti-CD28 Monoclonal Antibody–Stimulated Cytokines Released from Blood Suppress CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes In Vitro

  Maciej Czerwiński, Faraz Kazmi, Andrew Parkinson and David B. Buckley

  Drug Metabolism and Disposition January 2015, 43 (1) 42-52; DOI: https://doi.org/10.1124/dmd.114.060186
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  Mechanistic Understanding of Translational Pharmacokinetic-Pharmacodynamic Relationships in Nonclinical Tumor Models: A Case Study of Orally Available Novel Inhibitors of Anaplastic Lymphoma Kinase

  Shinji Yamazaki, Justine L Lam, Helen Y Zou, Hui Wang, Tod Smeal and Paolo Vicini

  Drug Metabolism and Disposition January 2015, 43 (1) 54-62; DOI: https://doi.org/10.1124/dmd.114.061143
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  The Hepatobiliary Disposition of Timosaponin B2 Is Highly Dependent on Influx/Efflux Transporters but Not Metabolism

  Jingjing Sheng, Xiaoting Tian, Guanglin Xu, Zhitao Wu, Chen Chen, Le Wang, Lili Pan, Chenggang Huang and Guoyu Pan

  Drug Metabolism and Disposition January 2015, 43 (1) 63-72; DOI: https://doi.org/10.1124/dmd.114.059923
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  Quantitative Structure-Pharmacokinetic Relationships for the Prediction of Renal Clearance in Humans

  Rutwij A. Dave and Marilyn E. Morris

  Drug Metabolism and Disposition January 2015, 43 (1) 73-81; DOI: https://doi.org/10.1124/dmd.114.059857
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  Imperatorin Is a Mechanism-Based Inactivator of CYP2B6

  Liwei Zheng, Jiaojiao Cao, Dan Lu, Lin Ji, Ying Peng and Jiang Zheng

  Drug Metabolism and Disposition January 2015, 43 (1) 82-88; DOI: https://doi.org/10.1124/dmd.114.060558
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  Identification of a Functional Antioxidant Response Element within the Eighth Intron of the Human ABCC3 Gene

  Mark J. Canet, Matthew D. Merrell, Bryan G. Harder, Jonathan M. Maher, Tongde Wu, Andrew J. Lickteig, Jonathan P. Jackson, Donna D. Zhang, Masayuki Yamamoto and Nathan J. Cherrington

  Drug Metabolism and Disposition January 2015, 43 (1) 93-99; DOI: https://doi.org/10.1124/dmd.114.060103
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  Effect of Experimental Kidney Disease on the Functional Expression of Hepatic Reductases

  Osama Y. Alshogran, Judith Naud, Andrew J. Ocque, François A. Leblond, Vincent Pichette and Thomas D. Nolin

  Drug Metabolism and Disposition January 2015, 43 (1) 100-106; DOI: https://doi.org/10.1124/dmd.114.061150
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  Dog UDP-Glucuronosyltransferase Enzymes of Subfamily 1A: Cloning, Expression, and Activity

  Johanna Troberg, Erkka Järvinen, Maria Muniz, Nina Sneitz, Johanna Mosorin, Marja Hagström and Moshe Finel

  Drug Metabolism and Disposition January 2015, 43 (1) 107-118; DOI: https://doi.org/10.1124/dmd.114.059303
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  HepaRG Cells as Human-Relevant In Vitro Model to Study the Effects of Inflammatory Stimuli on Cytochrome P450 Isoenzymes

  Katarina Rubin, Annika Janefeldt, Linda Andersson, Zsofia Berke, Ken Grime and Tommy B. Andersson

  Drug Metabolism and Disposition January 2015, 43 (1) 119-125; DOI: https://doi.org/10.1124/dmd.114.059246
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  Phase II Metabolism in Human Skin: Skin Explants Show Full Coverage for Glucuronidation, Sulfation, N-Acetylation, Catechol Methylation, and Glutathione Conjugation

  Nenad Manevski, Piet Swart, Kamal Kumar Balavenkatraman, Barbara Bertschi, Gian Camenisch, Olivier Kretz, Hilmar Schiller, Markus Walles, Barbara Ling, Reto Wettstein, Dirk J. Schaefer, Peter Itin, Joanna Ashton-Chess, Francois Pognan, Armin Wolf and Karine Litherland

  Drug Metabolism and Disposition January 2015, 43 (1) 126-139; DOI: https://doi.org/10.1124/dmd.114.060350
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  Brain Pharmacokinetics of Ganciclovir in Rats with Orthotopic BT4C Glioma

  Mikko Gynther, Tiina M. Kääriäinen, Jenni J. Hakkarainen, Aaro J. Jalkanen, Aleksanteri Petsalo, Marko Lehtonen, Lauri Peura, Jere Kurkipuro, Haritha Samaranayake, Seppo Ylä-Herttuala, Jarkko Rautio and Markus M. Forsberg

  Drug Metabolism and Disposition January 2015, 43 (1) 140-146; DOI: https://doi.org/10.1124/dmd.114.059840
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  Transporter-Mediated Uptake of UDP–Glucuronic Acid by Human Liver Microsomes: Assay Conditions, Kinetics, and Inhibition

  Andrew Rowland, Peter I. Mackenzie and John O. Miners

  Drug Metabolism and Disposition January 2015, 43 (1) 147-153; DOI: https://doi.org/10.1124/dmd.114.060509
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  Assessing Steatotic Liver Function after Ischemia-Reperfusion Injury by In Vivo Multiphoton Imaging of Fluorescein Disposition

  Camilla A. Thorling, Lu Jin, Michael Weiss, Darrell Crawford, Xin Liu, Frank J. Burczynski, David Liu, Haolu Wang and Michael S. Roberts

  Drug Metabolism and Disposition January 2015, 43 (1) 154-162; DOI: https://doi.org/10.1124/dmd.114.060848