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Drug Metabolism & Disposition

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Table of Contents

October 01, 2015; Volume 43,Issue 10

Special Section on Drug Metabolism and the Microbiome

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    Drug Metabolism by the Host and Gut Microbiota: A Partnership or Rivalry?
    Hollie I. Swanson
    Drug Metabolism and Disposition October 2015, 43 (10) 1499-1504; DOI: https://doi.org/10.1124/dmd.115.065714
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    Review: Mechanisms of How the Intestinal Microbiota Alters the Effects of Drugs and Bile Acids
    Curtis D. Klaassen and Julia Yue Cui
    Drug Metabolism and Disposition October 2015, 43 (10) 1505-1521; DOI: https://doi.org/10.1124/dmd.115.065698
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    Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation
    Troy D. Hubbard, Iain A. Murray and Gary H. Perdew
    Drug Metabolism and Disposition October 2015, 43 (10) 1522-1535; DOI: https://doi.org/10.1124/dmd.115.064246
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    Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes
    Yating Cheng, Un-Ho Jin, Clint D. Allred, Arul Jayaraman, Robert S. Chapkin and Stephen Safe
    Drug Metabolism and Disposition October 2015, 43 (10) 1536-1543; DOI: https://doi.org/10.1124/dmd.115.063677
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    Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice
    Felcy Pavithra Selwyn, Iván L. Csanaky, Youcai Zhang and Curtis D. Klaassen
    Drug Metabolism and Disposition October 2015, 43 (10) 1544-1556; DOI: https://doi.org/10.1124/dmd.115.065276
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    Microbiome Disturbances and Autism Spectrum Disorders
    Cheryl S. Rosenfeld
    Drug Metabolism and Disposition October 2015, 43 (10) 1557-1571; DOI: https://doi.org/10.1124/dmd.115.063826
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    RNA-Seq Quantification of Hepatic Drug Processing Genes in Germ-Free Mice
    Felcy Pavithra Selwyn, Julia Yue Cui and Curtis D. Klaassen
    Drug Metabolism and Disposition October 2015, 43 (10) 1572-1580; DOI: https://doi.org/10.1124/dmd.115.063545
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    Gut Microbiota-Mediated Drug-Antibiotic Interactions
    Dong-Hyun Kim
    Drug Metabolism and Disposition October 2015, 43 (10) 1581-1589; DOI: https://doi.org/10.1124/dmd.115.063867
  • Intestinal Absorption and Metabolism of Epimedium Flavonoids in Osteoporosis Rats
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    Intestinal Absorption and Metabolism of Epimedium Flavonoids in Osteoporosis Rats
    Jing Zhou, Yi Hua Ma, Zhong Zhou, Yan Chen, Ying Wang and Xia Gao
    Drug Metabolism and Disposition October 2015, 43 (10) 1590-1600; DOI: https://doi.org/10.1124/dmd.115.064386
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    The Presystemic Interplay between Gut Microbiota and Orally Administered Calycosin-7-O-β-d-Glucoside
    Jian-Qing Ruan, Shang Li, Ya-Ping Li, Wen-Jin Wu, Simon Ming-Yuen Lee and Ru Yan
    Drug Metabolism and Disposition October 2015, 43 (10) 1601-1611; DOI: https://doi.org/10.1124/dmd.115.065094
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    Defining the Role of Gut Bacteria in the Metabolism of Deleobuvir: In Vitro and In Vivo Studies
    Michelle McCabe, Rucha S. Sane, Monica Keith-Luzzi, Jun Xu, Illeaniz King, Andrea Whitcher-Johnstone, Nicholas Johnstone, Donald J. Tweedie and Yongmei Li
    Drug Metabolism and Disposition October 2015, 43 (10) 1612-1618; DOI: https://doi.org/10.1124/dmd.115.064477
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    Investigation of Host–Gut Microbiota Modulation of Therapeutic Outcome
    Lian Yee Yip and Eric Chun Yong Chan
    Drug Metabolism and Disposition October 2015, 43 (10) 1619-1631; DOI: https://doi.org/10.1124/dmd.115.063750

Short Communication

  • Making Transporter Models for Drug–Drug Interaction Prediction Mobile
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    Making Transporter Models for Drug–Drug Interaction Prediction Mobile
    Sean Ekins, Alex M. Clark and Stephen H. Wright
    Drug Metabolism and Disposition October 2015, 43 (10) 1642-1645; DOI: https://doi.org/10.1124/dmd.115.064956

Articles

  • Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, <em>S</em>-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole
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    Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole
    Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Mirai Kawano, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki
    Drug Metabolism and Disposition October 2015, 43 (10) 1408-1416; DOI: https://doi.org/10.1124/dmd.115.066100
  • Prediction of Drug-Drug Interactions with Crizotinib as the CYP3A Substrate Using a Physiologically Based Pharmacokinetic Model
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    Prediction of Drug-Drug Interactions with Crizotinib as the CYP3A Substrate Using a Physiologically Based Pharmacokinetic Model
    Shinji Yamazaki, Theodore R. Johnson and Bill J. Smith
    Drug Metabolism and Disposition October 2015, 43 (10) 1417-1429; DOI: https://doi.org/10.1124/dmd.115.064618
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    Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Controls Efflux Transport of Hesperetin Sulfates in Sulfotransferase 1A3–Overexpressing Human Embryonic Kidney 293 Cells
    Hua Sun, Xiao Wang, Xiaotong Zhou, Danyi Lu, Zhiguo Ma and Baojian Wu
    Drug Metabolism and Disposition October 2015, 43 (10) 1430-1440; DOI: https://doi.org/10.1124/dmd.115.065953
  • Lipid Peroxide–Mediated Oxidative Rearrangement of the Pyrazinone Carboxamide Core of Neutrophil Elastase Inhibitor AZD9819 in Blood Plasma Samples
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    Lipid Peroxide–Mediated Oxidative Rearrangement of the Pyrazinone Carboxamide Core of Neutrophil Elastase Inhibitor AZD9819 in Blood Plasma Samples
    Chungang Gu, Richard J. Lewis, Andrew S. Wells, Per H. Svensson, Vinayak P. Hosagrahara, Eskil Johnsson and Gösta Hallström
    Drug Metabolism and Disposition October 2015, 43 (10) 1441-1449; DOI: https://doi.org/10.1124/dmd.115.065136
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    Single-Nucleotide Polymorphisms in Cytochrome P450 2E1 (CYP2E1) 3′-Untranslated Region Affect the Regulation of CYP2E1 by miR-570
    Masataka Nakano, Takuya Mohri, Tatsuki Fukami, Masataka Takamiya, Yasuhiro Aoki, Howard L. McLeod and Miki Nakajima
    Drug Metabolism and Disposition October 2015, 43 (10) 1450-1457; DOI: https://doi.org/10.1124/dmd.115.065664
  • Role of Specificity Protein 1, Hepatocyte Nuclear Factor 1<em>α</em>, and Pregnane X Receptor in the Basal and Rifampicin-Induced Transcriptional Regulation of Porcine Cytochrome P450 3A46
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    Role of Specificity Protein 1, Hepatocyte Nuclear Factor 1α, and Pregnane X Receptor in the Basal and Rifampicin-Induced Transcriptional Regulation of Porcine Cytochrome P450 3A46
    Linfeng Dong, Qingmei Chen, Xin Liu, Jikai Wen, Jun Jiang and Yiqun Deng
    Drug Metabolism and Disposition October 2015, 43 (10) 1458-1467; DOI: https://doi.org/10.1124/dmd.115.065565
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    Inhibition of Human UDP-Glucuronosyltransferase Enzymes by Canagliflozin and Dapagliflozin: Implications for Drug-Drug Interactions
    Attarat Pattanawongsa, Nuy Chau, Andrew Rowland and John O. Miners
    Drug Metabolism and Disposition October 2015, 43 (10) 1468-1476; DOI: https://doi.org/10.1124/dmd.115.065870
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    Disposition of Basal Insulin Peglispro Compared with 20-kDa Polyethylene Glycol in Rats Following a Single Intravenous or Subcutaneous Dose
    Mary Pat Knadler, Bernice B. Ellis, Patricia L. Brown-Augsburger, Anthony T. Murphy, Jennifer A. Martin and Victor J. Wroblewski
    Drug Metabolism and Disposition October 2015, 43 (10) 1477-1483; DOI: https://doi.org/10.1124/dmd.115.064337
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    CYP3A Activity and Expression in Nonalcoholic Fatty Liver Disease
    Sarah J. Woolsey, Sara E. Mansell, Richard B. Kim, Rommel G. Tirona and Melanie D. Beaton
    Drug Metabolism and Disposition October 2015, 43 (10) 1484-1490; DOI: https://doi.org/10.1124/dmd.115.065979
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    In Vitro and In Vivo Characterization of Reactive Intermediates of Corynoline
    Xu Mao, Ying Peng and Jiang Zheng
    Drug Metabolism and Disposition October 2015, 43 (10) 1491-1498; DOI: https://doi.org/10.1124/dmd.115.065813
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    Human Liver Cytochrome P450 Enzymes and Microsomal Thiol Methyltransferase Are Involved in the Stereoselective Formation and Methylation of the Pharmacologically Active Metabolite of Clopidogrel
    Cai Liu, Zhaoqiang Chen, Kan Zhong, Liang Li, Weiliang Zhu, Xiaoyan Chen and Dafang Zhong
    Drug Metabolism and Disposition October 2015, 43 (10) 1632-1641; DOI: https://doi.org/10.1124/dmd.115.064949
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In this issue

Drug Metabolism and Disposition: 43 (10)
Drug Metabolism and Disposition
Vol. 43, Issue 10
1 Oct 2015
  • Table of Contents
  • Table of Contents (PDF)
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  • Index by author
  • Editorial Board (PDF)
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