Table of Contents

Articles

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  Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole

  Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Mirai Kawano, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki

  Drug Metabolism and Disposition October 2015, 43 (10) 1408-1416; DOI: https://doi.org/10.1124/dmd.115.066100
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  Prediction of Drug-Drug Interactions with Crizotinib as the CYP3A Substrate Using a Physiologically Based Pharmacokinetic Model

  Shinji Yamazaki, Theodore R. Johnson and Bill J. Smith

  Drug Metabolism and Disposition October 2015, 43 (10) 1417-1429; DOI: https://doi.org/10.1124/dmd.115.064618
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  Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Controls Efflux Transport of Hesperetin Sulfates in Sulfotransferase 1A3–Overexpressing Human Embryonic Kidney 293 Cells

  Hua Sun, Xiao Wang, Xiaotong Zhou, Danyi Lu, Zhiguo Ma and Baojian Wu

  Drug Metabolism and Disposition October 2015, 43 (10) 1430-1440; DOI: https://doi.org/10.1124/dmd.115.065953
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  Lipid Peroxide–Mediated Oxidative Rearrangement of the Pyrazinone Carboxamide Core of Neutrophil Elastase Inhibitor AZD9819 in Blood Plasma Samples

  Chungang Gu, Richard J. Lewis, Andrew S. Wells, Per H. Svensson, Vinayak P. Hosagrahara, Eskil Johnsson and Gösta Hallström

  Drug Metabolism and Disposition October 2015, 43 (10) 1441-1449; DOI: https://doi.org/10.1124/dmd.115.065136
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  Single-Nucleotide Polymorphisms in Cytochrome P450 2E1 (CYP2E1) 3′-Untranslated Region Affect the Regulation of CYP2E1 by miR-570

  Masataka Nakano, Takuya Mohri, Tatsuki Fukami, Masataka Takamiya, Yasuhiro Aoki, Howard L. McLeod and Miki Nakajima

  Drug Metabolism and Disposition October 2015, 43 (10) 1450-1457; DOI: https://doi.org/10.1124/dmd.115.065664
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  Role of Specificity Protein 1, Hepatocyte Nuclear Factor 1α, and Pregnane X Receptor in the Basal and Rifampicin-Induced Transcriptional Regulation of Porcine Cytochrome P450 3A46

  Linfeng Dong, Qingmei Chen, Xin Liu, Jikai Wen, Jun Jiang and Yiqun Deng

  Drug Metabolism and Disposition October 2015, 43 (10) 1458-1467; DOI: https://doi.org/10.1124/dmd.115.065565
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  Inhibition of Human UDP-Glucuronosyltransferase Enzymes by Canagliflozin and Dapagliflozin: Implications for Drug-Drug Interactions

  Attarat Pattanawongsa, Nuy Chau, Andrew Rowland and John O. Miners

  Drug Metabolism and Disposition October 2015, 43 (10) 1468-1476; DOI: https://doi.org/10.1124/dmd.115.065870
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  Disposition of Basal Insulin Peglispro Compared with 20-kDa Polyethylene Glycol in Rats Following a Single Intravenous or Subcutaneous Dose

  Mary Pat Knadler, Bernice B. Ellis, Patricia L. Brown-Augsburger, Anthony T. Murphy, Jennifer A. Martin and Victor J. Wroblewski

  Drug Metabolism and Disposition October 2015, 43 (10) 1477-1483; DOI: https://doi.org/10.1124/dmd.115.064337
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  CYP3A Activity and Expression in Nonalcoholic Fatty Liver Disease

  Sarah J. Woolsey, Sara E. Mansell, Richard B. Kim, Rommel G. Tirona and Melanie D. Beaton

  Drug Metabolism and Disposition October 2015, 43 (10) 1484-1490; DOI: https://doi.org/10.1124/dmd.115.065979
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  In Vitro and In Vivo Characterization of Reactive Intermediates of Corynoline

  Xu Mao, Ying Peng and Jiang Zheng

  Drug Metabolism and Disposition October 2015, 43 (10) 1491-1498; DOI: https://doi.org/10.1124/dmd.115.065813
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  Human Liver Cytochrome P450 Enzymes and Microsomal Thiol Methyltransferase Are Involved in the Stereoselective Formation and Methylation of the Pharmacologically Active Metabolite of Clopidogrel

  Cai Liu, Zhaoqiang Chen, Kan Zhong, Liang Li, Weiliang Zhu, Xiaoyan Chen and Dafang Zhong

  Drug Metabolism and Disposition October 2015, 43 (10) 1632-1641; DOI: https://doi.org/10.1124/dmd.115.064949