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History
- Received May 26, 2015
- Accepted August 5, 2015
- Published online September 1, 2015.
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- Earlier version (August 10, 2015 - 05:31).
- You are viewing the most recent version of this article.
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Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics
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In this issue
Intestinal Bacteria and Drug Metabolism
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- Article
- Abstract
- Introduction
- Intestinal Microbiota Delivers Drug to the Large Intestine
- Intestinal Microbiota Decreases Drug Available for Absorption but Altered by Dietary Intervention
- Intestinal Microbiota Decreases Absorption of Drug by Metabolizing and Possibly Binding the Drug
- Intestinal Microbiota Increases Availability of Drug because Microbiota Produce a Chemical that Competes with Drug for Detoxification by the Host
- Intestinal Microbiota Biotransform Common Food Constituents
- Intestinal Microbiota Biotransform Tryptophan into Aryl-Hydrocarbon Receptor Agonists that Stimulate the Immune System to Maintain a Healthy Intestine
- Intestinal Microbiota Biotransforms Food Constituents into Chemicals that Promote Cardiovascular Disease
- Intestinal Microbiota Forms a Drug Metabolite that Inactivates a Host Enzyme that Biotransforms a Second Drug
- Intestinal Microbiota Responsible for Intestinal Toxicity of Cancer Chemotherapeutic Drug
- Intestinal Microbiota Increases the Duration of Drug Action and Increases Drug Toxicity
- Intestinal Microbiota Responsible for Drug-Induced Intestinal Toxicity
- Intestinal Microbiota Decreases and Increases the Mutagenicity of Food-Pyrolysis Products
- Intestinal Microbiota Metabolizes Substrate that Cocrystalizes with the Substrate and Precipitates in Kidney Tubules to Produce Toxicity
- Intestinal Microbiota Metabolizes Drug to a Teratogen
- Intestinal Microbiota Converts Prodrug to an Active Drug
- Intestinal Microbiota Biotransforms Additional Drugs and Xenobiotics
- Intestinal Microbiota Affects Host Drug Metabolism
- Composition of the Intestinal Microbiota
- Intestinal Microbiota and Obesity
- Prebiotics and Probiotics Alter the Intestinal Microbiota
- Bile Acids and the Intestinal Microbiota
- Bile Acids Regulate the Intestinal Microbiota
- Bile Acids as Signaling Molecules
- Bile Acids, Intestinal Microbiota, and Metabolic Syndrome
- Effect of a Chemical on Intestinal Microbiota, Bile Acids, and Metabolic Syndrome
- Effect of Environmental Chemicals on Intestinal Microbiota
- Summary and Conclusion
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
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