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Research ArticleSpecial Section on Drug Metabolism and the Microbiome—Minireview

Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation

Troy D. Hubbard, Iain A. Murray and Gary H. Perdew
Drug Metabolism and Disposition October 2015, 43 (10) 1522-1535; DOI: https://doi.org/10.1124/dmd.115.064246
Troy D. Hubbard
Graduate Program in Biochemistry, Microbiology, and Molecular Biology (T.D.H.), and Center for Molecular Toxicology and Carcinogenesis and the Department of Veterinary and Biomedical Sciences (T.D.H., I.A.M., G.H.P)., Pennsylvania State University, University Park, Pennsylvania
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Iain A. Murray
Graduate Program in Biochemistry, Microbiology, and Molecular Biology (T.D.H.), and Center for Molecular Toxicology and Carcinogenesis and the Department of Veterinary and Biomedical Sciences (T.D.H., I.A.M., G.H.P)., Pennsylvania State University, University Park, Pennsylvania
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Gary H. Perdew
Graduate Program in Biochemistry, Microbiology, and Molecular Biology (T.D.H.), and Center for Molecular Toxicology and Carcinogenesis and the Department of Veterinary and Biomedical Sciences (T.D.H., I.A.M., G.H.P)., Pennsylvania State University, University Park, Pennsylvania
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Article Information

vol. 43 no. 10 1522-1535
DOI 
https://doi.org/10.1124/dmd.115.064246
PubMed 
26041783

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 10, 2015
  • Accepted June 2, 2015
  • Published online September 1, 2015.

Article Versions

  • Earlier version (June 3, 2015 - 05:15).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Troy D. Hubbard,
  2. Iain A. Murray, and
  3. Gary H. Perdew
  1. Graduate Program in Biochemistry, Microbiology, and Molecular Biology (T.D.H.), and Center for Molecular Toxicology and Carcinogenesis and the Department of Veterinary and Biomedical Sciences (T.D.H., I.A.M., G.H.P)., Pennsylvania State University, University Park, Pennsylvania
  1. Address correspondence to:
    Dr. Gary H. Perdew, CMTC, 309 LSB, Penn State University, University Park, PA 16802. E-mail: ghp2{at}psu.edu
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Drug Metabolism and Disposition: 43 (10)
Drug Metabolism and Disposition
Vol. 43, Issue 10
1 Oct 2015
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Research ArticleSpecial Section on Drug Metabolism and the Microbiome—Minireview

Indole and Tryptophan Derived Endogenous AHR Ligands

Troy D. Hubbard, Iain A. Murray and Gary H. Perdew
Drug Metabolism and Disposition October 1, 2015, 43 (10) 1522-1535; DOI: https://doi.org/10.1124/dmd.115.064246

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Research ArticleSpecial Section on Drug Metabolism and the Microbiome—Minireview

Indole and Tryptophan Derived Endogenous AHR Ligands

Troy D. Hubbard, Iain A. Murray and Gary H. Perdew
Drug Metabolism and Disposition October 1, 2015, 43 (10) 1522-1535; DOI: https://doi.org/10.1124/dmd.115.064246
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  • Article
    • Abstract
    • Introduction
    • The Physiologic Significance of AHR
    • The Case for Endogenous AHR Ligands
    • Search for Endogenous Ligands
    • Dietary Exposure to Indole-3-Carbinol
    • Microbiota-Derived AHR Ligands
    • Host Metabolism of Indoles
    • Host Metabolism of Tryptophan
    • Photo-Oxidation of Tryptophan
    • Human versus Mouse AHR Ligand Selectivity
    • Possible Mechanism of AHR Activation by Low-Molecular-Weight Compounds
    • Summary
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

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  • Host–Gut Microbiota Modulation of Therapeutic Outcome
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