Research ArticleSpecial Section on Drug Metabolism and the Microbiome—Minireview
Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation
Troy D. Hubbard, Iain A. Murray and Gary H. Perdew
Drug Metabolism and Disposition October 2015, 43 (10) 1522-1535; DOI: https://doi.org/10.1124/dmd.115.064246
Troy D. Hubbard
Graduate Program in Biochemistry, Microbiology, and Molecular Biology (T.D.H.), and Center for Molecular Toxicology and Carcinogenesis and the Department of Veterinary and Biomedical Sciences (T.D.H., I.A.M., G.H.P)., Pennsylvania State University, University Park, Pennsylvania
Iain A. Murray
Graduate Program in Biochemistry, Microbiology, and Molecular Biology (T.D.H.), and Center for Molecular Toxicology and Carcinogenesis and the Department of Veterinary and Biomedical Sciences (T.D.H., I.A.M., G.H.P)., Pennsylvania State University, University Park, Pennsylvania
Gary H. Perdew
Graduate Program in Biochemistry, Microbiology, and Molecular Biology (T.D.H.), and Center for Molecular Toxicology and Carcinogenesis and the Department of Veterinary and Biomedical Sciences (T.D.H., I.A.M., G.H.P)., Pennsylvania State University, University Park, Pennsylvania
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Research ArticleSpecial Section on Drug Metabolism and the Microbiome—Minireview
Indole and Tryptophan Derived Endogenous AHR Ligands
Troy D. Hubbard, Iain A. Murray and Gary H. Perdew
Drug Metabolism and Disposition October 1, 2015, 43 (10) 1522-1535; DOI: https://doi.org/10.1124/dmd.115.064246
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- Article
- Abstract
- Introduction
- The Physiologic Significance of AHR
- The Case for Endogenous AHR Ligands
- Search for Endogenous Ligands
- Dietary Exposure to Indole-3-Carbinol
- Microbiota-Derived AHR Ligands
- Host Metabolism of Indoles
- Host Metabolism of Tryptophan
- Photo-Oxidation of Tryptophan
- Human versus Mouse AHR Ligand Selectivity
- Possible Mechanism of AHR Activation by Low-Molecular-Weight Compounds
- Summary
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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