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Human Liver Cytochrome P450 Enzymes and Microsomal Thiol Methyltransferase Are Involved in the Stereoselective Formation and Methylation of the Pharmacologically Active Metabolite of Clopidogrel

Cai Liu, Zhaoqiang Chen, Kan Zhong, Liang Li, Weiliang Zhu, Xiaoyan Chen and Dafang Zhong
Drug Metabolism and Disposition October 2015, 43 (10) 1632-1641; DOI: https://doi.org/10.1124/dmd.115.064949

Article Information

vol. 43 no. 10 1632-1641
DOI 
https://doi.org/10.1124/dmd.115.064949
PubMed 
26220948
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 15, 2015
  • Accepted July 28, 2015
  • Published online September 3, 2015.

Article Versions

Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Cai Liu,
  2. Zhaoqiang Chen,
  3. Kan Zhong,
  4. Liang Li,
  5. Weiliang Zhu,
  6. Xiaoyan Chen, and
  7. Dafang Zhong
  1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
  1. Address correspondence to:
    Dr. Dafang Zhong, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China. E-mail: dfzhong{at}simm.ac.cn
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Stereoselectivity in Bioactivation of Clopidogrel

Cai Liu, Zhaoqiang Chen, Kan Zhong, Liang Li, Weiliang Zhu, Xiaoyan Chen and Dafang Zhong
Drug Metabolism and Disposition October 1, 2015, 43 (10) 1632-1641; DOI: https://doi.org/10.1124/dmd.115.064949
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