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Drug Metabolism & Disposition

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Table of Contents

November 01, 2015; Volume 43,Issue 11

Minireview

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    Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification
    Jennifer E. Sager, Jingjing Yu, Isabelle Ragueneau-Majlessi and Nina Isoherranen
    Drug Metabolism and Disposition November 2015, 43 (11) 1823-1837; DOI: https://doi.org/10.1124/dmd.115.065920

Short Communication

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    The Polymorphic Variant P24T of UDP-Glucuronosyltransferase 1A4 and Its Unusual Consequences
    Johanna Troberg and Moshe Finel
    Drug Metabolism and Disposition November 2015, 43 (11) 1769-1772; DOI: https://doi.org/10.1124/dmd.115.065680

Articles

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    In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice
    Kazuto Yasuda, Cynthia Cline, Yvonne S. Lin, Rachel Scheib, Samit Ganguly, Ranjit K. Thirumaran, Amarjit Chaudhry, Richard B. Kim and Erin G. Schuetz
    Drug Metabolism and Disposition November 2015, 43 (11) 1646-1654; DOI: https://doi.org/10.1124/dmd.115.065078
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    Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin
    Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
    Drug Metabolism and Disposition November 2015, 43 (11) 1655-1660; DOI: https://doi.org/10.1124/dmd.115.065938
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    P450-Based Drug-Drug Interactions of Amiodarone and its Metabolites: Diversity of Inhibitory Mechanisms
    Matthew G. McDonald, Nicholas T. Au and Allan E. Rettie
    Drug Metabolism and Disposition November 2015, 43 (11) 1661-1669; DOI: https://doi.org/10.1124/dmd.115.065623
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    High-Throughput Cytochrome P450 Cocktail Inhibition Assay for Assessing Drug-Drug and Drug-Botanical Interactions
    Guannan Li, Ke Huang, Dejan Nikolic and Richard B. van Breemen
    Drug Metabolism and Disposition November 2015, 43 (11) 1670-1678; DOI: https://doi.org/10.1124/dmd.115.065987
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    Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model
    Nico Scheer, Yury Kapelyukh, Anja Rode, Stefan Oswald, Diana Busch, Lesley A. McLaughlin, De Lin, Colin. J. Henderson and C. Roland Wolf
    Drug Metabolism and Disposition November 2015, 43 (11) 1679-1690; DOI: https://doi.org/10.1124/dmd.115.065656
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    Inhibition of Anthracycline Alcohol Metabolite Formation in Human Heart Cytosol: A Potential Role for Several Promising Drugs
    Alvaro Mordente, Andrea Silvestrini, Giuseppe Ettore Martorana, Daniela Tavian and Elisabetta Meucci
    Drug Metabolism and Disposition November 2015, 43 (11) 1691-1701; DOI: https://doi.org/10.1124/dmd.115.065110
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    Combined Contribution of Increased Intestinal Permeability and Inhibited Deglycosylation of Ginsenoside Rb1 in the Intestinal Tract to the Enhancement of Ginsenoside Rb1 Exposure in Diabetic Rats after Oral Administration
    Can Liu, Mengyue Hu, Haifang Guo, Mian Zhang, Ji Zhang, Feng Li, Zeyu Zhong, Yang Chen, Ying Li, Ping Xu, Jia Li, Li Liu and Xiaodong Liu
    Drug Metabolism and Disposition November 2015, 43 (11) 1702-1710; DOI: https://doi.org/10.1124/dmd.115.064881
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    A New Rapid In Vitro Assay for Assessing Reactivity of Acyl Glucuronides
    Sheng Zhong, Russell Jones, Wenzhe Lu, Simone Schadt and Giorgio Ottaviani
    Drug Metabolism and Disposition November 2015, 43 (11) 1711-1717; DOI: https://doi.org/10.1124/dmd.115.066159
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    A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo
    Anna L. Blobaum, Frank W. Byers, Thomas M. Bridges, Charles W. Locuson, P. Jeffrey Conn, Craig W. Lindsley and J. Scott Daniels
    Drug Metabolism and Disposition November 2015, 43 (11) 1718-1726; DOI: https://doi.org/10.1124/dmd.115.064006
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    Application of HC-AFW1 Hepatocarcinoma Cells for Mechanistic Studies: Regulation of Cytochrome P450 2B6 Expression by Dimethyl Sulfoxide and Early Growth Response 1
    Barbara Petzuch, Nicola Groll, Michael Schwarz and Albert Braeuning
    Drug Metabolism and Disposition November 2015, 43 (11) 1727-1733; DOI: https://doi.org/10.1124/dmd.115.064659
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    Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan Glucuronides
    Brandon T. Gufford, Tyler N. Graf, Noemi D. Paguigan, Nicholas H. Oberlies and Mary F. Paine
    Drug Metabolism and Disposition November 2015, 43 (11) 1734-1743; DOI: https://doi.org/10.1124/dmd.115.066076
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    The Reliability of Estimating Ki Values for Direct, Reversible Inhibition of Cytochrome P450 Enzymes from Corresponding IC50 Values: A Retrospective Analysis of 343 Experiments
    Lois J. Haupt, Faraz Kazmi, Brian W. Ogilvie, David B. Buckley, Brian D. Smith, Sarah Leatherman, Brandy Paris, Oliver Parkinson and Andrew Parkinson
    Drug Metabolism and Disposition November 2015, 43 (11) 1744-1750; DOI: https://doi.org/10.1124/dmd.115.066597
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    Fasiglifam (TAK-875) Inhibits Hepatobiliary Transporters: A Possible Factor Contributing to Fasiglifam-Induced Liver Injury
    Xiuli Li, Kan Zhong, Zitao Guo, Dafang Zhong and Xiaoyan Chen
    Drug Metabolism and Disposition November 2015, 43 (11) 1751-1759; DOI: https://doi.org/10.1124/dmd.115.064121
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    Prediction of the Clinical Risk of Drug-Induced Cholestatic Liver Injury Using an In Vitro Sandwich Cultured Hepatocyte Assay
    Takeshi Susukida, Shuichi Sekine, Mayuka Nozaki, Mayuko Tokizono and Kousei Ito
    Drug Metabolism and Disposition November 2015, 43 (11) 1760-1768; DOI: https://doi.org/10.1124/dmd.115.065425
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    Potent and Selective Inhibition of Plasma Membrane Monoamine Transporter by HIV Protease Inhibitors
    Haichuan Duan, Tao Hu, Robert S. Foti, Yongmei Pan, Peter W. Swaan and Joanne Wang
    Drug Metabolism and Disposition November 2015, 43 (11) 1773-1780; DOI: https://doi.org/10.1124/dmd.115.064824
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    Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists
    Albert Braeuning, Maria Thomas, Ute Hofmann, Silvia Vetter, Eva Zeller, Barbara Petzuch, Janina Johänning, Werner Schroth, Thomas S. Weiss, Ulrich M. Zanger and Michael Schwarz
    Drug Metabolism and Disposition November 2015, 43 (11) 1781-1787; DOI: https://doi.org/10.1124/dmd.115.064667
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    Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake
    Bridget L. Morse, Hong Cai, Jamus G. MacGuire, Maxine Fox, Lisa Zhang, Yueping Zhang, Xiaomei Gu, Hong Shen, Elizabeth A. Dierks, Hong Su, Chiuwa E. Luk, Punit Marathe, Yue-Zhong Shu, W. Griffith Humphreys and Yurong Lai
    Drug Metabolism and Disposition November 2015, 43 (11) 1788-1794; DOI: https://doi.org/10.1124/dmd.115.065946
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    Modulation of P-glycoprotein at the Human Blood-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study
    Li Liu, Ann C. Collier, Jeanne M. Link, Karen B. Domino, David A. Mankoff, Janet F. Eary, Charles F. Spiekerman, Peng Hsiao, Anand K. Deo and Jashvant D. Unadkat
    Drug Metabolism and Disposition November 2015, 43 (11) 1795-1804; DOI: https://doi.org/10.1124/dmd.114.058685
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    In Vitro Characterization of the Human Liver Microsomal Kinetics and Reaction Phenotyping of Olanzapine Metabolism
    Porntipa Korprasertthaworn, Thomas M. Polasek, Michael J. Sorich, Andrew J. McLachlan, John O. Miners, Geoffrey T. Tucker and Andrew Rowland
    Drug Metabolism and Disposition November 2015, 43 (11) 1806-1814; DOI: https://doi.org/10.1124/dmd.115.064790
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    New Photosafety Assessment Strategy Based on the Photochemical and Pharmacokinetic Properties of Both Parent Chemicals and Metabolites
    Masashi Kato, Gen Suzuki, Hiroto Ohtake, Yoshiki Seto and Satomi Onoue
    Drug Metabolism and Disposition November 2015, 43 (11) 1815-1822; DOI: https://doi.org/10.1124/dmd.115.065060

Erratum

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    Correction to: ‘‘A Novel Loading Method for Doxycycline Liposomes for Intracellular Drug Delivery: Characterization of In Vitro and In Vivo Release Kinetics and Efficacy in a J774A.1 Cell Line Model of Mycobacterium smegmatis Infection”
    Drug Metabolism and Disposition November 2015, 43 (11) 1805; DOI: https://doi.org/10.1124/dmd.115.063602err
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In this issue

Drug Metabolism and Disposition: 43 (11)
Drug Metabolism and Disposition
Vol. 43, Issue 11
1 Nov 2015
  • Table of Contents
  • Table of Contents (PDF)
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  • Minireview
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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