Table of Contents

Articles

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  In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice

  Kazuto Yasuda, Cynthia Cline, Yvonne S. Lin, Rachel Scheib, Samit Ganguly, Ranjit K. Thirumaran, Amarjit Chaudhry, Richard B. Kim and Erin G. Schuetz

  Drug Metabolism and Disposition November 2015, 43 (11) 1646-1654; DOI: https://doi.org/10.1124/dmd.115.065078
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  Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin

  Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman

  Drug Metabolism and Disposition November 2015, 43 (11) 1655-1660; DOI: https://doi.org/10.1124/dmd.115.065938
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  P450-Based Drug-Drug Interactions of Amiodarone and its Metabolites: Diversity of Inhibitory Mechanisms

  Matthew G. McDonald, Nicholas T. Au and Allan E. Rettie

  Drug Metabolism and Disposition November 2015, 43 (11) 1661-1669; DOI: https://doi.org/10.1124/dmd.115.065623
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  High-Throughput Cytochrome P450 Cocktail Inhibition Assay for Assessing Drug-Drug and Drug-Botanical Interactions

  Guannan Li, Ke Huang, Dejan Nikolic and Richard B. van Breemen

  Drug Metabolism and Disposition November 2015, 43 (11) 1670-1678; DOI: https://doi.org/10.1124/dmd.115.065987
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  Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

  Nico Scheer, Yury Kapelyukh, Anja Rode, Stefan Oswald, Diana Busch, Lesley A. McLaughlin, De Lin, Colin. J. Henderson and C. Roland Wolf

  Drug Metabolism and Disposition November 2015, 43 (11) 1679-1690; DOI: https://doi.org/10.1124/dmd.115.065656
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  Inhibition of Anthracycline Alcohol Metabolite Formation in Human Heart Cytosol: A Potential Role for Several Promising Drugs

  Alvaro Mordente, Andrea Silvestrini, Giuseppe Ettore Martorana, Daniela Tavian and Elisabetta Meucci

  Drug Metabolism and Disposition November 2015, 43 (11) 1691-1701; DOI: https://doi.org/10.1124/dmd.115.065110
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  Combined Contribution of Increased Intestinal Permeability and Inhibited Deglycosylation of Ginsenoside Rb1 in the Intestinal Tract to the Enhancement of Ginsenoside Rb1 Exposure in Diabetic Rats after Oral Administration

  Can Liu, Mengyue Hu, Haifang Guo, Mian Zhang, Ji Zhang, Feng Li, Zeyu Zhong, Yang Chen, Ying Li, Ping Xu, Jia Li, Li Liu and Xiaodong Liu

  Drug Metabolism and Disposition November 2015, 43 (11) 1702-1710; DOI: https://doi.org/10.1124/dmd.115.064881
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  A New Rapid In Vitro Assay for Assessing Reactivity of Acyl Glucuronides

  Sheng Zhong, Russell Jones, Wenzhe Lu, Simone Schadt and Giorgio Ottaviani

  Drug Metabolism and Disposition November 2015, 43 (11) 1711-1717; DOI: https://doi.org/10.1124/dmd.115.066159
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  A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo

  Anna L. Blobaum, Frank W. Byers, Thomas M. Bridges, Charles W. Locuson, P. Jeffrey Conn, Craig W. Lindsley and J. Scott Daniels

  Drug Metabolism and Disposition November 2015, 43 (11) 1718-1726; DOI: https://doi.org/10.1124/dmd.115.064006
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  Application of HC-AFW1 Hepatocarcinoma Cells for Mechanistic Studies: Regulation of Cytochrome P450 2B6 Expression by Dimethyl Sulfoxide and Early Growth Response 1

  Barbara Petzuch, Nicola Groll, Michael Schwarz and Albert Braeuning

  Drug Metabolism and Disposition November 2015, 43 (11) 1727-1733; DOI: https://doi.org/10.1124/dmd.115.064659
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  Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan Glucuronides

  Brandon T. Gufford, Tyler N. Graf, Noemi D. Paguigan, Nicholas H. Oberlies and Mary F. Paine

  Drug Metabolism and Disposition November 2015, 43 (11) 1734-1743; DOI: https://doi.org/10.1124/dmd.115.066076
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  The Reliability of Estimating K_i Values for Direct, Reversible Inhibition of Cytochrome P450 Enzymes from Corresponding IC₅₀ Values: A Retrospective Analysis of 343 Experiments

  Lois J. Haupt, Faraz Kazmi, Brian W. Ogilvie, David B. Buckley, Brian D. Smith, Sarah Leatherman, Brandy Paris, Oliver Parkinson and Andrew Parkinson

  Drug Metabolism and Disposition November 2015, 43 (11) 1744-1750; DOI: https://doi.org/10.1124/dmd.115.066597
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  Fasiglifam (TAK-875) Inhibits Hepatobiliary Transporters: A Possible Factor Contributing to Fasiglifam-Induced Liver Injury

  Xiuli Li, Kan Zhong, Zitao Guo, Dafang Zhong and Xiaoyan Chen

  Drug Metabolism and Disposition November 2015, 43 (11) 1751-1759; DOI: https://doi.org/10.1124/dmd.115.064121
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  Prediction of the Clinical Risk of Drug-Induced Cholestatic Liver Injury Using an In Vitro Sandwich Cultured Hepatocyte Assay

  Takeshi Susukida, Shuichi Sekine, Mayuka Nozaki, Mayuko Tokizono and Kousei Ito

  Drug Metabolism and Disposition November 2015, 43 (11) 1760-1768; DOI: https://doi.org/10.1124/dmd.115.065425
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  Potent and Selective Inhibition of Plasma Membrane Monoamine Transporter by HIV Protease Inhibitors

  Haichuan Duan, Tao Hu, Robert S. Foti, Yongmei Pan, Peter W. Swaan and Joanne Wang

  Drug Metabolism and Disposition November 2015, 43 (11) 1773-1780; DOI: https://doi.org/10.1124/dmd.115.064824
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  Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists

  Albert Braeuning, Maria Thomas, Ute Hofmann, Silvia Vetter, Eva Zeller, Barbara Petzuch, Janina Johänning, Werner Schroth, Thomas S. Weiss, Ulrich M. Zanger and Michael Schwarz

  Drug Metabolism and Disposition November 2015, 43 (11) 1781-1787; DOI: https://doi.org/10.1124/dmd.115.064667
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  Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake

  Bridget L. Morse, Hong Cai, Jamus G. MacGuire, Maxine Fox, Lisa Zhang, Yueping Zhang, Xiaomei Gu, Hong Shen, Elizabeth A. Dierks, Hong Su, Chiuwa E. Luk, Punit Marathe, Yue-Zhong Shu, W. Griffith Humphreys and Yurong Lai

  Drug Metabolism and Disposition November 2015, 43 (11) 1788-1794; DOI: https://doi.org/10.1124/dmd.115.065946
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  Modulation of P-glycoprotein at the Human Blood-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study

  Li Liu, Ann C. Collier, Jeanne M. Link, Karen B. Domino, David A. Mankoff, Janet F. Eary, Charles F. Spiekerman, Peng Hsiao, Anand K. Deo and Jashvant D. Unadkat

  Drug Metabolism and Disposition November 2015, 43 (11) 1795-1804; DOI: https://doi.org/10.1124/dmd.114.058685
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  In Vitro Characterization of the Human Liver Microsomal Kinetics and Reaction Phenotyping of Olanzapine Metabolism

  Porntipa Korprasertthaworn, Thomas M. Polasek, Michael J. Sorich, Andrew J. McLachlan, John O. Miners, Geoffrey T. Tucker and Andrew Rowland

  Drug Metabolism and Disposition November 2015, 43 (11) 1806-1814; DOI: https://doi.org/10.1124/dmd.115.064790
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  New Photosafety Assessment Strategy Based on the Photochemical and Pharmacokinetic Properties of Both Parent Chemicals and Metabolites

  Masashi Kato, Gen Suzuki, Hiroto Ohtake, Yoshiki Seto and Satomi Onoue

  Drug Metabolism and Disposition November 2015, 43 (11) 1815-1822; DOI: https://doi.org/10.1124/dmd.115.065060