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Research ArticleArticle

In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice

Kazuto Yasuda, Cynthia Cline, Yvonne S. Lin, Rachel Scheib, Samit Ganguly, Ranjit K. Thirumaran, Amarjit Chaudhry, Richard B. Kim and Erin G. Schuetz
Drug Metabolism and Disposition November 2015, 43 (11) 1646-1654; DOI: https://doi.org/10.1124/dmd.115.065078
Kazuto Yasuda
Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (K.Y., C.C., R.S., S.G., R.K.T., A.C., E.G.S.); Department of Medicine, Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada (R.B.K.); and Department of Pharmaceutics, The University of Washington, Seattle, Washington (Y.S.L.)
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Cynthia Cline
Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (K.Y., C.C., R.S., S.G., R.K.T., A.C., E.G.S.); Department of Medicine, Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada (R.B.K.); and Department of Pharmaceutics, The University of Washington, Seattle, Washington (Y.S.L.)
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Yvonne S. Lin
Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (K.Y., C.C., R.S., S.G., R.K.T., A.C., E.G.S.); Department of Medicine, Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada (R.B.K.); and Department of Pharmaceutics, The University of Washington, Seattle, Washington (Y.S.L.)
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Rachel Scheib
Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (K.Y., C.C., R.S., S.G., R.K.T., A.C., E.G.S.); Department of Medicine, Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada (R.B.K.); and Department of Pharmaceutics, The University of Washington, Seattle, Washington (Y.S.L.)
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Samit Ganguly
Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (K.Y., C.C., R.S., S.G., R.K.T., A.C., E.G.S.); Department of Medicine, Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada (R.B.K.); and Department of Pharmaceutics, The University of Washington, Seattle, Washington (Y.S.L.)
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Ranjit K. Thirumaran
Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (K.Y., C.C., R.S., S.G., R.K.T., A.C., E.G.S.); Department of Medicine, Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada (R.B.K.); and Department of Pharmaceutics, The University of Washington, Seattle, Washington (Y.S.L.)
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Amarjit Chaudhry
Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (K.Y., C.C., R.S., S.G., R.K.T., A.C., E.G.S.); Department of Medicine, Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada (R.B.K.); and Department of Pharmaceutics, The University of Washington, Seattle, Washington (Y.S.L.)
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Richard B. Kim
Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (K.Y., C.C., R.S., S.G., R.K.T., A.C., E.G.S.); Department of Medicine, Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada (R.B.K.); and Department of Pharmaceutics, The University of Washington, Seattle, Washington (Y.S.L.)
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Erin G. Schuetz
Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (K.Y., C.C., R.S., S.G., R.K.T., A.C., E.G.S.); Department of Medicine, Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada (R.B.K.); and Department of Pharmaceutics, The University of Washington, Seattle, Washington (Y.S.L.)
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Article Information

vol. 43 no. 11 1646-1654
DOI 
https://doi.org/10.1124/dmd.115.065078
PubMed 
26281846

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 24, 2015
  • Accepted August 12, 2015
  • Published online September 29, 2015.

Article Versions

  • Earlier version (August 17, 2015 - 08:26).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kazuto Yasuda,
  2. Cynthia Cline,
  3. Yvonne S. Lin,
  4. Rachel Scheib,
  5. Samit Ganguly,
  6. Ranjit K. Thirumaran,
  7. Amarjit Chaudhry,
  8. Richard B. Kim, and
  9. Erin G. Schuetz
  1. Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (K.Y., C.C., R.S., S.G., R.K.T., A.C., E.G.S.); Department of Medicine, Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada (R.B.K.); and Department of Pharmaceutics, The University of Washington, Seattle, Washington (Y.S.L.)
  1. Address correspondence to:
    Dr. Erin G. Schuetz, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105. E-mail: erin.schuetz{at}stjude.org
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Drug Metabolism and Disposition: 43 (11)
Drug Metabolism and Disposition
Vol. 43, Issue 11
1 Nov 2015
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Research ArticleArticle

Human MDR1-luc CNS Reporter Mice

Kazuto Yasuda, Cynthia Cline, Yvonne S. Lin, Rachel Scheib, Samit Ganguly, Ranjit K. Thirumaran, Amarjit Chaudhry, Richard B. Kim and Erin G. Schuetz
Drug Metabolism and Disposition November 1, 2015, 43 (11) 1646-1654; DOI: https://doi.org/10.1124/dmd.115.065078

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Research ArticleArticle

Human MDR1-luc CNS Reporter Mice

Kazuto Yasuda, Cynthia Cline, Yvonne S. Lin, Rachel Scheib, Samit Ganguly, Ranjit K. Thirumaran, Amarjit Chaudhry, Richard B. Kim and Erin G. Schuetz
Drug Metabolism and Disposition November 1, 2015, 43 (11) 1646-1654; DOI: https://doi.org/10.1124/dmd.115.065078
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