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Research ArticleArticle

Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan Glucuronides

Brandon T. Gufford, Tyler N. Graf, Noemi D. Paguigan, Nicholas H. Oberlies and Mary F. Paine
Drug Metabolism and Disposition November 2015, 43 (11) 1734-1743; DOI: https://doi.org/10.1124/dmd.115.066076
Brandon T. Gufford
Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, Washington (B.T.G., M.F.P.); and Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.D.P., N.H.O.)
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Tyler N. Graf
Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, Washington (B.T.G., M.F.P.); and Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.D.P., N.H.O.)
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Noemi D. Paguigan
Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, Washington (B.T.G., M.F.P.); and Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.D.P., N.H.O.)
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Nicholas H. Oberlies
Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, Washington (B.T.G., M.F.P.); and Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.D.P., N.H.O.)
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Mary F. Paine
Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, Washington (B.T.G., M.F.P.); and Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.D.P., N.H.O.)
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Article Information

vol. 43 no. 11 1734-1743
DOI 
https://doi.org/10.1124/dmd.115.066076
PubMed 
26316643

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 26, 2015
  • Accepted August 26, 2015
  • Published online October 7, 2015.

Article Versions

  • Earlier version (August 27, 2015 - 09:37).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Brandon T. Gufford,
  2. Tyler N. Graf,
  3. Noemi D. Paguigan,
  4. Nicholas H. Oberlies, and
  5. Mary F. Paine
  1. Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, Washington (B.T.G., M.F.P.); and Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.D.P., N.H.O.)
  1. Address correspondence to:
    Dr. Mary F. Paine, Experimental and Systems Pharmacology, WSU College of Pharmacy, PBS 341, P.O. Box 1495, Spokane, WA 99210-1495. E-mail: mary.paine{at}wsu.edu
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Drug Metabolism and Disposition: 43 (11)
Drug Metabolism and Disposition
Vol. 43, Issue 11
1 Nov 2015
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Research ArticleArticle

Synthesis and Characterization of Milk Thistle Glucuronides

Brandon T. Gufford, Tyler N. Graf, Noemi D. Paguigan, Nicholas H. Oberlies and Mary F. Paine
Drug Metabolism and Disposition November 1, 2015, 43 (11) 1734-1743; DOI: https://doi.org/10.1124/dmd.115.066076

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Research ArticleArticle

Synthesis and Characterization of Milk Thistle Glucuronides

Brandon T. Gufford, Tyler N. Graf, Noemi D. Paguigan, Nicholas H. Oberlies and Mary F. Paine
Drug Metabolism and Disposition November 1, 2015, 43 (11) 1734-1743; DOI: https://doi.org/10.1124/dmd.115.066076
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