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Research ArticleArticle

In Vitro Characterization of the Human Liver Microsomal Kinetics and Reaction Phenotyping of Olanzapine Metabolism

Porntipa Korprasertthaworn, Thomas M. Polasek, Michael J. Sorich, Andrew J. McLachlan, John O. Miners, Geoffrey T. Tucker and Andrew Rowland
Drug Metabolism and Disposition November 2015, 43 (11) 1806-1814; DOI: https://doi.org/10.1124/dmd.115.064790
Porntipa Korprasertthaworn
Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, Flinders University School of Medicine, Adelaide, Australia (P.K., T.M.P., M.J.S., J.O.M., A.R.); Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand (P.K.); Faculty of Pharmacy, University of Sydney, Sydney, Australia (A.J.M.); and University of Sheffield (Emeritus), Sheffield, United Kingdom (G.T.T.)
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Thomas M. Polasek
Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, Flinders University School of Medicine, Adelaide, Australia (P.K., T.M.P., M.J.S., J.O.M., A.R.); Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand (P.K.); Faculty of Pharmacy, University of Sydney, Sydney, Australia (A.J.M.); and University of Sheffield (Emeritus), Sheffield, United Kingdom (G.T.T.)
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Michael J. Sorich
Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, Flinders University School of Medicine, Adelaide, Australia (P.K., T.M.P., M.J.S., J.O.M., A.R.); Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand (P.K.); Faculty of Pharmacy, University of Sydney, Sydney, Australia (A.J.M.); and University of Sheffield (Emeritus), Sheffield, United Kingdom (G.T.T.)
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Andrew J. McLachlan
Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, Flinders University School of Medicine, Adelaide, Australia (P.K., T.M.P., M.J.S., J.O.M., A.R.); Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand (P.K.); Faculty of Pharmacy, University of Sydney, Sydney, Australia (A.J.M.); and University of Sheffield (Emeritus), Sheffield, United Kingdom (G.T.T.)
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John O. Miners
Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, Flinders University School of Medicine, Adelaide, Australia (P.K., T.M.P., M.J.S., J.O.M., A.R.); Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand (P.K.); Faculty of Pharmacy, University of Sydney, Sydney, Australia (A.J.M.); and University of Sheffield (Emeritus), Sheffield, United Kingdom (G.T.T.)
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Geoffrey T. Tucker
Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, Flinders University School of Medicine, Adelaide, Australia (P.K., T.M.P., M.J.S., J.O.M., A.R.); Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand (P.K.); Faculty of Pharmacy, University of Sydney, Sydney, Australia (A.J.M.); and University of Sheffield (Emeritus), Sheffield, United Kingdom (G.T.T.)
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Andrew Rowland
Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, Flinders University School of Medicine, Adelaide, Australia (P.K., T.M.P., M.J.S., J.O.M., A.R.); Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand (P.K.); Faculty of Pharmacy, University of Sydney, Sydney, Australia (A.J.M.); and University of Sheffield (Emeritus), Sheffield, United Kingdom (G.T.T.)
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Article Information

vol. 43 no. 11 1806-1814
DOI 
https://doi.org/10.1124/dmd.115.064790
PubMed 
26329789

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 29, 2015
  • Accepted August 31, 2015
  • Published online October 13, 2015.

Article Versions

  • Earlier version (September 1, 2015 - 07:19).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Porntipa Korprasertthaworn,
  2. Thomas M. Polasek,
  3. Michael J. Sorich,
  4. Andrew J. McLachlan,
  5. John O. Miners,
  6. Geoffrey T. Tucker, and
  7. Andrew Rowland
  1. Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, Flinders University School of Medicine, Adelaide, Australia (P.K., T.M.P., M.J.S., J.O.M., A.R.); Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand (P.K.); Faculty of Pharmacy, University of Sydney, Sydney, Australia (A.J.M.); and University of Sheffield (Emeritus), Sheffield, United Kingdom (G.T.T.)
  1. Address correspondence to:
    Dr. Andrew Rowland, Department of Clinical Pharmacology, Flinders University School of Medicine, Flinders Medical Centre, Bedford Park, SA 5042, Australia. E-mail andrew.rowland{at}flinders.edu.au
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Drug Metabolism and Disposition: 43 (11)
Drug Metabolism and Disposition
Vol. 43, Issue 11
1 Nov 2015
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Research ArticleArticle

In Vitro Characterization of Olanzapine Metabolism

Porntipa Korprasertthaworn, Thomas M. Polasek, Michael J. Sorich, Andrew J. McLachlan, John O. Miners, Geoffrey T. Tucker and Andrew Rowland
Drug Metabolism and Disposition November 1, 2015, 43 (11) 1806-1814; DOI: https://doi.org/10.1124/dmd.115.064790

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Research ArticleArticle

In Vitro Characterization of Olanzapine Metabolism

Porntipa Korprasertthaworn, Thomas M. Polasek, Michael J. Sorich, Andrew J. McLachlan, John O. Miners, Geoffrey T. Tucker and Andrew Rowland
Drug Metabolism and Disposition November 1, 2015, 43 (11) 1806-1814; DOI: https://doi.org/10.1124/dmd.115.064790
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