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Drug Metabolism & Disposition

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Table of Contents

December 01, 2015; Volume 43,Issue 12

Minireview

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    Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists
    J. Matthew Hutzler, Barbara J. Ring and Shelby R. Anderson
    Drug Metabolism and Disposition December 2015, 43 (12) 1917-1928; DOI: https://doi.org/10.1124/dmd.115.066431

Short Communications

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    Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450–Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor
    Ryan H. Takahashi, Shuguang Ma, Sarah J. Robinson, Qin Yue, Edna F. Choo and S. Cyrus Khojasteh
    Drug Metabolism and Disposition December 2015, 43 (12) 1929-1933; DOI: https://doi.org/10.1124/dmd.115.067181
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    The Nonspecific Binding of Tyrosine Kinase Inhibitors to Human Liver Microsomes
    Kushari Burns, Pramod C. Nair, Andrew Rowland, Peter I. Mackenzie, Kathleen M. Knights and John O. Miners
    Drug Metabolism and Disposition December 2015, 43 (12) 1934-1937; DOI: https://doi.org/10.1124/dmd.115.065292
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    Functional Characterization of Carrier-Mediated Transport of Pravastatin across the Blood-Retinal Barrier in Rats
    Shinobu Fujii, Chikako Setoguchi, Kouichi Kawazu and Ken-ichi Hosoya
    Drug Metabolism and Disposition December 2015, 43 (12) 1956-1959; DOI: https://doi.org/10.1124/dmd.115.066266
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    Leflunomide Induces Pulmonary and Hepatic CYP1A Enzymes via Aryl Hydrocarbon Receptor
    Ananddeep Patel, Shaojie Zhang, Maturu Paramahamsa, Weiwu Jiang, Lihua Wang, Bhagavatula Moorthy and Binoy Shivanna
    Drug Metabolism and Disposition December 2015, 43 (12) 1966-1970; DOI: https://doi.org/10.1124/dmd.115.066084

Articles

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    Xenobiotic Metabolism in Mice Lacking the UDP-Glucuronosyltransferase 2 Family
    Matthew J. Fay, My Trang Nguyen, John N. Snouwaert, Rebecca Dye, Delores J. Grant, Wanda M. Bodnar and Beverly H. Koller
    Drug Metabolism and Disposition December 2015, 43 (12) 1838-1846; DOI: https://doi.org/10.1124/dmd.115.065482
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    Organic Anion Transporter 1 Is Inhibited by Multiple Mechanisms and Shows a Transport Mode Independent of Exchange
    Adam G. Hotchkiss, Tiandai Gao, Usman Khan, Liam Berrigan, Mansong Li, Leslie Ingraham and Ryan M. Pelis
    Drug Metabolism and Disposition December 2015, 43 (12) 1847-1854; DOI: https://doi.org/10.1124/dmd.115.065748
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    Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors
    Wei Wu, Kevin T. Bush, Henry C. Liu, Christopher Zhu, Ruben Abagyan and Sanjay K. Nigam
    Drug Metabolism and Disposition December 2015, 43 (12) 1855-1863; DOI: https://doi.org/10.1124/dmd.115.065250
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    Chiral Plasma Pharmacokinetics of 3,4-Methylenedioxymethamphetamine and its Phase I and II Metabolites following Controlled Administration to Humans
    Andrea E. Steuer, Corina Schmidhauser, Yasmin Schmid, Anna Rickli, Matthias E. Liechti and Thomas Kraemer
    Drug Metabolism and Disposition December 2015, 43 (12) 1864-1871; DOI: https://doi.org/10.1124/dmd.115.066340
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    Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins
    Jia Yin, Haichuan Duan, Yoshiyuki Shirasaka, Bhagwat Prasad and Joanne Wang
    Drug Metabolism and Disposition December 2015, 43 (12) 1872-1881; DOI: https://doi.org/10.1124/dmd.115.066175
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    Insights into the Impact of Heterogeneous Glycosylation on the Pharmacokinetic Behavior of Follistatin-Fc–Based Biotherapeutics
    Amita Datta-Mannan, Lihua Huang, Jennifer Pereira, Benjamin Yaden, Andrew Korytko and Johnny E. Croy
    Drug Metabolism and Disposition December 2015, 43 (12) 1882-1890; DOI: https://doi.org/10.1124/dmd.115.064519
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    Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis
    Kaisa A. Salminen, Minna Rahnasto-Rilla, Raija Väänänen, Peter Imming, Achim Meyer, Aline Horling, Antti Poso, Tuomo Laitinen, Hannu Raunio and Maija Lahtela-Kakkonen
    Drug Metabolism and Disposition December 2015, 43 (12) 1891-1904; DOI: https://doi.org/10.1124/dmd.115.065755
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    In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases
    Josiane de Oliveira Cardoso, Regina Vincenzi Oliveira, Jessica Bo Li Lu and Zeruesenay Desta
    Drug Metabolism and Disposition December 2015, 43 (12) 1905-1916; DOI: https://doi.org/10.1124/dmd.115.065763
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    Dose of Phenobarbital and Age of Treatment at Early Life are Two Key Factors for the Persistent Induction of Cytochrome P450 Enzymes in Adult Mouse Liver
    Yun-Chen Tien, Ke Liu, Chad Pope, Pengcheng Wang, Xiaochao Ma and Xiao-bo Zhong
    Drug Metabolism and Disposition December 2015, 43 (12) 1938-1945; DOI: https://doi.org/10.1124/dmd.115.066316
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    Penetration of Treosulfan and its Active Monoepoxide Transformation Product into Central Nervous System of Juvenile and Young Adult Rats
    Michał Romański, Joachim Baumgart, Sonja Böhm and Franciszek K. Główka
    Drug Metabolism and Disposition December 2015, 43 (12) 1946-1954; DOI: https://doi.org/10.1124/dmd.115.066050
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    In Vitro and In Vivo Mechanistic Studies toward Understanding the Role of 1-Aminobenzotriazole in Rat Drug-Drug Interactions
    Marc-Olivier Boily, Nathalie Chauret, Julie Laterreur, François A. Leblond, Chantal Boudreau, Marie-Claude Duquet, Jean-François Lévesque, Line Ste-Marie and Vincent Pichette
    Drug Metabolism and Disposition December 2015, 43 (12) 1960-1965; DOI: https://doi.org/10.1124/dmd.115.066357

Erratum

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    Correction to “Metabolite Profiling of Bendamustine in Urine of Cancer Patients after Administration of [14C]Bendamustine”
    Drug Metabolism and Disposition December 2015, 43 (12) 1955; DOI: https://doi.org/10.1124/dmd.112.045229err
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Drug Metabolism and Disposition: 43 (12)
Drug Metabolism and Disposition
Vol. 43, Issue 12
1 Dec 2015
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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