Drug Metabolism and Disposition: 43 (12)

December 01, 2015; Volume 43,Issue 12

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Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists
J. Matthew Hutzler, Barbara J. Ring and Shelby R. Anderson

Drug Metabolism and Disposition December 2015, 43 (12) 1917-1928; DOI: https://doi.org/10.1124/dmd.115.066431

Short Communications

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Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450–Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor
Ryan H. Takahashi, Shuguang Ma, Sarah J. Robinson, Qin Yue, Edna F. Choo and S. Cyrus Khojasteh

Drug Metabolism and Disposition December 2015, 43 (12) 1929-1933; DOI: https://doi.org/10.1124/dmd.115.067181
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The Nonspecific Binding of Tyrosine Kinase Inhibitors to Human Liver Microsomes
Kushari Burns, Pramod C. Nair, Andrew Rowland, Peter I. Mackenzie, Kathleen M. Knights and John O. Miners

Drug Metabolism and Disposition December 2015, 43 (12) 1934-1937; DOI: https://doi.org/10.1124/dmd.115.065292
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Functional Characterization of Carrier-Mediated Transport of Pravastatin across the Blood-Retinal Barrier in Rats
Shinobu Fujii, Chikako Setoguchi, Kouichi Kawazu and Ken-ichi Hosoya

Drug Metabolism and Disposition December 2015, 43 (12) 1956-1959; DOI: https://doi.org/10.1124/dmd.115.066266
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Leflunomide Induces Pulmonary and Hepatic CYP1A Enzymes via Aryl Hydrocarbon Receptor
Ananddeep Patel, Shaojie Zhang, Maturu Paramahamsa, Weiwu Jiang, Lihua Wang, Bhagavatula Moorthy and Binoy Shivanna

Drug Metabolism and Disposition December 2015, 43 (12) 1966-1970; DOI: https://doi.org/10.1124/dmd.115.066084

Articles

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Xenobiotic Metabolism in Mice Lacking the UDP-Glucuronosyltransferase 2 Family
Matthew J. Fay, My Trang Nguyen, John N. Snouwaert, Rebecca Dye, Delores J. Grant, Wanda M. Bodnar and Beverly H. Koller

Drug Metabolism and Disposition December 2015, 43 (12) 1838-1846; DOI: https://doi.org/10.1124/dmd.115.065482
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Organic Anion Transporter 1 Is Inhibited by Multiple Mechanisms and Shows a Transport Mode Independent of Exchange
Adam G. Hotchkiss, Tiandai Gao, Usman Khan, Liam Berrigan, Mansong Li, Leslie Ingraham and Ryan M. Pelis

Drug Metabolism and Disposition December 2015, 43 (12) 1847-1854; DOI: https://doi.org/10.1124/dmd.115.065748
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Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors
Wei Wu, Kevin T. Bush, Henry C. Liu, Christopher Zhu, Ruben Abagyan and Sanjay K. Nigam

Drug Metabolism and Disposition December 2015, 43 (12) 1855-1863; DOI: https://doi.org/10.1124/dmd.115.065250
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Chiral Plasma Pharmacokinetics of 3,4-Methylenedioxymethamphetamine and its Phase I and II Metabolites following Controlled Administration to Humans
Andrea E. Steuer, Corina Schmidhauser, Yasmin Schmid, Anna Rickli, Matthias E. Liechti and Thomas Kraemer

Drug Metabolism and Disposition December 2015, 43 (12) 1864-1871; DOI: https://doi.org/10.1124/dmd.115.066340
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Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins
Jia Yin, Haichuan Duan, Yoshiyuki Shirasaka, Bhagwat Prasad and Joanne Wang

Drug Metabolism and Disposition December 2015, 43 (12) 1872-1881; DOI: https://doi.org/10.1124/dmd.115.066175
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Insights into the Impact of Heterogeneous Glycosylation on the Pharmacokinetic Behavior of Follistatin-Fc–Based Biotherapeutics
Amita Datta-Mannan, Lihua Huang, Jennifer Pereira, Benjamin Yaden, Andrew Korytko and Johnny E. Croy

Drug Metabolism and Disposition December 2015, 43 (12) 1882-1890; DOI: https://doi.org/10.1124/dmd.115.064519
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Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis
Kaisa A. Salminen, Minna Rahnasto-Rilla, Raija Väänänen, Peter Imming, Achim Meyer, Aline Horling, Antti Poso, Tuomo Laitinen, Hannu Raunio and Maija Lahtela-Kakkonen

Drug Metabolism and Disposition December 2015, 43 (12) 1891-1904; DOI: https://doi.org/10.1124/dmd.115.065755
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In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases
Josiane de Oliveira Cardoso, Regina Vincenzi Oliveira, Jessica Bo Li Lu and Zeruesenay Desta

Drug Metabolism and Disposition December 2015, 43 (12) 1905-1916; DOI: https://doi.org/10.1124/dmd.115.065763
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Dose of Phenobarbital and Age of Treatment at Early Life are Two Key Factors for the Persistent Induction of Cytochrome P450 Enzymes in Adult Mouse Liver
Yun-Chen Tien, Ke Liu, Chad Pope, Pengcheng Wang, Xiaochao Ma and Xiao-bo Zhong

Drug Metabolism and Disposition December 2015, 43 (12) 1938-1945; DOI: https://doi.org/10.1124/dmd.115.066316
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Penetration of Treosulfan and its Active Monoepoxide Transformation Product into Central Nervous System of Juvenile and Young Adult Rats
Michał Romański, Joachim Baumgart, Sonja Böhm and Franciszek K. Główka

Drug Metabolism and Disposition December 2015, 43 (12) 1946-1954; DOI: https://doi.org/10.1124/dmd.115.066050
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In Vitro and In Vivo Mechanistic Studies toward Understanding the Role of 1-Aminobenzotriazole in Rat Drug-Drug Interactions
Marc-Olivier Boily, Nathalie Chauret, Julie Laterreur, François A. Leblond, Chantal Boudreau, Marie-Claude Duquet, Jean-François Lévesque, Line Ste-Marie and Vincent Pichette

Drug Metabolism and Disposition December 2015, 43 (12) 1960-1965; DOI: https://doi.org/10.1124/dmd.115.066357

Erratum

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Correction to “Metabolite Profiling of Bendamustine in Urine of Cancer Patients after Administration of [¹⁴C]Bendamustine”
Drug Metabolism and Disposition December 2015, 43 (12) 1955; DOI: https://doi.org/10.1124/dmd.112.045229err

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