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Research ArticleArticle

Dose of Phenobarbital and Age of Treatment at Early Life are Two Key Factors for the Persistent Induction of Cytochrome P450 Enzymes in Adult Mouse Liver

Yun-Chen Tien, Ke Liu, Chad Pope, Pengcheng Wang, Xiaochao Ma and Xiao-bo Zhong
Drug Metabolism and Disposition December 2015, 43 (12) 1938-1945; DOI: https://doi.org/10.1124/dmd.115.066316
Yun-Chen Tien
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (Y.C.T., C.P., X.B.Z.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (K.L., P.W., X.M.)
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Ke Liu
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (Y.C.T., C.P., X.B.Z.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (K.L., P.W., X.M.)
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Chad Pope
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (Y.C.T., C.P., X.B.Z.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (K.L., P.W., X.M.)
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Pengcheng Wang
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (Y.C.T., C.P., X.B.Z.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (K.L., P.W., X.M.)
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Xiaochao Ma
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (Y.C.T., C.P., X.B.Z.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (K.L., P.W., X.M.)
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Xiao-bo Zhong
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (Y.C.T., C.P., X.B.Z.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (K.L., P.W., X.M.)
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Article Information

vol. 43 no. 12 1938-1945
DOI 
https://doi.org/10.1124/dmd.115.066316
PubMed 
26400395

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 16, 2015
  • Accepted September 21, 2015
  • Published online November 5, 2015.

Article Versions

  • Earlier version (September 23, 2015 - 07:09).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yun-Chen Tien,
  2. Ke Liu,
  3. Chad Pope,
  4. Pengcheng Wang,
  5. Xiaochao Ma, and
  6. Xiao-bo Zhong
  1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (Y.C.T., C.P., X.B.Z.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (K.L., P.W., X.M.)
  1. Address correspondence to:
    Dr. Xiao-bo Zhong, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 N Eagleville Road, Storrs, CT 06269. E-mail: xiaobo.zhong{at}uconn.edu.
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Drug Metabolism and Disposition: 43 (12)
Drug Metabolism and Disposition
Vol. 43, Issue 12
1 Dec 2015
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Research ArticleArticle

Persistent Induction of P450s by Phenobarbital Treatment

Yun-Chen Tien, Ke Liu, Chad Pope, Pengcheng Wang, Xiaochao Ma and Xiao-bo Zhong
Drug Metabolism and Disposition December 1, 2015, 43 (12) 1938-1945; DOI: https://doi.org/10.1124/dmd.115.066316

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Research ArticleArticle

Persistent Induction of P450s by Phenobarbital Treatment

Yun-Chen Tien, Ke Liu, Chad Pope, Pengcheng Wang, Xiaochao Ma and Xiao-bo Zhong
Drug Metabolism and Disposition December 1, 2015, 43 (12) 1938-1945; DOI: https://doi.org/10.1124/dmd.115.066316
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