Table of Contents

Articles

• You have access

  Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone

  Yuan Chen, Jialin Mao and Cornelis E. C. A. Hop

  Drug Metabolism and Disposition February 2015, 43 (2) 182-189; DOI: https://doi.org/10.1124/dmd.114.059311
• You have access

  Comparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing Assessment

  Raman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. Kalgutkar

  Drug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218
• You have access

  Zinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 Cells

  Kathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. Thompson

  Drug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216
• You have access

  Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo

  Zhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin Ding

  Drug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812
• You have access

  Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model

  Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki

  Drug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046
• You have access

  Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug Interactions

  Saki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi Sugiyama

  Drug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105
• You have access

  Mass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl Conjugate

  Óscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix Hernández

  Drug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416
• You have access

  Drug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese Mice

  Petra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka Skálová

  Drug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176
• You have access

  Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis

  Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. Cherrington

  Drug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574
• You have access

  A Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells

  Marcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. Zanger

  Drug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962
• You have access

  Absorption, Metabolism, and Excretion of Oral ¹⁴C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men

  Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens

  Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061