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Drug Metabolism & Disposition

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Table of Contents

February 01, 2015; Volume 43,Issue 2

Perspective

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    Mass Cytometry: A Highly Multiplexed Single-Cell Technology for Advancing Drug Development
    Kondala R. Atkuri, Jeffrey C. Stevens and Hendrik Neubert
    Drug Metabolism and Disposition February 2015, 43 (2) 227-233; DOI: https://doi.org/10.1124/dmd.114.060798

Short Communication

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    Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Relationship
    Vineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. Unadkat
    Drug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614

Articles

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    Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone
    Yuan Chen, Jialin Mao and Cornelis E. C. A. Hop
    Drug Metabolism and Disposition February 2015, 43 (2) 182-189; DOI: https://doi.org/10.1124/dmd.114.059311
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    Comparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing Assessment
    Raman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. Kalgutkar
    Drug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218
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    Zinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 Cells
    Kathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. Thompson
    Drug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216
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    Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo
    Zhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin Ding
    Drug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812
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    Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model
    Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki
    Drug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046
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    Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsGraphic
    Saki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi Sugiyama
    Drug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105
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    Mass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl Conjugate
    Óscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix Hernández
    Drug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416
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    Drug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese Mice
    Petra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka Skálová
    Drug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176
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    Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis
    Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. Cherrington
    Drug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574
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    A Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells
    Marcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. Zanger
    Drug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962
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    Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men
    Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
    Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061

Notice of Retraction

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    Notice of Retraction
    Drug Metabolism and Disposition February 2015, 43 (2) 234; DOI: https://doi.org/10.1124/dmd.114.045674err

Notice of Concern

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    Notice of Concern
    Drug Metabolism and Disposition February 2015, 43 (2) 298; DOI: https://doi.org/10.1124/dmd.114.03er15
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In this issue

Drug Metabolism and Disposition: 43 (2)
Drug Metabolism and Disposition
Vol. 43, Issue 2
1 Feb 2015
  • Table of Contents
  • Table of Contents (PDF)
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  • Index by author
  • Editorial Board (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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