Index by author
February 01, 2015; Volume 43,Issue 2
A
Atkinson, Karen
- You have accessComparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing AssessmentRaman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. KalgutkarDrug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218
Atkuri, Kondala R.
- You have accessMass Cytometry: A Highly Multiplexed Single-Cell Technology for Advancing Drug DevelopmentKondala R. Atkuri, Jeffrey C. Stevens and Hendrik NeubertDrug Metabolism and Disposition February 2015, 43 (2) 227-233; DOI: https://doi.org/10.1124/dmd.114.060798
B
Bártíková, Hana
- You have accessDrug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese MicePetra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka SkálováDrug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176
Bergman, Arthur
- You have accessComparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing AssessmentRaman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. KalgutkarDrug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218
Blasberg, Jim
- You have accessZinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 CellsKathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. ThompsonDrug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216
Bockx, Marc
- You have accessAbsorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy MenEllen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert MannensDrug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061
Bode, Nini
- You have accessAbsorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy MenEllen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert MannensDrug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061
Bourner, Maureen
- You have accessZinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 CellsKathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. ThompsonDrug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216
Boušová, Iva
- You have accessDrug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese MicePetra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka SkálováDrug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176
Brinker, Amanda
- You have accessZinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 CellsKathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. ThompsonDrug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216
C
Canet, Mark J.
- You have accessRenal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic SteatohepatitisMark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. CherringtonDrug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574
Chen, Yuan
- You have accessPhysiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of AmiodaroneYuan Chen, Jialin Mao and Cornelis E. C. A. HopDrug Metabolism and Disposition February 2015, 43 (2) 182-189; DOI: https://doi.org/10.1124/dmd.114.059311
Cherrington, Nathan J.
- You have accessRenal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic SteatohepatitisMark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. CherringtonDrug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574
Clarke, John D.
- You have accessRenal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic SteatohepatitisMark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. CherringtonDrug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574
Cuyckens, Filip
- You have accessAbsorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy MenEllen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert MannensDrug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061
D
Damm, Georg
- You have accessA Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG CellsMarcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. ZangerDrug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962
de Jong, Jan
- You have accessAbsorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy MenEllen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert MannensDrug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061
de la Torre, Rafael
- You have accessMass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl ConjugateÓscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix HernándezDrug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416
Di, Li
- You have accessComparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing AssessmentRaman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. KalgutkarDrug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218
Ding, Xinxin
- You have accessCharacterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In VivoZhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin DingDrug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812
Dzierlenga, Anika L.
- You have accessRenal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic SteatohepatitisMark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. CherringtonDrug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574
E
Evers, Raymond
- You have accessQuantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity RelationshipVineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. UnadkatDrug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614
F
Farré, Magí
- You have accessMass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl ConjugateÓscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix HernándezDrug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416
Fujikata, Akira
- You have accessAnalysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic ModelKazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi SuzukiDrug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046
G
Goedken, Michael J.
- You have accessRenal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic SteatohepatitisMark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. CherringtonDrug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574
Gupta, Anshul
- You have accessQuantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity RelationshipVineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. UnadkatDrug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614
Gustavson, Stephanie M.
- You have accessComparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing AssessmentRaman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. KalgutkarDrug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218
H
Hardwick, Rhiannon N.
- You have accessRenal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic SteatohepatitisMark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. CherringtonDrug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574
Hernández, Félix
- You have accessMass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl ConjugateÓscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix HernándezDrug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416
Hisaka, Akihiro
- You have accessAnalysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic ModelKazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi SuzukiDrug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046
Hofmann, Ute
- You have accessA Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG CellsMarcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. ZangerDrug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962
Hop, Cornelis E. C. A.
- You have accessPhysiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of AmiodaroneYuan Chen, Jialin Mao and Cornelis E. C. A. HopDrug Metabolism and Disposition February 2015, 43 (2) 182-189; DOI: https://doi.org/10.1124/dmd.114.059311
- You have accessQuantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity RelationshipVineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. UnadkatDrug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614
Hu, Jing
- You have accessCharacterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In VivoZhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin DingDrug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812
I
Ibáñez, María
- You have accessMass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl ConjugateÓscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix HernándezDrug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416
Izumi, Saki
- You have accessInvestigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsSaki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105
K
Kalgutkar, Amit S.
- You have accessComparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing AssessmentRaman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. KalgutkarDrug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218
Kaneko, Makoto
- You have accessAnalysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic ModelKazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi SuzukiDrug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046
Kazierad, David
- You have accessComparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing AssessmentRaman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. KalgutkarDrug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218
Klein, Marcus
- You have accessA Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG CellsMarcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. ZangerDrug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962
Komori, Takafumi
- You have accessInvestigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsSaki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105
Kumar, Vineet
- You have accessQuantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity RelationshipVineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. UnadkatDrug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614
Kusuhara, Hiroyuki
- You have accessInvestigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsSaki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105
L
Laenen, Aline
- You have accessAbsorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy MenEllen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert MannensDrug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061
Lahoz-Beneytez, Julio
- You have accessMass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl ConjugateÓscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix HernándezDrug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416
Lake, April D.
- You have accessRenal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic SteatohepatitisMark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. CherringtonDrug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574
Leclercq, Laurent
- You have accessAbsorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy MenEllen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert MannensDrug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061
Levorová, Lucie
- You have accessDrug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese MicePetra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka SkálováDrug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176
Li, Lei
- You have accessCharacterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In VivoZhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin DingDrug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812
Litchfield, John
- You have accessComparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing AssessmentRaman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. KalgutkarDrug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218
Liu, Zhihua
- You have accessCharacterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In VivoZhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin DingDrug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812
M
Ma, Jun
- You have accessCharacterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In VivoZhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin DingDrug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812
Maeda, Kazuya
- You have accessInvestigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsSaki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105
Mannens, Geert
- You have accessAbsorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy MenEllen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert MannensDrug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061
Mao, Jialin
- You have accessPhysiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of AmiodaroneYuan Chen, Jialin Mao and Cornelis E. C. A. HopDrug Metabolism and Disposition February 2015, 43 (2) 182-189; DOI: https://doi.org/10.1124/dmd.114.059311
Matoušková, Petra
- You have accessDrug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese MicePetra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka SkálováDrug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176
Minato, Kouichi
- You have accessAnalysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic ModelKazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi SuzukiDrug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046
Murphy, Joe
- You have accessAbsorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy MenEllen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert MannensDrug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061
N
Neubert, Hendrik
- You have accessMass Cytometry: A Highly Multiplexed Single-Cell Technology for Advancing Drug DevelopmentKondala R. Atkuri, Jeffrey C. Stevens and Hendrik NeubertDrug Metabolism and Disposition February 2015, 43 (2) 227-233; DOI: https://doi.org/10.1124/dmd.114.060798
Nozaki, Yoshitane
- You have accessInvestigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsSaki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105
O
Ohta, Shuji
- You have accessAnalysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic ModelKazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi SuzukiDrug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046
P
Papaseit, Esther
- You have accessMass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl ConjugateÓscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix HernándezDrug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416
Patilea, Gabriela
- You have accessQuantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity RelationshipVineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. UnadkatDrug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614
Pfefferkorn, Jeffrey A.
- You have accessComparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing AssessmentRaman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. KalgutkarDrug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218
Pozo, Óscar J.
- You have accessMass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl ConjugateÓscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix HernándezDrug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416
Prasad, Bhagwat
- You have accessQuantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity RelationshipVineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. UnadkatDrug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614
Pratt, Jennifer
- You have accessZinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 CellsKathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. ThompsonDrug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216
S
Salphati, Laurent
- You have accessQuantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity RelationshipVineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. UnadkatDrug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614
Sampson, Kathleen E.
- You have accessZinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 CellsKathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. ThompsonDrug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216
Sancho, Juan V.
- You have accessMass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl ConjugateÓscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix HernándezDrug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416
Sasaki, Makoto
- You have accessAnalysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic ModelKazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi SuzukiDrug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046
Scheers, Ellen
- You have accessAbsorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy MenEllen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert MannensDrug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061
Seehofer, Daniel
- You have accessA Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG CellsMarcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. ZangerDrug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962
Sharma, Raman
- You have accessComparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing AssessmentRaman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. KalgutkarDrug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218
Shirota, Kazuhiko
- You have accessAnalysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic ModelKazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi SuzukiDrug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046
Skálová, Lenka
- You have accessDrug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese MicePetra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka SkálováDrug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176
Skee, Donna
- You have accessAbsorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy MenEllen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert MannensDrug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061
Steiner, Toni
- You have accessZinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 CellsKathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. ThompsonDrug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216
Stevens, Jeffrey C.
- You have accessMass Cytometry: A Highly Multiplexed Single-Cell Technology for Advancing Drug DevelopmentKondala R. Atkuri, Jeffrey C. Stevens and Hendrik NeubertDrug Metabolism and Disposition February 2015, 43 (2) 227-233; DOI: https://doi.org/10.1124/dmd.114.060798
Sugiyama, Yuichi
- You have accessInvestigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsSaki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105
Sukbuntherng, Juthamas
- You have accessAbsorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy MenEllen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert MannensDrug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061
Suzuki, Hiroshi
- You have accessAnalysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic ModelKazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi SuzukiDrug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046
Szotáková, Barbora
- You have accessDrug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese MicePetra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka SkálováDrug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176
T
Takenaka, Osamu
- You have accessInvestigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsSaki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105
Thomas, Maria
- You have accessA Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG CellsMarcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. ZangerDrug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962
Thompson, David C.
- You have accessZinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 CellsKathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. ThompsonDrug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216
U
Unadkat, Jashvant D.
- You have accessQuantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity RelationshipVineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. UnadkatDrug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614
V
Venkatraman, Neetu
- You have accessZinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 CellsKathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. ThompsonDrug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216
W
Wu, Hong
- You have accessCharacterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In VivoZhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin DingDrug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812
X
Xiao, Yongling
- You have accessZinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 CellsKathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. ThompsonDrug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216
Z
Zanger, Ulrich M.
- You have accessA Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG CellsMarcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. ZangerDrug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962
Zhang, Qing-Yu
- You have accessCharacterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In VivoZhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin DingDrug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812
In this issue

Advertisement