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Index by author

February 01, 2015; Volume 43,Issue 2

A

  1. Atkinson, Karen

    1. Comparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing Assessment
      Raman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. Kalgutkar
      Drug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218

  2. Atkuri, Kondala R.

    1. Mass Cytometry: A Highly Multiplexed Single-Cell Technology for Advancing Drug Development
      Kondala R. Atkuri, Jeffrey C. Stevens and Hendrik Neubert
      Drug Metabolism and Disposition February 2015, 43 (2) 227-233; DOI: https://doi.org/10.1124/dmd.114.060798

B

  1. Bártíková, Hana

    1. Drug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese Mice
      Petra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka Skálová
      Drug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176

  2. Bergman, Arthur

    1. Comparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing Assessment
      Raman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. Kalgutkar
      Drug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218

  3. Blasberg, Jim

    1. Zinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 Cells
      Kathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. Thompson
      Drug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216

  4. Bockx, Marc

    1. Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men
      Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
      Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061

  5. Bode, Nini

    1. Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men
      Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
      Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061

  6. Bourner, Maureen

    1. Zinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 Cells
      Kathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. Thompson
      Drug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216

  7. Boušová, Iva

    1. Drug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese Mice
      Petra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka Skálová
      Drug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176

  8. Brinker, Amanda

    1. Zinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 Cells
      Kathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. Thompson
      Drug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216

C

  1. Canet, Mark J.

    1. Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574

  2. Chen, Yuan

    1. Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone
      Yuan Chen, Jialin Mao and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition February 2015, 43 (2) 182-189; DOI: https://doi.org/10.1124/dmd.114.059311

  3. Cherrington, Nathan J.

    1. Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574

  4. Clarke, John D.

    1. Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574

  5. Cuyckens, Filip

    1. Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men
      Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
      Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061

D

  1. Damm, Georg

    1. A Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells
      Marcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. Zanger
      Drug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962

  2. de Jong, Jan

    1. Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men
      Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
      Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061

  3. de la Torre, Rafael

    1. Mass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl Conjugate
      Óscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix Hernández
      Drug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416

  4. Di, Li

    1. Comparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing Assessment
      Raman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. Kalgutkar
      Drug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218

  5. Ding, Xinxin

    1. Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo
      Zhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812

  6. Dzierlenga, Anika L.

    1. Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574

E

  1. Evers, Raymond

    1. Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Relationship
      Vineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. Unadkat
      Drug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614

F

  1. Farré, Magí

    1. Mass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl Conjugate
      Óscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix Hernández
      Drug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416

  2. Fujikata, Akira

    1. Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model
      Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki
      Drug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046

G

  1. Goedken, Michael J.

    1. Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574

  2. Gupta, Anshul

    1. Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Relationship
      Vineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. Unadkat
      Drug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614

  3. Gustavson, Stephanie M.

    1. Comparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing Assessment
      Raman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. Kalgutkar
      Drug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218

H

  1. Hardwick, Rhiannon N.

    1. Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574

  2. Hernández, Félix

    1. Mass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl Conjugate
      Óscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix Hernández
      Drug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416

  3. Hisaka, Akihiro

    1. Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model
      Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki
      Drug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046

  4. Hofmann, Ute

    1. A Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells
      Marcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. Zanger
      Drug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962

  5. Hop, Cornelis E. C. A.

    1. Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone
      Yuan Chen, Jialin Mao and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition February 2015, 43 (2) 182-189; DOI: https://doi.org/10.1124/dmd.114.059311
    2. Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Relationship
      Vineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. Unadkat
      Drug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614

  6. Hu, Jing

    1. Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo
      Zhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812

I

  1. Ibáñez, María

    1. Mass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl Conjugate
      Óscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix Hernández
      Drug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416

  2. Izumi, Saki

    1. Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsGraphic
      Saki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105

K

  1. Kalgutkar, Amit S.

    1. Comparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing Assessment
      Raman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. Kalgutkar
      Drug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218

  2. Kaneko, Makoto

    1. Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model
      Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki
      Drug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046

  3. Kazierad, David

    1. Comparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing Assessment
      Raman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. Kalgutkar
      Drug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218

  4. Klein, Marcus

    1. A Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells
      Marcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. Zanger
      Drug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962

  5. Komori, Takafumi

    1. Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsGraphic
      Saki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105

  6. Kumar, Vineet

    1. Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Relationship
      Vineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. Unadkat
      Drug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614

  7. Kusuhara, Hiroyuki

    1. Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsGraphic
      Saki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105

L

  1. Laenen, Aline

    1. Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men
      Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
      Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061

  2. Lahoz-Beneytez, Julio

    1. Mass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl Conjugate
      Óscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix Hernández
      Drug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416

  3. Lake, April D.

    1. Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Anika L. Dzierlenga, John D. Clarke, Michael J. Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition February 2015, 43 (2) 266-272; DOI: https://doi.org/10.1124/dmd.114.060574

  4. Leclercq, Laurent

    1. Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men
      Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
      Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061

  5. Levorová, Lucie

    1. Drug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese Mice
      Petra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka Skálová
      Drug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176

  6. Li, Lei

    1. Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo
      Zhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812

  7. Litchfield, John

    1. Comparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing Assessment
      Raman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. Kalgutkar
      Drug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218

  8. Liu, Zhihua

    1. Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo
      Zhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812

M

  1. Ma, Jun

    1. Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo
      Zhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812

  2. Maeda, Kazuya

    1. Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsGraphic
      Saki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105

  3. Mannens, Geert

    1. Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men
      Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
      Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061

  4. Mao, Jialin

    1. Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone
      Yuan Chen, Jialin Mao and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition February 2015, 43 (2) 182-189; DOI: https://doi.org/10.1124/dmd.114.059311

  5. Matoušková, Petra

    1. Drug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese Mice
      Petra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka Skálová
      Drug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176

  6. Minato, Kouichi

    1. Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model
      Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki
      Drug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046

  7. Murphy, Joe

    1. Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men
      Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
      Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061

N

  1. Neubert, Hendrik

    1. Mass Cytometry: A Highly Multiplexed Single-Cell Technology for Advancing Drug Development
      Kondala R. Atkuri, Jeffrey C. Stevens and Hendrik Neubert
      Drug Metabolism and Disposition February 2015, 43 (2) 227-233; DOI: https://doi.org/10.1124/dmd.114.060798

  2. Nozaki, Yoshitane

    1. Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsGraphic
      Saki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105

O

  1. Ohta, Shuji

    1. Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model
      Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki
      Drug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046

P

  1. Papaseit, Esther

    1. Mass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl Conjugate
      Óscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix Hernández
      Drug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416

  2. Patilea, Gabriela

    1. Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Relationship
      Vineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. Unadkat
      Drug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614

  3. Pfefferkorn, Jeffrey A.

    1. Comparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing Assessment
      Raman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. Kalgutkar
      Drug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218

  4. Pozo, Óscar J.

    1. Mass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl Conjugate
      Óscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix Hernández
      Drug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416

  5. Prasad, Bhagwat

    1. Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Relationship
      Vineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. Unadkat
      Drug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614

  6. Pratt, Jennifer

    1. Zinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 Cells
      Kathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. Thompson
      Drug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216

S

  1. Salphati, Laurent

    1. Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Relationship
      Vineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. Unadkat
      Drug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614

  2. Sampson, Kathleen E.

    1. Zinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 Cells
      Kathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. Thompson
      Drug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216

  3. Sancho, Juan V.

    1. Mass Spectrometric Evaluation of Mephedrone In Vivo Human Metabolism: Identification of Phase I and Phase II Metabolites, Including a Novel Succinyl Conjugate
      Óscar J. Pozo, María Ibáñez, Juan V. Sancho, Julio Lahoz-Beneytez, Magí Farré, Esther Papaseit, Rafael de la Torre and Félix Hernández
      Drug Metabolism and Disposition February 2015, 43 (2) 248-257; DOI: https://doi.org/10.1124/dmd.114.061416

  4. Sasaki, Makoto

    1. Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model
      Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki
      Drug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046

  5. Scheers, Ellen

    1. Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men
      Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
      Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061

  6. Seehofer, Daniel

    1. A Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells
      Marcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. Zanger
      Drug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962

  7. Sharma, Raman

    1. Comparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing Assessment
      Raman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn and Amit S. Kalgutkar
      Drug Metabolism and Disposition February 2015, 43 (2) 190-198; DOI: https://doi.org/10.1124/dmd.114.061218

  8. Shirota, Kazuhiko

    1. Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model
      Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki
      Drug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046

  9. Skálová, Lenka

    1. Drug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese Mice
      Petra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka Skálová
      Drug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176

  10. Skee, Donna

    1. Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men
      Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
      Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061

  11. Steiner, Toni

    1. Zinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 Cells
      Kathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. Thompson
      Drug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216

  12. Stevens, Jeffrey C.

    1. Mass Cytometry: A Highly Multiplexed Single-Cell Technology for Advancing Drug Development
      Kondala R. Atkuri, Jeffrey C. Stevens and Hendrik Neubert
      Drug Metabolism and Disposition February 2015, 43 (2) 227-233; DOI: https://doi.org/10.1124/dmd.114.060798

  13. Sugiyama, Yuichi

    1. Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsGraphic
      Saki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105

  14. Sukbuntherng, Juthamas

    1. Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men
      Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
      Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061

  15. Suzuki, Hiroshi

    1. Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model
      Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki
      Drug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046

  16. Szotáková, Barbora

    1. Drug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese Mice
      Petra Matoušková, Hana Bártíková, Iva Boušová, Lucie Levorová, Barbora Szotáková and Lenka Skálová
      Drug Metabolism and Disposition February 2015, 43 (2) 258-265; DOI: https://doi.org/10.1124/dmd.114.061176

T

  1. Takenaka, Osamu

    1. Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug InteractionsGraphic
      Saki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition February 2015, 43 (2) 235-247; DOI: https://doi.org/10.1124/dmd.114.059105

  2. Thomas, Maria

    1. A Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells
      Marcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. Zanger
      Drug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962

  3. Thompson, David C.

    1. Zinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 Cells
      Kathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. Thompson
      Drug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216

U

  1. Unadkat, Jashvant D.

    1. Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Relationship
      Vineet Kumar, Bhagwat Prasad, Gabriela Patilea, Anshul Gupta, Laurent Salphati, Raymond Evers, Cornelis E. C. A. Hop and Jashvant D. Unadkat
      Drug Metabolism and Disposition February 2015, 43 (2) 284-288; DOI: https://doi.org/10.1124/dmd.114.061614

V

  1. Venkatraman, Neetu

    1. Zinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 Cells
      Kathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. Thompson
      Drug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216

W

  1. Wu, Hong

    1. Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo
      Zhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812

X

  1. Xiao, Yongling

    1. Zinc Finger Nuclease–Mediated Gene Knockout Results in Loss of Transport Activity for P-Glycoprotein, BCRP, and MRP2 in Caco-2 Cells
      Kathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yongling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner and David C. Thompson
      Drug Metabolism and Disposition February 2015, 43 (2) 199-207; DOI: https://doi.org/10.1124/dmd.114.057216

Z

  1. Zanger, Ulrich M.

    1. A Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells
      Marcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm and Ulrich M. Zanger
      Drug Metabolism and Disposition February 2015, 43 (2) 273-283; DOI: https://doi.org/10.1124/dmd.114.060962

  2. Zhang, Qing-Yu

    1. Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo
      Zhihua Liu, Lei Li, Hong Wu, Jing Hu, Jun Ma, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition February 2015, 43 (2) 208-216; DOI: https://doi.org/10.1124/dmd.114.061812
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