Advertisement
Research ArticleArticle

Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model

Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki
Drug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046

Article Information

vol. 43 no. 2 217-226
DOI 
https://doi.org/10.1124/dmd.114.060046
PubMed 
25422274
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 15, 2014
  • Accepted November 20, 2014
  • Published online December 22, 2014.

Article Versions

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kazuhiko Shirota,
  2. Makoto Kaneko,
  3. Makoto Sasaki,
  4. Kouichi Minato,
  5. Akira Fujikata,
  6. Shuji Ohta,
  7. Akihiro Hisaka1, and
  8. Hiroshi Suzuki
  1. Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
  1. Address correspondence to:
    Dr. Akihiro Hisaka, Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675, Japan. E-mail: hisaka{at}chiba-u.jp
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2017 to December 2023

AbstractFullPdf
Aug 201714016
Sep 201734815
Oct 201745515
Nov 201725411
Dec 2017035013
Jan 2018131018
Feb 2018619810
Mar 2018918117
Apr 2018111425
May 201806312
Jun 20180518
Jul 20180434
Aug 20180285
Sep 20180197
Oct 20181365
Nov 201807715
Dec 201816511
Jan 201916910
Feb 201914912
Mar 201903110
Apr 201951713
May 201912011
Jun 20191339
Jul 201903021
Aug 201901713
Oct 20191175
Nov 201911510
Dec 201952610
Jan 202062513
Feb 20200118
Mar 20200207
May 202002118
Jun 202002010
Jul 20200165
Aug 2020066
Sep 20205124
Oct 202001015
Nov 202002010
Dec 20204139
Jan 20212611
Feb 20214123
Mar 20212121
Apr 20212820
May 20211642
Jun 20211211
Jul 2021913
Aug 20214925
Sep 20211825
Oct 20211821
Nov 20211914
Dec 20212013
Jan 20221222
Feb 2022820
Mar 20222611
Apr 20222222
May 20222032
Jun 20221834
Jul 202221113
Aug 20222812
Sep 20221543
Oct 20222518
Nov 20222721
Dec 202219111
Jan 20233220
Feb 20231716
Mar 20231510
Apr 202311112
May 20233123
Jun 20231121
Jul 20234516
Aug 2023916
Sep 202320312
Oct 202322213
Nov 20232217
Dec 2023920

Back to top

In this issue

Download PDF
Article Alerts
Email Article
Citation Tools

Research ArticleArticle

Disposition of AKP-001 in Rats

Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki
Drug Metabolism and Disposition February 1, 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046
Reddit logo Twitter logo Facebook logo Mendeley logo

Jump to section

Advertisement