Research ArticleArticle
Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model
Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki
Drug Metabolism and Disposition February 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046
Kazuhiko Shirota
Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
Makoto Kaneko
Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
Makoto Sasaki
Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
Kouichi Minato
Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
Akira Fujikata
Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
Shuji Ohta
Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
Akihiro Hisaka
Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
Hiroshi Suzuki
Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

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Research ArticleArticle
Disposition of AKP-001 in Rats
Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka and Hiroshi Suzuki
Drug Metabolism and Disposition February 1, 2015, 43 (2) 217-226; DOI: https://doi.org/10.1124/dmd.114.060046
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