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Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men

Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
Drug Metabolism and Disposition February 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061

Article Information

vol. 43 no. 2 289-297
DOI 
https://doi.org/10.1124/dmd.114.060061
PubMed 
25488930
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 22, 2014
  • Accepted December 4, 2014
  • Published online December 31, 2014.

Article Versions

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ellen Scheers,
  2. Laurent Leclercq,
  3. Jan de Jong,
  4. Nini Bode,
  5. Marc Bockx,
  6. Aline Laenen,
  7. Filip Cuyckens,
  8. Donna Skee,
  9. Joe Murphy,
  10. Juthamas Sukbuntherng, and
  11. Geert Mannens
  1. Pharmacokinetics, Dynamics and Metabolism, Janssen R&D, Beerse, Belgium (E.S., L.L., M.B., A.L., F.C., G.M.); Clinical Pharmacology, Janssen R&D, San Diego, California (J.d.J.); Pre-Clinical Project Development, Janssen R&D, Beerse, Belgium (N.B.); Clinical Pharmacology, Janssen R&D, Raritan, New Jersey (D.S., J.M.); and Pharmacyclics, Sunnyvale, California (J.S.)
  1. Address correspondence to:
    Geert Mannens, Senior Scientific Director & Fellow, Pharmacokinetics, Dynamics and Metabolism, Janssen R&D, Turnhoutseweg 30, B-2340 Beerse, Belgium. E-mail: gmannens{at}its.jnj.com
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Research ArticleArticle

Absorption, Metabolism, and Excretion of Ibrutinib

Ellen Scheers, Laurent Leclercq, Jan de Jong, Nini Bode, Marc Bockx, Aline Laenen, Filip Cuyckens, Donna Skee, Joe Murphy, Juthamas Sukbuntherng and Geert Mannens
Drug Metabolism and Disposition February 1, 2015, 43 (2) 289-297; DOI: https://doi.org/10.1124/dmd.114.060061
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