Table of Contents

Articles

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  Characterization of Phase I Metabolism of Resibufogenin and Evaluation of the Metabolic Effects on Its Antitumor Activity and Toxicity

  Jing Ning, Zhen-Long Yu, Liang-Hai Hu, Chao Wang, Xiao-Kui Huo, Sa Deng, Jie Hou, Jing-Jing Wu, Guang-Bo Ge, Xiao-Chi Ma and Ling Yang

  Drug Metabolism and Disposition March 2015, 43 (3) 299-308; DOI: https://doi.org/10.1124/dmd.114.060996
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  Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice with Humanized Livers

  Hidetaka Kamimura, Satoshi Ito, Kohei Nozawa, Shota Nakamura, Hiroyuki Chijiwa, Shin-ichiro Nagatsuka, Miyuki Kuronuma, Yasuyuki Ohnishi, Hiroshi Suemizu and Shin-ichi Ninomiya

  Drug Metabolism and Disposition March 2015, 43 (3) 309-316; DOI: https://doi.org/10.1124/dmd.114.061689
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  Therapeutic Efficacy of Wuzhi Tablet (Schisandra sphenanthera Extract) on Acetaminophen-Induced Hepatotoxicity through a Mechanism Distinct from N-Acetylcysteine

  Xiaomei Fan, Pan Chen, Yiming Jiang, Ying Wang, Huasen Tan, Hang Zeng, Yongtao Wang, Aijuan Qu, Frank J. Gonzalez, Min Huang and Huichang Bi

  Drug Metabolism and Disposition March 2015, 43 (3) 317-324; DOI: https://doi.org/10.1124/dmd.114.062067
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  Prediction of Renal Transporter Mediated Drug-Drug Interactions for Pemetrexed Using Physiologically Based Pharmacokinetic Modeling

  Maria M. Posada, James A. Bacon, Karen B. Schneck, Rommel G. Tirona, Richard B. Kim, J. William Higgins, Y. Anne Pak, Stephen D. Hall and Kathleen M. Hillgren

  Drug Metabolism and Disposition March 2015, 43 (3) 325-334; DOI: https://doi.org/10.1124/dmd.114.059618
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  Pregnane X Receptor Modulates the Inflammatory Response in Primary Cultures of Hepatocytes

  Mengxi Sun, Wenqi Cui, Sarah K. Woody and Jeff L. Staudinger

  Drug Metabolism and Disposition March 2015, 43 (3) 335-343; DOI: https://doi.org/10.1124/dmd.114.062307
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  Stereoselective Inhibition of Human Butyrylcholinesterase by the Enantiomers of Bambuterol and Their Intermediates

  Marco Pistolozzi, Huaqiao Du, Hong Wei and Wen Tan

  Drug Metabolism and Disposition March 2015, 43 (3) 344-352; DOI: https://doi.org/10.1124/dmd.114.060251
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  Identification of 2-Aminothiazolobenzazepine Metabolites in Human, Rat, Dog, and Monkey Microsomes by Ion-Molecule Reactions in Linear Quadrupole Ion Trap Mass Spectrometry

  Minli Zhang, Ryan Eismin, Hilkka Kenttämaa, Hui Xiong, Ye Wu, Doug Burdette and Rebecca Urbanek

  Drug Metabolism and Disposition March 2015, 43 (3) 358-366; DOI: https://doi.org/10.1124/dmd.114.061978
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  Interspecies Variability in Expression of Hepatobiliary Transporters across Human, Dog, Monkey, and Rat as Determined by Quantitative Proteomics

  Li Wang, Bhagwat Prasad, Laurent Salphati, Xiaoyan Chu, Anshul Gupta, Cornelis E.C.A. Hop, Raymond Evers and Jashvant D. Unadkat

  Drug Metabolism and Disposition March 2015, 43 (3) 367-374; DOI: https://doi.org/10.1124/dmd.114.061580
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  The Role of Extrahepatic Metabolism in the Pharmacokinetics of the Targeted Covalent Inhibitors Afatinib, Ibrutinib, and Neratinib

  Yoshihiro Shibata and Masato Chiba

  Drug Metabolism and Disposition March 2015, 43 (3) 375-384; DOI: https://doi.org/10.1124/dmd.114.061424
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  Mg²⁺/Mn²⁺-Dependent Phosphatase 1A Is Involved in Regulating Pregnane X Receptor–Mediated Cytochrome p450 3A4 Gene Expression

  Satyanarayana R. Pondugula, Patrick C. Flannery, Udayan Apte, Jeganathan Ramesh Babu, Thangiah Geetha, Shraddha D. Rege, Taosheng Chen and Kodye L. Abbott

  Drug Metabolism and Disposition March 2015, 43 (3) 385-391; DOI: https://doi.org/10.1124/dmd.114.062083
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  Conversions of Tricyclic Antidepressants and Antipsychotics with Selected P450s from Sorangium cellulosum So ce56

  Martin Litzenburger, Fredy Kern, Yogan Khatri and Rita Bernhardt

  Drug Metabolism and Disposition March 2015, 43 (3) 392-399; DOI: https://doi.org/10.1124/dmd.114.061937
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  Are Capecitabine and the Active Metabolite 5-FU CNS Penetrable to Treat Breast Cancer Brain Metastasis?

  Jinqiang Zhang, Lingli Zhang, Yumei Yan, Shaorong Li, Liang Xie, Wei Zhong, Jing Lv, Xiuhua Zhang, Yu Bai and Ziqiang Cheng

  Drug Metabolism and Disposition March 2015, 43 (3) 411-417; DOI: https://doi.org/10.1124/dmd.114.061820
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  The Allosteric Binding Sites of Sulfotransferase 1A1

  Ian Cook, Ting Wang, Charles N. Falany and Thomas S. Leyh

  Drug Metabolism and Disposition March 2015, 43 (3) 418-423; DOI: https://doi.org/10.1124/dmd.114.061887