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Research ArticleArticle

The Role of Extrahepatic Metabolism in the Pharmacokinetics of the Targeted Covalent Inhibitors Afatinib, Ibrutinib, and Neratinib

Yoshihiro Shibata and Masato Chiba
Drug Metabolism and Disposition March 2015, 43 (3) 375-384; DOI: https://doi.org/10.1124/dmd.114.061424

Article Information

vol. 43 no. 3 375-384
DOI 
https://doi.org/10.1124/dmd.114.061424
PubMed 
25504185
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 30, 2014
  • Accepted December 10, 2014
  • Published online January 24, 2015.

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Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yoshihiro Shibata and
  2. Masato Chiba
  1. Discovery Drug Metabolism and Pharmacokinetics, Pharmacokinetics Research Laboratories, Tsukuba Research Center, Taiho Pharmaceutical Co. Ltd., Ibaraki, Japan
  1. Address correspondence to:
    Dr. Yoshihiro Shibata, Discovery Drug Metabolism and Pharmacokinetics, Pharmacokinetics Research Laboratories, Tsukuba Research Center, Taiho Pharmaceutical Co. Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan. E-mail: yoshi-shibata{at}taiho.co.jp
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Research ArticleArticle

Pharmacokinetics of Targeted Covalent Inhibitors

Yoshihiro Shibata and Masato Chiba
Drug Metabolism and Disposition March 1, 2015, 43 (3) 375-384; DOI: https://doi.org/10.1124/dmd.114.061424
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