The Role of Extrahepatic Metabolism in the Pharmacokinetics of the Targeted Covalent Inhibitors Afatinib, Ibrutinib, and Neratinib | Drug Metabolism & Disposition

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Article Information

vol. 43 no. 3 375-384

DOI

https://doi.org/10.1124/dmd.114.061424

PubMed

Published By

American Society for Pharmacology and Experimental Therapeutics

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Online ISSN

History

Received September 30, 2014
Accepted December 10, 2014
Published online January 24, 2015.

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Earlier version (December 10, 2014 - 07:18).
You are viewing the most recent version of this article.

Copyright & Usage

Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

Yoshihiro Shibata and
Masato Chiba

Discovery Drug Metabolism and Pharmacokinetics, Pharmacokinetics Research Laboratories, Tsukuba Research Center, Taiho Pharmaceutical Co. Ltd., Ibaraki, Japan

Address correspondence to:
Dr. Yoshihiro Shibata, Discovery Drug Metabolism and Pharmacokinetics, Pharmacokinetics Research Laboratories, Tsukuba Research Center, Taiho Pharmaceutical Co. Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan. E-mail: yoshi-shibata{at}taiho.co.jp

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	Abstract	Full	Pdf
Dec 2014	391	0	179
Jan 2015	521	20	174
Feb 2015	648	48	239
Mar 2015	323	38	101
Apr 2015	161	24	62
May 2015	135	22	42
Jun 2015	114	15	45
Jul 2015	91	27	43
Aug 2015	52	41	35
Sep 2015	89	30	34
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Jul 2016	43	34	67
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Jun 2017	15	69	71
Jul 2017	14	52	79
Aug 2017	9	39	42
Sep 2017	11	61	85
Oct 2017	15	83	61
Nov 2017	10	80	63
Dec 2017	17	54	44
Jan 2018	6	95	73
Feb 2018	19	91	90
Mar 2018	7	75	71
Apr 2018	14	64	59
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Jun 2018	14	78	75
Jul 2018	6	62	43
Aug 2018	13	48	36
Sep 2018	5	105	61
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Dec 2018	2	108	29
Jan 2019	21	145	49
Feb 2019	15	128	48
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Apr 2019	12	53	49
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Jun 2019	9	49	38
Jul 2019	7	49	32
Aug 2019	11	47	49
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Jan 2020	11	77	48
Feb 2020	11	45	44
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May 2020	6	53	57
Jun 2020	9	101	49
Jul 2020	5	68	49
Aug 2020	7	40	43
Sep 2020	10	88	48
Oct 2020	7	58	57
Nov 2020	14	82	65
Dec 2020	16	52	31
Jan 2021	25	39	28
Feb 2021	111	26	26

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