Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleArticle

The Role of Extrahepatic Metabolism in the Pharmacokinetics of the Targeted Covalent Inhibitors Afatinib, Ibrutinib, and Neratinib

Yoshihiro Shibata and Masato Chiba
Drug Metabolism and Disposition March 2015, 43 (3) 375-384; DOI: https://doi.org/10.1124/dmd.114.061424
Yoshihiro Shibata
Discovery Drug Metabolism and Pharmacokinetics, Pharmacokinetics Research Laboratories, Tsukuba Research Center, Taiho Pharmaceutical Co. Ltd., Ibaraki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masato Chiba
Discovery Drug Metabolism and Pharmacokinetics, Pharmacokinetics Research Laboratories, Tsukuba Research Center, Taiho Pharmaceutical Co. Ltd., Ibaraki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF
Loading

Article Information

vol. 43 no. 3 375-384
DOI 
https://doi.org/10.1124/dmd.114.061424
PubMed 
25504185

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 30, 2014
  • Accepted December 10, 2014
  • Published online January 24, 2015.

Article Versions

  • Earlier version (December 10, 2014 - 07:18).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yoshihiro Shibata and
  2. Masato Chiba
  1. Discovery Drug Metabolism and Pharmacokinetics, Pharmacokinetics Research Laboratories, Tsukuba Research Center, Taiho Pharmaceutical Co. Ltd., Ibaraki, Japan
  1. Address correspondence to:
    Dr. Yoshihiro Shibata, Discovery Drug Metabolism and Pharmacokinetics, Pharmacokinetics Research Laboratories, Tsukuba Research Center, Taiho Pharmaceutical Co. Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan. E-mail: yoshi-shibata{at}taiho.co.jp
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2017 to March 2023

AbstractFullPdf
Aug 201793942
Sep 2017115779
Oct 2017158361
Nov 2017108063
Dec 2017175444
Jan 201869573
Feb 2018199190
Mar 201877571
Apr 2018146459
May 201896240
Jun 2018147875
Jul 201866243
Aug 2018134836
Sep 2018510561
Oct 20181512139
Nov 20182015348
Dec 2018210829
Jan 20192114549
Feb 20191512848
Mar 201977632
Apr 2019125349
May 201927032
Jun 201994938
Jul 201974932
Aug 2019114749
Oct 2019166250
Nov 201958038
Dec 201984247
Jan 2020117748
Feb 2020114544
Mar 202065851
May 202065357
Jun 2020910149
Jul 202056849
Aug 202073538
Sep 2020108848
Oct 202075857
Nov 2020148265
Dec 2020165231
Jan 2021253928
Feb 20211132726
Mar 2021951221
Apr 2021541416
May 20211431622
Jun 2021901720
Jul 2021791324
Aug 2021832827
Sep 202165816
Oct 2021901419
Nov 202186829
Dec 2021931922
Jan 2022893443
Feb 2022841919
Mar 20221142528
Apr 20221511629
May 20221001918
Jun 2022922119
Jul 20221092036
Aug 20221052430
Sep 2022951416
Oct 20221001819
Nov 2022105918
Dec 20221011619
Jan 20231001326
Feb 2023881729
Mar 2023962019

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 43 (3)
Drug Metabolism and Disposition
Vol. 43, Issue 3
1 Mar 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
The Role of Extrahepatic Metabolism in the Pharmacokinetics of the Targeted Covalent Inhibitors Afatinib, Ibrutinib, and Neratinib
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Pharmacokinetics of Targeted Covalent Inhibitors

Yoshihiro Shibata and Masato Chiba
Drug Metabolism and Disposition March 1, 2015, 43 (3) 375-384; DOI: https://doi.org/10.1124/dmd.114.061424

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Pharmacokinetics of Targeted Covalent Inhibitors

Yoshihiro Shibata and Masato Chiba
Drug Metabolism and Disposition March 1, 2015, 43 (3) 375-384; DOI: https://doi.org/10.1124/dmd.114.061424
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • AKRs and GUSs in Testosterone Disposition
  • Olanzapine Glucuronidation in Humanized Mice
  • rs2242480 Regulates the Expression of CYP3A4 and CYP3A5
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics