Drug Metabolism and Disposition: 43 (4)

April 01, 2015; Volume 43,Issue 4

Perspective

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Contribution of Metabolites to P450 Inhibition–Based Drug–Drug Interactions: Scholarship from the Drug Metabolism Leadership Group of the Innovation and Quality Consortium Metabolite Group
Hongbin Yu, Suresh K. Balani, Weichao Chen, Donghui Cui, Ling He, W. Griffith Humphreys, Jialin Mao, W. George Lai, Anthony J. Lee, Heng-Keang Lim, Christopher MacLauchlin, Chandra Prakash, Sekhar Surapaneni, Susanna Tse, Alana Upthagrove, Robert L. Walsky, Bo Wen and Zhaopie Zeng

Drug Metabolism and Disposition April 2015, 43 (4) 620-630; DOI: https://doi.org/10.1124/dmd.114.059345

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Breast Cancer Resistance Protein (ABCG2) in Clinical Pharmacokinetics and Drug Interactions: Practical Recommendations for Clinical Victim and Perpetrator Drug-Drug Interaction Study Design
Caroline A. Lee, Meeghan A. O’Connor, Tasha K. Ritchie, Aleksandra Galetin, Jack A. Cook, Isabelle Ragueneau-Majlessi, Harma Ellens, Bo Feng, Mitchell E. Taub, Mary F. Paine, Joseph W. Polli, Joseph A. Ware and Maciej J. Zamek-Gliszczynski

Drug Metabolism and Disposition April 2015, 43 (4) 490-509; DOI: https://doi.org/10.1124/dmd.114.062174

Short Communications

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Associations of HSD11B1 Polymorphisms with Tacrolimus Concentrations in Chinese Renal Transplant Recipients with Prednisone Combined Therapy
Xiaoman Liu, Jiali Li, Qian Fu, Shu Liu, Yu Zhang, Xueding Wang, Hongyang Wang, Jun Li, Chen Zhu, Changxi Wang and Min Huang

Drug Metabolism and Disposition April 2015, 43 (4) 455-458; DOI: https://doi.org/10.1124/dmd.114.062117
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Impact on Creatinine Renal Clearance by the Interplay of Multiple Renal Transporters: A Case Study with INCB039110
Yan Zhang, Mark S. Warren, Xuexiang Zhang, Sharon Diamond, Bill Williams, Naresh Punwani, Jane Huang, Yong Huang and Swamy Yeleswaram

Drug Metabolism and Disposition April 2015, 43 (4) 485-489; DOI: https://doi.org/10.1124/dmd.114.060673

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PBPK Modeling to Unravel Nonlinear Pharmacokinetics of Verapamil to Estimate the Fractional Clearance for Verapamil N-Demethylation in the Recirculating Rat Liver Preparation
Qi Joy Yang, Luqin Si, Hui Tang, Helle H. Sveigaard, Edwin C. Y. Chow and K. Sandy Pang

Drug Metabolism and Disposition April 2015, 43 (4) 631-645; DOI: https://doi.org/10.1124/dmd.114.062265

Articles

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Meta-Analysis of Expression of Hepatic Organic Anion–Transporting Polypeptide (OATP) Transporters in Cellular Systems Relative to Human Liver Tissue
Justine Badée, Brahim Achour, Amin Rostami-Hodjegan and Aleksandra Galetin

Drug Metabolism and Disposition April 2015, 43 (4) 424-432; DOI: https://doi.org/10.1124/dmd.114.062034
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Characterization of Chrysin Glucuronidation in UGT1A1-Overexpressing HeLa Cells: Elucidating the Transporters Responsible for Efflux of Glucuronide
Enxi Quan, Huailing Wang, Dong Dong, Xingwang Zhang and Baojian Wu

Drug Metabolism and Disposition April 2015, 43 (4) 433-443; DOI: https://doi.org/10.1124/dmd.114.061598
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Mechanism-Based Inhibitory and Peroxisome Proliferator-Activated Receptor α–Dependent Modulating Effects of Silybin on Principal Hepatic Drug-Metabolizing Enzymes
Hong Wang, Tingting Yan, Yuan Xie, Min Zhao, Yuan Che, Jun Zhang, Huiying Liu, Lijuan Cao, Xuefang Cheng, Yang Xie, Feiyan Li, Qu Qi, Guangji Wang and Haiping Hao

Drug Metabolism and Disposition April 2015, 43 (4) 444-454; DOI: https://doi.org/10.1124/dmd.114.061622
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Utility of Bilirubins and Bile Acids as Endogenous Biomarkers for the Inhibition of Hepatic Transporters
Tomoko Watanabe, Manami Miyake, Toshinobu Shimizu, Miho Kamezawa, Naoya Masutomi, Takesada Shimura and Rikiya Ohashi

Drug Metabolism and Disposition April 2015, 43 (4) 459-466; DOI: https://doi.org/10.1124/dmd.114.061051
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Conjugation and Deconjugation Reactions within the Fetoplacental Compartment in a Sheep Model: A Key Factor Determining Bisphenol A Fetal Exposure
Tanguy Corbel, Elisabeth Perdu, Véronique Gayrard, Sylvie Puel, Marlène Z. Lacroix, Catherine Viguié, Pierre-Louis Toutain, Daniel Zalko and Nicole Picard-Hagen

Drug Metabolism and Disposition April 2015, 43 (4) 467-476; DOI: https://doi.org/10.1124/dmd.114.061291
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Dipeptidyl Peptidase-4 Greatly Contributes to the Hydrolysis of Vildagliptin in Human Liver
Mitsutoshi Asakura, Hideaki Fujii, Koichiro Atsuda, Tomoo Itoh and Ryoichi Fujiwara

Drug Metabolism and Disposition April 2015, 43 (4) 477-484; DOI: https://doi.org/10.1124/dmd.114.062331
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Physiologically Based Pharmacokinetic Modeling for Sequential Metabolism: Effect of CYP2C19 Genetic Polymorphism on Clopidogrel and Clopidogrel Active Metabolite Pharmacokinetics
Nassim Djebli, David Fabre, Xavier Boulenc, Gérard Fabre, Eric Sultan and Fabrice Hurbin

Drug Metabolism and Disposition April 2015, 43 (4) 510-522; DOI: https://doi.org/10.1124/dmd.114.062596
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A Long-Standing Mystery Solved: The Formation of 3-Hydroxydesloratadine Is Catalyzed by CYP2C8 But Prior Glucuronidation of Desloratadine by UDP-Glucuronosyltransferase 2B10 Is an Obligatory Requirement
Faraz Kazmi, Joanna E. Barbara, Phyllis Yerino and Andrew Parkinson

Drug Metabolism and Disposition April 2015, 43 (4) 523-533; DOI: https://doi.org/10.1124/dmd.114.062620
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Hydrastine Pharmacokinetics and Metabolism after a Single Oral Dose of Goldenseal (Hydrastis canadensis) to Humans
Prem K. Gupta, Gary Barone, Bill J. Gurley, E. Kim Fifer and Howard P. Hendrickson

Drug Metabolism and Disposition April 2015, 43 (4) 534-552; DOI: https://doi.org/10.1124/dmd.114.059410
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Structural Modifications at the C-4 Position Strongly Affect the Glucuronidation of 6,7-Dihydroxycoumarins
Yang-Liu Xia, Guang-Bo Ge, Ping Wang, Si-Cheng Liang, Yu-Qi He, Jing Ning, Xing-Kai Qian, Yan Li and Ling Yang

Drug Metabolism and Disposition April 2015, 43 (4) 553-560; DOI: https://doi.org/10.1124/dmd.114.060681
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In Vitro and In Vivo Characterization of 13 CYP2C9 Allelic Variants Found in Chinese Han Population
Guo-Xin Hu, Pei-Pei Pan, Zeng-Shou Wang, Li-Ping Yang, Da-Peng Dai, Shuang-Hu Wang, Guang-Hui Zhu, Xiang-Jun Qiu, Tao Xu, Jun Luo, Qing-Quan Lian, Ren-Shan Ge and Jian-Ping Cai

Drug Metabolism and Disposition April 2015, 43 (4) 561-569; DOI: https://doi.org/10.1124/dmd.114.061200
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Enantioselective Pharmacokinetics of Primaquine in Healthy Human Volunteers
Babu L. Tekwani, Bharathi Avula, Rajnish Sahu, Narayan D. Chaurasiya, Shabana I. Khan, Surendra Jain, Pius S. Fasinu, H.M.T. Bandara Herath, Donald Stanford, N.P. Dhammika Nanayakkara, James D. McChesney, Travis W. Yates, Mahmoud A. ElSohly, Ikhlas A. Khan and Larry A. Walker

Drug Metabolism and Disposition April 2015, 43 (4) 571-577; DOI: https://doi.org/10.1124/dmd.114.061127
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Identification of Glutathione Conjugates of Acetylene-Containing Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Xiaoliang Zhuo, Xiaohua Stella Huang, Andrew P. Degnan, Lawrence B. Snyder, Fukang Yang, Hong Huang, Yue-Zhong Shu and Benjamin M. Johnson

Drug Metabolism and Disposition April 2015, 43 (4) 578-589; DOI: https://doi.org/10.1124/dmd.114.061879
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A New Physiologically Based Pharmacokinetic Model for the Prediction of Gastrointestinal Drug Absorption: Translocation Model
Hirotaka Ando, Akihiro Hisaka and Hiroshi Suzuki

Drug Metabolism and Disposition April 2015, 43 (4) 590-602; DOI: https://doi.org/10.1124/dmd.114.060038
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Generation of Enterocyte-Like Cells with Pharmacokinetic Functions from Human Induced Pluripotent Stem Cells Using Small-Molecule Compounds
Takahiro Iwao, Nao Kodama, Yuki Kondo, Tomoki Kabeya, Katsunori Nakamura, Takashi Horikawa, Takuro Niwa, Kouichi Kurose and Tamihide Matsunaga

Drug Metabolism and Disposition April 2015, 43 (4) 603-610; DOI: https://doi.org/10.1124/dmd.114.062604
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Quantitative Profiling of Human Renal UDP-glucuronosyltransferases and Glucuronidation Activity: A Comparison of Normal and Tumoral Kidney Tissues
Guillaume Margaillan, Michèle Rouleau, John K. Fallon, Patrick Caron, Lyne Villeneuve, Véronique Turcotte, Philip C. Smith, Melanie S. Joy and Chantal Guillemette

Drug Metabolism and Disposition April 2015, 43 (4) 611-619; DOI: https://doi.org/10.1124/dmd.114.062877

Erratum

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Correction to: “Imperatorin Is a Mechanism-Based Inactivator of CYP2B6”
Drug Metabolism and Disposition April 2015, 43 (4) 570; DOI: https://doi.org/10.1124/dmd.115.060558err

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