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Research ArticleArticle

Physiologically Based Pharmacokinetic Modeling for Sequential Metabolism: Effect of CYP2C19 Genetic Polymorphism on Clopidogrel and Clopidogrel Active Metabolite Pharmacokinetics

Nassim Djebli, David Fabre, Xavier Boulenc, Gérard Fabre, Eric Sultan and Fabrice Hurbin
Drug Metabolism and Disposition April 2015, 43 (4) 510-522; DOI: https://doi.org/10.1124/dmd.114.062596
Nassim Djebli
Sanofi R&D, Drug Disposition, Disposition Safety and Animal Research, Montpellier, France
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David Fabre
Sanofi R&D, Drug Disposition, Disposition Safety and Animal Research, Montpellier, France
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Xavier Boulenc
Sanofi R&D, Drug Disposition, Disposition Safety and Animal Research, Montpellier, France
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Gérard Fabre
Sanofi R&D, Drug Disposition, Disposition Safety and Animal Research, Montpellier, France
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Eric Sultan
Sanofi R&D, Drug Disposition, Disposition Safety and Animal Research, Montpellier, France
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Fabrice Hurbin
Sanofi R&D, Drug Disposition, Disposition Safety and Animal Research, Montpellier, France
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Article Information

vol. 43 no. 4 510-522
DOI 
https://doi.org/10.1124/dmd.114.062596
PubMed 
25609219

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 9, 2014
  • Accepted January 21, 2015
  • Published online February 20, 2015.

Article Versions

  • Earlier version (January 21, 2015 - 06:56).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Nassim Djebli,
  2. David Fabre,
  3. Xavier Boulenc,
  4. Gérard Fabre,
  5. Eric Sultan, and
  6. Fabrice Hurbin
  1. Sanofi R&D, Drug Disposition, Disposition Safety and Animal Research, Montpellier, France
  1. Address correspondence to:
    Dr. Nassim Djebli, Drug Disposition, Disposition Safety and Animal Research, Sanofi Recherche et Développement, 371 rue du Professeur Blayac, Montpellier, France. E-mail: nassim.djebli{at}sanofi.com
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Drug Metabolism and Disposition: 43 (4)
Drug Metabolism and Disposition
Vol. 43, Issue 4
1 Apr 2015
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Research ArticleArticle

PBPK Modeling for Clopidogrel and Its Active Metabolite

Nassim Djebli, David Fabre, Xavier Boulenc, Gérard Fabre, Eric Sultan and Fabrice Hurbin
Drug Metabolism and Disposition April 1, 2015, 43 (4) 510-522; DOI: https://doi.org/10.1124/dmd.114.062596

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Research ArticleArticle

PBPK Modeling for Clopidogrel and Its Active Metabolite

Nassim Djebli, David Fabre, Xavier Boulenc, Gérard Fabre, Eric Sultan and Fabrice Hurbin
Drug Metabolism and Disposition April 1, 2015, 43 (4) 510-522; DOI: https://doi.org/10.1124/dmd.114.062596
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