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Physiologically Based Pharmacokinetic Modeling for Sequential Metabolism: Effect of CYP2C19 Genetic Polymorphism on Clopidogrel and Clopidogrel Active Metabolite Pharmacokinetics

Nassim Djebli, David Fabre, Xavier Boulenc, Gérard Fabre, Eric Sultan and Fabrice Hurbin
Drug Metabolism and Disposition April 2015, 43 (4) 510-522; DOI: https://doi.org/10.1124/dmd.114.062596

Article Information

vol. 43 no. 4 510-522
DOI 
https://doi.org/10.1124/dmd.114.062596
PubMed 
25609219
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 9, 2014
  • Accepted January 21, 2015
  • Published online February 20, 2015.

Article Versions

Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Nassim Djebli,
  2. David Fabre,
  3. Xavier Boulenc,
  4. Gérard Fabre,
  5. Eric Sultan, and
  6. Fabrice Hurbin
  1. Sanofi R&D, Drug Disposition, Disposition Safety and Animal Research, Montpellier, France
  1. Address correspondence to:
    Dr. Nassim Djebli, Drug Disposition, Disposition Safety and Animal Research, Sanofi Recherche et Développement, 371 rue du Professeur Blayac, Montpellier, France. E-mail: nassim.djebli{at}sanofi.com
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PBPK Modeling for Clopidogrel and Its Active Metabolite

Nassim Djebli, David Fabre, Xavier Boulenc, Gérard Fabre, Eric Sultan and Fabrice Hurbin
Drug Metabolism and Disposition April 1, 2015, 43 (4) 510-522; DOI: https://doi.org/10.1124/dmd.114.062596
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